Amino acid dipepetide frequency for Candidatus Sneabacter namystus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.709AlaAla: 4.709 ± 0.263
1.107AlaCys: 1.107 ± 0.078
2.836AlaAsp: 2.836 ± 0.166
3.097AlaGlu: 3.097 ± 0.187
3.06AlaPhe: 3.06 ± 0.192
3.608AlaGly: 3.608 ± 0.22
1.362AlaHis: 1.362 ± 0.08
5.513AlaIle: 5.513 ± 0.191
5.481AlaLys: 5.481 ± 0.207
6.721AlaLeu: 6.721 ± 0.205
1.522AlaMet: 1.522 ± 0.09
2.618AlaAsn: 2.618 ± 0.117
1.873AlaPro: 1.873 ± 0.156
2.485AlaGln: 2.485 ± 0.124
2.943AlaArg: 2.943 ± 0.13
4.73AlaSer: 4.73 ± 0.16
3.326AlaThr: 3.326 ± 0.185
4.56AlaVal: 4.56 ± 0.177
0.495AlaTrp: 0.495 ± 0.054
1.889AlaTyr: 1.889 ± 0.111
0.0AlaXaa: 0.0 ± 0.0
Cys
1.314CysAla: 1.314 ± 0.082
0.346CysCys: 0.346 ± 0.042
0.958CysAsp: 0.958 ± 0.076
0.819CysGlu: 0.819 ± 0.077
0.846CysPhe: 0.846 ± 0.069
1.149CysGly: 1.149 ± 0.075
0.341CysHis: 0.341 ± 0.044
1.57CysIle: 1.57 ± 0.097
1.277CysLys: 1.277 ± 0.077
1.479CysLeu: 1.479 ± 0.086
0.394CysMet: 0.394 ± 0.044
0.899CysAsn: 0.899 ± 0.083
0.521CysPro: 0.521 ± 0.055
0.351CysGln: 0.351 ± 0.044
0.612CysArg: 0.612 ± 0.054
1.501CysSer: 1.501 ± 0.097
0.979CysThr: 0.979 ± 0.07
1.495CysVal: 1.495 ± 0.097
0.133CysTrp: 0.133 ± 0.026
0.713CysTyr: 0.713 ± 0.087
0.0CysXaa: 0.0 ± 0.0
Asp
3.262AspAla: 3.262 ± 0.196
0.873AspCys: 0.873 ± 0.068
2.421AspAsp: 2.421 ± 0.117
2.751AspGlu: 2.751 ± 0.144
2.528AspPhe: 2.528 ± 0.11
2.559AspGly: 2.559 ± 0.105
0.931AspHis: 0.931 ± 0.085
5.289AspIle: 5.289 ± 0.162
4.539AspLys: 4.539 ± 0.186
5.108AspLeu: 5.108 ± 0.199
1.49AspMet: 1.49 ± 0.094
2.661AspAsn: 2.661 ± 0.123
1.437AspPro: 1.437 ± 0.096
1.341AspGln: 1.341 ± 0.095
1.767AspArg: 1.767 ± 0.098
3.565AspSer: 3.565 ± 0.154
3.033AspThr: 3.033 ± 0.112
4.55AspVal: 4.55 ± 0.21
0.298AspTrp: 0.298 ± 0.047
1.559AspTyr: 1.559 ± 0.087
0.0AspXaa: 0.0 ± 0.0
Glu
3.703GluAla: 3.703 ± 0.217
0.857GluCys: 0.857 ± 0.088
3.049GluAsp: 3.049 ± 0.13
4.762GluGlu: 4.762 ± 0.221
2.081GluPhe: 2.081 ± 0.111
3.246GluGly: 3.246 ± 0.177
1.383GluHis: 1.383 ± 0.086
4.821GluIle: 4.821 ± 0.172
5.97GluLys: 5.97 ± 0.193
4.938GluLeu: 4.938 ± 0.17
1.527GluMet: 1.527 ± 0.095
3.123GluAsn: 3.123 ± 0.137
1.133GluPro: 1.133 ± 0.101
2.363GluGln: 2.363 ± 0.111
2.692GluArg: 2.692 ± 0.14
3.773GluSer: 3.773 ± 0.124
1.948GluThr: 1.948 ± 0.099
3.836GluVal: 3.836 ± 0.138
