Amino acid dipepetide frequency for Devosia sp. M6-77

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.518AlaAla: 16.518 ± 0.171	0.778AlaCys: 0.778 ± 0.028	7.087AlaAsp: 7.087 ± 0.083	7.797AlaGlu: 7.797 ± 0.092	4.551AlaPhe: 4.551 ± 0.067	10.448AlaGly: 10.448 ± 0.106	2.154AlaHis: 2.154 ± 0.044	7.118AlaIle: 7.118 ± 0.082	3.737AlaLys: 3.737 ± 0.059	14.331AlaLeu: 14.331 ± 0.136	3.899AlaMet: 3.899 ± 0.063	3.316AlaAsn: 3.316 ± 0.057	5.473AlaPro: 5.473 ± 0.098	4.344AlaGln: 4.344 ± 0.062	7.85AlaArg: 7.85 ± 0.096	6.339AlaSer: 6.339 ± 0.075	6.07AlaThr: 6.07 ± 0.069	8.802AlaVal: 8.802 ± 0.099	1.418AlaTrp: 1.418 ± 0.037	2.646AlaTyr: 2.646 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.786CysAla: 0.786 ± 0.028	0.091CysCys: 0.091 ± 0.009	0.452CysAsp: 0.452 ± 0.019	0.327CysGlu: 0.327 ± 0.015	0.254CysPhe: 0.254 ± 0.014	0.717CysGly: 0.717 ± 0.024	0.197CysHis: 0.197 ± 0.01	0.334CysIle: 0.334 ± 0.016	0.147CysLys: 0.147 ± 0.012	0.647CysLeu: 0.647 ± 0.024	0.128CysMet: 0.128 ± 0.011	0.162CysAsn: 0.162 ± 0.012	0.344CysPro: 0.344 ± 0.018	0.215CysGln: 0.215 ± 0.013	0.466CysArg: 0.466 ± 0.02	0.361CysSer: 0.361 ± 0.018	0.339CysThr: 0.339 ± 0.017	0.48CysVal: 0.48 ± 0.021	0.101CysTrp: 0.101 ± 0.01	0.182CysTyr: 0.182 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.049AspAla: 7.049 ± 0.083	0.409AspCys: 0.409 ± 0.018	2.993AspAsp: 2.993 ± 0.052	3.325AspGlu: 3.325 ± 0.06	2.327AspPhe: 2.327 ± 0.04	5.232AspGly: 5.232 ± 0.073	1.208AspHis: 1.208 ± 0.031	3.587AspIle: 3.587 ± 0.061	1.788AspLys: 1.788 ± 0.04	5.915AspLeu: 5.915 ± 0.075	1.455AspMet: 1.455 ± 0.036	1.549AspAsn: 1.549 ± 0.036	3.353AspPro: 3.353 ± 0.048	1.858AspGln: 1.858 ± 0.044	3.817AspArg: 3.817 ± 0.062	2.295AspSer: 2.295 ± 0.044	2.771AspThr: 2.771 ± 0.048	4.005AspVal: 4.005 ± 0.047	1.027AspTrp: 1.027 ± 0.032	1.604AspTyr: 1.604 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.555GluAla: 7.555 ± 0.087	0.278GluCys: 0.278 ± 0.018	2.868GluAsp: 2.868 ± 0.049	2.941GluGlu: 2.941 ± 0.056	1.734GluPhe: 1.734 ± 0.045	4.211GluGly: 4.211 ± 0.059	1.214GluHis: 1.214 ± 0.033	3.397GluIle: 3.397 ± 0.056	2.02GluLys: 2.02 ± 0.047	5.245GluLeu: 5.245 ± 0.073	1.477GluMet: 1.477 ± 0.034	1.582GluAsn: 1.582 ± 0.04	2.66GluPro: 2.66 ± 0.056	2.199GluGln: 2.199 ± 0.048	4.434GluArg: 4.434 ± 0.067	2.194GluSer: 2.194 ± 0.046	3.534GluThr: 3.534 ± 0.061	3.817GluVal: 3.817 ± 0.067	0.649GluTrp: 0.649 ± 0.023	0.928GluTyr: 0.928 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	5.002PheAla: 5.002 ± 0.06	0.344PheCys: 0.344 ± 0.016	2.64PheAsp: 2.64 ± 0.043	2.162PheGlu: 2.162 ± 0.039	1.554PhePhe: 1.554 ± 0.043	3.896PheGly: 3.896 ± 0.065	0.732PheHis: 0.732 ± 0.027	1.904PheIle: 1.904 ± 0.043	1.006PheLys: 1.006 ± 0.033	3.445PheLeu: 3.445 ± 0.065	0.862PheMet: 0.862 ± 0.028	1.149PheAsn: 1.149 ± 0.03	1.543PhePro: 1.543 ± 0.035	1.029PheGln: 1.029 ± 0.029	1.991PheArg: 1.991 ± 0.043	2.378PheSer: 2.378 ± 0.042	2.086PheThr: 2.086 ± 0.042	3.077PheVal: 3.077 ± 0.061	0.628PheTrp: 0.628 ± 0.024	0.981PheTyr: 0.981 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.191GlyAla: 9.191 ± 0.111	0.651GlyCys: 0.651 ± 0.025	4.373GlyAsp: 4.373 ± 0.065	4.738GlyGlu: 4.738 ± 0.066	3.753GlyPhe: 3.753 ± 0.056	7.147GlyGly: 7.147 ± 0.102	1.861GlyHis: 1.861 ± 0.043	4.944GlyIle: 4.944 ± 0.064	3.397GlyLys: 3.397 ± 0.065	9.312GlyLeu: 9.312 ± 0.092	2.361GlyMet: 2.361 ± 0.047	2.41GlyAsn: 2.41 ± 0.051	3.417GlyPro: 3.417 ± 0.057	3.285GlyGln: 3.285 ± 0.056	5.493GlyArg: 5.493 ± 0.07	4.525GlySer: 4.525 ± 0.076	4.785GlyThr: 4.785 ± 0.067	6.248GlyVal: 6.248 ± 0.085	1.363GlyTrp: 1.363 ± 0.04	2.32GlyTyr: 2.32 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.227HisAla: 2.227 ± 0.05	0.182HisCys: 0.182 ± 0.012	1.201HisAsp: 1.201 ± 0.031	1.056HisGlu: 1.056 ± 0.03	0.867HisPhe: 0.867 ± 0.028	1.853HisGly: 1.853 ± 0.042	0.575HisHis: 0.575 ± 0.026	1.017HisIle: 1.017 ± 0.028	0.507HisLys: 0.507 ± 0.02	2.006HisLeu: 2.006 ± 0.039	0.553HisMet: 0.553 ± 0.021	0.514HisAsn: 0.514 ± 0.022	1.218HisPro: 1.218 ± 0.035	0.638HisGln: 0.638 ± 0.025	1.314HisArg: 1.314 ± 0.038	0.907HisSer: 0.907 ± 0.028	0.846HisThr: 0.846 ± 0.033	1.412HisVal: 1.412 ± 0.037	0.335HisTrp: 0.335 ± 0.016	0.536HisTyr: 0.536 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.988IleAla: 7.988 ± 0.083	0.475IleCys: 0.475 ± 0.02	3.748IleAsp: 3.748 ± 0.062	3.571IleGlu: 3.571 ± 0.057	1.966IlePhe: 1.966 ± 0.042	5.451IleGly: 5.451 ± 0.078	0.92IleHis: 0.92 ± 0.029	2.72IleIle: 2.72 ± 0.053	1.586IleLys: 1.586 ± 0.04	4.787IleLeu: 4.787 ± 0.073	1.14IleMet: 1.14 ± 0.033	1.61IleAsn: 1.61 ± 0.035	2.328IlePro: 2.328 ± 0.05	1.188IleGln: 1.188 ± 0.03	3.039IleArg: 3.039 ± 0.048	3.109IleSer: 3.109 ± 0.057	3.026IleThr: 3.026 ± 0.052	4.532IleVal: 4.532 ± 0.069	0.662IleTrp: 0.662 ± 0.024	1.292IleTyr: 1.292 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.136LysAla: 4.136 ± 0.065	0.138LysCys: 0.138 ± 0.01	1.595LysAsp: 1.595 ± 0.041	1.265LysGlu: 1.265 ± 0.034	0.922LysPhe: 0.922 ± 0.032	2.49LysGly: 2.49 ± 0.047	0.574LysHis: 0.574 ± 0.023	1.572LysIle: 1.572 ± 0.042	1.079LysLys: 1.079 ± 0.032	3.17LysLeu: 3.17 ± 0.059	0.727LysMet: 0.727 ± 0.025	0.784LysAsn: 0.784 ± 0.03	2.04LysPro: 2.04 ± 0.051	0.995LysGln: 0.995 ± 0.029	2.173LysArg: 2.173 ± 0.044	1.897LysSer: 1.897 ± 0.046	1.919LysThr: 1.919 ± 0.045	2.439LysVal: 2.439 ± 0.049	0.357LysTrp: 0.357 ± 0.021	0.559LysTyr: 0.559 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.95LeuAla: 13.95 ± 0.134	0.759LeuCys: 0.759 ± 0.022	6.541LeuAsp: 6.541 ± 0.078	5.315LeuGlu: 5.315 ± 0.073	3.795LeuPhe: 3.795 ± 0.06	8.733LeuGly: 8.733 ± 0.107	1.802LeuHis: 1.802 ± 0.041	5.28LeuIle: 5.28 ± 0.078	3.345LeuLys: 3.345 ± 0.057	9.943LeuLeu: 9.943 ± 0.123	2.532LeuMet: 2.532 ± 0.048	2.764LeuAsn: 2.764 ± 0.046	5.663LeuPro: 5.663 ± 0.073	2.694LeuGln: 2.694 ± 0.055	6.436LeuArg: 6.436 ± 0.073	6.664LeuSer: 6.664 ± 0.081	5.803LeuThr: 5.803 ± 0.07	8.379LeuVal: 8.379 ± 0.102	1.107LeuTrp: 1.107 ± 0.031	2.228LeuTyr: 2.228 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.564MetAla: 3.564 ± 0.065	0.112MetCys: 0.112 ± 0.008	1.23MetAsp: 1.23 ± 0.035	1.049MetGlu: 1.049 ± 0.032	0.795MetPhe: 0.795 ± 0.025	2.011MetGly: 2.011 ± 0.043	0.461MetHis: 0.461 ± 0.018	1.381MetIle: 1.381 ± 0.039	0.792MetLys: 0.792 ± 0.029	2.672MetLeu: 2.672 ± 0.052	0.666MetMet: 0.666 ± 0.022	0.741MetAsn: 0.741 ± 0.02	1.477MetPro: 1.477 ± 0.036	0.878MetGln: 0.878 ± 0.024	1.77MetArg: 1.77 ± 0.036	1.89MetSer: 1.89 ± 0.038	1.954MetThr: 1.954 ± 0.04	2.009MetVal: 2.009 ± 0.044	0.208MetTrp: 0.208 ± 0.012	0.295MetTyr: 0.295 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.451AsnAla: 3.451 ± 0.059	0.211AsnCys: 0.211 ± 0.016	1.481AsnAsp: 1.481 ± 0.035	1.27AsnGlu: 1.27 ± 0.033	1.062AsnPhe: 1.062 ± 0.03	2.679AsnGly: 2.679 ± 0.049	0.524AsnHis: 0.524 ± 0.019	1.512AsnIle: 1.512 ± 0.039	0.786AsnLys: 0.786 ± 0.027	2.813AsnLeu: 2.813 ± 0.053	0.654AsnMet: 0.654 ± 0.023	0.746AsnAsn: 0.746 ± 0.03	1.915AsnPro: 1.915 ± 0.04	0.909AsnGln: 0.909 ± 0.028	1.85AsnArg: 1.85 ± 0.04	1.411AsnSer: 1.411 ± 0.033	1.359AsnThr: 1.359 ± 0.035	2.036AsnVal: 2.036 ± 0.045	0.494AsnTrp: 0.494 ± 0.022	0.788AsnTyr: 0.788 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.098ProAla: 6.098 ± 0.104	0.222ProCys: 0.222 ± 0.013	3.578ProAsp: 3.578 ± 0.062	3.596ProGlu: 3.596 ± 0.059	1.953ProPhe: 1.953 ± 0.043	4.246ProGly: 4.246 ± 0.067	1.088ProHis: 1.088 ± 0.029	2.495ProIle: 2.495 ± 0.044	1.581ProLys: 1.581 ± 0.043	4.818ProLeu: 4.818 ± 0.067	1.232ProMet: 1.232 ± 0.033	1.539ProAsn: 1.539 ± 0.038	2.272ProPro: 2.272 ± 0.055	1.72ProGln: 1.72 ± 0.037	2.571ProArg: 2.571 ± 0.05	2.718ProSer: 2.718 ± 0.057	2.626ProThr: 2.626 ± 0.051	4.208ProVal: 4.208 ± 0.06	0.638ProTrp: 0.638 ± 0.028	1.214ProTyr: 1.214 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.115GlnAla: 4.115 ± 0.073	0.203GlnCys: 0.203 ± 0.015	1.58GlnAsp: 1.58 ± 0.037	1.336GlnGlu: 1.336 ± 0.033	1.27GlnPhe: 1.27 ± 0.031	2.466GlnGly: 2.466 ± 0.053	0.678GlnHis: 0.678 ± 0.021	1.867GlnIle: 1.867 ± 0.041	1.031GlnLys: 1.031 ± 0.032	3.322GlnLeu: 3.322 ± 0.065	1.02GlnMet: 1.02 ± 0.027	0.953GlnAsn: 0.953 ± 0.03	1.859GlnPro: 1.859 ± 0.044	1.322GlnGln: 1.322 ± 0.044	2.6GlnArg: 2.6 ± 0.056	1.984GlnSer: 1.984 ± 0.037	1.863GlnThr: 1.863 ± 0.043	2.466GlnVal: 2.466 ± 0.044	0.43GlnTrp: 0.43 ± 0.017	0.669GlnTyr: 0.669 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.165ArgAla: 7.165 ± 0.081	0.372ArgCys: 0.372 ± 0.019	3.808ArgAsp: 3.808 ± 0.063	3.385ArgGlu: 3.385 ± 0.057	2.79ArgPhe: 2.79 ± 0.053	4.295ArgGly: 4.295 ± 0.057	1.525ArgHis: 1.525 ± 0.037	3.792ArgIle: 3.792 ± 0.059	2.094ArgLys: 2.094 ± 0.045	7.508ArgLeu: 7.508 ± 0.081	1.724ArgMet: 1.724 ± 0.037	1.862ArgAsn: 1.862 ± 0.034	3.219ArgPro: 3.219 ± 0.064	2.772ArgGln: 2.772 ± 0.052	4.662ArgArg: 4.662 ± 0.07	3.413ArgSer: 3.413 ± 0.061	3.086ArgThr: 3.086 ± 0.052	4.429ArgVal: 4.429 ± 0.069	0.877ArgTrp: 0.877 ± 0.026	1.61ArgTyr: 1.61 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.457SerAla: 6.457 ± 0.079	0.331SerCys: 0.331 ± 0.016	2.895SerAsp: 2.895 ± 0.051	2.718SerGlu: 2.718 ± 0.053	2.396SerPhe: 2.396 ± 0.052	5.713SerGly: 5.713 ± 0.075	1.073SerHis: 1.073 ± 0.032	3.048SerIle: 3.048 ± 0.047	1.473SerLys: 1.473 ± 0.033	5.493SerLeu: 5.493 ± 0.073	1.411SerMet: 1.411 ± 0.036	1.469SerAsn: 1.469 ± 0.038	2.616SerPro: 2.616 ± 0.049	1.815SerGln: 1.815 ± 0.043	3.432SerArg: 3.432 ± 0.061	2.876SerSer: 2.876 ± 0.059	2.822SerThr: 2.822 ± 0.05	4.282SerVal: 4.282 ± 0.061	0.745SerTrp: 0.745 ± 0.028	1.379SerTyr: 1.379 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.313ThrAla: 6.313 ± 0.085	0.333ThrCys: 0.333 ± 0.016	2.963ThrAsp: 2.963 ± 0.054	2.748ThrGlu: 2.748 ± 0.051	1.957ThrPhe: 1.957 ± 0.042	5.142ThrGly: 5.142 ± 0.071	1.053ThrHis: 1.053 ± 0.033	3.311ThrIle: 3.311 ± 0.054	1.469ThrLys: 1.469 ± 0.035	6.366ThrLeu: 6.366 ± 0.066	1.267ThrMet: 1.267 ± 0.034	1.513ThrAsn: 1.513 ± 0.036	3.293ThrPro: 3.293 ± 0.056	1.649ThrGln: 1.649 ± 0.041	3.25ThrArg: 3.25 ± 0.054	2.92ThrSer: 2.92 ± 0.042	3.118ThrThr: 3.118 ± 0.056	4.144ThrVal: 4.144 ± 0.068	0.6ThrTrp: 0.6 ± 0.023	1.218ThrTyr: 1.218 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.206ValAla: 9.206 ± 0.104	0.489ValCys: 0.489 ± 0.02	4.439ValAsp: 4.439 ± 0.059	4.587ValGlu: 4.587 ± 0.071	2.858ValPhe: 2.858 ± 0.047	5.832ValGly: 5.832 ± 0.078	1.361ValHis: 1.361 ± 0.033	4.254ValIle: 4.254 ± 0.068	2.011ValLys: 2.011 ± 0.044	8.067ValLeu: 8.067 ± 0.084	2.003ValMet: 2.003 ± 0.041	2.109ValAsn: 2.109 ± 0.045	3.871ValPro: 3.871 ± 0.053	2.155ValGln: 2.155 ± 0.046	4.589ValArg: 4.589 ± 0.061	4.535ValSer: 4.535 ± 0.059	4.67ValThr: 4.67 ± 0.068	6.351ValVal: 6.351 ± 0.095	0.91ValTrp: 0.91 ± 0.028	1.486ValTyr: 1.486 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.268TrpAla: 1.268 ± 0.041	0.123TrpCys: 0.123 ± 0.011	0.659TrpAsp: 0.659 ± 0.025	0.504TrpGlu: 0.504 ± 0.02	0.546TrpPhe: 0.546 ± 0.023	0.912TrpGly: 0.912 ± 0.029	0.312TrpHis: 0.312 ± 0.015	0.61TrpIle: 0.61 ± 0.023	0.375TrpLys: 0.375 ± 0.018	1.589TrpLeu: 1.589 ± 0.04	0.388TrpMet: 0.388 ± 0.018	0.49TrpAsn: 0.49 ± 0.019	0.726TrpPro: 0.726 ± 0.024	0.623TrpGln: 0.623 ± 0.025	1.002TrpArg: 1.002 ± 0.03	0.813TrpSer: 0.813 ± 0.026	0.818TrpThr: 0.818 ± 0.027	0.873TrpVal: 0.873 ± 0.028	0.24TrpTrp: 0.24 ± 0.015	0.3TrpTyr: 0.3 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.638TyrAla: 2.638 ± 0.052	0.23TyrCys: 0.23 ± 0.015	1.44TyrAsp: 1.44 ± 0.037	1.247TyrGlu: 1.247 ± 0.034	1.058TyrPhe: 1.058 ± 0.031	2.1TyrGly: 2.1 ± 0.044	0.453TyrHis: 0.453 ± 0.022	0.996TyrIle: 0.996 ± 0.031	0.604TyrLys: 0.604 ± 0.024	2.284TyrLeu: 2.284 ± 0.041	0.453TyrMet: 0.453 ± 0.02	0.686TyrAsn: 0.686 ± 0.021	1.126TyrPro: 1.126 ± 0.03	0.746TyrGln: 0.746 ± 0.024	1.651TyrArg: 1.651 ± 0.04	1.218TyrSer: 1.218 ± 0.036	1.131TyrThr: 1.131 ± 0.034	1.792TyrVal: 1.792 ± 0.036	0.383TyrTrp: 0.383 ± 0.019	0.641TyrTyr: 0.641 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3943 proteins (1228497 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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