Amino acid dipepetide frequency for Mumia flava

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.333AlaAla: 20.333 ± 0.193
0.983AlaCys: 0.983 ± 0.029
9.52AlaAsp: 9.52 ± 0.1
8.155AlaGlu: 8.155 ± 0.092
3.72AlaPhe: 3.72 ± 0.059
12.675AlaGly: 12.675 ± 0.104
2.424AlaHis: 2.424 ± 0.053
4.652AlaIle: 4.652 ± 0.066
2.143AlaLys: 2.143 ± 0.061
14.327AlaLeu: 14.327 ± 0.138
2.804AlaMet: 2.804 ± 0.046
1.811AlaAsn: 1.811 ± 0.04
6.575AlaPro: 6.575 ± 0.086
3.548AlaGln: 3.548 ± 0.055
10.203AlaArg: 10.203 ± 0.103
7.094AlaSer: 7.094 ± 0.087
7.842AlaThr: 7.842 ± 0.088
12.583AlaVal: 12.583 ± 0.128
2.12AlaTrp: 2.12 ± 0.045
3.021AlaTyr: 3.021 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.857CysAla: 0.857 ± 0.027
0.077CysCys: 0.077 ± 0.007
0.445CysAsp: 0.445 ± 0.019
0.363CysGlu: 0.363 ± 0.016
0.195CysPhe: 0.195 ± 0.013
0.841CysGly: 0.841 ± 0.026
0.159CysHis: 0.159 ± 0.01
0.192CysIle: 0.192 ± 0.012
0.08CysLys: 0.08 ± 0.008
0.597CysLeu: 0.597 ± 0.022
0.089CysMet: 0.089 ± 0.009
0.109CysAsn: 0.109 ± 0.01
0.379CysPro: 0.379 ± 0.017
0.104CysGln: 0.104 ± 0.008
0.477CysArg: 0.477 ± 0.02
0.374CysSer: 0.374 ± 0.016
0.458CysThr: 0.458 ± 0.02
0.614CysVal: 0.614 ± 0.023
0.106CysTrp: 0.106 ± 0.009
0.128CysTyr: 0.128 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
10.061AspAla: 10.061 ± 0.105
0.339AspCys: 0.339 ± 0.016
5.61AspAsp: 5.61 ± 0.077
4.854AspGlu: 4.854 ± 0.065
1.485AspPhe: 1.485 ± 0.035
7.345AspGly: 7.345 ± 0.1
1.506AspHis: 1.506 ± 0.04
1.612AspIle: 1.612 ± 0.036
0.831AspLys: 0.831 ± 0.028
7.571AspLeu: 7.571 ± 0.08
0.745AspMet: 0.745 ± 0.022
0.852AspAsn: 0.852 ± 0.03
5.223AspPro: 5.223 ± 0.07
1.621AspGln: 1.621 ± 0.036
5.35AspArg: 5.35 ± 0.068
2.553AspSer: 2.553 ± 0.042
2.993AspThr: 2.993 ± 0.051
6.86AspVal: 6.86 ± 0.074
0.944AspTrp: 0.944 ± 0.027
1.189AspTyr: 1.189 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
7.371GluAla: 7.371 ± 0.095
0.292GluCys: 0.292 ± 0.016
3.059GluAsp: 3.059 ± 0.053
2.955GluGlu: 2.955 ± 0.054
1.254GluPhe: 1.254 ± 0.036
3.92GluGly: 3.92 ± 0.058
1.636GluHis: 1.636 ± 0.034
2.487GluIle: 2.487 ± 0.049
1.03GluLys: 1.03 ± 0.034
5.799GluLeu: 5.799 ± 0.083
0.94GluMet: 0.94 ± 0.025
0.928GluAsn: 0.928 ± 0.032
3.597GluPro: 3.597 ± 0.064
2.272GluGln: 2.272 ± 0.045
5.653GluArg: 5.653 ± 0.077
2.822GluSer: 2.822 ± 0.043
3.3GluThr: 3.3 ± 0.059
5.518GluVal: 5.518 ± 0.069
0.664GluTrp: 0.664 ± 0.026