0.346GluTrp: 0.346 ± 0.046
2.288GluTyr: 2.288 ± 0.117
0.0GluXaa: 0.0 ± 0.0
Phe
3.134PheAla: 3.134 ± 0.158
1.101PheCys: 1.101 ± 0.084
2.325PheAsp: 2.325 ± 0.115
2.171PheGlu: 2.171 ± 0.125
3.001PhePhe: 3.001 ± 0.159
2.959PheGly: 2.959 ± 0.179
0.681PheHis: 0.681 ± 0.07
3.294PheIle: 3.294 ± 0.159
2.474PheLys: 2.474 ± 0.111
5.183PheLeu: 5.183 ± 0.192
0.899PheMet: 0.899 ± 0.072
1.841PheAsn: 1.841 ± 0.101
1.431PhePro: 1.431 ± 0.098
1.25PheGln: 1.25 ± 0.11
1.437PheArg: 1.437 ± 0.092
4.837PheSer: 4.837 ± 0.178
2.23PheThr: 2.23 ± 0.112
3.315PheVal: 3.315 ± 0.172
0.442PheTrp: 0.442 ± 0.049
1.501PheTyr: 1.501 ± 0.098
0.0PheXaa: 0.0 ± 0.0
Gly
3.938GlyAla: 3.938 ± 0.195
0.968GlyCys: 0.968 ± 0.072
2.778GlyAsp: 2.778 ± 0.133
2.788GlyGlu: 2.788 ± 0.159
2.421GlyPhe: 2.421 ± 0.137
3.805GlyGly: 3.805 ± 0.234
1.266GlyHis: 1.266 ± 0.08
5.364GlyIle: 5.364 ± 0.195
5.135GlyLys: 5.135 ± 0.175
4.954GlyLeu: 4.954 ± 0.211
1.57GlyMet: 1.57 ± 0.1
2.501GlyAsn: 2.501 ± 0.135
1.245GlyPro: 1.245 ± 0.087
1.596GlyGln: 1.596 ± 0.103
2.368GlyArg: 2.368 ± 0.137
3.821GlySer: 3.821 ± 0.172
2.916GlyThr: 2.916 ± 0.124
4.651GlyVal: 4.651 ± 0.179
0.458GlyTrp: 0.458 ± 0.055
1.963GlyTyr: 1.963 ± 0.118
0.0GlyXaa: 0.0 ± 0.0
His
1.511HisAla: 1.511 ± 0.093
0.378HisCys: 0.378 ± 0.044
1.224HisAsp: 1.224 ± 0.088
1.085HisGlu: 1.085 ± 0.073
1.022HisPhe: 1.022 ± 0.086
1.192HisGly: 1.192 ± 0.098
0.569HisHis: 0.569 ± 0.06
1.963HisIle: 1.963 ± 0.121
1.586HisLys: 1.586 ± 0.092
2.347HisLeu: 2.347 ± 0.123
0.511HisMet: 0.511 ± 0.055
1.33HisAsn: 1.33 ± 0.113
0.825HisPro: 0.825 ± 0.065
0.479HisGln: 0.479 ± 0.051
0.761HisArg: 0.761 ± 0.073
1.447HisSer: 1.447 ± 0.083
1.096HisThr: 1.096 ± 0.076
1.532HisVal: 1.532 ± 0.1
0.154HisTrp: 0.154 ± 0.026
1.0HisTyr: 1.0 ± 0.067
0.0HisXaa: 0.0 ± 0.0
Ile
6.343IleAla: 6.343 ± 0.213
1.346IleCys: 1.346 ± 0.089
4.693IleAsp: 4.693 ± 0.16
5.066IleGlu: 5.066 ± 0.231
3.879IlePhe: 3.879 ± 0.192
4.613IleGly: 4.613 ± 0.196
1.458IleHis: 1.458 ± 0.09
5.486IleIle: 5.486 ± 0.216
6.486IleLys: 6.486 ± 0.218
8.226IleLeu: 8.226 ± 0.251
1.713IleMet: 1.713 ± 0.107
3.645IleAsn: 3.645 ± 0.144
3.145IlePro: 3.145 ± 0.139
2.932IleGln: 2.932 ± 0.154
3.288IleArg: 3.288 ± 0.16
7.849IleSer: 7.849 ± 0.268
4.619IleThr: 4.619 ± 0.155
5.561IleVal: 5.561 ± 0.186
0.495IleTrp: 0.495 ± 0.061
2.139IleTyr: 2.139 ± 0.108
0.0IleXaa: 0.0 ± 0.0
Lys
4.901LysAla: 4.901 ± 0.181
1.048LysCys: 1.048 ± 0.065
4.789LysAsp: 4.789 ± 0.186
6.007LysGlu: 6.007 ± 0.204
3.065LysPhe: 3.065 ± 0.136
4.353LysGly: 4.353 ± 0.191
1.852LysHis: 1.852 ± 0.104
7.519LysIle: 7.519 ± 0.214
7.402LysLys: 7.402 ± 0.281
6.859LysLeu: 6.859 ± 0.241
2.107LysMet: 2.107 ± 0.093
4.879LysAsn: 4.879 ± 0.167
1.66LysPro: 1.66 ± 0.095
2.703LysGln: 2.703 ± 0.136
3.602LysArg: 3.602 ± 0.142
5.518LysSer: 5.518 ± 0.189
4.113LysThr: 4.113 ± 0.145
5.906LysVal: 5.906 ± 0.2
0.591LysTrp: 0.591 ± 0.064
2.815LysTyr: 2.815 ± 0.162
0.0LysXaa: 0.0 ± 0.0
Leu
5.949LeuAla: 5.949 ± 0.208
1.932LeuCys: 1.932 ± 0.109
5.646LeuAsp: 5.646 ± 0.236
6.045LeuGlu: 6.045 ± 0.178
4.113LeuPhe: 4.113 ± 0.188
5.534LeuGly: 5.534 ± 0.227
2.543LeuHis: 2.543 ± 0.132
6.566LeuIle: 6.566 ± 0.195
7.242LeuLys: 7.242 ± 0.214
10.355LeuLeu: 10.355 ± 0.407
1.921LeuMet: 1.921 ± 0.095
4.656LeuAsn: 4.656 ± 0.226
3.858LeuPro: 3.858 ± 0.143
3.985LeuGln: 3.985 ± 0.176
4.268LeuArg: 4.268 ± 0.163
10.387LeuSer: 10.387 ± 0.301
4.619LeuThr: 4.619 ± 0.243
5.571LeuVal: 5.571 ± 0.167
0.809LeuTrp: 0.809 ± 0.062
3.139LeuTyr: 3.139 ± 0.135
0.0LeuXaa: 0.0 ± 0.0
Met
1.357MetAla: 1.357 ± 0.086
0.463MetCys: 0.463 ± 0.051
0.91MetAsp: 0.91 ± 0.077
1.091MetGlu: 1.091 ± 0.069
0.968MetPhe: 0.968 ± 0.077
1.176MetGly: 1.176 ± 0.084
0.559MetHis: 0.559 ± 0.06
1.586MetIle: 1.586 ± 0.091
1.83MetLys: 1.83 ± 0.103
2.687MetLeu: 2.687 ± 0.131
0.591MetMet: 0.591 ± 0.06
1.048MetAsn: 1.048 ± 0.077
1.048MetPro: 1.048 ± 0.07
1.234MetGln: 1.234 ± 0.084
1.043MetArg: 1.043 ± 0.077
2.379MetSer: 2.379 ± 0.11
1.08MetThr: 1.08 ± 0.073
1.234MetVal: 1.234 ± 0.076
0.181MetTrp: 0.181 ± 0.031
0.697MetTyr: 0.697 ± 0.052
0.0MetXaa: 0.0 ± 0.0
Asn
3.022AsnAla: 3.022 ± 0.13
0.857AsnCys: 0.857 ± 0.065
2.208AsnAsp: 2.208 ± 0.128
2.299AsnGlu: 2.299 ± 0.123
2.533AsnPhe: 2.533 ± 0.123
2.086AsnGly: 2.086 ± 0.123
0.841AsnHis: 0.841 ± 0.065
4.874AsnIle: 4.874 ± 0.202
4.459AsnLys: 4.459 ± 0.155
5.119AsnLeu: 5.119 ± 0.227
1.208AsnMet: 1.208 ± 0.077
3.022AsnAsn: 3.022 ± 0.2
1.57AsnPro: 1.57 ± 0.09
1.346AsnGln: 1.346 ± 0.09
1.612AsnArg: 1.612 ± 0.108
3.544AsnSer: 3.544 ± 0.146
2.996AsnThr: 2.996 ± 0.128
3.954AsnVal: 3.954 ± 0.156
0.426AsnTrp: 0.426 ± 0.049
1.453AsnTyr: 1.453 ± 0.096
0.0AsnXaa: 0.0 ± 0.0
Pro
1.564ProAla: 1.564 ± 0.113
0.575ProCys: 0.575 ± 0.06
1.596ProAsp: 1.596 ± 0.093
1.862ProGlu: 1.862 ± 0.105
1.522ProPhe: 1.522 ± 0.098
1.932ProGly: 1.932 ± 0.147
0.819ProHis: 0.819 ± 0.072
2.49ProIle: 2.49 ± 0.122
2.166ProLys: 2.166 ± 0.108
3.06ProLeu: 3.06 ± 0.178
0.484ProMet: 0.484 ± 0.049
1.586ProAsn: 1.586 ± 0.106
0.889ProPro: 0.889 ± 0.075
0.995ProGln: 0.995 ± 0.07
0.958ProArg: 0.958 ± 0.081
2.469ProSer: 2.469 ± 0.099
1.554ProThr: 1.554 ± 0.092
2.336ProVal: 2.336 ± 0.131
0.239ProTrp: 0.239 ± 0.035
1.165ProTyr: 1.165 ± 0.087
0.0ProXaa: 0.0 ± 0.0
Gln
1.932GlnAla: 1.932 ± 0.114
0.553GlnCys: 0.553 ± 0.05
2.182GlnAsp: 2.182 ± 0.098
2.655GlnGlu: 2.655 ± 0.131
1.197GlnPhe: 1.197 ± 0.079
1.884GlnGly: 1.884 ± 0.115
0.984GlnHis: 0.984 ± 0.078
2.778GlnIle: 2.778 ± 0.136
2.985GlnLys: 2.985 ± 0.145
3.097GlnLeu: 3.097 ± 0.176
0.91GlnMet: 0.91 ± 0.075
1.979GlnAsn: 1.979 ± 0.103
0.761GlnPro: 0.761 ± 0.061
1.506GlnGln: 1.506 ± 0.104
1.373GlnArg: 1.373 ± 0.089
2.293GlnSer: 2.293 ± 0.117
1.399GlnThr: 1.399 ± 0.085
2.352GlnVal: 2.352 ± 0.13
0.245GlnTrp: 0.245 ± 0.039
1.394GlnTyr: 1.394 ± 0.093
0.0GlnXaa: 0.0 ± 0.0
Arg
2.384ArgAla: 2.384 ± 0.118
0.686ArgCys: 0.686 ± 0.053
2.022ArgAsp: 2.022 ± 0.112
2.416ArgGlu: 2.416 ± 0.128
1.873ArgPhe: 1.873 ± 0.094
2.128ArgGly: 2.128 ± 0.12
0.958ArgHis: 0.958 ± 0.079
3.39ArgIle: 3.39 ± 0.134
3.57ArgLys: 3.57 ± 0.155
3.549ArgLeu: 3.549 ± 0.141
0.979ArgMet: 0.979 ± 0.069
2.022ArgAsn: 2.022 ± 0.101
1.165ArgPro: 1.165 ± 0.071
1.602ArgGln: 1.602 ± 0.099
1.9ArgArg: 1.9 ± 0.101
2.778ArgSer: 2.778 ± 0.134
1.538ArgThr: 1.538 ± 0.09
2.911ArgVal: 2.911 ± 0.156
0.325ArgTrp: 0.325 ± 0.042
1.618ArgTyr: 1.618 ± 0.083
0.0ArgXaa: 0.0 ± 0.0
Ser
4.826SerAla: 4.826 ± 0.152
1.586SerCys: 1.586 ± 0.092
4.108SerAsp: 4.108 ± 0.165
4.087SerGlu: 4.087 ± 0.152
3.911SerPhe: 3.911 ± 0.175
4.869SerGly: 4.869 ± 0.208
1.894SerHis: 1.894 ± 0.096
7.008SerIle: 7.008 ± 0.233
6.172SerLys: 6.172 ± 0.19
8.423SerLeu: 8.423 ± 0.312
1.932SerMet: 1.932 ± 0.094
3.98SerAsn: 3.98 ± 0.17
2.198SerPro: 2.198 ± 0.102
2.528SerGln: 2.528 ± 0.109
2.98SerArg: 2.98 ± 0.139
6.694SerSer: 6.694 ± 0.238
3.874SerThr: 3.874 ± 0.143
6.396SerVal: 6.396 ± 0.203
0.66SerTrp: 0.66 ± 0.061
2.927SerTyr: 2.927 ± 0.137
0.0SerXaa: 0.0 ± 0.0
Thr
2.857ThrAla: 2.857 ± 0.127
0.841ThrCys: 0.841 ± 0.074
2.277ThrAsp: 2.277 ± 0.118
2.74ThrGlu: 2.74 ± 0.129
2.336ThrPhe: 2.336 ± 0.117
2.895ThrGly: 2.895 ± 0.103
1.059ThrHis: 1.059 ± 0.079
4.278ThrIle: 4.278 ± 0.191
3.991ThrLys: 3.991 ± 0.177
5.598ThrLeu: 5.598 ± 0.155
1.016ThrMet: 1.016 ± 0.07
2.315ThrAsn: 2.315 ± 0.104
1.905ThrPro: 1.905 ± 0.098
1.846ThrGln: 1.846 ± 0.121
1.729ThrArg: 1.729 ± 0.094
4.156ThrSer: 4.156 ± 0.185
2.884ThrThr: 2.884 ± 0.112
3.283ThrVal: 3.283 ± 0.137
0.378ThrTrp: 0.378 ± 0.045
1.532ThrTyr: 1.532 ± 0.097
0.0ThrXaa: 0.0 ± 0.0
Val
4.778ValAla: 4.778 ± 0.198
1.378ValCys: 1.378 ± 0.087
3.629ValAsp: 3.629 ± 0.156
4.071ValGlu: 4.071 ± 0.169
3.129ValPhe: 3.129 ± 0.142
4.124ValGly: 4.124 ± 0.177
1.548ValHis: 1.548 ± 0.095
6.071ValIle: 6.071 ± 0.208
5.699ValLys: 5.699 ± 0.174
7.247ValLeu: 7.247 ± 0.251
1.479ValMet: 1.479 ± 0.097
3.086ValAsn: 3.086 ± 0.133
2.325ValPro: 2.325 ± 0.107
2.575ValGln: 2.575 ± 0.123
2.873ValArg: 2.873 ± 0.125
6.061ValSer: 6.061 ± 0.201
3.938ValThr: 3.938 ± 0.139
5.906ValVal: 5.906 ± 0.216
0.468ValTrp: 0.468 ± 0.049
1.83ValTyr: 1.83 ± 0.105
0.0ValXaa: 0.0 ± 0.0
Trp
0.303TrpAla: 0.303 ± 0.038
0.218TrpCys: 0.218 ± 0.038
0.309TrpAsp: 0.309 ± 0.04
0.341TrpGlu: 0.341 ± 0.037
0.351TrpPhe: 0.351 ± 0.044
0.41TrpGly: 0.41 ± 0.041
0.213TrpHis: 0.213 ± 0.03
0.585TrpIle: 0.585 ± 0.057
0.665TrpLys: 0.665 ± 0.062
0.729TrpLeu: 0.729 ± 0.068
0.192TrpMet: 0.192 ± 0.033
0.383TrpAsn: 0.383 ± 0.043
0.271TrpPro: 0.271 ± 0.036
0.394TrpGln: 0.394 ± 0.04
0.42TrpArg: 0.42 ± 0.044
0.553TrpSer: 0.553 ± 0.058
0.277TrpThr: 0.277 ± 0.037
0.431TrpVal: 0.431 ± 0.05
0.101TrpTrp: 0.101 ± 0.024
0.319TrpTyr: 0.319 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.144TyrAla: 2.144 ± 0.123
0.585TyrCys: 0.585 ± 0.059
2.001TyrAsp: 2.001 ± 0.129
1.687TyrGlu: 1.687 ± 0.098
1.671TyrPhe: 1.671 ± 0.103
1.985TyrGly: 1.985 ± 0.111
0.75TyrHis: 0.75 ± 0.071
2.538TyrIle: 2.538 ± 0.112
2.559TyrLys: 2.559 ± 0.131
3.459TyrLeu: 3.459 ± 0.157
0.713TyrMet: 0.713 ± 0.058
1.852TyrAsn: 1.852 ± 0.115
1.0TyrPro: 1.0 ± 0.075
0.947TyrGln: 0.947 ± 0.075
1.187TyrArg: 1.187 ± 0.075
2.703TyrSer: 2.703 ± 0.13
1.501TyrThr: 1.501 ± 0.089
2.437TyrVal: 2.437 ± 0.14
0.223TyrTrp: 0.223 ± 0.033
1.022TyrTyr: 1.022 ± 0.094
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 583 proteins (187933 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski