Amino acid dipepetide frequency for Nitrosococcus halophilus (strain Nc4)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.58AlaAla: 9.58 ± 0.12	1.013AlaCys: 1.013 ± 0.031	4.047AlaAsp: 4.047 ± 0.06	6.37AlaGlu: 6.37 ± 0.087	3.458AlaPhe: 3.458 ± 0.058	6.846AlaGly: 6.846 ± 0.08	2.187AlaHis: 2.187 ± 0.042	5.455AlaIle: 5.455 ± 0.073	3.601AlaLys: 3.601 ± 0.065	11.521AlaLeu: 11.521 ± 0.12	2.332AlaMet: 2.332 ± 0.045	2.624AlaAsn: 2.624 ± 0.049	3.932AlaPro: 3.932 ± 0.06	4.315AlaGln: 4.315 ± 0.064	6.144AlaArg: 6.144 ± 0.083	4.676AlaSer: 4.676 ± 0.066	4.487AlaThr: 4.487 ± 0.066	6.457AlaVal: 6.457 ± 0.084	1.397AlaTrp: 1.397 ± 0.036	2.589AlaTyr: 2.589 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.841CysAla: 0.841 ± 0.026	0.165CysCys: 0.165 ± 0.014	0.438CysAsp: 0.438 ± 0.021	0.537CysGlu: 0.537 ± 0.021	0.415CysPhe: 0.415 ± 0.018	0.958CysGly: 0.958 ± 0.034	0.441CysHis: 0.441 ± 0.024	0.462CysIle: 0.462 ± 0.021	0.292CysLys: 0.292 ± 0.017	1.096CysLeu: 1.096 ± 0.03	0.161CysMet: 0.161 ± 0.014	0.306CysAsn: 0.306 ± 0.016	0.614CysPro: 0.614 ± 0.029	0.495CysGln: 0.495 ± 0.025	0.715CysArg: 0.715 ± 0.026	0.541CysSer: 0.541 ± 0.021	0.454CysThr: 0.454 ± 0.021	0.594CysVal: 0.594 ± 0.021	0.134CysTrp: 0.134 ± 0.011	0.34CysTyr: 0.34 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.446AspAla: 3.446 ± 0.057	0.517AspCys: 0.517 ± 0.02	2.065AspAsp: 2.065 ± 0.047	3.054AspGlu: 3.054 ± 0.06	2.267AspPhe: 2.267 ± 0.045	3.235AspGly: 3.235 ± 0.065	1.119AspHis: 1.119 ± 0.035	2.929AspIle: 2.929 ± 0.052	2.01AspLys: 2.01 ± 0.045	5.451AspLeu: 5.451 ± 0.078	1.022AspMet: 1.022 ± 0.029	1.5AspAsn: 1.5 ± 0.045	3.041AspPro: 3.041 ± 0.051	1.875AspGln: 1.875 ± 0.037	3.245AspArg: 3.245 ± 0.05	2.51AspSer: 2.51 ± 0.046	2.384AspThr: 2.384 ± 0.049	2.702AspVal: 2.702 ± 0.052	0.858AspTrp: 0.858 ± 0.029	1.755AspTyr: 1.755 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.461GluAla: 7.461 ± 0.098	0.496GluCys: 0.496 ± 0.023	2.992GluAsp: 2.992 ± 0.056	5.339GluGlu: 5.339 ± 0.098	2.186GluPhe: 2.186 ± 0.046	5.123GluGly: 5.123 ± 0.068	1.513GluHis: 1.513 ± 0.038	4.149GluIle: 4.149 ± 0.063	3.424GluLys: 3.424 ± 0.059	6.844GluLeu: 6.844 ± 0.085	1.586GluMet: 1.586 ± 0.037	2.218GluAsn: 2.218 ± 0.042	2.676GluPro: 2.676 ± 0.054	3.844GluGln: 3.844 ± 0.07	5.019GluArg: 5.019 ± 0.075	3.081GluSer: 3.081 ± 0.049	3.696GluThr: 3.696 ± 0.055	4.843GluVal: 4.843 ± 0.073	0.85GluTrp: 0.85 ± 0.028	1.66GluTyr: 1.66 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.202PheAla: 3.202 ± 0.056	0.448PheCys: 0.448 ± 0.018	2.218PheAsp: 2.218 ± 0.046	2.333PheGlu: 2.333 ± 0.047	1.873PhePhe: 1.873 ± 0.053	2.94PheGly: 2.94 ± 0.057	0.993PheHis: 0.993 ± 0.033	2.298PheIle: 2.298 ± 0.049	1.483PheLys: 1.483 ± 0.039	4.29PheLeu: 4.29 ± 0.068	0.818PheMet: 0.818 ± 0.025	1.439PheAsn: 1.439 ± 0.034	1.913PhePro: 1.913 ± 0.041	1.465PheGln: 1.465 ± 0.034	2.223PheArg: 2.223 ± 0.046	2.638PheSer: 2.638 ± 0.051	2.067PheThr: 2.067 ± 0.041	2.429PheVal: 2.429 ± 0.042	0.662PheTrp: 0.662 ± 0.025	1.241PheTyr: 1.241 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.257GlyAla: 6.257 ± 0.081	0.916GlyCys: 0.916 ± 0.029	3.501GlyAsp: 3.501 ± 0.051	5.222GlyGlu: 5.222 ± 0.077	3.149GlyPhe: 3.149 ± 0.054	5.972GlyGly: 5.972 ± 0.097	1.795GlyHis: 1.795 ± 0.04	4.849GlyIle: 4.849 ± 0.069	3.598GlyLys: 3.598 ± 0.054	8.44GlyLeu: 8.44 ± 0.089	1.975GlyMet: 1.975 ± 0.042	2.348GlyAsn: 2.348 ± 0.047	2.687GlyPro: 2.687 ± 0.049	3.187GlyGln: 3.187 ± 0.056	4.948GlyArg: 4.948 ± 0.072	3.978GlySer: 3.978 ± 0.056	3.894GlyThr: 3.894 ± 0.066	5.534GlyVal: 5.534 ± 0.075	1.32GlyTrp: 1.32 ± 0.032	2.559GlyTyr: 2.559 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.804HisAla: 1.804 ± 0.043	0.361HisCys: 0.361 ± 0.018	0.999HisAsp: 0.999 ± 0.027	1.216HisGlu: 1.216 ± 0.032	1.089HisPhe: 1.089 ± 0.029	1.848HisGly: 1.848 ± 0.046	0.909HisHis: 0.909 ± 0.032	1.291HisIle: 1.291 ± 0.035	0.799HisLys: 0.799 ± 0.023	2.984HisLeu: 2.984 ± 0.058	0.463HisMet: 0.463 ± 0.017	0.717HisAsn: 0.717 ± 0.026	1.755HisPro: 1.755 ± 0.047	1.168HisGln: 1.168 ± 0.033	1.886HisArg: 1.886 ± 0.044	1.394HisSer: 1.394 ± 0.036	1.095HisThr: 1.095 ± 0.03	1.215HisVal: 1.215 ± 0.032	0.506HisTrp: 0.506 ± 0.02	1.026HisTyr: 1.026 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.63IleAla: 5.63 ± 0.075	0.522IleCys: 0.522 ± 0.021	3.06IleAsp: 3.06 ± 0.061	4.073IleGlu: 4.073 ± 0.068	2.062IlePhe: 2.062 ± 0.042	4.321IleGly: 4.321 ± 0.065	1.367IleHis: 1.367 ± 0.039	3.051IleIle: 3.051 ± 0.051	2.351IleLys: 2.351 ± 0.049	5.626IleLeu: 5.626 ± 0.079	0.957IleMet: 0.957 ± 0.031	1.915IleAsn: 1.915 ± 0.036	3.135IlePro: 3.135 ± 0.047	2.261IleGln: 2.261 ± 0.051	3.452IleArg: 3.452 ± 0.047	3.232IleSer: 3.232 ± 0.051	3.063IleThr: 3.063 ± 0.06	3.374IleVal: 3.374 ± 0.053	0.634IleTrp: 0.634 ± 0.024	1.556IleTyr: 1.556 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.09LysAla: 4.09 ± 0.075	0.263LysCys: 0.263 ± 0.014	1.886LysAsp: 1.886 ± 0.046	3.081LysGlu: 3.081 ± 0.065	1.125LysPhe: 1.125 ± 0.03	3.038LysGly: 3.038 ± 0.048	0.971LysHis: 0.971 ± 0.027	2.32LysIle: 2.32 ± 0.047	2.134LysLys: 2.134 ± 0.054	4.097LysLeu: 4.097 ± 0.072	0.899LysMet: 0.899 ± 0.026	1.452LysAsn: 1.452 ± 0.037	1.963LysPro: 1.963 ± 0.045	1.885LysGln: 1.885 ± 0.041	2.901LysArg: 2.901 ± 0.059	2.0LysSer: 2.0 ± 0.043	2.249LysThr: 2.249 ± 0.05	2.815LysVal: 2.815 ± 0.05	0.457LysTrp: 0.457 ± 0.018	0.989LysTyr: 0.989 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	11.789LeuAla: 11.789 ± 0.127	1.091LeuCys: 1.091 ± 0.033	5.554LeuAsp: 5.554 ± 0.077	8.144LeuGlu: 8.144 ± 0.104	4.3LeuPhe: 4.3 ± 0.077	8.668LeuGly: 8.668 ± 0.095	2.441LeuHis: 2.441 ± 0.05	5.794LeuIle: 5.794 ± 0.092	4.817LeuLys: 4.817 ± 0.065	12.84LeuLeu: 12.84 ± 0.151	2.351LeuMet: 2.351 ± 0.05	3.439LeuAsn: 3.439 ± 0.062	6.153LeuPro: 6.153 ± 0.078	4.617LeuGln: 4.617 ± 0.062	7.292LeuArg: 7.292 ± 0.085	7.065LeuSer: 7.065 ± 0.085	5.696LeuThr: 5.696 ± 0.063	7.384LeuVal: 7.384 ± 0.087	1.576LeuTrp: 1.576 ± 0.043	2.798LeuTyr: 2.798 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.513MetAla: 2.513 ± 0.048	0.144MetCys: 0.144 ± 0.013	1.097MetAsp: 1.097 ± 0.033	1.614MetGlu: 1.614 ± 0.038	0.609MetPhe: 0.609 ± 0.023	1.832MetGly: 1.832 ± 0.037	0.397MetHis: 0.397 ± 0.021	1.078MetIle: 1.078 ± 0.033	1.0MetLys: 1.0 ± 0.03	2.156MetLeu: 2.156 ± 0.046	0.515MetMet: 0.515 ± 0.023	0.787MetAsn: 0.787 ± 0.024	1.137MetPro: 1.137 ± 0.029	0.772MetGln: 0.772 ± 0.027	1.294MetArg: 1.294 ± 0.035	1.252MetSer: 1.252 ± 0.031	1.216MetThr: 1.216 ± 0.031	1.638MetVal: 1.638 ± 0.041	0.177MetTrp: 0.177 ± 0.012	0.328MetTyr: 0.328 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.459AsnAla: 2.459 ± 0.046	0.341AsnCys: 0.341 ± 0.019	1.343AsnAsp: 1.343 ± 0.035	1.729AsnGlu: 1.729 ± 0.038	1.274AsnPhe: 1.274 ± 0.036	2.187AsnGly: 2.187 ± 0.05	0.79AsnHis: 0.79 ± 0.029	1.905AsnIle: 1.905 ± 0.04	1.182AsnLys: 1.182 ± 0.035	3.412AsnLeu: 3.412 ± 0.057	0.616AsnMet: 0.616 ± 0.025	1.059AsnAsn: 1.059 ± 0.037	2.217AsnPro: 2.217 ± 0.05	1.439AsnGln: 1.439 ± 0.038	2.194AsnArg: 2.194 ± 0.046	1.542AsnSer: 1.542 ± 0.04	1.652AsnThr: 1.652 ± 0.044	1.734AsnVal: 1.734 ± 0.034	0.487AsnTrp: 0.487 ± 0.024	0.99AsnTyr: 0.99 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.087ProAla: 4.087 ± 0.06	0.432ProCys: 0.432 ± 0.02	2.703ProAsp: 2.703 ± 0.057	4.463ProGlu: 4.463 ± 0.07	2.024ProPhe: 2.024 ± 0.045	3.945ProGly: 3.945 ± 0.062	1.258ProHis: 1.258 ± 0.038	2.514ProIle: 2.514 ± 0.049	1.919ProLys: 1.919 ± 0.043	5.916ProLeu: 5.916 ± 0.09	1.063ProMet: 1.063 ± 0.026	1.461ProAsn: 1.461 ± 0.035	3.089ProPro: 3.089 ± 0.061	2.336ProGln: 2.336 ± 0.047	2.839ProArg: 2.839 ± 0.053	3.026ProSer: 3.026 ± 0.054	2.364ProThr: 2.364 ± 0.042	3.605ProVal: 3.605 ± 0.056	0.763ProTrp: 0.763 ± 0.025	1.42ProTyr: 1.42 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	5.1GlnAla: 5.1 ± 0.078	0.356GlnCys: 0.356 ± 0.019	1.92GlnAsp: 1.92 ± 0.04	3.317GlnGlu: 3.317 ± 0.07	1.438GlnPhe: 1.438 ± 0.033	3.684GlnGly: 3.684 ± 0.054	1.063GlnHis: 1.063 ± 0.03	2.375GlnIle: 2.375 ± 0.049	1.701GlnLys: 1.701 ± 0.042	4.692GlnLeu: 4.692 ± 0.067	0.886GlnMet: 0.886 ± 0.028	1.148GlnAsn: 1.148 ± 0.028	2.159GlnPro: 2.159 ± 0.044	2.637GlnGln: 2.637 ± 0.07	3.534GlnArg: 3.534 ± 0.062	2.096GlnSer: 2.096 ± 0.046	2.034GlnThr: 2.034 ± 0.045	3.528GlnVal: 3.528 ± 0.056	0.728GlnTrp: 0.728 ± 0.026	0.999GlnTyr: 0.999 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.512ArgAla: 5.512 ± 0.064	0.686ArgCys: 0.686 ± 0.028	3.101ArgAsp: 3.101 ± 0.053	4.856ArgGlu: 4.856 ± 0.073	3.022ArgPhe: 3.022 ± 0.057	4.227ArgGly: 4.227 ± 0.063	1.88ArgHis: 1.88 ± 0.038	3.824ArgIle: 3.824 ± 0.064	2.648ArgLys: 2.648 ± 0.051	8.255ArgLeu: 8.255 ± 0.098	1.437ArgMet: 1.437 ± 0.034	2.009ArgAsn: 2.009 ± 0.044	2.902ArgPro: 2.902 ± 0.056	3.616ArgGln: 3.616 ± 0.064	5.087ArgArg: 5.087 ± 0.078	3.234ArgSer: 3.234 ± 0.056	2.829ArgThr: 2.829 ± 0.048	4.482ArgVal: 4.482 ± 0.067	1.15ArgTrp: 1.15 ± 0.032	2.393ArgTyr: 2.393 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.611SerAla: 4.611 ± 0.064	0.584SerCys: 0.584 ± 0.023	2.333SerAsp: 2.333 ± 0.047	3.325SerGlu: 3.325 ± 0.053	2.249SerPhe: 2.249 ± 0.045	4.64SerGly: 4.64 ± 0.065	1.451SerHis: 1.451 ± 0.031	2.804SerIle: 2.804 ± 0.054	2.183SerLys: 2.183 ± 0.049	6.509SerLeu: 6.509 ± 0.069	1.234SerMet: 1.234 ± 0.036	1.586SerAsn: 1.586 ± 0.041	3.105SerPro: 3.105 ± 0.055	2.5SerGln: 2.5 ± 0.051	3.697SerArg: 3.697 ± 0.061	3.348SerSer: 3.348 ± 0.068	2.66SerThr: 2.66 ± 0.051	3.289SerVal: 3.289 ± 0.052	0.861SerTrp: 0.861 ± 0.026	1.524SerTyr: 1.524 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.674ThrAla: 4.674 ± 0.069	0.439ThrCys: 0.439 ± 0.02	2.268ThrAsp: 2.268 ± 0.046	3.105ThrGlu: 3.105 ± 0.059	1.819ThrPhe: 1.819 ± 0.037	4.253ThrGly: 4.253 ± 0.074	1.303ThrHis: 1.303 ± 0.033	2.556ThrIle: 2.556 ± 0.045	1.45ThrLys: 1.45 ± 0.038	6.63ThrLeu: 6.63 ± 0.074	0.893ThrMet: 0.893 ± 0.027	1.222ThrAsn: 1.222 ± 0.036	3.252ThrPro: 3.252 ± 0.061	2.204ThrGln: 2.204 ± 0.047	2.913ThrArg: 2.913 ± 0.049	2.591ThrSer: 2.591 ± 0.056	2.538ThrThr: 2.538 ± 0.049	3.89ThrVal: 3.89 ± 0.06	0.659ThrTrp: 0.659 ± 0.027	1.288ThrTyr: 1.288 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	6.642ValAla: 6.642 ± 0.094	0.67ValCys: 0.67 ± 0.024	3.524ValAsp: 3.524 ± 0.055	4.635ValGlu: 4.635 ± 0.07	2.695ValPhe: 2.695 ± 0.05	5.041ValGly: 5.041 ± 0.078	1.433ValHis: 1.433 ± 0.038	4.005ValIle: 4.005 ± 0.057	2.601ValLys: 2.601 ± 0.05	7.467ValLeu: 7.467 ± 0.096	1.529ValMet: 1.529 ± 0.036	2.104ValAsn: 2.104 ± 0.047	3.25ValPro: 3.25 ± 0.056	2.345ValGln: 2.345 ± 0.042	4.157ValArg: 4.157 ± 0.056	3.908ValSer: 3.908 ± 0.06	3.69ValThr: 3.69 ± 0.049	5.34ValVal: 5.34 ± 0.087	0.851ValTrp: 0.851 ± 0.027	1.696ValTyr: 1.696 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.093TrpAla: 1.093 ± 0.035	0.169TrpCys: 0.169 ± 0.013	0.667TrpAsp: 0.667 ± 0.022	0.983TrpGlu: 0.983 ± 0.033	0.609TrpPhe: 0.609 ± 0.028	1.005TrpGly: 1.005 ± 0.035	0.377TrpHis: 0.377 ± 0.017	0.766TrpIle: 0.766 ± 0.027	0.516TrpLys: 0.516 ± 0.024	2.049TrpLeu: 2.049 ± 0.052	0.338TrpMet: 0.338 ± 0.017	0.425TrpAsn: 0.425 ± 0.024	0.671TrpPro: 0.671 ± 0.023	0.835TrpGln: 0.835 ± 0.028	1.137TrpArg: 1.137 ± 0.037	0.825TrpSer: 0.825 ± 0.029	0.608TrpThr: 0.608 ± 0.024	1.076TrpVal: 1.076 ± 0.032	0.287TrpTrp: 0.287 ± 0.017	0.402TrpTyr: 0.402 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.24TyrAla: 2.24 ± 0.044	0.384TyrCys: 0.384 ± 0.018	1.268TyrAsp: 1.268 ± 0.036	1.603TyrGlu: 1.603 ± 0.042	1.311TyrPhe: 1.311 ± 0.035	2.367TyrGly: 2.367 ± 0.05	0.838TyrHis: 0.838 ± 0.031	1.217TyrIle: 1.217 ± 0.034	0.906TyrLys: 0.906 ± 0.029	3.536TyrLeu: 3.536 ± 0.058	0.477TyrMet: 0.477 ± 0.018	0.794TyrAsn: 0.794 ± 0.028	1.574TyrPro: 1.574 ± 0.035	1.6TyrGln: 1.6 ± 0.037	2.473TyrArg: 2.473 ± 0.052	1.558TyrSer: 1.558 ± 0.037	1.27TyrThr: 1.27 ± 0.037	1.657TyrVal: 1.657 ± 0.037	0.48TyrTrp: 0.48 ± 0.02	0.999TyrTyr: 0.999 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3770 proteins (1165698 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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