Amino acid dipepetide frequency for Henriciella algicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.119AlaAla: 15.119 ± 0.172	1.28AlaCys: 1.28 ± 0.045	7.393AlaAsp: 7.393 ± 0.1	7.987AlaGlu: 7.987 ± 0.137	4.575AlaPhe: 4.575 ± 0.075	10.553AlaGly: 10.553 ± 0.115	2.05AlaHis: 2.05 ± 0.049	6.158AlaIle: 6.158 ± 0.089	4.123AlaLys: 4.123 ± 0.086	12.206AlaLeu: 12.206 ± 0.137	3.23AlaMet: 3.23 ± 0.07	3.227AlaAsn: 3.227 ± 0.062	5.429AlaPro: 5.429 ± 0.097	3.696AlaGln: 3.696 ± 0.065	7.971AlaArg: 7.971 ± 0.119	7.086AlaSer: 7.086 ± 0.092	5.132AlaThr: 5.132 ± 0.076	7.406AlaVal: 7.406 ± 0.1	1.423AlaTrp: 1.423 ± 0.037	2.598AlaTyr: 2.598 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	1.023CysAla: 1.023 ± 0.038	0.091CysCys: 0.091 ± 0.012	0.598CysAsp: 0.598 ± 0.023	0.574CysGlu: 0.574 ± 0.029	0.329CysPhe: 0.329 ± 0.02	0.828CysGly: 0.828 ± 0.031	0.169CysHis: 0.169 ± 0.013	0.391CysIle: 0.391 ± 0.023	0.259CysLys: 0.259 ± 0.018	0.814CysLeu: 0.814 ± 0.032	0.157CysMet: 0.157 ± 0.013	0.223CysAsn: 0.223 ± 0.015	0.426CysPro: 0.426 ± 0.021	0.226CysGln: 0.226 ± 0.014	0.531CysArg: 0.531 ± 0.025	0.474CysSer: 0.474 ± 0.02	0.434CysThr: 0.434 ± 0.021	0.615CysVal: 0.615 ± 0.026	0.099CysTrp: 0.099 ± 0.01	0.198CysTyr: 0.198 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.397AspAla: 7.397 ± 0.097	0.471AspCys: 0.471 ± 0.024	3.705AspAsp: 3.705 ± 0.07	4.763AspGlu: 4.763 ± 0.074	2.4AspPhe: 2.4 ± 0.056	5.984AspGly: 5.984 ± 0.104	1.202AspHis: 1.202 ± 0.039	3.379AspIle: 3.379 ± 0.064	2.048AspLys: 2.048 ± 0.048	5.974AspLeu: 5.974 ± 0.081	1.661AspMet: 1.661 ± 0.045	1.53AspAsn: 1.53 ± 0.048	3.348AspPro: 3.348 ± 0.057	1.886AspGln: 1.886 ± 0.045	4.159AspArg: 4.159 ± 0.074	2.489AspSer: 2.489 ± 0.06	3.282AspThr: 3.282 ± 0.066	4.477AspVal: 4.477 ± 0.074	1.222AspTrp: 1.222 ± 0.036	1.756AspTyr: 1.756 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	9.294GluAla: 9.294 ± 0.132	0.377GluCys: 0.377 ± 0.02	4.168GluAsp: 4.168 ± 0.077	4.536GluGlu: 4.536 ± 0.08	2.02GluPhe: 2.02 ± 0.044	5.271GluGly: 5.271 ± 0.078	1.137GluHis: 1.137 ± 0.036	3.864GluIle: 3.864 ± 0.065	2.746GluLys: 2.746 ± 0.065	5.889GluLeu: 5.889 ± 0.077	1.782GluMet: 1.782 ± 0.045	1.993GluAsn: 1.993 ± 0.049	2.817GluPro: 2.817 ± 0.059	2.311GluGln: 2.311 ± 0.05	5.044GluArg: 5.044 ± 0.091	2.968GluSer: 2.968 ± 0.051	4.806GluThr: 4.806 ± 0.072	4.11GluVal: 4.11 ± 0.063	0.802GluTrp: 0.802 ± 0.03	1.22GluTyr: 1.22 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.459PheAla: 4.459 ± 0.079	0.412PheCys: 0.412 ± 0.019	2.936PheAsp: 2.936 ± 0.058	2.758PheGlu: 2.758 ± 0.056	1.439PhePhe: 1.439 ± 0.05	3.721PheGly: 3.721 ± 0.071	0.688PheHis: 0.688 ± 0.027	1.86PheIle: 1.86 ± 0.044	1.125PheLys: 1.125 ± 0.033	3.315PheLeu: 3.315 ± 0.065	0.952PheMet: 0.952 ± 0.033	1.203PheAsn: 1.203 ± 0.037	1.454PhePro: 1.454 ± 0.036	1.014PheGln: 1.014 ± 0.032	2.129PheArg: 2.129 ± 0.049	2.484PheSer: 2.484 ± 0.056	2.025PheThr: 2.025 ± 0.048	2.589PheVal: 2.589 ± 0.054	0.5PheTrp: 0.5 ± 0.023	0.966PheTyr: 0.966 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.241GlyAla: 9.241 ± 0.119	0.793GlyCys: 0.793 ± 0.027	5.208GlyAsp: 5.208 ± 0.091	5.988GlyGlu: 5.988 ± 0.081	3.638GlyPhe: 3.638 ± 0.055	7.389GlyGly: 7.389 ± 0.154	1.75GlyHis: 1.75 ± 0.049	4.128GlyIle: 4.128 ± 0.069	3.284GlyLys: 3.284 ± 0.061	8.658GlyLeu: 8.658 ± 0.118	2.269GlyMet: 2.269 ± 0.056	2.318GlyAsn: 2.318 ± 0.063	3.508GlyPro: 3.508 ± 0.058	2.783GlyGln: 2.783 ± 0.055	5.495GlyArg: 5.495 ± 0.077	4.497GlySer: 4.497 ± 0.085	4.413GlyThr: 4.413 ± 0.114	6.161GlyVal: 6.161 ± 0.096	1.486GlyTrp: 1.486 ± 0.047	2.31GlyTyr: 2.31 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.131HisAla: 2.131 ± 0.054	0.201HisCys: 0.201 ± 0.015	1.092HisAsp: 1.092 ± 0.038	1.221HisGlu: 1.221 ± 0.037	0.76HisPhe: 0.76 ± 0.03	1.705HisGly: 1.705 ± 0.048	0.461HisHis: 0.461 ± 0.025	0.939HisIle: 0.939 ± 0.029	0.529HisLys: 0.529 ± 0.025	1.75HisLeu: 1.75 ± 0.048	0.467HisMet: 0.467 ± 0.022	0.446HisAsn: 0.446 ± 0.022	1.108HisPro: 1.108 ± 0.035	0.539HisGln: 0.539 ± 0.024	1.156HisArg: 1.156 ± 0.038	0.881HisSer: 0.881 ± 0.032	0.828HisThr: 0.828 ± 0.032	1.252HisVal: 1.252 ± 0.04	0.325HisTrp: 0.325 ± 0.018	0.554HisTyr: 0.554 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.894IleAla: 6.894 ± 0.094	0.545IleCys: 0.545 ± 0.023	3.757IleAsp: 3.757 ± 0.065	4.132IleGlu: 4.132 ± 0.066	1.772IlePhe: 1.772 ± 0.05	4.73IleGly: 4.73 ± 0.088	0.921IleHis: 0.921 ± 0.031	2.673IleIle: 2.673 ± 0.055	1.57IleLys: 1.57 ± 0.042	4.543IleLeu: 4.543 ± 0.073	1.131IleMet: 1.131 ± 0.035	1.522IleAsn: 1.522 ± 0.041	2.157IlePro: 2.157 ± 0.043	1.329IleGln: 1.329 ± 0.036	2.997IleArg: 2.997 ± 0.044	3.414IleSer: 3.414 ± 0.071	2.695IleThr: 2.695 ± 0.056	3.771IleVal: 3.771 ± 0.075	0.68IleTrp: 0.68 ± 0.031	1.17IleTyr: 1.17 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.676LysAla: 4.676 ± 0.076	0.183LysCys: 0.183 ± 0.015	2.021LysAsp: 2.021 ± 0.046	1.924LysGlu: 1.924 ± 0.055	1.042LysPhe: 1.042 ± 0.032	2.735LysGly: 2.735 ± 0.06	0.632LysHis: 0.632 ± 0.026	1.754LysIle: 1.754 ± 0.047	1.574LysLys: 1.574 ± 0.049	3.62LysLeu: 3.62 ± 0.068	0.825LysMet: 0.825 ± 0.028	0.871LysAsn: 0.871 ± 0.028	2.231LysPro: 2.231 ± 0.056	1.142LysGln: 1.142 ± 0.035	2.518LysArg: 2.518 ± 0.055	2.272LysSer: 2.272 ± 0.05	2.17LysThr: 2.17 ± 0.052	2.383LysVal: 2.383 ± 0.052	0.413LysTrp: 0.413 ± 0.024	0.702LysTyr: 0.702 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	11.875LeuAla: 11.875 ± 0.15	0.787LeuCys: 0.787 ± 0.031	5.883LeuAsp: 5.883 ± 0.088	6.036LeuGlu: 6.036 ± 0.099	3.632LeuPhe: 3.632 ± 0.069	7.709LeuGly: 7.709 ± 0.097	1.665LeuHis: 1.665 ± 0.056	5.466LeuIle: 5.466 ± 0.08	3.91LeuLys: 3.91 ± 0.07	8.116LeuLeu: 8.116 ± 0.124	2.366LeuMet: 2.366 ± 0.051	2.868LeuAsn: 2.868 ± 0.059	4.87LeuPro: 4.87 ± 0.075	2.786LeuGln: 2.786 ± 0.056	5.745LeuArg: 5.745 ± 0.081	6.95LeuSer: 6.95 ± 0.101	5.425LeuThr: 5.425 ± 0.087	6.462LeuVal: 6.462 ± 0.101	1.043LeuTrp: 1.043 ± 0.04	2.012LeuTyr: 2.012 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.939MetAla: 2.939 ± 0.061	0.168MetCys: 0.168 ± 0.014	1.397MetAsp: 1.397 ± 0.044	1.38MetGlu: 1.38 ± 0.046	0.731MetPhe: 0.731 ± 0.029	1.894MetGly: 1.894 ± 0.048	0.383MetHis: 0.383 ± 0.02	1.332MetIle: 1.332 ± 0.042	1.264MetLys: 1.264 ± 0.034	2.299MetLeu: 2.299 ± 0.051	0.739MetMet: 0.739 ± 0.03	0.791MetAsn: 0.791 ± 0.027	1.394MetPro: 1.394 ± 0.038	0.841MetGln: 0.841 ± 0.031	1.788MetArg: 1.788 ± 0.04	1.987MetSer: 1.987 ± 0.043	1.826MetThr: 1.826 ± 0.042	1.528MetVal: 1.528 ± 0.036	0.217MetTrp: 0.217 ± 0.017	0.329MetTyr: 0.329 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.284AsnAla: 3.284 ± 0.058	0.265AsnCys: 0.265 ± 0.018	1.615AsnAsp: 1.615 ± 0.044	1.674AsnGlu: 1.674 ± 0.042	1.173AsnPhe: 1.173 ± 0.035	2.562AsnGly: 2.562 ± 0.076	0.503AsnHis: 0.503 ± 0.026	1.458AsnIle: 1.458 ± 0.044	0.812AsnLys: 0.812 ± 0.027	2.532AsnLeu: 2.532 ± 0.052	0.72AsnMet: 0.72 ± 0.029	0.801AsnAsn: 0.801 ± 0.029	1.787AsnPro: 1.787 ± 0.05	0.859AsnGln: 0.859 ± 0.031	1.825AsnArg: 1.825 ± 0.048	1.539AsnSer: 1.539 ± 0.039	1.433AsnThr: 1.433 ± 0.043	2.085AsnVal: 2.085 ± 0.048	0.501AsnTrp: 0.501 ± 0.023	0.751AsnTyr: 0.751 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.503ProAla: 5.503 ± 0.089	0.309ProCys: 0.309 ± 0.017	3.872ProAsp: 3.872 ± 0.071	4.085ProGlu: 4.085 ± 0.077	1.945ProPhe: 1.945 ± 0.04	4.146ProGly: 4.146 ± 0.075	0.901ProHis: 0.901 ± 0.032	2.166ProIle: 2.166 ± 0.046	1.779ProLys: 1.779 ± 0.043	4.191ProLeu: 4.191 ± 0.078	1.076ProMet: 1.076 ± 0.031	1.391ProAsn: 1.391 ± 0.04	2.337ProPro: 2.337 ± 0.074	1.648ProGln: 1.648 ± 0.048	2.571ProArg: 2.571 ± 0.057	2.705ProSer: 2.705 ± 0.068	2.202ProThr: 2.202 ± 0.052	4.07ProVal: 4.07 ± 0.061	0.619ProTrp: 0.619 ± 0.027	1.146ProTyr: 1.146 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.863GlnAla: 3.863 ± 0.068	0.208GlnCys: 0.208 ± 0.013	1.661GlnAsp: 1.661 ± 0.042	1.61GlnGlu: 1.61 ± 0.045	1.148GlnPhe: 1.148 ± 0.031	2.339GlnGly: 2.339 ± 0.048	0.61GlnHis: 0.61 ± 0.03	1.792GlnIle: 1.792 ± 0.043	1.186GlnLys: 1.186 ± 0.039	2.988GlnLeu: 2.988 ± 0.061	0.871GlnMet: 0.871 ± 0.03	0.868GlnAsn: 0.868 ± 0.035	1.665GlnPro: 1.665 ± 0.04	1.202GlnGln: 1.202 ± 0.049	2.24GlnArg: 2.24 ± 0.044	2.099GlnSer: 2.099 ± 0.054	2.005GlnThr: 2.005 ± 0.054	2.059GlnVal: 2.059 ± 0.05	0.353GlnTrp: 0.353 ± 0.021	0.615GlnTyr: 0.615 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.142ArgAla: 7.142 ± 0.101	0.443ArgCys: 0.443 ± 0.024	3.931ArgAsp: 3.931 ± 0.063	4.415ArgGlu: 4.415 ± 0.072	2.656ArgPhe: 2.656 ± 0.052	4.509ArgGly: 4.509 ± 0.069	1.328ArgHis: 1.328 ± 0.036	3.647ArgIle: 3.647 ± 0.064	2.561ArgLys: 2.561 ± 0.058	7.222ArgLeu: 7.222 ± 0.098	1.667ArgMet: 1.667 ± 0.037	1.885ArgAsn: 1.885 ± 0.043	3.117ArgPro: 3.117 ± 0.063	2.482ArgGln: 2.482 ± 0.049	4.794ArgArg: 4.794 ± 0.078	3.501ArgSer: 3.501 ± 0.061	3.239ArgThr: 3.239 ± 0.056	4.26ArgVal: 4.26 ± 0.067	0.874ArgTrp: 0.874 ± 0.027	1.635ArgTyr: 1.635 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.716SerAla: 6.716 ± 0.096	0.485SerCys: 0.485 ± 0.023	3.918SerAsp: 3.918 ± 0.068	3.835SerGlu: 3.835 ± 0.067	2.427SerPhe: 2.427 ± 0.06	5.874SerGly: 5.874 ± 0.106	1.016SerHis: 1.016 ± 0.031	2.91SerIle: 2.91 ± 0.066	1.958SerLys: 1.958 ± 0.051	5.719SerLeu: 5.719 ± 0.086	1.538SerMet: 1.538 ± 0.042	1.688SerAsn: 1.688 ± 0.044	2.864SerPro: 2.864 ± 0.054	1.861SerGln: 1.861 ± 0.045	3.742SerArg: 3.742 ± 0.057	3.482SerSer: 3.482 ± 0.085	2.759SerThr: 2.759 ± 0.059	4.207SerVal: 4.207 ± 0.074	0.854SerTrp: 0.854 ± 0.031	1.456SerTyr: 1.456 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.961ThrAla: 5.961 ± 0.085	0.412ThrCys: 0.412 ± 0.021	3.247ThrAsp: 3.247 ± 0.063	3.181ThrGlu: 3.181 ± 0.063	1.964ThrPhe: 1.964 ± 0.044	5.371ThrGly: 5.371 ± 0.09	0.973ThrHis: 0.973 ± 0.029	2.723ThrIle: 2.723 ± 0.059	1.468ThrLys: 1.468 ± 0.044	5.754ThrLeu: 5.754 ± 0.092	1.111ThrMet: 1.111 ± 0.033	1.387ThrAsn: 1.387 ± 0.046	3.298ThrPro: 3.298 ± 0.061	1.403ThrGln: 1.403 ± 0.037	3.247ThrArg: 3.247 ± 0.054	3.268ThrSer: 3.268 ± 0.064	2.657ThrThr: 2.657 ± 0.065	3.995ThrVal: 3.995 ± 0.069	0.659ThrTrp: 0.659 ± 0.026	1.544ThrTyr: 1.544 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	7.342ValAla: 7.342 ± 0.115	0.64ValCys: 0.64 ± 0.026	4.247ValAsp: 4.247 ± 0.067	4.776ValGlu: 4.776 ± 0.078	2.888ValPhe: 2.888 ± 0.054	4.885ValGly: 4.885 ± 0.088	1.224ValHis: 1.224 ± 0.035	4.0ValIle: 4.0 ± 0.063	2.256ValLys: 2.256 ± 0.056	6.252ValLeu: 6.252 ± 0.087	1.794ValMet: 1.794 ± 0.05	2.03ValAsn: 2.03 ± 0.049	3.158ValPro: 3.158 ± 0.059	1.982ValGln: 1.982 ± 0.054	4.588ValArg: 4.588 ± 0.07	4.917ValSer: 4.917 ± 0.077	4.237ValThr: 4.237 ± 0.081	4.513ValVal: 4.513 ± 0.073	1.084ValTrp: 1.084 ± 0.038	1.532ValTyr: 1.532 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.254TrpAla: 1.254 ± 0.044	0.138TrpCys: 0.138 ± 0.012	0.744TrpAsp: 0.744 ± 0.027	0.652TrpGlu: 0.652 ± 0.024	0.526TrpPhe: 0.526 ± 0.024	0.915TrpGly: 0.915 ± 0.032	0.286TrpHis: 0.286 ± 0.017	0.72TrpIle: 0.72 ± 0.026	0.515TrpLys: 0.515 ± 0.021	1.622TrpLeu: 1.622 ± 0.052	0.409TrpMet: 0.409 ± 0.02	0.41TrpAsn: 0.41 ± 0.023	0.684TrpPro: 0.684 ± 0.027	0.583TrpGln: 0.583 ± 0.027	1.132TrpArg: 1.132 ± 0.035	0.927TrpSer: 0.927 ± 0.03	0.905TrpThr: 0.905 ± 0.029	0.822TrpVal: 0.822 ± 0.033	0.206TrpTrp: 0.206 ± 0.017	0.29TrpTyr: 0.29 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.528TyrAla: 2.528 ± 0.051	0.253TyrCys: 0.253 ± 0.017	1.74TyrAsp: 1.74 ± 0.052	1.626TyrGlu: 1.626 ± 0.048	0.965TyrPhe: 0.965 ± 0.035	2.197TyrGly: 2.197 ± 0.046	0.447TyrHis: 0.447 ± 0.023	1.042TyrIle: 1.042 ± 0.035	0.723TyrLys: 0.723 ± 0.027	2.139TyrLeu: 2.139 ± 0.053	0.462TyrMet: 0.462 ± 0.025	0.728TyrAsn: 0.728 ± 0.03	1.011TyrPro: 1.011 ± 0.032	0.809TyrGln: 0.809 ± 0.026	1.637TyrArg: 1.637 ± 0.046	1.367TyrSer: 1.367 ± 0.039	1.15TyrThr: 1.15 ± 0.04	1.58TyrVal: 1.58 ± 0.039	0.378TyrTrp: 0.378 ± 0.023	0.676TyrTyr: 0.676 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3048 proteins (965903 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---