Amino acid dipepetide frequency for Trichinella papuae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.569AlaAla: 5.569 ± 0.061
1.511AlaCys: 1.511 ± 0.016
3.562AlaAsp: 3.562 ± 0.023
4.568AlaGlu: 4.568 ± 0.03
2.796AlaPhe: 2.796 ± 0.021
3.297AlaGly: 3.297 ± 0.027
1.358AlaHis: 1.358 ± 0.014
3.511AlaIle: 3.511 ± 0.028
3.747AlaLys: 3.747 ± 0.031
6.205AlaLeu: 6.205 ± 0.041
1.577AlaMet: 1.577 ± 0.018
3.027AlaAsn: 3.027 ± 0.026
2.296AlaPro: 2.296 ± 0.023
2.264AlaGln: 2.264 ± 0.02
2.923AlaArg: 2.923 ± 0.02
5.221AlaSer: 5.221 ± 0.032
3.519AlaThr: 3.519 ± 0.027
4.939AlaVal: 4.939 ± 0.029
0.723AlaTrp: 0.723 ± 0.013
1.861AlaTyr: 1.861 ± 0.016
0.0AlaXaa: 0.0 ± 0.0
Cys
1.446CysAla: 1.446 ± 0.018
0.891CysCys: 0.891 ± 0.014
1.357CysAsp: 1.357 ± 0.022
1.487CysGlu: 1.487 ± 0.022
1.323CysPhe: 1.323 ± 0.014
1.4CysGly: 1.4 ± 0.02
0.676CysHis: 0.676 ± 0.011
1.52CysIle: 1.52 ± 0.02
1.544CysLys: 1.544 ± 0.023
2.596CysLeu: 2.596 ± 0.023
0.565CysMet: 0.565 ± 0.008
1.263CysAsn: 1.263 ± 0.015
1.236CysPro: 1.236 ± 0.028
1.125CysGln: 1.125 ± 0.016
1.581CysArg: 1.581 ± 0.017
2.432CysSer: 2.432 ± 0.027
1.346CysThr: 1.346 ± 0.018
1.504CysVal: 1.504 ± 0.018
0.327CysTrp: 0.327 ± 0.008
0.789CysTyr: 0.789 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
3.309AspAla: 3.309 ± 0.022
1.36AspCys: 1.36 ± 0.018
3.928AspAsp: 3.928 ± 0.037
4.244AspGlu: 4.244 ± 0.027
2.376AspPhe: 2.376 ± 0.018
3.064AspGly: 3.064 ± 0.036
1.234AspHis: 1.234 ± 0.013
2.761AspIle: 2.761 ± 0.023
2.59AspLys: 2.59 ± 0.019
4.68AspLeu: 4.68 ± 0.03
1.189AspMet: 1.189 ± 0.014
2.383AspAsn: 2.383 ± 0.019
2.065AspPro: 2.065 ± 0.019
2.063AspGln: 2.063 ± 0.021
2.676AspArg: 2.676 ± 0.02
4.208AspSer: 4.208 ± 0.033
2.154AspThr: 2.154 ± 0.017
3.657AspVal: 3.657 ± 0.026
0.654AspTrp: 0.654 ± 0.01
1.653AspTyr: 1.653 ± 0.016
0.0AspXaa: 0.0 ± 0.0
Glu
3.894GluAla: 3.894 ± 0.028
1.342GluCys: 1.342 ± 0.018
3.206GluAsp: 3.206 ± 0.024
5.725GluGlu: 5.725 ± 0.053
2.411GluPhe: 2.411 ± 0.023
2.312GluGly: 2.312 ± 0.025
1.5GluHis: 1.5 ± 0.015
4.014GluIle: 4.014 ± 0.034
5.094GluLys: 5.094 ± 0.036
5.931GluLeu: 5.931 ± 0.036
1.916GluMet: 1.916 ± 0.019
4.141GluAsn: 4.141 ± 0.032
2.121GluPro: 2.121 ± 0.023
3.058GluGln: 3.058 ± 0.027
3.526GluArg: 3.526 ± 0.029
4.47GluSer: 4.47 ± 0.033
3.338GluThr: 3.338 ± 0.026
3.485GluVal: 3.485 ± 0.031
0.657GluTrp: 0.657 ± 0.011
1.752GluTyr: 1.752 ± 0.019
0.0GluXaa: 0.0 ± 0.0
Phe
2.797PheAla: 2.797 ± 0.022
1.385PheCys: 1.385 ± 0.015
2.582PheAsp: 2.582 ± 0.018
2.682PheGlu: 2.682 ± 0.019
2.246PhePhe: 2.246 ± 0.021
2.574PheGly: 2.574 ± 0.023
1.226PheHis: 1.226 ± 0.014
2.666PheIle: 2.666 ± 0.024
2.261PheLys: 2.261 ± 0.022
4.395PheLeu: 4.395 ± 0.03
0.921PheMet: 0.921 ± 0.012
2.118PheAsn: 2.118 ± 0.018
1.925PhePro: 1.925 ± 0.019
1.938PheGln: 1.938 ± 0.018
2.242PheArg: 2.242 ± 0.018
3.901PheSer: 3.901 ± 0.024
2.467PheThr: 2.467 ± 0.018
3.064PheVal: 3.064 ± 0.023
0.58PheTrp: 0.58 ± 0.009
1.738PheTyr: 1.738 ± 0.018
0.001PheXaa: 0.001 ± 0.0
Gly
2.74GlyAla: 2.74 ± 0.025
1.233GlyCys: 1.233 ± 0.016
2.54GlyAsp: 2.54 ± 0.023
2.841GlyGlu: 2.841 ± 0.027
2.224GlyPhe: 2.224 ± 0.021
3.223GlyGly: 3.223 ± 0.037
1.268GlyHis: 1.268 ± 0.015
2.861GlyIle: 2.861 ± 0.027
3.307GlyLys: 3.307 ± 0.023
4.046GlyLeu: 4.046 ± 0.033
1.189GlyMet: 1.189 ± 0.014
2.505GlyAsn: 2.505 ± 0.02
1.72GlyPro: 1.72 ± 0.03
2.074GlyGln: 2.074 ± 0.018
3.094GlyArg: 3.094 ± 0.024
4.135GlySer: 4.135 ± 0.032
2.558GlyThr: 2.558 ± 0.025
3.03GlyVal: 3.03 ± 0.025
0.62GlyTrp: 0.62 ± 0.012
1.71GlyTyr: 1.71 ± 0.017
0.0GlyXaa: 0.0 ± 0.0
His
1.424HisAla: 1.424 ± 0.015
0.909HisCys: 0.909 ± 0.014
1.005HisAsp: 1.005 ± 0.012
1.26HisGlu: 1.26 ± 0.015
1.398HisPhe: 1.398 ± 0.013
1.315HisGly: 1.315 ± 0.013
0.97HisHis: 0.97 ± 0.018
1.283HisIle: 1.283 ± 0.013
1.005HisLys: 1.005 ± 0.013
2.724HisLeu: 2.724 ± 0.023
0.555HisMet: 0.555 ± 0.009
1.005HisAsn: 1.005 ± 0.011
1.198HisPro: 1.198 ± 0.014
1.149HisGln: 1.149 ± 0.017
1.507HisArg: 1.507 ± 0.015
2.085HisSer: 2.085 ± 0.017
1.095HisThr: 1.095 ± 0.013
1.528HisVal: 1.528 ± 0.015
0.359HisTrp: 0.359 ± 0.007
0.878HisTyr: 0.878 ± 0.013
0.0HisXaa: 0.0 ± 0.0
Ile
3.804IleAla: 3.804 ± 0.025
1.741IleCys: 1.741 ± 0.02
2.981IleAsp: 2.981 ± 0.022
3.361IleGlu: 3.361 ± 0.03
2.833IlePhe: 2.833 ± 0.026
2.825IleGly: 2.825 ± 0.021
1.303IleHis: 1.303 ± 0.013
3.184IleIle: 3.184 ± 0.03
2.942IleLys: 2.942 ± 0.024
5.428IleLeu: 5.428 ± 0.033
1.211IleMet: 1.211 ± 0.015
2.536IleAsn: 2.536 ± 0.02
2.519IlePro: 2.519 ± 0.02
2.236IleGln: 2.236 ± 0.021
3.179IleArg: 3.179 ± 0.028
4.717IleSer: 4.717 ± 0.029
2.836IleThr: 2.836 ± 0.023
3.637IleVal: 3.637 ± 0.024
0.685IleTrp: 0.685 ± 0.011
1.979IleTyr: 1.979 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
3.721LysAla: 3.721 ± 0.028
1.488LysCys: 1.488 ± 0.017
2.727LysAsp: 2.727 ± 0.024
4.044LysGlu: 4.044 ± 0.033
2.517LysPhe: 2.517 ± 0.022
2.321LysGly: 2.321 ± 0.029
1.558LysHis: 1.558 ± 0.018
3.634LysIle: 3.634 ± 0.027
4.662LysLys: 4.662 ± 0.045
6.253LysLeu: 6.253 ± 0.031
1.768LysMet: 1.768 ± 0.019
3.247LysAsn: 3.247 ± 0.025
2.457LysPro: 2.457 ± 0.024
2.983LysGln: 2.983 ± 0.027
3.872LysArg: 3.872 ± 0.029
4.699LysSer: 4.699 ± 0.031
2.999LysThr: 2.999 ± 0.02
3.381LysVal: 3.381 ± 0.027
0.737LysTrp: 0.737 ± 0.012
1.839LysTyr: 1.839 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
6.059LeuAla: 6.059 ± 0.035
2.519LeuCys: 2.519 ± 0.023
4.563LeuAsp: 4.563 ± 0.03
5.854LeuGlu: 5.854 ± 0.042
4.611LeuPhe: 4.611 ± 0.037
3.78LeuGly: 3.78 ± 0.027
2.716LeuHis: 2.716 ± 0.02
5.477LeuIle: 5.477 ± 0.036
6.686LeuLys: 6.686 ± 0.04
10.842LeuLeu: 10.842 ± 0.059
2.3LeuMet: 2.3 ± 0.021
5.104LeuAsn: 5.104 ± 0.028
4.706LeuPro: 4.706 ± 0.033
4.651LeuGln: 4.651 ± 0.034
5.466LeuArg: 5.466 ± 0.033
7.679LeuSer: 7.679 ± 0.04
4.97LeuThr: 4.97 ± 0.027
5.39LeuVal: 5.39 ± 0.03
1.073LeuTrp: 1.073 ± 0.012
2.909LeuTyr: 2.909 ± 0.023
0.0LeuXaa: 0.0 ± 0.0
Met
1.596MetAla: 1.596 ± 0.015
0.504MetCys: 0.504 ± 0.008
1.272MetAsp: 1.272 ± 0.013
1.641MetGlu: 1.641 ± 0.017
1.031MetPhe: 1.031 ± 0.012
0.907MetGly: 0.907 ± 0.01
0.658MetHis: 0.658 ± 0.009
1.34MetIle: 1.34 ± 0.013
1.786MetLys: 1.786 ± 0.017
2.491MetLeu: 2.491 ± 0.018
0.706MetMet: 0.706 ± 0.011
1.397MetAsn: 1.397 ± 0.013
1.145MetPro: 1.145 ± 0.016
1.228MetGln: 1.228 ± 0.015
1.25MetArg: 1.25 ± 0.014
1.753MetSer: 1.753 ± 0.018
1.267MetThr: 1.267 ± 0.013
1.39MetVal: 1.39 ± 0.014
0.232MetTrp: 0.232 ± 0.005
0.698MetTyr: 0.698 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
3.376AsnAla: 3.376 ± 0.024
1.463AsnCys: 1.463 ± 0.018
2.858AsnAsp: 2.858 ± 0.023
3.357AsnGlu: 3.357 ± 0.024
2.594AsnPhe: 2.594 ± 0.019
2.957AsnGly: 2.957 ± 0.028
1.053AsnHis: 1.053 ± 0.011
2.799AsnIle: 2.799 ± 0.023
2.605AsnLys: 2.605 ± 0.025
4.637AsnLeu: 4.637 ± 0.031
1.145AsnMet: 1.145 ± 0.012
3.247AsnAsn: 3.247 ± 0.046
1.921AsnPro: 1.921 ± 0.016
1.887AsnGln: 1.887 ± 0.017
2.598AsnArg: 2.598 ± 0.019
4.371AsnSer: 4.371 ± 0.025
2.31AsnThr: 2.31 ± 0.018
3.497AsnVal: 3.497 ± 0.027
0.586AsnTrp: 0.586 ± 0.01
1.726AsnTyr: 1.726 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
2.857ProAla: 2.857 ± 0.027
0.919ProCys: 0.919 ± 0.016
2.237ProAsp: 2.237 ± 0.017
2.611ProGlu: 2.611 ± 0.027
1.949ProPhe: 1.949 ± 0.016
2.281ProGly: 2.281 ± 0.067
0.866ProHis: 0.866 ± 0.012
2.132ProIle: 2.132 ± 0.017
2.324ProLys: 2.324 ± 0.021
3.944ProLeu: 3.944 ± 0.028
0.969ProMet: 0.969 ± 0.012
2.085ProAsn: 2.085 ± 0.021
2.98ProPro: 2.98 ± 0.048
1.496ProGln: 1.496 ± 0.017
1.871ProArg: 1.871 ± 0.02
3.75ProSer: 3.75 ± 0.033
2.57ProThr: 2.57 ± 0.023
3.123ProVal: 3.123 ± 0.026
0.477ProTrp: 0.477 ± 0.009
1.396ProTyr: 1.396 ± 0.017
0.0ProXaa: 0.0 ± 0.0
Gln
2.681GlnAla: 2.681 ± 0.021
1.194GlnCys: 1.194 ± 0.019
1.518GlnAsp: 1.518 ± 0.014
2.269GlnGlu: 2.269 ± 0.021
1.968GlnPhe: 1.968 ± 0.019
1.444GlnGly: 1.444 ± 0.015
1.29GlnHis: 1.29 ± 0.015
2.411GlnIle: 2.411 ± 0.024
2.539GlnLys: 2.539 ± 0.022
4.92GlnLeu: 4.92 ± 0.035
1.211GlnMet: 1.211 ± 0.015
2.138GlnAsn: 2.138 ± 0.019
1.915GlnPro: 1.915 ± 0.02
3.915GlnGln: 3.915 ± 0.086
2.662GlnArg: 2.662 ± 0.019
3.38GlnSer: 3.38 ± 0.026
2.122GlnThr: 2.122 ± 0.019
2.146GlnVal: 2.146 ± 0.018
0.576GlnTrp: 0.576 ± 0.01
1.31GlnTyr: 1.31 ± 0.014
0.0GlnXaa: 0.0 ± 0.0
Arg
2.946ArgAla: 2.946 ± 0.022
1.624ArgCys: 1.624 ± 0.022
2.393ArgAsp: 2.393 ± 0.019
2.994ArgGlu: 2.994 ± 0.025
2.483ArgPhe: 2.483 ± 0.021
2.415ArgGly: 2.415 ± 0.023
1.498ArgHis: 1.498 ± 0.015
3.231ArgIle: 3.231 ± 0.023
3.763ArgLys: 3.763 ± 0.027
5.778ArgLeu: 5.778 ± 0.036
1.455ArgMet: 1.455 ± 0.016
2.717ArgAsn: 2.717 ± 0.021
2.28ArgPro: 2.28 ± 0.023
2.564ArgGln: 2.564 ± 0.022
4.57ArgArg: 4.57 ± 0.04
4.389ArgSer: 4.389 ± 0.033
2.711ArgThr: 2.711 ± 0.02
2.925ArgVal: 2.925 ± 0.024
0.778ArgTrp: 0.778 ± 0.011
1.693ArgTyr: 1.693 ± 0.015
0.0ArgXaa: 0.0 ± 0.0
Ser
5.485SerAla: 5.485 ± 0.034
2.088SerCys: 2.088 ± 0.025
4.506SerAsp: 4.506 ± 0.028
4.895SerGlu: 4.895 ± 0.031
3.606SerPhe: 3.606 ± 0.024
4.489SerGly: 4.489 ± 0.03
1.626SerHis: 1.626 ± 0.016
4.261SerIle: 4.261 ± 0.026
4.818SerLys: 4.818 ± 0.032
7.469SerLeu: 7.469 ± 0.04
1.829SerMet: 1.829 ± 0.017
4.236SerAsn: 4.236 ± 0.028
3.503SerPro: 3.503 ± 0.032
2.889SerGln: 2.889 ± 0.022
4.312SerArg: 4.312 ± 0.029
9.454SerSer: 9.454 ± 0.079
5.244SerThr: 5.244 ± 0.036
5.59SerVal: 5.59 ± 0.03
0.928SerTrp: 0.928 ± 0.012
2.163SerTyr: 2.163 ± 0.018
0.0SerXaa: 0.0 ± 0.0
Thr
4.048ThrAla: 4.048 ± 0.03
1.329ThrCys: 1.329 ± 0.021
2.794ThrAsp: 2.794 ± 0.02
3.119ThrGlu: 3.119 ± 0.023
2.399ThrPhe: 2.399 ± 0.019
2.848ThrGly: 2.848 ± 0.027
0.938ThrHis: 0.938 ± 0.012
2.908ThrIle: 2.908 ± 0.02
2.786ThrLys: 2.786 ± 0.022
4.985ThrLeu: 4.985 ± 0.033
1.307ThrMet: 1.307 ± 0.013
2.482ThrAsn: 2.482 ± 0.021
2.374ThrPro: 2.374 ± 0.022
1.536ThrGln: 1.536 ± 0.016
2.222ThrArg: 2.222 ± 0.017
4.503ThrSer: 4.503 ± 0.029
3.951ThrThr: 3.951 ± 0.049
4.384ThrVal: 4.384 ± 0.029
0.524ThrTrp: 0.524 ± 0.008
1.372ThrTyr: 1.372 ± 0.013
0.001ThrXaa: 0.001 ± 0.0
Val
4.19ValAla: 4.19 ± 0.028
1.668ValCys: 1.668 ± 0.02
4.036ValAsp: 4.036 ± 0.027
4.587ValGlu: 4.587 ± 0.036
2.621ValPhe: 2.621 ± 0.019
3.274ValGly: 3.274 ± 0.025
1.764ValHis: 1.764 ± 0.016
3.52ValIle: 3.52 ± 0.025
3.82ValLys: 3.82 ± 0.028
5.747ValLeu: 5.747 ± 0.029
1.424ValMet: 1.424 ± 0.013
3.12ValAsn: 3.12 ± 0.021
2.661ValPro: 2.661 ± 0.021
2.803ValGln: 2.803 ± 0.021
3.234ValArg: 3.234 ± 0.021
4.752ValSer: 4.752 ± 0.028
3.223ValThr: 3.223 ± 0.023
4.525ValVal: 4.525 ± 0.028
0.703ValTrp: 0.703 ± 0.011
1.865ValTyr: 1.865 ± 0.017
0.0ValXaa: 0.0 ± 0.0
Trp
0.646TrpAla: 0.646 ± 0.013
0.265TrpCys: 0.265 ± 0.007
0.525TrpAsp: 0.525 ± 0.009
0.538TrpGlu: 0.538 ± 0.009
0.581TrpPhe: 0.581 ± 0.011
0.405TrpGly: 0.405 ± 0.008
0.327TrpHis: 0.327 ± 0.007
0.769TrpIle: 0.769 ± 0.012
0.898TrpLys: 0.898 ± 0.012
1.29TrpLeu: 1.29 ± 0.015
0.336TrpMet: 0.336 ± 0.007
0.74TrpAsn: 0.74 ± 0.012
0.504TrpPro: 0.504 ± 0.009
0.537TrpGln: 0.537 ± 0.01
0.693TrpArg: 0.693 ± 0.009
0.986TrpSer: 0.986 ± 0.015
0.683TrpThr: 0.683 ± 0.01
0.507TrpVal: 0.507 ± 0.009
0.173TrpTrp: 0.173 ± 0.005
0.426TrpTyr: 0.426 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.889TyrAla: 1.889 ± 0.018
0.972TyrCys: 0.972 ± 0.015
1.657TyrAsp: 1.657 ± 0.017
1.818TyrGlu: 1.818 ± 0.02
1.739TyrPhe: 1.739 ± 0.017
1.785TyrGly: 1.785 ± 0.019
0.823TyrHis: 0.823 ± 0.01
1.656TyrIle: 1.656 ± 0.016
1.732TyrLys: 1.732 ± 0.02
2.992TyrLeu: 2.992 ± 0.027
0.718TyrMet: 0.718 ± 0.011
1.498TyrAsn: 1.498 ± 0.018
1.311TyrPro: 1.311 ± 0.015
1.21TyrGln: 1.21 ± 0.014
1.729TyrArg: 1.729 ± 0.016
2.506TyrSer: 2.506 ± 0.023
1.446TyrThr: 1.446 ± 0.016
1.838TyrVal: 1.838 ± 0.012
0.435TyrTrp: 0.435 ± 0.009
1.241TyrTyr: 1.241 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.001XaaPhe: 0.001 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.001XaaIle: 0.001 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.001XaaXaa: 0.001 ± 0.001
Statistics based on 15285 proteins (7709026 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski