Amino acid dipepetide frequency for Aestuariispira insulae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.645AlaAla: 11.645 ± 0.125	1.115AlaCys: 1.115 ± 0.028	6.433AlaAsp: 6.433 ± 0.088	6.899AlaGlu: 6.899 ± 0.077	3.97AlaPhe: 3.97 ± 0.058	8.828AlaGly: 8.828 ± 0.102	1.906AlaHis: 1.906 ± 0.035	5.679AlaIle: 5.679 ± 0.073	4.297AlaLys: 4.297 ± 0.062	10.959AlaLeu: 10.959 ± 0.101	3.143AlaMet: 3.143 ± 0.048	2.974AlaAsn: 2.974 ± 0.05	3.929AlaPro: 3.929 ± 0.06	3.536AlaGln: 3.536 ± 0.047	6.251AlaArg: 6.251 ± 0.078	5.316AlaSer: 5.316 ± 0.073	4.493AlaThr: 4.493 ± 0.067	7.393AlaVal: 7.393 ± 0.077	1.167AlaTrp: 1.167 ± 0.026	2.423AlaTyr: 2.423 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.892CysAla: 0.892 ± 0.027	0.127CysCys: 0.127 ± 0.011	0.629CysAsp: 0.629 ± 0.021	0.522CysGlu: 0.522 ± 0.019	0.435CysPhe: 0.435 ± 0.017	0.983CysGly: 0.983 ± 0.032	0.304CysHis: 0.304 ± 0.015	0.442CysIle: 0.442 ± 0.019	0.285CysLys: 0.285 ± 0.015	1.148CysLeu: 1.148 ± 0.032	0.213CysMet: 0.213 ± 0.012	0.256CysAsn: 0.256 ± 0.012	0.499CysPro: 0.499 ± 0.02	0.342CysGln: 0.342 ± 0.016	0.717CysArg: 0.717 ± 0.024	0.539CysSer: 0.539 ± 0.018	0.404CysThr: 0.404 ± 0.018	0.596CysVal: 0.596 ± 0.022	0.141CysTrp: 0.141 ± 0.009	0.273CysTyr: 0.273 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.514AspAla: 5.514 ± 0.072	0.661AspCys: 0.661 ± 0.026	3.605AspAsp: 3.605 ± 0.071	3.806AspGlu: 3.806 ± 0.055	2.581AspPhe: 2.581 ± 0.043	5.524AspGly: 5.524 ± 0.113	1.739AspHis: 1.739 ± 0.04	3.77AspIle: 3.77 ± 0.052	2.26AspLys: 2.26 ± 0.037	6.793AspLeu: 6.793 ± 0.078	1.795AspMet: 1.795 ± 0.034	1.763AspAsn: 1.763 ± 0.038	3.328AspPro: 3.328 ± 0.055	2.618AspGln: 2.618 ± 0.046	4.355AspArg: 4.355 ± 0.062	2.88AspSer: 2.88 ± 0.047	2.464AspThr: 2.464 ± 0.067	3.928AspVal: 3.928 ± 0.06	1.056AspTrp: 1.056 ± 0.026	1.931AspTyr: 1.931 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.011GluAla: 7.011 ± 0.098	0.49GluCys: 0.49 ± 0.017	3.692GluAsp: 3.692 ± 0.055	4.833GluGlu: 4.833 ± 0.084	2.1GluPhe: 2.1 ± 0.042	4.813GluGly: 4.813 ± 0.066	1.166GluHis: 1.166 ± 0.031	4.474GluIle: 4.474 ± 0.063	3.673GluLys: 3.673 ± 0.06	5.817GluLeu: 5.817 ± 0.067	2.091GluMet: 2.091 ± 0.046	2.577GluAsn: 2.577 ± 0.047	2.418GluPro: 2.418 ± 0.048	2.712GluGln: 2.712 ± 0.047	4.152GluArg: 4.152 ± 0.066	2.892GluSer: 2.892 ± 0.044	4.111GluThr: 4.111 ± 0.061	3.86GluVal: 3.86 ± 0.068	0.702GluTrp: 0.702 ± 0.023	1.292GluTyr: 1.292 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.551PheAla: 3.551 ± 0.053	0.475PheCys: 0.475 ± 0.021	2.77PheAsp: 2.77 ± 0.045	2.366PheGlu: 2.366 ± 0.039	1.648PhePhe: 1.648 ± 0.036	3.456PheGly: 3.456 ± 0.054	0.887PheHis: 0.887 ± 0.028	1.982PheIle: 1.982 ± 0.042	1.44PheLys: 1.44 ± 0.029	4.083PheLeu: 4.083 ± 0.058	0.937PheMet: 0.937 ± 0.029	1.345PheAsn: 1.345 ± 0.032	1.651PhePro: 1.651 ± 0.038	1.378PheGln: 1.378 ± 0.031	2.129PheArg: 2.129 ± 0.043	2.628PheSer: 2.628 ± 0.044	2.084PheThr: 2.084 ± 0.041	2.44PheVal: 2.44 ± 0.044	0.576PheTrp: 0.576 ± 0.02	1.023PheTyr: 1.023 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	7.277GlyAla: 7.277 ± 0.106	0.922GlyCys: 0.922 ± 0.023	4.84GlyAsp: 4.84 ± 0.105	4.924GlyGlu: 4.924 ± 0.07	3.486GlyPhe: 3.486 ± 0.047	6.792GlyGly: 6.792 ± 0.125	1.92GlyHis: 1.92 ± 0.041	4.874GlyIle: 4.874 ± 0.064	3.741GlyLys: 3.741 ± 0.055	8.76GlyLeu: 8.76 ± 0.089	2.576GlyMet: 2.576 ± 0.05	2.734GlyAsn: 2.734 ± 0.061	2.886GlyPro: 2.886 ± 0.049	3.17GlyGln: 3.17 ± 0.046	5.246GlyArg: 5.246 ± 0.064	4.526GlySer: 4.526 ± 0.072	4.189GlyThr: 4.189 ± 0.075	5.215GlyVal: 5.215 ± 0.062	1.227GlyTrp: 1.227 ± 0.031	2.547GlyTyr: 2.547 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.061HisAla: 2.061 ± 0.047	0.297HisCys: 0.297 ± 0.016	1.291HisAsp: 1.291 ± 0.028	1.29HisGlu: 1.29 ± 0.036	1.0HisPhe: 1.0 ± 0.031	1.861HisGly: 1.861 ± 0.035	0.687HisHis: 0.687 ± 0.025	1.115HisIle: 1.115 ± 0.031	0.753HisLys: 0.753 ± 0.025	2.342HisLeu: 2.342 ± 0.038	0.604HisMet: 0.604 ± 0.022	0.62HisAsn: 0.62 ± 0.02	1.355HisPro: 1.355 ± 0.034	0.846HisGln: 0.846 ± 0.026	1.261HisArg: 1.261 ± 0.035	1.115HisSer: 1.115 ± 0.033	0.787HisThr: 0.787 ± 0.026	1.428HisVal: 1.428 ± 0.029	0.357HisTrp: 0.357 ± 0.017	0.692HisTyr: 0.692 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.202IleAla: 6.202 ± 0.066	0.688IleCys: 0.688 ± 0.024	3.708IleAsp: 3.708 ± 0.058	3.783IleGlu: 3.783 ± 0.056	1.967IlePhe: 1.967 ± 0.05	4.983IleGly: 4.983 ± 0.068	1.189IleHis: 1.189 ± 0.027	2.846IleIle: 2.846 ± 0.053	2.064IleLys: 2.064 ± 0.038	6.106IleLeu: 6.106 ± 0.084	1.281IleMet: 1.281 ± 0.03	1.92IleAsn: 1.92 ± 0.038	2.555IlePro: 2.555 ± 0.041	1.91IleGln: 1.91 ± 0.036	3.725IleArg: 3.725 ± 0.046	3.628IleSer: 3.628 ± 0.055	3.19IleThr: 3.19 ± 0.049	3.456IleVal: 3.456 ± 0.057	0.68IleTrp: 0.68 ± 0.021	1.378IleTyr: 1.378 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.553LysAla: 4.553 ± 0.069	0.256LysCys: 0.256 ± 0.014	2.346LysAsp: 2.346 ± 0.041	2.463LysGlu: 2.463 ± 0.047	1.233LysPhe: 1.233 ± 0.03	3.326LysGly: 3.326 ± 0.047	0.789LysHis: 0.789 ± 0.025	2.449LysIle: 2.449 ± 0.043	2.109LysLys: 2.109 ± 0.05	4.191LysLeu: 4.191 ± 0.055	1.093LysMet: 1.093 ± 0.03	1.408LysAsn: 1.408 ± 0.036	2.287LysPro: 2.287 ± 0.042	1.588LysGln: 1.588 ± 0.036	2.728LysArg: 2.728 ± 0.042	2.436LysSer: 2.436 ± 0.045	2.427LysThr: 2.427 ± 0.044	2.722LysVal: 2.722 ± 0.051	0.438LysTrp: 0.438 ± 0.017	0.869LysTyr: 0.869 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	11.615LeuAla: 11.615 ± 0.104	0.98LeuCys: 0.98 ± 0.028	6.533LeuAsp: 6.533 ± 0.071	6.979LeuGlu: 6.979 ± 0.075	4.079LeuPhe: 4.079 ± 0.061	7.612LeuGly: 7.612 ± 0.08	1.934LeuHis: 1.934 ± 0.039	5.637LeuIle: 5.637 ± 0.07	4.627LeuLys: 4.627 ± 0.058	9.621LeuLeu: 9.621 ± 0.107	2.802LeuMet: 2.802 ± 0.04	3.371LeuAsn: 3.371 ± 0.046	5.287LeuPro: 5.287 ± 0.071	3.109LeuGln: 3.109 ± 0.043	5.621LeuArg: 5.621 ± 0.071	7.278LeuSer: 7.278 ± 0.083	5.599LeuThr: 5.599 ± 0.073	7.021LeuVal: 7.021 ± 0.085	1.079LeuTrp: 1.079 ± 0.029	2.286LeuTyr: 2.286 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.376MetAla: 3.376 ± 0.047	0.167MetCys: 0.167 ± 0.012	1.71MetAsp: 1.71 ± 0.035	1.744MetGlu: 1.744 ± 0.037	0.774MetPhe: 0.774 ± 0.025	2.084MetGly: 2.084 ± 0.043	0.503MetHis: 0.503 ± 0.02	1.705MetIle: 1.705 ± 0.039	1.351MetLys: 1.351 ± 0.029	2.683MetLeu: 2.683 ± 0.041	0.863MetMet: 0.863 ± 0.024	0.95MetAsn: 0.95 ± 0.025	1.508MetPro: 1.508 ± 0.035	0.897MetGln: 0.897 ± 0.024	1.662MetArg: 1.662 ± 0.036	1.673MetSer: 1.673 ± 0.036	1.964MetThr: 1.964 ± 0.036	1.969MetVal: 1.969 ± 0.039	0.202MetTrp: 0.202 ± 0.012	0.38MetTyr: 0.38 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.21AsnAla: 3.21 ± 0.055	0.342AsnCys: 0.342 ± 0.014	1.928AsnAsp: 1.928 ± 0.059	1.655AsnGlu: 1.655 ± 0.038	1.1AsnPhe: 1.1 ± 0.029	2.902AsnGly: 2.902 ± 0.053	0.725AsnHis: 0.725 ± 0.022	1.906AsnIle: 1.906 ± 0.038	1.121AsnLys: 1.121 ± 0.033	3.44AsnLeu: 3.44 ± 0.055	0.907AsnMet: 0.907 ± 0.024	1.112AsnAsn: 1.112 ± 0.03	1.992AsnPro: 1.992 ± 0.044	1.227AsnGln: 1.227 ± 0.029	2.345AsnArg: 2.345 ± 0.039	1.732AsnSer: 1.732 ± 0.038	1.354AsnThr: 1.354 ± 0.032	2.01AsnVal: 2.01 ± 0.038	0.554AsnTrp: 0.554 ± 0.021	0.854AsnTyr: 0.854 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.525ProAla: 4.525 ± 0.068	0.333ProCys: 0.333 ± 0.018	3.82ProAsp: 3.82 ± 0.054	3.997ProGlu: 3.997 ± 0.05	1.903ProPhe: 1.903 ± 0.04	3.872ProGly: 3.872 ± 0.056	1.012ProHis: 1.012 ± 0.028	2.215ProIle: 2.215 ± 0.041	1.919ProLys: 1.919 ± 0.039	4.421ProLeu: 4.421 ± 0.062	1.204ProMet: 1.204 ± 0.03	1.428ProAsn: 1.428 ± 0.029	1.875ProPro: 1.875 ± 0.052	1.389ProGln: 1.389 ± 0.031	1.996ProArg: 1.996 ± 0.038	2.362ProSer: 2.362 ± 0.039	2.08ProThr: 2.08 ± 0.037	4.034ProVal: 4.034 ± 0.051	0.62ProTrp: 0.62 ± 0.023	1.194ProTyr: 1.194 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.554GlnAla: 4.554 ± 0.066	0.27GlnCys: 0.27 ± 0.015	2.123GlnAsp: 2.123 ± 0.038	2.321GlnGlu: 2.321 ± 0.042	1.247GlnPhe: 1.247 ± 0.03	2.643GlnGly: 2.643 ± 0.044	0.645GlnHis: 0.645 ± 0.023	2.145GlnIle: 2.145 ± 0.039	1.571GlnLys: 1.571 ± 0.04	3.435GlnLeu: 3.435 ± 0.055	1.126GlnMet: 1.126 ± 0.026	1.118GlnAsn: 1.118 ± 0.03	1.712GlnPro: 1.712 ± 0.039	1.504GlnGln: 1.504 ± 0.038	2.07GlnArg: 2.07 ± 0.043	2.181GlnSer: 2.181 ± 0.041	1.847GlnThr: 1.847 ± 0.041	2.59GlnVal: 2.59 ± 0.045	0.453GlnTrp: 0.453 ± 0.019	0.774GlnTyr: 0.774 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	5.596ArgAla: 5.596 ± 0.076	0.514ArgCys: 0.514 ± 0.021	3.955ArgAsp: 3.955 ± 0.059	4.319ArgGlu: 4.319 ± 0.056	2.667ArgPhe: 2.667 ± 0.049	3.728ArgGly: 3.728 ± 0.053	1.647ArgHis: 1.647 ± 0.035	3.746ArgIle: 3.746 ± 0.055	2.732ArgLys: 2.732 ± 0.043	6.967ArgLeu: 6.967 ± 0.09	1.801ArgMet: 1.801 ± 0.041	2.026ArgAsn: 2.026 ± 0.04	2.721ArgPro: 2.721 ± 0.048	2.694ArgGln: 2.694 ± 0.039	3.987ArgArg: 3.987 ± 0.063	3.111ArgSer: 3.111 ± 0.044	2.685ArgThr: 2.685 ± 0.049	3.758ArgVal: 3.758 ± 0.056	0.772ArgTrp: 0.772 ± 0.025	1.701ArgTyr: 1.701 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.337SerAla: 5.337 ± 0.061	0.522SerCys: 0.522 ± 0.018	3.419SerAsp: 3.419 ± 0.051	3.285SerGlu: 3.285 ± 0.056	2.542SerPhe: 2.542 ± 0.043	5.467SerGly: 5.467 ± 0.081	1.342SerHis: 1.342 ± 0.032	3.093SerIle: 3.093 ± 0.045	2.139SerLys: 2.139 ± 0.041	6.276SerLeu: 6.276 ± 0.078	1.579SerMet: 1.579 ± 0.034	1.876SerAsn: 1.876 ± 0.039	2.624SerPro: 2.624 ± 0.052	2.066SerGln: 2.066 ± 0.039	3.372SerArg: 3.372 ± 0.044	3.047SerSer: 3.047 ± 0.059	2.406SerThr: 2.406 ± 0.039	3.854SerVal: 3.854 ± 0.052	0.758SerTrp: 0.758 ± 0.025	1.539SerTyr: 1.539 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.309ThrAla: 5.309 ± 0.078	0.454ThrCys: 0.454 ± 0.018	3.256ThrAsp: 3.256 ± 0.054	3.037ThrGlu: 3.037 ± 0.053	1.841ThrPhe: 1.841 ± 0.041	5.095ThrGly: 5.095 ± 0.072	1.042ThrHis: 1.042 ± 0.026	3.022ThrIle: 3.022 ± 0.052	1.646ThrLys: 1.646 ± 0.033	5.267ThrLeu: 5.267 ± 0.072	1.193ThrMet: 1.193 ± 0.025	1.476ThrAsn: 1.476 ± 0.034	2.633ThrPro: 2.633 ± 0.045	1.48ThrGln: 1.48 ± 0.034	2.708ThrArg: 2.708 ± 0.046	2.606ThrSer: 2.606 ± 0.046	2.328ThrThr: 2.328 ± 0.043	4.187ThrVal: 4.187 ± 0.076	0.538ThrTrp: 0.538 ± 0.021	1.159ThrTyr: 1.159 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	6.866ValAla: 6.866 ± 0.078	0.675ValCys: 0.675 ± 0.021	3.987ValAsp: 3.987 ± 0.053	4.591ValGlu: 4.591 ± 0.064	2.618ValPhe: 2.618 ± 0.046	4.896ValGly: 4.896 ± 0.059	1.294ValHis: 1.294 ± 0.03	4.353ValIle: 4.353 ± 0.06	2.65ValLys: 2.65 ± 0.039	6.398ValLeu: 6.398 ± 0.079	2.013ValMet: 2.013 ± 0.04	2.269ValAsn: 2.269 ± 0.041	3.095ValPro: 3.095 ± 0.048	2.114ValGln: 2.114 ± 0.039	3.98ValArg: 3.98 ± 0.062	4.414ValSer: 4.414 ± 0.062	4.253ValThr: 4.253 ± 0.058	4.752ValVal: 4.752 ± 0.067	0.766ValTrp: 0.766 ± 0.025	1.509ValTyr: 1.509 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.038TrpAla: 1.038 ± 0.029	0.146TrpCys: 0.146 ± 0.01	0.691TrpAsp: 0.691 ± 0.023	0.65TrpGlu: 0.65 ± 0.023	0.587TrpPhe: 0.587 ± 0.025	0.843TrpGly: 0.843 ± 0.024	0.343TrpHis: 0.343 ± 0.014	0.715TrpIle: 0.715 ± 0.025	0.566TrpLys: 0.566 ± 0.022	1.552TrpLeu: 1.552 ± 0.036	0.371TrpMet: 0.371 ± 0.017	0.43TrpAsn: 0.43 ± 0.016	0.622TrpPro: 0.622 ± 0.021	0.66TrpGln: 0.66 ± 0.024	0.915TrpArg: 0.915 ± 0.025	0.737TrpSer: 0.737 ± 0.024	0.584TrpThr: 0.584 ± 0.019	0.74TrpVal: 0.74 ± 0.02	0.207TrpTrp: 0.207 ± 0.012	0.315TrpTyr: 0.315 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.224TyrAla: 2.224 ± 0.036	0.313TyrCys: 0.313 ± 0.014	1.634TyrAsp: 1.634 ± 0.038	1.409TyrGlu: 1.409 ± 0.033	1.073TyrPhe: 1.073 ± 0.03	2.145TyrGly: 2.145 ± 0.042	0.689TyrHis: 0.689 ± 0.023	1.089TyrIle: 1.089 ± 0.027	0.767TyrLys: 0.767 ± 0.023	2.81TyrLeu: 2.81 ± 0.046	0.575TyrMet: 0.575 ± 0.025	0.759TyrAsn: 0.759 ± 0.022	1.22TyrPro: 1.22 ± 0.032	1.089TyrGln: 1.089 ± 0.028	1.906TyrArg: 1.906 ± 0.041	1.441TyrSer: 1.441 ± 0.031	1.03TyrThr: 1.03 ± 0.028	1.543TyrVal: 1.543 ± 0.033	0.42TyrTrp: 0.42 ± 0.019	0.754TyrTyr: 0.754 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4490 proteins (1443071 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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