Amino acid dipepetide frequency for Calocera cornea HHB12733

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.705AlaAla: 10.705 ± 0.067	1.224AlaCys: 1.224 ± 0.017	4.495AlaAsp: 4.495 ± 0.03	5.548AlaGlu: 5.548 ± 0.041	3.296AlaPhe: 3.296 ± 0.027	6.74AlaGly: 6.74 ± 0.043	2.391AlaHis: 2.391 ± 0.027	3.94AlaIle: 3.94 ± 0.032	3.691AlaLys: 3.691 ± 0.028	9.596AlaLeu: 9.596 ± 0.058	2.138AlaMet: 2.138 ± 0.021	2.656AlaAsn: 2.656 ± 0.024	6.561AlaPro: 6.561 ± 0.058	3.877AlaGln: 3.877 ± 0.036	6.265AlaArg: 6.265 ± 0.043	7.67AlaSer: 7.67 ± 0.044	5.223AlaThr: 5.223 ± 0.041	6.051AlaVal: 6.051 ± 0.044	1.435AlaTrp: 1.435 ± 0.017	2.462AlaTyr: 2.462 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	1.111CysAla: 1.111 ± 0.017	0.297CysCys: 0.297 ± 0.009	0.606CysAsp: 0.606 ± 0.012	0.591CysGlu: 0.591 ± 0.009	0.513CysPhe: 0.513 ± 0.011	0.973CysGly: 0.973 ± 0.017	0.333CysHis: 0.333 ± 0.008	0.612CysIle: 0.612 ± 0.011	0.458CysLys: 0.458 ± 0.01	1.295CysLeu: 1.295 ± 0.015	0.311CysMet: 0.311 ± 0.008	0.404CysAsn: 0.404 ± 0.01	0.808CysPro: 0.808 ± 0.013	0.42CysGln: 0.42 ± 0.011	0.876CysArg: 0.876 ± 0.014	0.952CysSer: 0.952 ± 0.015	0.822CysThr: 0.822 ± 0.013	0.834CysVal: 0.834 ± 0.012	0.243CysTrp: 0.243 ± 0.007	0.33CysTyr: 0.33 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.027AspAla: 5.027 ± 0.032	0.597AspCys: 0.597 ± 0.011	3.859AspAsp: 3.859 ± 0.037	4.391AspGlu: 4.391 ± 0.037	1.863AspPhe: 1.863 ± 0.022	4.1AspGly: 4.1 ± 0.031	1.116AspHis: 1.116 ± 0.017	2.598AspIle: 2.598 ± 0.025	1.995AspLys: 1.995 ± 0.021	4.865AspLeu: 4.865 ± 0.036	1.283AspMet: 1.283 ± 0.017	1.452AspAsn: 1.452 ± 0.015	3.477AspPro: 3.477 ± 0.03	1.601AspGln: 1.601 ± 0.019	3.022AspArg: 3.022 ± 0.024	3.295AspSer: 3.295 ± 0.028	2.727AspThr: 2.727 ± 0.027	3.86AspVal: 3.86 ± 0.03	0.98AspTrp: 0.98 ± 0.014	1.388AspTyr: 1.388 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.471GluAla: 5.471 ± 0.039	0.606GluCys: 0.606 ± 0.012	4.209GluAsp: 4.209 ± 0.039	6.002GluGlu: 6.002 ± 0.063	1.62GluPhe: 1.62 ± 0.019	4.418GluGly: 4.418 ± 0.034	1.506GluHis: 1.506 ± 0.018	2.435GluIle: 2.435 ± 0.026	3.036GluLys: 3.036 ± 0.033	5.55GluLeu: 5.55 ± 0.039	1.493GluMet: 1.493 ± 0.018	1.612GluAsn: 1.612 ± 0.016	2.97GluPro: 2.97 ± 0.032	2.484GluGln: 2.484 ± 0.021	4.624GluArg: 4.624 ± 0.038	3.407GluSer: 3.407 ± 0.028	2.855GluThr: 2.855 ± 0.027	3.82GluVal: 3.82 ± 0.032	1.024GluTrp: 1.024 ± 0.015	1.466GluTyr: 1.466 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.069PheAla: 3.069 ± 0.03	0.525PheCys: 0.525 ± 0.011	2.025PheAsp: 2.025 ± 0.021	1.903PheGlu: 1.903 ± 0.02	1.39PhePhe: 1.39 ± 0.017	2.672PheGly: 2.672 ± 0.028	0.84PheHis: 0.84 ± 0.012	1.514PheIle: 1.514 ± 0.017	1.234PheLys: 1.234 ± 0.016	3.346PheLeu: 3.346 ± 0.03	0.702PheMet: 0.702 ± 0.012	1.124PheAsn: 1.124 ± 0.014	2.099PhePro: 2.099 ± 0.024	1.2PheGln: 1.2 ± 0.014	1.904PheArg: 1.904 ± 0.019	2.618PheSer: 2.618 ± 0.026	1.952PheThr: 1.952 ± 0.019	2.283PheVal: 2.283 ± 0.023	0.6PheTrp: 0.6 ± 0.012	0.966PheTyr: 0.966 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	6.299GlyAla: 6.299 ± 0.047	0.914GlyCys: 0.914 ± 0.015	3.511GlyAsp: 3.511 ± 0.033	4.263GlyGlu: 4.263 ± 0.036	2.452GlyPhe: 2.452 ± 0.025	6.153GlyGly: 6.153 ± 0.052	1.694GlyHis: 1.694 ± 0.024	3.107GlyIle: 3.107 ± 0.027	3.424GlyLys: 3.424 ± 0.03	6.121GlyLeu: 6.121 ± 0.034	1.843GlyMet: 1.843 ± 0.021	2.145GlyAsn: 2.145 ± 0.021	3.919GlyPro: 3.919 ± 0.033	2.636GlyGln: 2.636 ± 0.025	4.865GlyArg: 4.865 ± 0.039	5.49GlySer: 5.49 ± 0.044	4.276GlyThr: 4.276 ± 0.034	4.615GlyVal: 4.615 ± 0.03	1.398GlyTrp: 1.398 ± 0.017	1.948GlyTyr: 1.948 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	2.333HisAla: 2.333 ± 0.024	0.379HisCys: 0.379 ± 0.009	1.21HisAsp: 1.21 ± 0.017	1.251HisGlu: 1.251 ± 0.016	0.86HisPhe: 0.86 ± 0.014	1.742HisGly: 1.742 ± 0.021	0.799HisHis: 0.799 ± 0.017	1.195HisIle: 1.195 ± 0.015	0.772HisLys: 0.772 ± 0.013	2.527HisLeu: 2.527 ± 0.025	0.533HisMet: 0.533 ± 0.009	0.732HisAsn: 0.732 ± 0.012	2.143HisPro: 2.143 ± 0.025	0.881HisGln: 0.881 ± 0.016	1.614HisArg: 1.614 ± 0.019	1.855HisSer: 1.855 ± 0.024	1.506HisThr: 1.506 ± 0.017	1.561HisVal: 1.561 ± 0.016	0.382HisTrp: 0.382 ± 0.009	0.674HisTyr: 0.674 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.974IleAla: 3.974 ± 0.032	0.663IleCys: 0.663 ± 0.011	2.429IleAsp: 2.429 ± 0.022	2.285IleGlu: 2.285 ± 0.02	1.599IlePhe: 1.599 ± 0.02	2.914IleGly: 2.914 ± 0.033	1.06IleHis: 1.06 ± 0.016	2.029IleIle: 2.029 ± 0.024	1.705IleLys: 1.705 ± 0.02	4.052IleLeu: 4.052 ± 0.034	0.942IleMet: 0.942 ± 0.015	1.353IleAsn: 1.353 ± 0.019	3.028IlePro: 3.028 ± 0.024	1.564IleGln: 1.564 ± 0.019	2.623IleArg: 2.623 ± 0.022	3.227IleSer: 3.227 ± 0.027	2.546IleThr: 2.546 ± 0.025	3.079IleVal: 3.079 ± 0.029	0.709IleTrp: 0.709 ± 0.011	1.133IleTyr: 1.133 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.977LysAla: 