Amino acid dipepetide frequency for Cupriavidus basilensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.071AlaAla: 19.071 ± 0.131	1.526AlaCys: 1.526 ± 0.028	6.612AlaAsp: 6.612 ± 0.058	6.48AlaGlu: 6.48 ± 0.058	4.277AlaPhe: 4.277 ± 0.046	12.322AlaGly: 12.322 ± 0.099	2.706AlaHis: 2.706 ± 0.034	5.624AlaIle: 5.624 ± 0.051	3.492AlaLys: 3.492 ± 0.052	14.821AlaLeu: 14.821 ± 0.102	3.879AlaMet: 3.879 ± 0.037	3.144AlaAsn: 3.144 ± 0.041	6.512AlaPro: 6.512 ± 0.071	5.928AlaGln: 5.928 ± 0.061	9.824AlaArg: 9.824 ± 0.079	7.429AlaSer: 7.429 ± 0.064	6.523AlaThr: 6.523 ± 0.063	9.107AlaVal: 9.107 ± 0.074	1.847AlaTrp: 1.847 ± 0.034	2.733AlaTyr: 2.733 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.403CysAla: 1.403 ± 0.026	0.151CysCys: 0.151 ± 0.008	0.538CysAsp: 0.538 ± 0.016	0.525CysGlu: 0.525 ± 0.015	0.347CysPhe: 0.347 ± 0.012	1.1CysGly: 1.1 ± 0.024	0.273CysHis: 0.273 ± 0.011	0.413CysIle: 0.413 ± 0.012	0.227CysLys: 0.227 ± 0.01	0.918CysLeu: 0.918 ± 0.02	0.239CysMet: 0.239 ± 0.01	0.256CysAsn: 0.256 ± 0.011	0.476CysPro: 0.476 ± 0.015	0.298CysGln: 0.298 ± 0.01	0.658CysArg: 0.658 ± 0.017	0.506CysSer: 0.506 ± 0.014	0.476CysThr: 0.476 ± 0.015	0.731CysVal: 0.731 ± 0.018	0.131CysTrp: 0.131 ± 0.008	0.235CysTyr: 0.235 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.235AspAla: 7.235 ± 0.064	0.469AspCys: 0.469 ± 0.016	2.584AspAsp: 2.584 ± 0.036	2.801AspGlu: 2.801 ± 0.035	1.952AspPhe: 1.952 ± 0.031	4.617AspGly: 4.617 ± 0.051	1.062AspHis: 1.062 ± 0.02	2.468AspIle: 2.468 ± 0.037	1.625AspLys: 1.625 ± 0.032	5.033AspLeu: 5.033 ± 0.043	1.299AspMet: 1.299 ± 0.024	1.287AspAsn: 1.287 ± 0.024	2.972AspPro: 2.972 ± 0.039	1.52AspGln: 1.52 ± 0.027	3.184AspArg: 3.184 ± 0.036	2.314AspSer: 2.314 ± 0.033	2.621AspThr: 2.621 ± 0.035	3.924AspVal: 3.924 ± 0.041	0.863AspTrp: 0.863 ± 0.019	1.403AspTyr: 1.403 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.736GluAla: 6.736 ± 0.065	0.376GluCys: 0.376 ± 0.014	2.29GluAsp: 2.29 ± 0.03	2.335GluGlu: 2.335 ± 0.035	1.609GluPhe: 1.609 ± 0.031	3.517GluGly: 3.517 ± 0.043	1.351GluHis: 1.351 ± 0.025	2.732GluIle: 2.732 ± 0.037	1.615GluLys: 1.615 ± 0.027	5.331GluLeu: 5.331 ± 0.053	1.26GluMet: 1.26 ± 0.025	1.276GluAsn: 1.276 ± 0.026	2.425GluPro: 2.425 ± 0.032	2.55GluGln: 2.55 ± 0.036	4.578GluArg: 4.578 ± 0.049	2.455GluSer: 2.455 ± 0.034	2.456GluThr: 2.456 ± 0.03	3.727GluVal: 3.727 ± 0.048	0.681GluTrp: 0.681 ± 0.014	1.099GluTyr: 1.099 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.479PheAla: 4.479 ± 0.045	0.431PheCys: 0.431 ± 0.013	2.319PheAsp: 2.319 ± 0.032	1.863PheGlu: 1.863 ± 0.027	1.341PhePhe: 1.341 ± 0.026	3.589PheGly: 3.589 ± 0.046	0.758PheHis: 0.758 ± 0.02	1.446PheIle: 1.446 ± 0.026	0.99PheLys: 0.99 ± 0.023	3.091PheLeu: 3.091 ± 0.035	0.781PheMet: 0.781 ± 0.019	1.088PheAsn: 1.088 ± 0.021	1.591PhePro: 1.591 ± 0.029	0.991PheGln: 0.991 ± 0.021	2.004PheArg: 2.004 ± 0.028	2.161PheSer: 2.161 ± 0.033	1.845PheThr: 1.845 ± 0.031	2.732PheVal: 2.732 ± 0.033	0.492PheTrp: 0.492 ± 0.015	0.901PheTyr: 0.901 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.117GlyAla: 10.117 ± 0.092	0.935GlyCys: 0.935 ± 0.018	3.878GlyAsp: 3.878 ± 0.044	4.499GlyGlu: 4.499 ± 0.049	3.291GlyPhe: 3.291 ± 0.041	7.435GlyGly: 7.435 ± 0.089	1.908GlyHis: 1.908 ± 0.032	4.348GlyIle: 4.348 ± 0.043	3.54GlyLys: 3.54 ± 0.046	8.796GlyLeu: 8.796 ± 0.065	2.639GlyMet: 2.639 ± 0.034	2.562GlyAsn: 2.562 ± 0.041	3.162GlyPro: 3.162 ± 0.04	3.323GlyGln: 3.323 ± 0.038	5.48GlyArg: 5.48 ± 0.048	4.742GlySer: 4.742 ± 0.048	4.872GlyThr: 4.872 ± 0.055	6.607GlyVal: 6.607 ± 0.061	1.435GlyTrp: 1.435 ± 0.026	2.524GlyTyr: 2.524 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	3.087HisAla: 3.087 ± 0.042	0.279HisCys: 0.279 ± 0.01	1.191HisAsp: 1.191 ± 0.02	1.058HisGlu: 1.058 ± 0.022	0.931HisPhe: 0.931 ± 0.023	2.206HisGly: 2.206 ± 0.033	0.604HisHis: 0.604 ± 0.016	0.964HisIle: 0.964 ± 0.023	0.528HisLys: 0.528 ± 0.015	2.158HisLeu: 2.158 ± 0.034	0.521HisMet: 0.521 ± 0.014	0.509HisAsn: 0.509 ± 0.014	1.513HisPro: 1.513 ± 0.027	0.726HisGln: 0.726 ± 0.019	1.473HisArg: 1.473 ± 0.028	0.987HisSer: 0.987 ± 0.024	1.029HisThr: 1.029 ± 0.023	1.617HisVal: 1.617 ± 0.028	0.386HisTrp: 0.386 ± 0.011	0.631HisTyr: 0.631 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.362IleAla: 6.362 ± 0.058	0.489IleCys: 0.489 ± 0.017	3.027IleAsp: 3.027 ± 0.037	2.941IleGlu: 2.941 ± 0.038	1.344IlePhe: 1.344 ± 0.024	4.543IleGly: 4.543 ± 0.05	0.927IleHis: 0.927 ± 0.019	1.525IleIle: 1.525 ± 0.028	1.392IleLys: 1.392 ± 0.031	3.521IleLeu: 3.521 ± 0.043	0.777IleMet: 0.777 ± 0.02	1.358IleAsn: 1.358 ± 0.029	2.107IlePro: 2.107 ± 0.031	1.303IleGln: 1.303 ± 0.022	2.897IleArg: 2.897 ± 0.04	2.456IleSer: 2.456 ± 0.034	2.299IleThr: 2.299 ± 0.035	3.653IleVal: 3.653 ± 0.043	0.489IleTrp: 0.489 ± 0.015	1.0IleTyr: 1.0 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.792LysAla: 3.792 ± 0.048	0.172LysCys: 0.172 ± 0.01	1.49LysAsp: 1.49 ± 0.03	1.411LysGlu: 1.411 ± 0.028	0.818LysPhe: 0.818 ± 0.022	2.229LysGly: 2.229 ± 0.034	0.64LysHis: 0.64 ± 0.016	1.396LysIle: 1.396 ± 0.028	1.1LysLys: 1.1 ± 0.034	3.338LysLeu: 3.338 ± 0.045	0.763LysMet: 0.763 ± 0.019	0.791LysAsn: 0.791 ± 0.021	1.978LysPro: 1.978 ± 0.03	1.173LysGln: 1.173 ± 0.026	2.141LysArg: 2.141 ± 0.029	1.566LysSer: 1.566 ± 0.028	1.757LysThr: 1.757 ± 0.032	2.447LysVal: 2.447 ± 0.038	0.369LysTrp: 0.369 ± 0.012	0.675LysTyr: 0.675 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.62LeuAla: 15.62 ± 0.121	1.137LeuCys: 1.137 ± 0.02	5.637LeuAsp: 5.637 ± 0.054	4.941LeuGlu: 4.941 ± 0.058	3.488LeuPhe: 3.488 ± 0.04	8.693LeuGly: 8.693 ± 0.073	2.272LeuHis: 2.272 ± 0.034	4.208LeuIle: 4.208 ± 0.046	3.175LeuLys: 3.175 ± 0.042	10.782LeuLeu: 10.782 ± 0.107	2.417LeuMet: 2.417 ± 0.037	2.601LeuAsn: 2.601 ± 0.037	6.235LeuPro: 6.235 ± 0.055	3.589LeuGln: 3.589 ± 0.036	7.585LeuArg: 7.585 ± 0.065	6.093LeuSer: 6.093 ± 0.054	5.308LeuThr: 5.308 ± 0.052	7.603LeuVal: 7.603 ± 0.066	1.192LeuTrp: 1.192 ± 0.024	2.196LeuTyr: 2.196 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	3.185MetAla: 3.185 ± 0.038	0.193MetCys: 0.193 ± 0.008	1.079MetAsp: 1.079 ± 0.022	1.146MetGlu: 1.146 ± 0.023	0.76MetPhe: 0.76 ± 0.018	1.788MetGly: 1.788 ± 0.029	0.564MetHis: 0.564 ± 0.017	1.109MetIle: 1.109 ± 0.027	0.91MetLys: 0.91 ± 0.02	2.909MetLeu: 2.909 ± 0.036	0.675MetMet: 0.675 ± 0.02	0.793MetAsn: 0.793 ± 0.02	1.649MetPro: 1.649 ± 0.028	1.115MetGln: 1.115 ± 0.024	1.913MetArg: 1.913 ± 0.032	1.605MetSer: 1.605 ± 0.028	1.645MetThr: 1.645 ± 0.025	1.842MetVal: 1.842 ± 0.023	0.235MetTrp: 0.235 ± 0.01	0.401MetTyr: 0.401 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.509AsnAla: 3.509 ± 0.047	0.255AsnCys: 0.255 ± 0.01	1.264AsnAsp: 1.264 ± 0.026	1.138AsnGlu: 1.138 ± 0.024	0.892AsnPhe: 0.892 ± 0.018	2.44AsnGly: 2.44 ± 0.041	0.549AsnHis: 0.549 ± 0.015	1.207AsnIle: 1.207 ± 0.025	0.77AsnLys: 0.77 ± 0.019	2.641AsnLeu: 2.641 ± 0.035	0.595AsnMet: 0.595 ± 0.016	0.736AsnAsn: 0.736 ± 0.022	1.846AsnPro: 1.846 ± 0.027	0.885AsnGln: 0.885 ± 0.021	1.712AsnArg: 1.712 ± 0.027	1.21AsnSer: 1.21 ± 0.026	1.448AsnThr: 1.448 ± 0.034	2.049AsnVal: 2.049 ± 0.031	0.406AsnTrp: 0.406 ± 0.013	0.679AsnTyr: 0.679 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.96ProAla: 7.96 ± 0.075	0.407ProCys: 0.407 ± 0.014	3.301ProAsp: 3.301 ± 0.042	3.123ProGlu: 3.123 ± 0.04	1.821ProPhe: 1.821 ± 0.027	4.969ProGly: 4.969 ± 0.054	1.18ProHis: 1.18 ± 0.025	1.921ProIle: 1.921 ± 0.029	1.399ProLys: 1.399 ± 0.026	5.198ProLeu: 5.198 ± 0.052	1.3ProMet: 1.3 ± 0.024	1.319ProAsn: 1.319 ± 0.022	2.59ProPro: 2.59 ± 0.04	2.034ProGln: 2.034 ± 0.03	3.033ProArg: 3.033 ± 0.037	2.683ProSer: 2.683 ± 0.037	2.466ProThr: 2.466 ± 0.032	4.462ProVal: 4.462 ± 0.046	0.717ProTrp: 0.717 ± 0.018	1.298ProTyr: 1.298 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	5.984GlnAla: 5.984 ± 0.06	0.306GlnCys: 0.306 ± 0.013	1.652GlnAsp: 1.652 ± 0.029	1.551GlnGlu: 1.551 ± 0.025	1.219GlnPhe: 1.219 ± 0.026	2.981GlnGly: 2.981 ± 0.04	0.915GlnHis: 0.915 ± 0.019	1.747GlnIle: 1.747 ± 0.031	1.023GlnLys: 1.023 ± 0.024	3.857GlnLeu: 3.857 ± 0.045	0.993GlnMet: 0.993 ± 0.024	0.858GlnAsn: 0.858 ± 0.023	2.295GlnPro: 2.295 ± 0.038	1.889GlnGln: 1.889 ± 0.043	3.146GlnArg: 3.146 ± 0.033	1.996GlnSer: 1.996 ± 0.028	1.844GlnThr: 1.844 ± 0.027	2.851GlnVal: 2.851 ± 0.04	0.577GlnTrp: 0.577 ± 0.017	0.871GlnTyr: 0.871 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	8.454ArgAla: 8.454 ± 0.07	0.644ArgCys: 0.644 ± 0.015	3.667ArgAsp: 3.667 ± 0.041	4.192ArgGlu: 4.192 ± 0.044	2.812ArgPhe: 2.812 ± 0.036	4.772ArgGly: 4.772 ± 0.044	1.902ArgHis: 1.902 ± 0.032	3.621ArgIle: 3.621 ± 0.038	2.175ArgLys: 2.175 ± 0.032	7.775ArgLeu: 7.775 ± 0.062	1.963ArgMet: 1.963 ± 0.03	1.913ArgAsn: 1.913 ± 0.028	3.216ArgPro: 3.216 ± 0.039	3.115ArgGln: 3.115 ± 0.042	5.217ArgArg: 5.217 ± 0.05	3.392ArgSer: 3.392 ± 0.038	3.385ArgThr: 3.385 ± 0.041	4.977ArgVal: 4.977 ± 0.051	1.104ArgTrp: 1.104 ± 0.022	1.921ArgTyr: 1.921 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.86SerAla: 6.86 ± 0.059	0.475SerCys: 0.475 ± 0.014	2.491SerAsp: 2.491 ± 0.038	2.456SerGlu: 2.456 ± 0.029	2.004SerPhe: 2.004 ± 0.033	5.378SerGly: 5.378 ± 0.055	1.253SerHis: 1.253 ± 0.024	2.347SerIle: 2.347 ± 0.029	1.469SerLys: 1.469 ± 0.029	5.753SerLeu: 5.753 ± 0.053	1.426SerMet: 1.426 ± 0.025	1.388SerAsn: 1.388 ± 0.028	2.879SerPro: 2.879 ± 0.039	1.902SerGln: 1.902 ± 0.032	3.576SerArg: 3.576 ± 0.037	2.936SerSer: 2.936 ± 0.045	2.81SerThr: 2.81 ± 0.044	4.043SerVal: 4.043 ± 0.047	0.739SerTrp: 0.739 ± 0.016	1.276SerTyr: 1.276 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	6.052ThrAla: 6.052 ± 0.066	0.433ThrCys: 0.433 ± 0.015	2.458ThrAsp: 2.458 ± 0.037	2.356ThrGlu: 2.356 ± 0.037	1.819ThrPhe: 1.819 ± 0.027	4.829ThrGly: 4.829 ± 0.062	1.174ThrHis: 1.174 ± 0.023	2.29ThrIle: 2.29 ± 0.032	1.136ThrLys: 1.136 ± 0.021	6.303ThrLeu: 6.303 ± 0.055	1.194ThrMet: 1.194 ± 0.022	1.247ThrAsn: 1.247 ± 0.026	3.407ThrPro: 3.407 ± 0.042	1.892ThrGln: 1.892 ± 0.03	3.481ThrArg: 3.481 ± 0.034	2.649ThrSer: 2.649 ± 0.039	2.716ThrThr: 2.716 ± 0.042	4.408ThrVal: 4.408 ± 0.054	0.66ThrTrp: 0.66 ± 0.017	1.206ThrTyr: 1.206 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	9.927ValAla: 9.927 ± 0.072	0.783ValCys: 0.783 ± 0.019	3.867ValAsp: 3.867 ± 0.039	3.912ValGlu: 3.912 ± 0.042	2.679ValPhe: 2.679 ± 0.037	5.508ValGly: 5.508 ± 0.054	1.476ValHis: 1.476 ± 0.026	3.548ValIle: 3.548 ± 0.044	2.349ValLys: 2.349 ± 0.032	7.985ValLeu: 7.985 ± 0.063	1.938ValMet: 1.938 ± 0.029	2.113ValAsn: 2.113 ± 0.035	4.367ValPro: 4.367 ± 0.047	2.613ValGln: 2.613 ± 0.035	5.229ValArg: 5.229 ± 0.056	4.385ValSer: 4.385 ± 0.043	4.293ValThr: 4.293 ± 0.052	6.35ValVal: 6.35 ± 0.068	0.864ValTrp: 0.864 ± 0.018	1.557ValTyr: 1.557 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.216TrpAla: 1.216 ± 0.02	0.169TrpCys: 0.169 ± 0.009	0.611TrpAsp: 0.611 ± 0.017	0.559TrpGlu: 0.559 ± 0.016	0.551TrpPhe: 0.551 ± 0.016	0.963TrpGly: 0.963 ± 0.021	0.395TrpHis: 0.395 ± 0.012	0.655TrpIle: 0.655 ± 0.016	0.415TrpLys: 0.415 ± 0.014	2.018TrpLeu: 2.018 ± 0.032	0.409TrpMet: 0.409 ± 0.016	0.384TrpAsn: 0.384 ± 0.014	0.665TrpPro: 0.665 ± 0.015	0.771TrpGln: 0.771 ± 0.017	1.191TrpArg: 1.191 ± 0.023	0.73TrpSer: 0.73 ± 0.017	0.651TrpThr: 0.651 ± 0.018	0.879TrpVal: 0.879 ± 0.018	0.233TrpTrp: 0.233 ± 0.012	0.318TrpTyr: 0.318 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.806TyrAla: 2.806 ± 0.032	0.273TyrCys: 0.273 ± 0.011	1.276TyrAsp: 1.276 ± 0.021	1.111TyrGlu: 1.111 ± 0.022	0.94TyrPhe: 0.94 ± 0.02	2.213TyrGly: 2.213 ± 0.031	0.488TyrHis: 0.488 ± 0.014	0.84TyrIle: 0.84 ± 0.02	0.718TyrLys: 0.718 ± 0.016	2.542TyrLeu: 2.542 ± 0.034	0.448TyrMet: 0.448 ± 0.013	0.608TyrAsn: 0.608 ± 0.02	1.295TyrPro: 1.295 ± 0.022	0.939TyrGln: 0.939 ± 0.019	1.899TyrArg: 1.899 ± 0.026	1.169TyrSer: 1.169 ± 0.023	1.267TyrThr: 1.267 ± 0.027	1.733TyrVal: 1.733 ± 0.028	0.36TyrTrp: 0.36 ± 0.013	0.67TyrTyr: 0.67 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7643 proteins (2361659 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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