Amino acid dipepetide frequency for Candidatus Marinamargulisbacteria bacterium SCGC AG-414-C22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.221AlaAla: 4.221 ± 0.217
0.882AlaCys: 0.882 ± 0.063
3.234AlaAsp: 3.234 ± 0.099
3.416AlaGlu: 3.416 ± 0.179
2.524AlaPhe: 2.524 ± 0.103
3.579AlaGly: 3.579 ± 0.123
1.316AlaHis: 1.316 ± 0.069
5.082AlaIle: 5.082 ± 0.147
4.104AlaLys: 4.104 ± 0.127
6.235AlaLeu: 6.235 ± 0.174
1.322AlaMet: 1.322 ± 0.064
2.801AlaAsn: 2.801 ± 0.098
1.553AlaPro: 1.553 ± 0.08
2.327AlaGln: 2.327 ± 0.112
1.866AlaArg: 1.866 ± 0.082
3.779AlaSer: 3.779 ± 0.123
3.659AlaThr: 3.659 ± 0.111
3.612AlaVal: 3.612 ± 0.135
0.483AlaTrp: 0.483 ± 0.038
2.06AlaTyr: 2.06 ± 0.086
0.0AlaXaa: 0.0 ± 0.0
Cys
0.698CysAla: 0.698 ± 0.051
0.237CysCys: 0.237 ± 0.027
0.898CysAsp: 0.898 ± 0.053
0.652CysGlu: 0.652 ± 0.044
0.818CysPhe: 0.818 ± 0.061
0.87CysGly: 0.87 ± 0.057
0.43CysHis: 0.43 ± 0.038
0.981CysIle: 0.981 ± 0.063
0.833CysLys: 0.833 ± 0.048
1.436CysLeu: 1.436 ± 0.082
0.249CysMet: 0.249 ± 0.026
0.63CysAsn: 0.63 ± 0.049
0.51CysPro: 0.51 ± 0.046
0.48CysGln: 0.48 ± 0.036
0.36CysArg: 0.36 ± 0.032
0.882CysSer: 0.882 ± 0.064
0.541CysThr: 0.541 ± 0.04
0.861CysVal: 0.861 ± 0.051
0.12CysTrp: 0.12 ± 0.02
0.523CysTyr: 0.523 ± 0.039
0.0CysXaa: 0.0 ± 0.0
Asp
2.875AspAla: 2.875 ± 0.102
0.744AspCys: 0.744 ± 0.052
3.145AspAsp: 3.145 ± 0.16
3.031AspGlu: 3.031 ± 0.111
3.013AspPhe: 3.013 ± 0.126
2.555AspGly: 2.555 ± 0.098
1.66AspHis: 1.66 ± 0.085
5.743AspIle: 5.743 ± 0.123
3.612AspLys: 3.612 ± 0.169
5.934AspLeu: 5.934 ± 0.151
1.199AspMet: 1.199 ± 0.068
2.844AspAsn: 2.844 ± 0.095
2.001AspPro: 2.001 ± 0.095
2.444AspGln: 2.444 ± 0.099
1.673AspArg: 1.673 ± 0.081
3.757AspSer: 3.757 ± 0.155
3.179AspThr: 3.179 ± 0.097
3.696AspVal: 3.696 ± 0.14
0.464AspTrp: 0.464 ± 0.043
2.659AspTyr: 2.659 ± 0.102
0.0AspXaa: 0.0 ± 0.0
Glu
3.299GluAla: 3.299 ± 0.159
0.673GluCys: 0.673 ± 0.05
2.988GluAsp: 2.988 ± 0.125
3.348GluGlu: 3.348 ± 0.125
2.589GluPhe: 2.589 ± 0.093
2.684GluGly: 2.684 ± 0.091
1.393GluHis: 1.393 ± 0.072
4.181GluIle: 4.181 ± 0.157
5.417GluLys: 5.417 ± 0.181
6.14GluLeu: 6.14 ± 0.165
1.214GluMet: 1.214 ± 0.064
3.36GluAsn: 3.36 ± 0.111
1.657GluPro: 1.657 ± 0.068
2.632GluGln: 2.632 ± 0.113
2.106GluArg: 2.106 ± 0.098
4.123GluSer: 4.123 ± 0.124
3.557GluThr: 3.557 ± 0.132
2.709GluVal: 2.709 ± 0.098
0.52GluTrp: 0.52 ± 0.045
2.005GluTyr: 2.005 ± 0.088
0.0GluXaa: 0.0 ± 0.0
Phe
2.367PheAla: 2.367 ± 0.094
0.861PheCys: 0.861 ± 0.059
3.176PheAsp: 3.176 ± 0.108
2.924PheGlu: 2.924 ± 0.096
3.179PhePhe: 3.179 ± 0.155
2.918PheGly: 2.918 ± 0.112
1.033PheHis: 1.033 ± 0.064
4.215PheIle: 4.215 ± 0.133
3.981PheLys: 3.981 ± 0.118
5.236PheLeu: 5.236 ± 0.199
1.134PheMet: 1.134 ± 0.07
3.563PheAsn: 3.563 ± 0.132
1.709PhePro: 1.709 ± 0.076
1.802PheGln: 1.802 ± 0.081
1.377PheArg: 1.377 ± 0.074
4.486PheSer: 4.486 ± 0.125
2.619PheThr: 2.619 ± 0.098
2.908PheVal: 2.908 ± 0.104
0.529PheTrp: 0.529 ± 0.042
2.131PheTyr: 2.131 ± 0.106
0.0PheXaa: 0.0 ± 0.0
Gly
3.244GlyAla: 3.244 ± 0.131
0.759GlyCys: 0.759 ± 0.054
2.884GlyAsp: 2.884 ± 0.114
2.481GlyGlu: 2.481 ± 0.094
2.961GlyPhe: 2.961 ± 0.115
3.234GlyGly: 3.234 ± 0.137
1.423GlyHis: 1.423 ± 0.088
4.833GlyIle: 4.833 ± 0.155
3.806GlyLys: 3.806 ± 0.128
5.531GlyLeu: 5.531 ± 0.159
1.242GlyMet: 1.242 ± 0.077
2.229GlyAsn: 2.229 ± 0.085
1.519GlyPro: 1.519 ± 0.091
1.626GlyGln: 1.626 ± 0.081
1.925GlyArg: 1.925 ± 0.094
3.625GlySer: 3.625 ± 0.115
2.807GlyThr: 2.807 ± 0.101
3.825GlyVal: 3.825 ± 0.116
0.504GlyTrp: 0.504 ± 0.041
2.321GlyTyr: 2.321 ± 0.091
0.0GlyXaa: 0.0 ± 0.0
His
1.353HisAla: 1.353 ± 0.077
0.375HisCys: 0.375 ± 0.036
1.399HisAsp: 1.399 ± 0.072
1.245HisGlu: 1.245 ± 0.058
1.577HisPhe: 1.577 ± 0.087
1.202HisGly: 1.202 ± 0.076
1.045HisHis: 1.045 ± 0.066
2.503HisIle: 2.503 ± 0.092
1.559HisLys: 1.559 ± 0.071
2.521HisLeu: 2.521 ± 0.104
0.507HisMet: 0.507 ± 0.042
1.42HisAsn: 1.42 ± 0.064
1.147HisPro: 1.147 ± 0.059
1.024HisGln: 1.024 ± 0.064
0.821HisArg: 0.821 ± 0.048
1.746HisSer: 1.746 ± 0.083
1.46HisThr: 1.46 ± 0.064
1.62HisVal: 1.62 ± 0.078
0.271HisTrp: 0.271 ± 0.028
1.245HisTyr: 1.245 ± 0.059
0.0HisXaa: 0.0 ± 0.0
Ile
5.34IleAla: 5.34 ± 0.144
1.058IleCys: 1.058 ± 0.053
5.018IleAsp: 5.018 ± 0.13
5.15IleGlu: 5.15 ± 0.137
3.843IlePhe: 3.843 ± 0.137
4.719IleGly: 4.719 ± 0.151
1.94IleHis: 1.94 ± 0.09
6.795IleIle: 6.795 ± 0.203
6.958IleLys: 6.958 ± 0.198
7.459IleLeu: 7.459 ± 0.202
1.54IleMet: 1.54 ± 0.08
5.137IleAsn: 5.137 ± 0.167
3.32IlePro: 3.32 ± 0.123
3.692IleGln: 3.692 ± 0.115
2.493IleArg: 2.493 ± 0.095
6.069IleSer: 6.069 ± 0.162
5.125IleThr: 5.125 ± 0.135
4.369IleVal: 4.369 ± 0.14
0.501IleTrp: 0.501 ± 0.049
2.672IleTyr: 2.672 ± 0.107
0.0IleXaa: 0.0 ± 0.0
Lys
4.077LysAla: 4.077 ± 0.141
0.796LysCys: 0.796 ± 0.06
4.59LysAsp: 4.59 ± 0.143
5.365LysGlu: 5.365 ± 0.199
2.527LysPhe: 2.527 ± 0.099
3.477LysGly: 3.477 ± 0.119
2.143LysHis: 2.143 ± 0.089
5.771LysIle: 5.771 ± 0.167
8.461LysLys: 8.461 ± 0.282
7.299LysLeu: 7.299 ± 0.188
1.58LysMet: 1.58 ± 0.081
5.033LysAsn: 5.033 ± 0.151
2.521LysPro: 2.521 ± 0.09
4.286LysGln: 4.286 ± 0.127
2.927LysArg: 2.927 ± 0.089
4.981LysSer: 4.981 ± 0.158
5.057LysThr: 5.057 ± 0.152
3.895LysVal: 3.895 ± 0.146
0.624LysTrp: 0.624 ± 0.047
2.453LysTyr: 2.453 ± 0.087
0.0LysXaa: 0.0 ± 0.0
Leu
6.549LeuAla: 6.549 ± 0.154
1.328LeuCys: 1.328 ± 0.084
5.119LeuAsp: 5.119 ± 0.153
5.546LeuGlu: 5.546 ± 0.192
5.983LeuPhe: 5.983 ± 0.202
5.651LeuGly: 5.651 ± 0.173
2.463LeuHis: 2.463 ± 0.098
8.172LeuIle: 8.172 ± 0.214
8.418LeuLys: 8.418 ± 0.188
10.312LeuLeu: 10.312 ± 0.296
2.112LeuMet: 2.112 ± 0.087
6.087LeuAsn: 6.087 ± 0.176
3.901LeuPro: 3.901 ± 0.125
3.603LeuGln: 3.603 ± 0.131
2.948LeuArg: 2.948 ± 0.112
8.326LeuSer: 8.326 ± 0.164
7.044LeuThr: 7.044 ± 0.189
5.319LeuVal: 5.319 ± 0.154
0.624LeuTrp: 0.624 ± 0.042
3.471LeuTyr: 3.471 ± 0.12
0.0LeuXaa: 0.0 ± 0.0
Met
1.377MetAla: 1.377 ± 0.07
0.258MetCys: 0.258 ± 0.029
1.113MetAsp: 1.113 ± 0.074
0.852MetGlu: 0.852 ± 0.06
0.919MetPhe: 0.919 ± 0.053
1.273MetGly: 1.273 ± 0.065
0.412MetHis: 0.412 ± 0.037
1.697MetIle: 1.697 ± 0.075
1.752MetLys: 1.752 ± 0.073
2.106MetLeu: 2.106 ± 0.1
0.47MetMet: 0.47 ± 0.041
1.313MetAsn: 1.313 ± 0.065
0.689MetPro: 0.689 ± 0.043
0.726MetGln: 0.726 ± 0.048
0.636MetArg: 0.636 ± 0.047
1.639MetSer: 1.639 ± 0.069
1.316MetThr: 1.316 ± 0.075
1.239MetVal: 1.239 ± 0.072
0.123MetTrp: 0.123 ± 0.02
0.584MetTyr: 0.584 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
2.678AsnAla: 2.678 ± 0.083
0.633AsnCys: 0.633 ± 0.047
3.201AsnAsp: 3.201 ± 0.101
2.742AsnGlu: 2.742 ± 0.111
2.629AsnPhe: 2.629 ± 0.097
2.429AsnGly: 2.429 ± 0.112
1.608AsnHis: 1.608 ± 0.078
5.383AsnIle: 5.383 ± 0.191
4.855AsnLys: 4.855 ± 0.127
5.137AsnLeu: 5.137 ± 0.135
1.147AsnMet: 1.147 ± 0.069
3.772AsnAsn: 3.772 ± 0.164
2.407AsnPro: 2.407 ± 0.099
3.038AsnGln: 3.038 ± 0.108
1.888AsnArg: 1.888 ± 0.08
3.348AsnSer: 3.348 ± 0.131
3.379AsnThr: 3.379 ± 0.124
3.234AsnVal: 3.234 ± 0.101
0.44AsnTrp: 0.44 ± 0.036
2.174AsnTyr: 2.174 ± 0.102
0.0AsnXaa: 0.0 ± 0.0
Pro
2.097ProAla: 2.097 ± 0.086
0.341ProCys: 0.341 ± 0.034
2.032ProAsp: 2.032 ± 0.095
2.334ProGlu: 2.334 ± 0.092
2.152ProPhe: 2.152 ± 0.088
1.743ProGly: 1.743 ± 0.086
0.993ProHis: 0.993 ± 0.061
2.832ProIle: 2.832 ± 0.095
2.438ProLys: 2.438 ± 0.096
3.674ProLeu: 3.674 ± 0.103
0.553ProMet: 0.553 ± 0.042
2.038ProAsn: 2.038 ± 0.084
1.048ProPro: 1.048 ± 0.066
1.273ProGln: 1.273 ± 0.068
0.916ProArg: 0.916 ± 0.055
2.37ProSer: 2.37 ± 0.093
2.272ProThr: 2.272 ± 0.088
2.217ProVal: 2.217 ± 0.092
0.283ProTrp: 0.283 ± 0.03
1.414ProTyr: 1.414 ± 0.076
0.0ProXaa: 0.0 ± 0.0
Gln
2.65GlnAla: 2.65 ± 0.099
0.593GlnCys: 0.593 ± 0.039
2.091GlnAsp: 2.091 ± 0.079
2.493GlnGlu: 2.493 ± 0.096
2.186GlnPhe: 2.186 ± 0.09
1.774GlnGly: 1.774 ± 0.091
1.46GlnHis: 1.46 ± 0.061
2.742GlnIle: 2.742 ± 0.101
3.376GlnLys: 3.376 ± 0.11
5.586GlnLeu: 5.586 ± 0.176
0.716GlnMet: 0.716 ± 0.051
2.041GlnAsn: 2.041 ± 0.091
1.248GlnPro: 1.248 ± 0.065
2.672GlnGln: 2.672 ± 0.12
1.673GlnArg: 1.673 ± 0.072
2.915GlnSer: 2.915 ± 0.11
2.49GlnThr: 2.49 ± 0.087
1.968GlnVal: 1.968 ± 0.096
0.452GlnTrp: 0.452 ± 0.04
1.47GlnTyr: 1.47 ± 0.07
0.0GlnXaa: 0.0 ± 0.0
Arg
1.645ArgAla: 1.645 ± 0.074
0.421ArgCys: 0.421 ± 0.042
1.802ArgAsp: 1.802 ± 0.082
1.654ArgGlu: 1.654 ± 0.089
1.971ArgPhe: 1.971 ± 0.08
1.605ArgGly: 1.605 ± 0.086
0.978ArgHis: 0.978 ± 0.059
2.361ArgIle: 2.361 ± 0.084
2.201ArgLys: 2.201 ± 0.092
3.502ArgLeu: 3.502 ± 0.117
0.581ArgMet: 0.581 ± 0.046
1.574ArgAsn: 1.574 ± 0.075
1.079ArgPro: 1.079 ± 0.061
1.405ArgGln: 1.405 ± 0.069
1.288ArgArg: 1.288 ± 0.075
2.171ArgSer: 2.171 ± 0.088
1.577ArgThr: 1.577 ± 0.078
2.137ArgVal: 2.137 ± 0.094
0.28ArgTrp: 0.28 ± 0.031
1.513ArgTyr: 1.513 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
3.526SerAla: 3.526 ± 0.129
0.876SerCys: 0.876 ± 0.063
4.135SerAsp: 4.135 ± 0.128
4.203SerGlu: 4.203 ± 0.149
4.286SerPhe: 4.286 ± 0.138
3.686SerGly: 3.686 ± 0.138
1.685SerHis: 1.685 ± 0.077
5.915SerIle: 5.915 ± 0.165
4.83SerLys: 4.83 ± 0.152
8.098SerLeu: 8.098 ± 0.177
1.423SerMet: 1.423 ± 0.077
3.732SerAsn: 3.732 ± 0.147
2.493SerPro: 2.493 ± 0.104
2.964SerGln: 2.964 ± 0.108
2.048SerArg: 2.048 ± 0.082
5.257SerSer: 5.257 ± 0.214
3.969SerThr: 3.969 ± 0.109
3.929SerVal: 3.929 ± 0.141
0.658SerTrp: 0.658 ± 0.049
3.01SerTyr: 3.01 ± 0.099
0.0SerXaa: 0.0 ± 0.0
Thr
3.699ThrAla: 3.699 ± 0.11
0.75ThrCys: 0.75 ± 0.057
3.296ThrAsp: 3.296 ± 0.108
3.456ThrGlu: 3.456 ± 0.12
3.145ThrPhe: 3.145 ± 0.099
3.253ThrGly: 3.253 ± 0.127
1.626ThrHis: 1.626 ± 0.083
5.571ThrIle: 5.571 ± 0.142
4.083ThrLys: 4.083 ± 0.123
6.358ThrLeu: 6.358 ± 0.162
1.171ThrMet: 1.171 ± 0.061
2.884ThrAsn: 2.884 ± 0.112
2.536ThrPro: 2.536 ± 0.116
2.527ThrGln: 2.527 ± 0.102
1.629ThrArg: 1.629 ± 0.073
3.542ThrSer: 3.542 ± 0.126
4.071ThrThr: 4.071 ± 0.136
3.831ThrVal: 3.831 ± 0.113
0.424ThrTrp: 0.424 ± 0.04
2.5ThrTyr: 2.5 ± 0.095
0.0ThrXaa: 0.0 ± 0.0
Val
3.818ValAla: 3.818 ± 0.147
0.756ValCys: 0.756 ± 0.048
3.339ValAsp: 3.339 ± 0.131
3.065ValGlu: 3.065 ± 0.117
3.167ValPhe: 3.167 ± 0.1
3.462ValGly: 3.462 ± 0.107
1.196ValHis: 1.196 ± 0.063
4.959ValIle: 4.959 ± 0.146
3.991ValLys: 3.991 ± 0.106
5.534ValLeu: 5.534 ± 0.161
1.411ValMet: 1.411 ± 0.069
3.142ValAsn: 3.142 ± 0.118
2.029ValPro: 2.029 ± 0.089
1.808ValGln: 1.808 ± 0.074
1.691ValArg: 1.691 ± 0.087
4.492ValSer: 4.492 ± 0.134
3.883ValThr: 3.883 ± 0.118
3.772ValVal: 3.772 ± 0.147
0.409ValTrp: 0.409 ± 0.044
1.915ValTyr: 1.915 ± 0.079
0.0ValXaa: 0.0 ± 0.0
Trp
0.427TrpAla: 0.427 ± 0.042
0.077TrpCys: 0.077 ± 0.017
0.467TrpAsp: 0.467 ± 0.04
0.535TrpGlu: 0.535 ± 0.044
0.406TrpPhe: 0.406 ± 0.038
0.569TrpGly: 0.569 ± 0.044
0.178TrpHis: 0.178 ± 0.025
0.661TrpIle: 0.661 ± 0.053
0.556TrpLys: 0.556 ± 0.052
0.849TrpLeu: 0.849 ± 0.066
0.24TrpMet: 0.24 ± 0.028
0.455TrpAsn: 0.455 ± 0.035
0.237TrpPro: 0.237 ± 0.028
0.289TrpGln: 0.289 ± 0.028
0.243TrpArg: 0.243 ± 0.026
0.529TrpSer: 0.529 ± 0.039
0.415TrpThr: 0.415 ± 0.043
0.606TrpVal: 0.606 ± 0.052
0.114TrpTrp: 0.114 ± 0.02
0.329TrpTyr: 0.329 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.115TyrAla: 2.115 ± 0.079
0.587TyrCys: 0.587 ± 0.047
2.303TyrAsp: 2.303 ± 0.089
2.103TyrGlu: 2.103 ± 0.098
2.275TyrPhe: 2.275 ± 0.087
2.1TyrGly: 2.1 ± 0.1
1.058TyrHis: 1.058 ± 0.065
2.801TyrIle: 2.801 ± 0.113
2.632TyrLys: 2.632 ± 0.091
4.031TyrLeu: 4.031 ± 0.129
0.676TyrMet: 0.676 ± 0.051
2.063TyrAsn: 2.063 ± 0.096
1.414TyrPro: 1.414 ± 0.068
1.98TyrGln: 1.98 ± 0.091
1.236TyrArg: 1.236 ± 0.055
2.69TyrSer: 2.69 ± 0.115
1.931TyrThr: 1.931 ± 0.082
2.094TyrVal: 2.094 ± 0.095
0.36TyrTrp: 0.36 ± 0.033
1.583TyrTyr: 1.583 ± 0.106
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 930 proteins (325261 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski