Amino acid dipepetide frequency for Pseudoalteromonas translucida (strain TAC 125)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.1AlaAla: 8.1 ± 0.092	0.938AlaCys: 0.938 ± 0.03	4.678AlaAsp: 4.678 ± 0.069	4.635AlaGlu: 4.635 ± 0.075	3.461AlaPhe: 3.461 ± 0.064	5.977AlaGly: 5.977 ± 0.084	1.856AlaHis: 1.856 ± 0.045	6.631AlaIle: 6.631 ± 0.075	5.798AlaLys: 5.798 ± 0.104	10.176AlaLeu: 10.176 ± 0.117	2.49AlaMet: 2.49 ± 0.053	4.278AlaAsn: 4.278 ± 0.068	3.048AlaPro: 3.048 ± 0.063	4.918AlaGln: 4.918 ± 0.071	3.388AlaArg: 3.388 ± 0.055	5.358AlaSer: 5.358 ± 0.073	4.739AlaThr: 4.739 ± 0.069	5.747AlaVal: 5.747 ± 0.076	0.87AlaTrp: 0.87 ± 0.032	2.446AlaTyr: 2.446 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.792CysAla: 0.792 ± 0.028	0.154CysCys: 0.154 ± 0.011	0.594CysAsp: 0.594 ± 0.022	0.647CysGlu: 0.647 ± 0.025	0.463CysPhe: 0.463 ± 0.022	0.761CysGly: 0.761 ± 0.034	0.314CysHis: 0.314 ± 0.017	0.708CysIle: 0.708 ± 0.025	0.491CysLys: 0.491 ± 0.02	0.955CysLeu: 0.955 ± 0.029	0.214CysMet: 0.214 ± 0.016	0.415CysAsn: 0.415 ± 0.021	0.399CysPro: 0.399 ± 0.021	0.429CysGln: 0.429 ± 0.019	0.379CysArg: 0.379 ± 0.017	0.699CysSer: 0.699 ± 0.027	0.46CysThr: 0.46 ± 0.02	0.648CysVal: 0.648 ± 0.024	0.111CysTrp: 0.111 ± 0.01	0.331CysTyr: 0.331 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.533AspAla: 4.533 ± 0.069	0.495AspCys: 0.495 ± 0.021	3.323AspAsp: 3.323 ± 0.09	3.959AspGlu: 3.959 ± 0.068	2.639AspPhe: 2.639 ± 0.057	3.409AspGly: 3.409 ± 0.069	0.983AspHis: 0.983 ± 0.025	4.188AspIle: 4.188 ± 0.06	3.61AspLys: 3.61 ± 0.063	5.062AspLeu: 5.062 ± 0.077	1.296AspMet: 1.296 ± 0.037	2.547AspAsn: 2.547 ± 0.05	1.784AspPro: 1.784 ± 0.041	1.674AspGln: 1.674 ± 0.043	1.757AspArg: 1.757 ± 0.05	3.157AspSer: 3.157 ± 0.065	2.808AspThr: 2.808 ± 0.048	3.736AspVal: 3.736 ± 0.062	0.726AspTrp: 0.726 ± 0.023	2.161AspTyr: 2.161 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.344GluAla: 4.344 ± 0.072	0.44GluCys: 0.44 ± 0.022	2.396GluAsp: 2.396 ± 0.052	2.763GluGlu: 2.763 ± 0.067	2.646GluPhe: 2.646 ± 0.048	3.083GluGly: 3.083 ± 0.058	1.73GluHis: 1.73 ± 0.042	3.569GluIle: 3.569 ± 0.063	3.439GluLys: 3.439 ± 0.058	6.975GluLeu: 6.975 ± 0.088	1.327GluMet: 1.327 ± 0.036	2.642GluAsn: 2.642 ± 0.049	1.885GluPro: 1.885 ± 0.044	4.883GluGln: 4.883 ± 0.077	2.902GluArg: 2.902 ± 0.054	3.196GluSer: 3.196 ± 0.052	2.535GluThr: 2.535 ± 0.053	3.835GluVal: 3.835 ± 0.069	0.542GluTrp: 0.542 ± 0.021	1.81GluTyr: 1.81 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	4.072PheAla: 4.072 ± 0.071	0.508PheCys: 0.508 ± 0.02	2.899PheAsp: 2.899 ± 0.055	2.543PheGlu: 2.543 ± 0.051	1.733PhePhe: 1.733 ± 0.045	2.968PheGly: 2.968 ± 0.059	0.67PheHis: 0.67 ± 0.026	3.389PheIle: 3.389 ± 0.064	2.668PheLys: 2.668 ± 0.063	3.377PheLeu: 3.377 ± 0.066	1.016PheMet: 1.016 ± 0.032	2.714PheAsn: 2.714 ± 0.056	1.216PhePro: 1.216 ± 0.034	0.949PheGln: 0.949 ± 0.03	1.271PheArg: 1.271 ± 0.033	3.613PheSer: 3.613 ± 0.058	2.661PheThr: 2.661 ± 0.048	2.734PheVal: 2.734 ± 0.045	0.512PheTrp: 0.512 ± 0.024	1.5PheTyr: 1.5 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	5.292GlyAla: 5.292 ± 0.08	0.84GlyCys: 0.84 ± 0.029	3.52GlyAsp: 3.52 ± 0.068	3.922GlyGlu: 3.922 ± 0.059	3.402GlyPhe: 3.402 ± 0.062	4.401GlyGly: 4.401 ± 0.096	1.421GlyHis: 1.421 ± 0.035	4.543GlyIle: 4.543 ± 0.069	3.768GlyLys: 3.768 ± 0.061	6.77GlyLeu: 6.77 ± 0.107	1.773GlyMet: 1.773 ± 0.048	2.567GlyAsn: 2.567 ± 0.049	1.635GlyPro: 1.635 ± 0.043	2.556GlyGln: 2.556 ± 0.04	2.676GlyArg: 2.676 ± 0.058	3.903GlySer: 3.903 ± 0.063	3.235GlyThr: 3.235 ± 0.057	4.846GlyVal: 4.846 ± 0.07	0.769GlyTrp: 0.769 ± 0.027	2.402GlyTyr: 2.402 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.648HisAla: 1.648 ± 0.037	0.352HisCys: 0.352 ± 0.019	1.059HisAsp: 1.059 ± 0.033	1.019HisGlu: 1.019 ± 0.033	1.143HisPhe: 1.143 ± 0.036	1.448HisGly: 1.448 ± 0.041	0.619HisHis: 0.619 ± 0.024	1.523HisIle: 1.523 ± 0.039	1.145HisLys: 1.145 ± 0.029	2.234HisLeu: 2.234 ± 0.047	0.488HisMet: 0.488 ± 0.019	1.118HisAsn: 1.118 ± 0.039	1.077HisPro: 1.077 ± 0.035	1.083HisGln: 1.083 ± 0.029	0.82HisArg: 0.82 ± 0.027	1.564HisSer: 1.564 ± 0.036	1.199HisThr: 1.199 ± 0.033	1.227HisVal: 1.227 ± 0.033	0.299HisTrp: 0.299 ± 0.016	0.939HisTyr: 0.939 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	7.176IleAla: 7.176 ± 0.088	0.684IleCys: 0.684 ± 0.028	4.335IleAsp: 4.335 ± 0.068	4.653IleGlu: 4.653 ± 0.067	2.385IlePhe: 2.385 ± 0.049	4.417IleGly: 4.417 ± 0.074	1.101IleHis: 1.101 ± 0.031	4.407IleIle: 4.407 ± 0.07	4.491IleLys: 4.491 ± 0.074	5.554IleLeu: 5.554 ± 0.09	1.439IleMet: 1.439 ± 0.038	4.161IleAsn: 4.161 ± 0.075	2.424IlePro: 2.424 ± 0.045	1.929IleGln: 1.929 ± 0.04	2.44IleArg: 2.44 ± 0.049	4.906IleSer: 4.906 ± 0.065	4.4IleThr: 4.4 ± 0.052	4.122IleVal: 4.122 ± 0.068	0.633IleTrp: 0.633 ± 0.022	1.9IleTyr: 1.9 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	5.435LysAla: 5.435 ± 0.092	0.354LysCys: 0.354 ± 0.023	2.814LysAsp: 2.814 ± 0.051	3.202LysGlu: 3.202 ± 0.059	1.757LysPhe: 1.757 ± 0.043	3.399LysGly: 3.399 ± 0.064	1.612LysHis: 1.612 ± 0.042	3.499LysIle: 3.499 ± 0.051	3.426LysLys: 3.426 ± 0.068	6.052LysLeu: 6.052 ± 0.085	1.475LysMet: 1.475 ± 0.038	3.152LysAsn: 3.152 ± 0.061	2.398LysPro: 2.398 ± 0.051	3.753LysGln: 3.753 ± 0.063	2.832LysArg: 2.832 ± 0.059	3.548LysSer: 3.548 ± 0.063	3.375LysThr: 3.375 ± 0.057	4.194LysVal: 4.194 ± 0.066	0.546LysTrp: 0.546 ± 0.023	1.647LysTyr: 1.647 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	10.225LeuAla: 10.225 ± 0.106	1.072LeuCys: 1.072 ± 0.033	5.456LeuAsp: 5.456 ± 0.076	5.825LeuGlu: 5.825 ± 0.081	4.404LeuPhe: 4.404 ± 0.074	6.661LeuGly: 6.661 ± 0.097	2.071LeuHis: 2.071 ± 0.049	6.953LeuIle: 6.953 ± 0.095	6.226LeuLys: 6.226 ± 0.067	10.733LeuLeu: 10.733 ± 0.149	2.497LeuMet: 2.497 ± 0.051	5.761LeuAsn: 5.761 ± 0.07	4.445LeuPro: 4.445 ± 0.057	3.884LeuGln: 3.884 ± 0.066	3.833LeuArg: 3.833 ± 0.063	7.916LeuSer: 7.916 ± 0.086	6.46LeuThr: 6.46 ± 0.085	6.83LeuVal: 6.83 ± 0.092	0.977LeuTrp: 0.977 ± 0.033	2.81LeuTyr: 2.81 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.417MetAla: 2.417 ± 0.051	0.196MetCys: 0.196 ± 0.014	1.071MetAsp: 1.071 ± 0.035	0.925MetGlu: 0.925 ± 0.031	0.878MetPhe: 0.878 ± 0.032	1.561MetGly: 1.561 ± 0.042	0.527MetHis: 0.527 ± 0.024	1.378MetIle: 1.378 ± 0.039	1.191MetLys: 1.191 ± 0.033	2.702MetLeu: 2.702 ± 0.051	0.615MetMet: 0.615 ± 0.03	0.987MetAsn: 0.987 ± 0.031	1.202MetPro: 1.202 ± 0.03	1.373MetGln: 1.373 ± 0.038	1.138MetArg: 1.138 ± 0.034	1.953MetSer: 1.953 ± 0.046	1.391MetThr: 1.391 ± 0.039	1.514MetVal: 1.514 ± 0.039	0.225MetTrp: 0.225 ± 0.013	0.498MetTyr: 0.498 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	4.168AsnAla: 4.168 ± 0.069	0.514AsnCys: 0.514 ± 0.021	2.785AsnAsp: 2.785 ± 0.056	2.935AsnGlu: 2.935 ± 0.053	1.843AsnPhe: 1.843 ± 0.044	3.118AsnGly: 3.118 ± 0.064	0.975AsnHis: 0.975 ± 0.031	3.543AsnIle: 3.543 ± 0.067	3.28AsnLys: 3.28 ± 0.06	4.584AsnLeu: 4.584 ± 0.065	1.113AsnMet: 1.113 ± 0.029	3.201AsnAsn: 3.201 ± 0.073	2.083AsnPro: 2.083 ± 0.042	2.262AsnGln: 2.262 ± 0.051	1.828AsnArg: 1.828 ± 0.044	3.191AsnSer: 3.191 ± 0.063	3.157AsnThr: 3.157 ± 0.06	2.992AsnVal: 2.992 ± 0.059	0.655AsnTrp: 0.655 ± 0.025	1.744AsnTyr: 1.744 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	3.076ProAla: 3.076 ± 0.06	0.291ProCys: 0.291 ± 0.016	2.083ProAsp: 2.083 ± 0.042	2.571ProGlu: 2.571 ± 0.056	1.65ProPhe: 1.65 ± 0.037	2.196ProGly: 2.196 ± 0.058	0.841ProHis: 0.841 ± 0.028	2.544ProIle: 2.544 ± 0.049	2.047ProLys: 2.047 ± 0.04	4.07ProLeu: 4.07 ± 0.069	0.824ProMet: 0.824 ± 0.032	1.812ProAsn: 1.812 ± 0.042	0.967ProPro: 0.967 ± 0.03	1.677ProGln: 1.677 ± 0.047	1.235ProArg: 1.235 ± 0.039	2.425ProSer: 2.425 ± 0.049	1.987ProThr: 1.987 ± 0.05	2.683ProVal: 2.683 ± 0.05	0.463ProTrp: 0.463 ± 0.021	1.202ProTyr: 1.202 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.718GlnAla: 4.718 ± 0.077	0.467GlnCys: 0.467 ± 0.024	1.872GlnAsp: 1.872 ± 0.048	2.007GlnGlu: 2.007 ± 0.045	1.958GlnPhe: 1.958 ± 0.039	3.227GlnGly: 3.227 ± 0.062	1.303GlnHis: 1.303 ± 0.036	2.661GlnIle: 2.661 ± 0.053	2.212GlnLys: 2.212 ± 0.043	5.937GlnLeu: 5.937 ± 0.098	1.006GlnMet: 1.006 ± 0.029	2.004GlnAsn: 2.004 ± 0.048	1.638GlnPro: 1.638 ± 0.038	3.933GlnGln: 3.933 ± 0.102	2.104GlnArg: 2.104 ± 0.05	3.195GlnSer: 3.195 ± 0.059	2.561GlnThr: 2.561 ± 0.052	3.209GlnVal: 3.209 ± 0.055	0.666GlnTrp: 0.666 ± 0.025	1.566GlnTyr: 1.566 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.232ArgAla: 3.232 ± 0.064	0.356ArgCys: 0.356 ± 0.02	2.178ArgAsp: 2.178 ± 0.05	2.556ArgGlu: 2.556 ± 0.056	2.149ArgPhe: 2.149 ± 0.048	2.276ArgGly: 2.276 ± 0.054	0.911ArgHis: 0.911 ± 0.032	2.822ArgIle: 2.822 ± 0.051	2.172ArgLys: 2.172 ± 0.047	4.442ArgLeu: 4.442 ± 0.066	0.954ArgMet: 0.954 ± 0.033	1.706ArgAsn: 1.706 ± 0.036	1.38ArgPro: 1.38 ± 0.034	1.717ArgGln: 1.717 ± 0.041	1.854ArgArg: 1.854 ± 0.045	2.329ArgSer: 2.329 ± 0.049	1.866ArgThr: 1.866 ± 0.041	2.784ArgVal: 2.784 ± 0.051	0.5ArgTrp: 0.5 ± 0.019	1.596ArgTyr: 1.596 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.846SerAla: 5.846 ± 0.071	0.578SerCys: 0.578 ± 0.024	3.839SerAsp: 3.839 ± 0.074	3.941SerGlu: 3.941 ± 0.061	3.085SerPhe: 3.085 ± 0.054	4.493SerGly: 4.493 ± 0.072	1.509SerHis: 1.509 ± 0.038	4.335SerIle: 4.335 ± 0.061	3.676SerLys: 3.676 ± 0.06	7.027SerLeu: 7.027 ± 0.071	1.499SerMet: 1.499 ± 0.04	3.189SerAsn: 3.189 ± 0.059	2.205SerPro: 2.205 ± 0.053	3.1SerGln: 3.1 ± 0.058	2.53SerArg: 2.53 ± 0.05	4.518SerSer: 4.518 ± 0.077	3.439SerThr: 3.439 ± 0.053	4.458SerVal: 4.458 ± 0.068	0.751SerTrp: 0.751 ± 0.024	2.268SerTyr: 2.268 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.944ThrAla: 4.944 ± 0.066	0.47ThrCys: 0.47 ± 0.022	2.997ThrAsp: 2.997 ± 0.058	2.852ThrGlu: 2.852 ± 0.056	2.26ThrPhe: 2.26 ± 0.05	3.93ThrGly: 3.93 ± 0.064	1.29ThrHis: 1.29 ± 0.038	3.539ThrIle: 3.539 ± 0.065	2.766ThrLys: 2.766 ± 0.052	6.794ThrLeu: 6.794 ± 0.079	1.061ThrMet: 1.061 ± 0.029	2.466ThrAsn: 2.466 ± 0.049	2.774ThrPro: 2.774 ± 0.052	2.962ThrGln: 2.962 ± 0.059	2.219ThrArg: 2.219 ± 0.049	3.39ThrSer: 3.39 ± 0.06	3.114ThrThr: 3.114 ± 0.058	3.654ThrVal: 3.654 ± 0.06	0.572ThrTrp: 0.572 ± 0.025	1.493ThrTyr: 1.493 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	6.245ValAla: 6.245 ± 0.075	0.735ValCys: 0.735 ± 0.029	3.759ValAsp: 3.759 ± 0.068	4.05ValGlu: 4.05 ± 0.061	2.997ValPhe: 2.997 ± 0.052	4.19ValGly: 4.19 ± 0.072	1.225ValHis: 1.225 ± 0.034	4.915ValIle: 4.915 ± 0.075	3.808ValLys: 3.808 ± 0.065	6.541ValLeu: 6.541 ± 0.092	1.743ValMet: 1.743 ± 0.045	3.344ValAsn: 3.344 ± 0.053	2.376ValPro: 2.376 ± 0.046	2.195ValGln: 2.195 ± 0.04	2.468ValArg: 2.468 ± 0.055	4.557ValSer: 4.557 ± 0.062	4.06ValThr: 4.06 ± 0.06	4.645ValVal: 4.645 ± 0.073	0.637ValTrp: 0.637 ± 0.025	1.906ValTyr: 1.906 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.766TrpAla: 0.766 ± 0.028	0.12TrpCys: 0.12 ± 0.011	0.529TrpAsp: 0.529 ± 0.025	0.424TrpGlu: 0.424 ± 0.018	0.551TrpPhe: 0.551 ± 0.025	0.656TrpGly: 0.656 ± 0.026	0.336TrpHis: 0.336 ± 0.016	0.554TrpIle: 0.554 ± 0.024	0.342TrpLys: 0.342 ± 0.019	1.659TrpLeu: 1.659 ± 0.045	0.269TrpMet: 0.269 ± 0.015	0.381TrpAsn: 0.381 ± 0.02	0.434TrpPro: 0.434 ± 0.02	1.135TrpGln: 1.135 ± 0.038	0.598TrpArg: 0.598 ± 0.025	0.606TrpSer: 0.606 ± 0.025	0.384TrpThr: 0.384 ± 0.019	0.749TrpVal: 0.749 ± 0.027	0.161TrpTrp: 0.161 ± 0.012	0.357TrpTyr: 0.357 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.505TyrAla: 2.505 ± 0.054	0.399TyrCys: 0.399 ± 0.019	1.661TyrAsp: 1.661 ± 0.046	1.51TyrGlu: 1.51 ± 0.038	1.611TyrPhe: 1.611 ± 0.036	2.068TyrGly: 2.068 ± 0.046	0.711TyrHis: 0.711 ± 0.024	1.858TyrIle: 1.858 ± 0.041	1.915TyrLys: 1.915 ± 0.045	3.394TyrLeu: 3.394 ± 0.061	0.644TyrMet: 0.644 ± 0.027	1.525TyrAsn: 1.525 ± 0.037	1.274TyrPro: 1.274 ± 0.033	1.833TyrGln: 1.833 ± 0.049	1.507TyrArg: 1.507 ± 0.037	2.263TyrSer: 2.263 ± 0.048	1.715TyrThr: 1.715 ± 0.045	1.79TyrVal: 1.79 ± 0.038	0.396TyrTrp: 0.396 ± 0.017	1.183TyrTyr: 1.183 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3484 proteins (1116400 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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