3.977 ± 0.029	0.41LysCys: 0.41 ± 0.01	2.239LysAsp: 2.239 ± 0.024	3.019LysGlu: 3.019 ± 0.029	1.12LysPhe: 1.12 ± 0.016	2.774LysGly: 2.774 ± 0.025	1.035LysHis: 1.035 ± 0.015	1.633LysIle: 1.633 ± 0.02	2.584LysLys: 2.584 ± 0.031	3.585LysLeu: 3.585 ± 0.028	0.882LysMet: 0.882 ± 0.014	1.161LysAsn: 1.161 ± 0.018	2.393LysPro: 2.393 ± 0.027	1.552LysGln: 1.552 ± 0.019	3.287LysArg: 3.287 ± 0.03	2.538LysSer: 2.538 ± 0.024	2.261LysThr: 2.261 ± 0.021	2.481LysVal: 2.481 ± 0.023	0.66LysTrp: 0.66 ± 0.011	1.111LysTyr: 1.111 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	9.12LeuAla: 9.12 ± 0.055	1.359LeuCys: 1.359 ± 0.018	5.088LeuAsp: 5.088 ± 0.034	5.442LeuGlu: 5.442 ± 0.036	3.283LeuPhe: 3.283 ± 0.032	6.229LeuGly: 6.229 ± 0.044	2.516LeuHis: 2.516 ± 0.025	3.676LeuIle: 3.676 ± 0.031	3.694LeuLys: 3.694 ± 0.033	9.632LeuLeu: 9.632 ± 0.067	1.865LeuMet: 1.865 ± 0.021	2.735LeuAsn: 2.735 ± 0.026	7.276LeuPro: 7.276 ± 0.047	3.874LeuGln: 3.874 ± 0.033	6.542LeuArg: 6.542 ± 0.043	7.709LeuSer: 7.709 ± 0.045	5.16LeuThr: 5.16 ± 0.036	5.784LeuVal: 5.784 ± 0.039	1.369LeuTrp: 1.369 ± 0.017	2.381LeuTyr: 2.381 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.105MetAla: 2.105 ± 0.02	0.272MetCys: 0.272 ± 0.007	1.324MetAsp: 1.324 ± 0.016	1.31MetGlu: 1.31 ± 0.017	0.721MetPhe: 0.721 ± 0.012	1.524MetGly: 1.524 ± 0.023	0.584MetHis: 0.584 ± 0.01	0.897MetIle: 0.897 ± 0.014	0.898MetLys: 0.898 ± 0.014	2.051MetLeu: 2.051 ± 0.021	0.56MetMet: 0.56 ± 0.012	0.657MetAsn: 0.657 ± 0.012	1.518MetPro: 1.518 ± 0.018	0.965MetGln: 0.965 ± 0.016	1.504MetArg: 1.504 ± 0.016	1.934MetSer: 1.934 ± 0.016	1.268MetThr: 1.268 ± 0.017	1.241MetVal: 1.241 ± 0.017	0.319MetTrp: 0.319 ± 0.009	0.533MetTyr: 0.533 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.927AsnAla: 2.927 ± 0.029	0.379AsnCys: 0.379 ± 0.009	1.496AsnAsp: 1.496 ± 0.017	1.498AsnGlu: 1.498 ± 0.019	1.049AsnPhe: 1.049 ± 0.015	2.56AsnGly: 2.56 ± 0.027	0.662AsnHis: 0.662 ± 0.012	1.536AsnIle: 1.536 ± 0.019	1.093AsnLys: 1.093 ± 0.016	2.705AsnLeu: 2.705 ± 0.026	0.725AsnMet: 0.725 ± 0.013	1.002AsnAsn: 1.002 ± 0.016	2.093AsnPro: 2.093 ± 0.022	0.973AsnGln: 0.973 ± 0.016	1.619AsnArg: 1.619 ± 0.018	1.952AsnSer: 1.952 ± 0.023	1.768AsnThr: 1.768 ± 0.021	2.105AsnVal: 2.105 ± 0.022	0.487AsnTrp: 0.487 ± 0.011	0.811AsnTyr: 0.811 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	7.357ProAla: 7.357 ± 0.058	0.635ProCys: 0.635 ± 0.012	3.317ProAsp: 3.317 ± 0.024	3.912ProGlu: 3.912 ± 0.035	2.199ProPhe: 2.199 ± 0.02	4.62ProGly: 4.62 ± 0.037	1.733ProHis: 1.733 ± 0.019	2.629ProIle: 2.629 ± 0.023	2.341ProLys: 2.341 ± 0.026	6.025ProLeu: 6.025 ± 0.045	1.238ProMet: 1.238 ± 0.017	2.019ProAsn: 2.019 ± 0.022	7.385ProPro: 7.385 ± 0.096	2.543ProGln: 2.543 ± 0.03	4.163ProArg: 4.163 ± 0.038	7.152ProSer: 7.152 ± 0.06	4.747ProThr: 4.747 ± 0.037	4.095ProVal: 4.095 ± 0.031	0.848ProTrp: 0.848 ± 0.012	1.683ProTyr: 1.683 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.798GlnAla: 3.798 ± 0.036	0.478GlnCys: 0.478 ± 0.009	1.761GlnAsp: 1.761 ± 0.018	2.264GlnGlu: 2.264 ± 0.023	1.143GlnPhe: 1.143 ± 0.016	2.481GlnGly: 2.481 ± 0.025	1.164GlnHis: 1.164 ± 0.016	1.549GlnIle: 1.549 ± 0.019	1.449GlnLys: 1.449 ± 0.017	3.667GlnLeu: 3.667 ± 0.035	0.879GlnMet: 0.879 ± 0.015	1.11GlnAsn: 1.11 ± 0.016	2.764GlnPro: 2.764 ± 0.037	2.44GlnGln: 2.44 ± 0.074	2.679GlnArg: 2.679 ± 0.025	2.675GlnSer: 2.675 ± 0.027	2.054GlnThr: 2.054 ± 0.019	2.141GlnVal: 2.141 ± 0.02	0.627GlnTrp: 0.627 ± 0.011	1.117GlnTyr: 1.117 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	6.277ArgAla: 6.277 ± 0.048	0.849ArgCys: 0.849 ± 0.014	3.272ArgAsp: 3.272 ± 0.03	4.215ArgGlu: 4.215 ± 0.042	2.064ArgPhe: 2.064 ± 0.021	4.25ArgGly: 4.25 ± 0.041	1.61ArgHis: 1.61 ± 0.021	2.776ArgIle: 2.776 ± 0.026	3.155ArgLys: 3.155 ± 0.029	6.252ArgLeu: 6.252 ± 0.039	1.533ArgMet: 1.533 ± 0.022	1.843ArgAsn: 1.843 ± 0.02	4.401ArgPro: 4.401 ± 0.042	2.552ArgGln: 2.552 ± 0.025	5.801ArgArg: 5.801 ± 0.051	4.997ArgSer: 4.997 ± 0.035	3.832ArgThr: 3.832 ± 0.031	3.872ArgVal: 3.872 ± 0.027	1.134ArgTrp: 1.134 ± 0.016	1.677ArgTyr: 1.677 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	7.523SerAla: 7.523 ± 0.047	0.892SerCys: 0.892 ± 0.012	3.765SerAsp: 3.765 ± 0.028	3.592SerGlu: 3.592 ± 0.028	2.707SerPhe: 2.707 ± 0.024	5.529SerGly: 5.529 ± 0.041	1.846SerHis: 1.846 ± 0.02	3.321SerIle: 3.321 ± 0.028	2.807SerLys: 2.807 ± 0.028	7.3SerLeu: 7.3 ± 0.045	1.654SerMet: 1.654 ± 0.02	2.259SerAsn: 2.259 ± 0.023	6.289SerPro: 6.289 ± 0.063	2.757SerGln: 2.757 ± 0.028	4.773SerArg: 4.773 ± 0.035	8.102SerSer: 8.102 ± 0.067	5.436SerThr: 5.436 ± 0.041	4.624SerVal: 4.624 ± 0.035	1.056SerTrp: 1.056 ± 0.013	1.847SerTyr: 1.847 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.701ThrAla: 5.701 ± 0.034	0.779ThrCys: 0.779 ± 0.011	2.619ThrAsp: 2.619 ± 0.023	2.759ThrGlu: 2.759 ± 0.023	2.192ThrPhe: 2.192 ± 0.023	4.133ThrGly: 4.133 ± 0.035	1.364ThrHis: 1.364 ± 0.017	2.671ThrIle: 2.671 ± 0.024	2.084ThrLys: 2.084 ± 0.02	5.699ThrLeu: 5.699 ± 0.039	1.19ThrMet: 1.19 ± 0.016	1.714ThrAsn: 1.714 ± 0.019	4.8ThrPro: 4.8 ± 0.041	1.92ThrGln: 1.92 ± 0.021	3.389ThrArg: 3.389 ± 0.027	5.197ThrSer: 5.197 ± 0.039	3.881ThrThr: 3.881 ± 0.036	3.842ThrVal: 3.842 ± 0.027	0.883ThrTrp: 0.883 ± 0.014	1.532ThrTyr: 1.532 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	5.441ValAla: 5.441 ± 0.037	0.878ValCys: 0.878 ± 0.014	3.742ValAsp: 3.742 ± 0.03	3.934ValGlu: 3.934 ± 0.036	2.318ValPhe: 2.318 ± 0.02	4.234ValGly: 4.234 ± 0.032	1.634ValHis: 1.634 ± 0.016	2.798ValIle: 2.798 ± 0.027	2.585ValLys: 2.585 ± 0.026	6.481ValLeu: 6.481 ± 0.043	1.361ValMet: 1.361 ± 0.017	1.924ValAsn: 1.924 ± 0.022	4.367ValPro: 4.367 ± 0.026	2.517ValGln: 2.517 ± 0.022	4.076ValArg: 4.076 ± 0.03	4.405ValSer: 4.405 ± 0.035	3.428ValThr: 3.428 ± 0.029	4.477ValVal: 4.477 ± 0.034	1.073ValTrp: 1.073 ± 0.016	1.728ValTyr: 1.728 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	1.387TrpAla: 1.387 ± 0.02	0.24TrpCys: 0.24 ± 0.007	0.963TrpAsp: 0.963 ± 0.016	1.008TrpGlu: 1.008 ± 0.015	0.551TrpPhe: 0.551 ± 0.011	1.031TrpGly: 1.031 ± 0.016	0.399TrpHis: 0.399 ± 0.01	0.77TrpIle: 0.77 ± 0.014	0.746TrpLys: 0.746 ± 0.012	1.459TrpLeu: 1.459 ± 0.02	0.459TrpMet: 0.459 ± 0.01	0.595TrpAsn: 0.595 ± 0.011	0.764TrpPro: 0.764 ± 0.013	0.571TrpGln: 0.571 ± 0.009	1.13TrpArg: 1.13 ± 0.016	1.153TrpSer: 1.153 ± 0.016	1.013TrpThr: 1.013 ± 0.015	0.985TrpVal: 0.985 ± 0.015	0.341TrpTrp: 0.341 ± 0.009	0.451TrpTyr: 0.451 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.36TyrAla: 2.36 ± 0.022	0.41TyrCys: 0.41 ± 0.009	1.568TyrAsp: 1.568 ± 0.019	1.423TyrGlu: 1.423 ± 0.017	1.029TyrPhe: 1.029 ± 0.015	1.998TyrGly: 1.998 ± 0.024	0.663TyrHis: 0.663 ± 0.013	1.227TyrIle: 1.227 ± 0.017	0.947TyrLys: 0.947 ± 0.016	2.526TyrLeu: 2.526 ± 0.025	0.594TyrMet: 0.594 ± 0.01	0.946TyrAsn: 0.946 ± 0.014	1.587TyrPro: 1.587 ± 0.021	0.914TyrGln: 0.914 ± 0.014	1.608TyrArg: 1.608 ± 0.018	1.75TyrSer: 1.75 ± 0.019	1.593TyrThr: 1.593 ± 0.017	1.65TyrVal: 1.65 ± 0.019	0.448TyrTrp: 0.448 ± 0.009	0.853TyrTyr: 0.853 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13078 proteins (5237295 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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