1.0GluTyr: 1.0 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
3.799PheAla: 3.799 ± 0.056
0.238PheCys: 0.238 ± 0.013
2.161PheAsp: 2.161 ± 0.043
1.485PheGlu: 1.485 ± 0.04
0.882PhePhe: 0.882 ± 0.027
3.009PheGly: 3.009 ± 0.048
0.515PheHis: 0.515 ± 0.02
0.608PheIle: 0.608 ± 0.023
0.371PheLys: 0.371 ± 0.019
2.364PheLeu: 2.364 ± 0.047
0.359PheMet: 0.359 ± 0.018
0.505PheAsn: 0.505 ± 0.022
1.151PhePro: 1.151 ± 0.031
0.524PheGln: 0.524 ± 0.021
1.651PheArg: 1.651 ± 0.036
1.435PheSer: 1.435 ± 0.033
1.807PheThr: 1.807 ± 0.038
2.756PheVal: 2.756 ± 0.046
0.425PheTrp: 0.425 ± 0.02
0.576PheTyr: 0.576 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
11.049GlyAla: 11.049 ± 0.109
0.757GlyCys: 0.757 ± 0.025
6.056GlyAsp: 6.056 ± 0.076
4.864GlyGlu: 4.864 ± 0.066
2.932GlyPhe: 2.932 ± 0.048
8.284GlyGly: 8.284 ± 0.101
1.893GlyHis: 1.893 ± 0.036
3.754GlyIle: 3.754 ± 0.057
1.75GlyLys: 1.75 ± 0.043
9.264GlyLeu: 9.264 ± 0.106
1.921GlyMet: 1.921 ± 0.037
1.46GlyAsn: 1.46 ± 0.039
4.768GlyPro: 4.768 ± 0.068
2.321GlyGln: 2.321 ± 0.047
7.383GlyArg: 7.383 ± 0.082
5.633GlySer: 5.633 ± 0.08
5.929GlyThr: 5.929 ± 0.083
8.175GlyVal: 8.175 ± 0.083
1.818GlyTrp: 1.818 ± 0.037
2.224GlyTyr: 2.224 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.556HisAla: 2.556 ± 0.046
0.134HisCys: 0.134 ± 0.01
1.559HisAsp: 1.559 ± 0.035
1.132HisGlu: 1.132 ± 0.03
0.487HisPhe: 0.487 ± 0.02
2.168HisGly: 2.168 ± 0.038
0.633HisHis: 0.633 ± 0.026
0.387HisIle: 0.387 ± 0.018
0.258HisLys: 0.258 ± 0.014
2.227HisLeu: 2.227 ± 0.048
0.25HisMet: 0.25 ± 0.014
0.319HisAsn: 0.319 ± 0.016
1.556HisPro: 1.556 ± 0.034
0.55HisGln: 0.55 ± 0.021
1.81HisArg: 1.81 ± 0.035
0.731HisSer: 0.731 ± 0.023
0.986HisThr: 0.986 ± 0.022
1.948HisVal: 1.948 ± 0.037
0.263HisTrp: 0.263 ± 0.014
0.413HisTyr: 0.413 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.406IleAla: 5.406 ± 0.064
0.252IleCys: 0.252 ± 0.015
2.762IleAsp: 2.762 ± 0.044
2.314IleGlu: 2.314 ± 0.041
0.766IlePhe: 0.766 ± 0.028
3.91IleGly: 3.91 ± 0.061
0.548IleHis: 0.548 ± 0.021
0.842IleIle: 0.842 ± 0.028
0.566IleLys: 0.566 ± 0.02
2.528IleLeu: 2.528 ± 0.049
0.442IleMet: 0.442 ± 0.02
0.633IleAsn: 0.633 ± 0.023
1.726IlePro: 1.726 ± 0.036
0.666IleGln: 0.666 ± 0.022
2.166IleArg: 2.166 ± 0.039
1.674IleSer: 1.674 ± 0.032
2.351IleThr: 2.351 ± 0.045
3.432IleVal: 3.432 ± 0.055
0.39IleTrp: 0.39 ± 0.019
0.55IleTyr: 0.55 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
2.149LysAla: 2.149 ± 0.058
0.072LysCys: 0.072 ± 0.007
0.854LysAsp: 0.854 ± 0.03
0.767LysGlu: 0.767 ± 0.026
0.328LysPhe: 0.328 ± 0.018
1.239LysGly: 1.239 ± 0.036
0.36LysHis: 0.36 ± 0.016
0.697LysIle: 0.697 ± 0.027
0.712LysLys: 0.712 ± 0.051
1.367LysLeu: 1.367 ± 0.033
0.259LysMet: 0.259 ± 0.014
0.386LysAsn: 0.386 ± 0.018
1.037LysPro: 1.037 ± 0.032
0.584LysGln: 0.584 ± 0.023
1.373LysArg: 1.373 ± 0.036
0.876LysSer: 0.876 ± 0.032
0.983LysThr: 0.983 ± 0.037
1.626LysVal: 1.626 ± 0.039
0.15LysTrp: 0.15 ± 0.012
0.301LysTyr: 0.301 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
15.285LeuAla: 15.285 ± 0.157
0.649LeuCys: 0.649 ± 0.021
7.497LeuAsp: 7.497 ± 0.095
5.395LeuGlu: 5.395 ± 0.073
2.326LeuPhe: 2.326 ± 0.049
9.509LeuGly: 9.509 ± 0.104
1.9LeuHis: 1.9 ± 0.042
2.935LeuIle: 2.935 ± 0.056
1.369LeuLys: 1.369 ± 0.036
10.166LeuLeu: 10.166 ± 0.113
1.564LeuMet: 1.564 ± 0.04
1.402LeuAsn: 1.402 ± 0.035
5.295LeuPro: 5.295 ± 0.069
2.075LeuGln: 2.075 ± 0.04
8.114LeuArg: 8.114 ± 0.092
5.221LeuSer: 5.221 ± 0.057
5.999LeuThr: 5.999 ± 0.077
10.558LeuVal: 10.558 ± 0.113
1.184LeuTrp: 1.184 ± 0.029
1.542LeuTyr: 1.542 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.147MetAla: 2.147 ± 0.038
0.102MetCys: 0.102 ± 0.008
0.834MetAsp: 0.834 ± 0.025
0.674MetGlu: 0.674 ± 0.022
0.487MetPhe: 0.487 ± 0.021
1.23MetGly: 1.23 ± 0.031
0.363MetHis: 0.363 ± 0.016
0.732MetIle: 0.732 ± 0.024
0.351MetLys: 0.351 ± 0.017
1.869MetLeu: 1.869 ± 0.039
0.323MetMet: 0.323 ± 0.02
0.399MetAsn: 0.399 ± 0.017
1.079MetPro: 1.079 ± 0.029
0.428MetGln: 0.428 ± 0.017
1.455MetArg: 1.455 ± 0.03
1.509MetSer: 1.509 ± 0.034
1.69MetThr: 1.69 ± 0.03
1.406MetVal: 1.406 ± 0.034
0.207MetTrp: 0.207 ± 0.013
0.277MetTyr: 0.277 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.038AsnAla: 2.038 ± 0.042
0.096AsnCys: 0.096 ± 0.008
1.024AsnAsp: 1.024 ± 0.03
0.78AsnGlu: 0.78 ± 0.027
0.402AsnPhe: 0.402 ± 0.019
1.586AsnGly: 1.586 ± 0.048
0.326AsnHis: 0.326 ± 0.018
0.549AsnIle: 0.549 ± 0.024
0.27AsnLys: 0.27 ± 0.014
1.624AsnLeu: 1.624 ± 0.034
0.208AsnMet: 0.208 ± 0.012
0.348AsnAsn: 0.348 ± 0.017
1.316AsnPro: 1.316 ± 0.035
0.441AsnGln: 0.441 ± 0.02
1.142AsnArg: 1.142 ± 0.031
0.653AsnSer: 0.653 ± 0.023
0.884AsnThr: 0.884 ± 0.032
1.442AsnVal: 1.442 ± 0.035
0.215AsnTrp: 0.215 ± 0.014
0.33AsnTyr: 0.33 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
7.293ProAla: 7.293 ± 0.08
0.27ProCys: 0.27 ± 0.015
4.915ProAsp: 4.915 ± 0.07
3.768ProGlu: 3.768 ± 0.052
1.449ProPhe: 1.449 ± 0.031
5.424ProGly: 5.424 ± 0.076
1.113ProHis: 1.113 ± 0.027
1.672ProIle: 1.672 ± 0.037
0.9ProLys: 0.9 ± 0.029
4.541ProLeu: 4.541 ± 0.066
1.007ProMet: 1.007 ± 0.024
0.86ProAsn: 0.86 ± 0.027
3.045ProPro: 3.045 ± 0.074
1.483ProGln: 1.483 ± 0.032
3.938ProArg: 3.938 ± 0.059
3.358ProSer: 3.358 ± 0.054
3.885ProThr: 3.885 ± 0.081
5.097ProVal: 5.097 ± 0.063
0.884ProTrp: 0.884 ± 0.028
1.44ProTyr: 1.44 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
3.382GlnAla: 3.382 ± 0.055
0.142GlnCys: 0.142 ± 0.01
1.15GlnAsp: 1.15 ± 0.03
1.093GlnGlu: 1.093 ± 0.028
0.622GlnPhe: 0.622 ± 0.024
1.735GlnGly: 1.735 ± 0.039
0.64GlnHis: 0.64 ± 0.023
1.158GlnIle: 1.158 ± 0.03
0.471GlnLys: 0.471 ± 0.02
2.405GlnLeu: 2.405 ± 0.049
0.501GlnMet: 0.501 ± 0.02
0.442GlnAsn: 0.442 ± 0.019
1.549GlnPro: 1.549 ± 0.04
0.982GlnGln: 0.982 ± 0.034
2.427GlnArg: 2.427 ± 0.042
1.202GlnSer: 1.202 ± 0.033
1.389GlnThr: 1.389 ± 0.031
2.656GlnVal: 2.656 ± 0.044
0.456GlnTrp: 0.456 ± 0.018
0.516GlnTyr: 0.516 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
9.819ArgAla: 9.819 ± 0.108
0.518ArgCys: 0.518 ± 0.021
4.95ArgAsp: 4.95 ± 0.06
4.318ArgGlu: 4.318 ± 0.059
2.247ArgPhe: 2.247 ± 0.04
5.875ArgGly: 5.875 ± 0.08
1.786ArgHis: 1.786 ± 0.039
3.367ArgIle: 3.367 ± 0.056
1.258ArgLys: 1.258 ± 0.034
8.283ArgLeu: 8.283 ± 0.088
1.817ArgMet: 1.817 ± 0.035
1.212ArgAsn: 1.212 ± 0.031
4.353ArgPro: 4.353 ± 0.059
1.819ArgGln: 1.819 ± 0.04
8.002ArgArg: 8.002 ± 0.091
4.633ArgSer: 4.633 ± 0.064
5.537ArgThr: 5.537 ± 0.064
6.672ArgVal: 6.672 ± 0.085
1.526ArgTrp: 1.526 ± 0.034
1.718ArgTyr: 1.718 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.933SerAla: 6.933 ± 0.081
0.323SerCys: 0.323 ± 0.019
3.561SerAsp: 3.561 ± 0.057
2.796SerGlu: 2.796 ± 0.051
1.629SerPhe: 1.629 ± 0.036
5.844SerGly: 5.844 ± 0.069
0.889SerHis: 0.889 ± 0.029
1.78SerIle: 1.78 ± 0.039
0.839SerLys: 0.839 ± 0.028
4.876SerLeu: 4.876 ± 0.065
1.15SerMet: 1.15 ± 0.03
0.875SerAsn: 0.875 ± 0.023
2.885SerPro: 2.885 ± 0.053
1.217SerGln: 1.217 ± 0.032
3.809SerArg: 3.809 ± 0.057
3.162SerSer: 3.162 ± 0.054
3.531SerThr: 3.531 ± 0.051
4.679SerVal: 4.679 ± 0.057
0.924SerTrp: 0.924 ± 0.031
1.243SerTyr: 1.243 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
7.823ThrAla: 7.823 ± 0.084
0.425ThrCys: 0.425 ± 0.017
4.087ThrAsp: 4.087 ± 0.058
3.154ThrGlu: 3.154 ± 0.052
1.928ThrPhe: 1.928 ± 0.043
5.906ThrGly: 5.906 ± 0.079
1.131ThrHis: 1.131 ± 0.03
2.366ThrIle: 2.366 ± 0.042
1.037ThrLys: 1.037 ± 0.032
6.049ThrLeu: 6.049 ± 0.078
1.076ThrMet: 1.076 ± 0.033
1.011ThrAsn: 1.011 ± 0.027
3.858ThrPro: 3.858 ± 0.068
1.391ThrGln: 1.391 ± 0.039
4.097ThrArg: 4.097 ± 0.053
3.578ThrSer: 3.578 ± 0.059
4.419ThrThr: 4.419 ± 0.074
6.232ThrVal: 6.232 ± 0.1
1.0ThrTrp: 1.0 ± 0.027
1.57ThrTyr: 1.57 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
13.776ValAla: 13.776 ± 0.121
0.696ValCys: 0.696 ± 0.025
6.91ValAsp: 6.91 ± 0.072
5.667ValGlu: 5.667 ± 0.069
2.368ValPhe: 2.368 ± 0.046
8.306ValGly: 8.306 ± 0.089
1.806ValHis: 1.806 ± 0.044
3.144ValIle: 3.144 ± 0.052
1.344ValLys: 1.344 ± 0.035
10.304ValLeu: 10.304 ± 0.116
1.571ValMet: 1.571 ± 0.038
1.491ValAsn: 1.491 ± 0.037
5.123ValPro: 5.123 ± 0.064
1.936ValGln: 1.936 ± 0.035
7.738ValArg: 7.738 ± 0.086
4.586ValSer: 4.586 ± 0.06
6.081ValThr: 6.081 ± 0.09
11.356ValVal: 11.356 ± 0.113
1.178ValTrp: 1.178 ± 0.032
1.468ValTyr: 1.468 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.631TrpAla: 1.631 ± 0.041
0.137TrpCys: 0.137 ± 0.01
0.896TrpAsp: 0.896 ± 0.03
0.687TrpGlu: 0.687 ± 0.021
0.527TrpPhe: 0.527 ± 0.021
1.13TrpGly: 1.13 ± 0.029
0.363TrpHis: 0.363 ± 0.016
0.597TrpIle: 0.597 ± 0.022
0.278TrpLys: 0.278 ± 0.017
1.759TrpLeu: 1.759 ± 0.038
0.335TrpMet: 0.335 ± 0.016
0.309TrpAsn: 0.309 ± 0.016
0.797TrpPro: 0.797 ± 0.024
0.474TrpGln: 0.474 ± 0.022
1.254TrpArg: 1.254 ± 0.03
0.997TrpSer: 0.997 ± 0.031
1.02TrpThr: 1.02 ± 0.029
1.213TrpVal: 1.213 ± 0.03
0.41TrpTrp: 0.41 ± 0.022
0.326TrpTyr: 0.326 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.823TyrAla: 2.823 ± 0.046
0.143TyrCys: 0.143 ± 0.01
1.693TyrAsp: 1.693 ± 0.038
1.275TyrGlu: 1.275 ± 0.038
0.588TyrPhe: 0.588 ± 0.021
2.301TyrGly: 2.301 ± 0.057
0.374TyrHis: 0.374 ± 0.017
0.392TyrIle: 0.392 ± 0.016
0.264TyrLys: 0.264 ± 0.015
2.069TyrLeu: 2.069 ± 0.036
0.202TyrMet: 0.202 ± 0.012
0.323TyrAsn: 0.323 ± 0.016
1.028TyrPro: 1.028 ± 0.03
0.484TyrGln: 0.484 ± 0.019
1.67TyrArg: 1.67 ± 0.037
0.853TyrSer: 0.853 ± 0.025
1.051TyrThr: 1.051 ± 0.051
2.025TyrVal: 2.025 ± 0.037
0.276TyrTrp: 0.276 ± 0.012
0.416TyrTyr: 0.416 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4037 proteins (1354464 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski