Amino acid dipepetide frequency for Halovivax ruber (strain DSM 18193 / JCM 13892 / XH-70)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.315AlaAla: 13.315 ± 0.166	0.731AlaCys: 0.731 ± 0.032	10.667AlaAsp: 10.667 ± 0.13	8.188AlaGlu: 8.188 ± 0.109	3.842AlaPhe: 3.842 ± 0.078	9.656AlaGly: 9.656 ± 0.117	1.987AlaHis: 1.987 ± 0.046	6.178AlaIle: 6.178 ± 0.098	1.676AlaLys: 1.676 ± 0.048	9.925AlaLeu: 9.925 ± 0.146	2.133AlaMet: 2.133 ± 0.051	2.389AlaAsn: 2.389 ± 0.058	4.062AlaPro: 4.062 ± 0.073	2.253AlaGln: 2.253 ± 0.06	6.008AlaArg: 6.008 ± 0.104	6.122AlaSer: 6.122 ± 0.09	7.877AlaThr: 7.877 ± 0.099	10.155AlaVal: 10.155 ± 0.126	1.075AlaTrp: 1.075 ± 0.038	2.68AlaTyr: 2.68 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.655CysAla: 0.655 ± 0.029	0.112CysCys: 0.112 ± 0.012	0.612CysAsp: 0.612 ± 0.024	0.628CysGlu: 0.628 ± 0.029	0.216CysPhe: 0.216 ± 0.016	0.823CysGly: 0.823 ± 0.032	0.229CysHis: 0.229 ± 0.016	0.248CysIle: 0.248 ± 0.016	0.098CysLys: 0.098 ± 0.01	0.622CysLeu: 0.622 ± 0.028	0.092CysMet: 0.092 ± 0.011	0.177CysAsn: 0.177 ± 0.012	0.55CysPro: 0.55 ± 0.027	0.188CysGln: 0.188 ± 0.014	0.467CysArg: 0.467 ± 0.024	0.419CysSer: 0.419 ± 0.022	0.473CysThr: 0.473 ± 0.023	0.516CysVal: 0.516 ± 0.024	0.098CysTrp: 0.098 ± 0.009	0.249CysTyr: 0.249 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	10.619AspAla: 10.619 ± 0.122	0.666AspCys: 0.666 ± 0.029	8.508AspAsp: 8.508 ± 0.133	9.263AspGlu: 9.263 ± 0.13	2.034AspPhe: 2.034 ± 0.047	8.906AspGly: 8.906 ± 0.131	1.952AspHis: 1.952 ± 0.049	2.777AspIle: 2.777 ± 0.054	0.768AspLys: 0.768 ± 0.032	6.737AspLeu: 6.737 ± 0.107	1.056AspMet: 1.056 ± 0.035	1.178AspAsn: 1.178 ± 0.045	5.102AspPro: 5.102 ± 0.078	1.828AspGln: 1.828 ± 0.05	7.557AspArg: 7.557 ± 0.114	4.189AspSer: 4.189 ± 0.083	4.137AspThr: 4.137 ± 0.075	8.315AspVal: 8.315 ± 0.101	0.973AspTrp: 0.973 ± 0.041	1.645AspTyr: 1.645 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.612GluAla: 8.612 ± 0.12	0.583GluCys: 0.583 ± 0.026	5.024GluAsp: 5.024 ± 0.093	5.375GluGlu: 5.375 ± 0.113	2.433GluPhe: 2.433 ± 0.057	5.112GluGly: 5.112 ± 0.083	2.096GluHis: 2.096 ± 0.055	3.881GluIle: 3.881 ± 0.079	1.563GluLys: 1.563 ± 0.053	7.677GluLeu: 7.677 ± 0.112	1.697GluMet: 1.697 ± 0.042	2.18GluAsn: 2.18 ± 0.057	4.587GluPro: 4.587 ± 0.085	2.432GluGln: 2.432 ± 0.054	7.36GluArg: 7.36 ± 0.105	5.92GluSer: 5.92 ± 0.093	7.371GluThr: 7.371 ± 0.111	4.726GluVal: 4.726 ± 0.078	1.141GluTrp: 1.141 ± 0.037	2.531GluTyr: 2.531 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.446PheAla: 3.446 ± 0.074	0.306PheCys: 0.306 ± 0.02	3.53PheAsp: 3.53 ± 0.067	3.035PheGlu: 3.035 ± 0.059	0.964PhePhe: 0.964 ± 0.034	3.054PheGly: 3.054 ± 0.074	0.625PheHis: 0.625 ± 0.027	0.941PheIle: 0.941 ± 0.035	0.364PheLys: 0.364 ± 0.022	2.641PheLeu: 2.641 ± 0.068	0.43PheMet: 0.43 ± 0.021	0.585PheAsn: 0.585 ± 0.025	1.22PhePro: 1.22 ± 0.037	0.743PheGln: 0.743 ± 0.027	1.592PheArg: 1.592 ± 0.043	1.598PheSer: 1.598 ± 0.044	1.896PheThr: 1.896 ± 0.049	3.359PheVal: 3.359 ± 0.076	0.371PheTrp: 0.371 ± 0.021	0.826PheTyr: 0.826 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.406GlyAla: 8.406 ± 0.129	0.738GlyCys: 0.738 ± 0.027	6.91GlyAsp: 6.91 ± 0.106	6.976GlyGlu: 6.976 ± 0.103	2.956GlyPhe: 2.956 ± 0.063	7.182GlyGly: 7.182 ± 0.132	1.788GlyHis: 1.788 ± 0.048	4.223GlyIle: 4.223 ± 0.078	1.583GlyLys: 1.583 ± 0.047	7.434GlyLeu: 7.434 ± 0.109	1.712GlyMet: 1.712 ± 0.045	1.801GlyAsn: 1.801 ± 0.054	3.738GlyPro: 3.738 ± 0.064	2.11GlyGln: 2.11 ± 0.05	4.889GlyArg: 4.889 ± 0.101	5.503GlySer: 5.503 ± 0.086	6.212GlyThr: 6.212 ± 0.096	7.203GlyVal: 7.203 ± 0.099	1.206GlyTrp: 1.206 ± 0.033	2.661GlyTyr: 2.661 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.04HisAla: 2.04 ± 0.047	0.217HisCys: 0.217 ± 0.017	1.96HisAsp: 1.96 ± 0.051	1.754HisGlu: 1.754 ± 0.046	0.577HisPhe: 0.577 ± 0.025	1.983HisGly: 1.983 ± 0.054	0.561HisHis: 0.561 ± 0.027	0.632HisIle: 0.632 ± 0.029	0.252HisLys: 0.252 ± 0.019	1.748HisLeu: 1.748 ± 0.045	0.291HisMet: 0.291 ± 0.018	0.403HisAsn: 0.403 ± 0.022	1.252HisPro: 1.252 ± 0.036	0.49HisGln: 0.49 ± 0.026	1.412HisArg: 1.412 ± 0.049	0.862HisSer: 0.862 ± 0.033	1.108HisThr: 1.108 ± 0.038	2.071HisVal: 2.071 ± 0.044	0.243HisTrp: 0.243 ± 0.018	0.604HisTyr: 0.604 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.979IleAla: 4.979 ± 0.083	0.291IleCys: 0.291 ± 0.016	4.733IleAsp: 4.733 ± 0.082	4.56IleGlu: 4.56 ± 0.076	1.045IlePhe: 1.045 ± 0.043	4.072IleGly: 4.072 ± 0.082	0.849IleHis: 0.849 ± 0.033	1.121IleIle: 1.121 ± 0.043	0.603IleLys: 0.603 ± 0.03	3.037IleLeu: 3.037 ± 0.06	0.494IleMet: 0.494 ± 0.025	0.86IleAsn: 0.86 ± 0.026	2.017IlePro: 2.017 ± 0.046	1.081IleGln: 1.081 ± 0.034	2.593IleArg: 2.593 ± 0.047	2.269IleSer: 2.269 ± 0.057	2.471IleThr: 2.471 ± 0.053	4.421IleVal: 4.421 ± 0.069	0.339IleTrp: 0.339 ± 0.02	0.91IleTyr: 0.91 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	1.575LysAla: 1.575 ± 0.043	0.093LysCys: 0.093 ± 0.013	0.874LysAsp: 0.874 ± 0.034	0.994LysGlu: 0.994 ± 0.038	0.418LysPhe: 0.418 ± 0.022	1.125LysGly: 1.125 ± 0.043	0.41LysHis: 0.41 ± 0.023	0.682LysIle: 0.682 ± 0.03	0.434LysLys: 0.434 ± 0.032	1.475LysLeu: 1.475 ± 0.04	0.324LysMet: 0.324 ± 0.019	0.473LysAsn: 0.473 ± 0.025	0.876LysPro: 0.876 ± 0.036	0.593LysGln: 0.593 ± 0.029	1.479LysArg: 1.479 ± 0.049	1.025LysSer: 1.025 ± 0.037	1.165LysThr: 1.165 ± 0.041	0.975LysVal: 0.975 ± 0.034	0.196LysTrp: 0.196 ± 0.017	0.487LysTyr: 0.487 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.496LeuAla: 11.496 ± 0.181	0.631LeuCys: 0.631 ± 0.026	7.636LeuAsp: 7.636 ± 0.115	7.097LeuGlu: 7.097 ± 0.111	3.024LeuPhe: 3.024 ± 0.062	7.584LeuGly: 7.584 ± 0.106	1.397LeuHis: 1.397 ± 0.05	2.827LeuIle: 2.827 ± 0.068	1.29LeuLys: 1.29 ± 0.043	7.842LeuLeu: 7.842 ± 0.141	1.162LeuMet: 1.162 ± 0.034	1.452LeuAsn: 1.452 ± 0.044	3.839LeuPro: 3.839 ± 0.072	2.051LeuGln: 2.051 ± 0.046	4.856LeuArg: 4.856 ± 0.076	5.899LeuSer: 5.899 ± 0.086	5.551LeuThr: 5.551 ± 0.092	8.547LeuVal: 8.547 ± 0.125	0.904LeuTrp: 0.904 ± 0.031	2.12LeuTyr: 2.12 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	1.843MetAla: 1.843 ± 0.044	0.107MetCys: 0.107 ± 0.011	1.353MetAsp: 1.353 ± 0.041	1.083MetGlu: 1.083 ± 0.036	0.435MetPhe: 0.435 ± 0.026	1.5MetGly: 1.5 ± 0.047	0.347MetHis: 0.347 ± 0.018	0.703MetIle: 0.703 ± 0.028	0.418MetLys: 0.418 ± 0.023	1.35MetLeu: 1.35 ± 0.04	0.316MetMet: 0.316 ± 0.02	0.548MetAsn: 0.548 ± 0.022	0.782MetPro: 0.782 ± 0.031	0.477MetGln: 0.477 ± 0.023	0.968MetArg: 0.968 ± 0.034	1.342MetSer: 1.342 ± 0.034	1.468MetThr: 1.468 ± 0.039	1.239MetVal: 1.239 ± 0.04	0.142MetTrp: 0.142 ± 0.012	0.393MetTyr: 0.393 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.405AsnAla: 2.405 ± 0.054	0.201AsnCys: 0.201 ± 0.015	1.591AsnAsp: 1.591 ± 0.044	1.777AsnGlu: 1.777 ± 0.052	0.566AsnPhe: 0.566 ± 0.028	1.971AsnGly: 1.971 ± 0.058	0.486AsnHis: 0.486 ± 0.023	0.721AsnIle: 0.721 ± 0.029	0.373AsnLys: 0.373 ± 0.021	1.712AsnLeu: 1.712 ± 0.043	0.35AsnMet: 0.35 ± 0.017	0.491AsnAsn: 0.491 ± 0.027	1.46AsnPro: 1.46 ± 0.042	0.551AsnGln: 0.551 ± 0.026	1.52AsnArg: 1.52 ± 0.035	0.941AsnSer: 0.941 ± 0.033	1.177AsnThr: 1.177 ± 0.047	2.193AsnVal: 2.193 ± 0.055	0.282AsnTrp: 0.282 ± 0.018	0.543AsnTyr: 0.543 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.249ProAla: 5.249 ± 0.075	0.248ProCys: 0.248 ± 0.018	5.316ProAsp: 5.316 ± 0.081	4.044ProGlu: 4.044 ± 0.066	1.582ProPhe: 1.582 ± 0.046	3.878ProGly: 3.878 ± 0.062	0.917ProHis: 0.917 ± 0.03	2.418ProIle: 2.418 ± 0.053	0.803ProLys: 0.803 ± 0.03	3.682ProLeu: 3.682 ± 0.064	0.801ProMet: 0.801 ± 0.03	1.101ProAsn: 1.101 ± 0.036	2.269ProPro: 2.269 ± 0.054	1.043ProGln: 1.043 ± 0.033	2.274ProArg: 2.274 ± 0.053	2.982ProSer: 2.982 ± 0.063	3.717ProThr: 3.717 ± 0.077	4.129ProVal: 4.129 ± 0.081	0.489ProTrp: 0.489 ± 0.024	1.142ProTyr: 1.142 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.534GlnAla: 2.534 ± 0.054	0.167GlnCys: 0.167 ± 0.013	1.404GlnAsp: 1.404 ± 0.038	1.626GlnGlu: 1.626 ± 0.045	0.981GlnPhe: 0.981 ± 0.034	1.576GlnGly: 1.576 ± 0.043	0.56GlnHis: 0.56 ± 0.025	1.098GlnIle: 1.098 ± 0.034	0.464GlnLys: 0.464 ± 0.025	2.604GlnLeu: 2.604 ± 0.059	0.446GlnMet: 0.446 ± 0.023	0.647GlnAsn: 0.647 ± 0.028	1.271GlnPro: 1.271 ± 0.04	0.92GlnGln: 0.92 ± 0.039	1.853GlnArg: 1.853 ± 0.058	1.606GlnSer: 1.606 ± 0.045	1.704GlnThr: 1.704 ± 0.041	1.791GlnVal: 1.791 ± 0.047	0.317GlnTrp: 0.317 ± 0.019	0.811GlnTyr: 0.811 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.421ArgAla: 6.421 ± 0.104	0.526ArgCys: 0.526 ± 0.026	4.98ArgAsp: 4.98 ± 0.077	6.015ArgGlu: 6.015 ± 0.09	2.279ArgPhe: 2.279 ± 0.048	4.261ArgGly: 4.261 ± 0.073	1.249ArgHis: 1.249 ± 0.038	3.119ArgIle: 3.119 ± 0.073	1.191ArgLys: 1.191 ± 0.041	6.037ArgLeu: 6.037 ± 0.091	1.271ArgMet: 1.271 ± 0.038	1.51ArgAsn: 1.51 ± 0.043	2.796ArgPro: 2.796 ± 0.065	1.84ArgGln: 1.84 ± 0.041	4.884ArgArg: 4.884 ± 0.087	4.064ArgSer: 4.064 ± 0.076	4.357ArgThr: 4.357 ± 0.078	4.907ArgVal: 4.907 ± 0.072	0.753ArgTrp: 0.753 ± 0.03	1.989ArgTyr: 1.989 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.859SerAla: 5.859 ± 0.088	0.346SerCys: 0.346 ± 0.018	4.762SerAsp: 4.762 ± 0.077	4.113SerGlu: 4.113 ± 0.077	1.995SerPhe: 1.995 ± 0.042	5.436SerGly: 5.436 ± 0.099	1.134SerHis: 1.134 ± 0.033	3.084SerIle: 3.084 ± 0.065	1.063SerLys: 1.063 ± 0.036	5.347SerLeu: 5.347 ± 0.082	1.274SerMet: 1.274 ± 0.038	1.318SerAsn: 1.318 ± 0.045	2.895SerPro: 2.895 ± 0.067	1.462SerGln: 1.462 ± 0.042	3.341SerArg: 3.341 ± 0.068	3.389SerSer: 3.389 ± 0.078	4.249SerThr: 4.249 ± 0.08	5.427SerVal: 5.427 ± 0.071	0.656SerTrp: 0.656 ± 0.029	1.428SerTyr: 1.428 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	7.603ThrAla: 7.603 ± 0.1	0.431ThrCys: 0.431 ± 0.025	6.595ThrAsp: 6.595 ± 0.112	4.884ThrGlu: 4.884 ± 0.091	2.23ThrPhe: 2.23 ± 0.06	6.147ThrGly: 6.147 ± 0.088	1.349ThrHis: 1.349 ± 0.043	3.689ThrIle: 3.689 ± 0.073	0.974ThrLys: 0.974 ± 0.031	5.948ThrLeu: 5.948 ± 0.088	1.114ThrMet: 1.114 ± 0.036	1.569ThrAsn: 1.569 ± 0.049	3.396ThrPro: 3.396 ± 0.067	1.498ThrGln: 1.498 ± 0.037	3.354ThrArg: 3.354 ± 0.064	3.298ThrSer: 3.298 ± 0.061	4.614ThrThr: 4.614 ± 0.078	7.172ThrVal: 7.172 ± 0.108	0.684ThrTrp: 0.684 ± 0.03	1.785ThrTyr: 1.785 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	10.113ValAla: 10.113 ± 0.117	0.729ValCys: 0.729 ± 0.027	8.263ValAsp: 8.263 ± 0.108	7.646ValGlu: 7.646 ± 0.094	2.746ValPhe: 2.746 ± 0.057	7.825ValGly: 7.825 ± 0.124	1.686ValHis: 1.686 ± 0.042	3.17ValIle: 3.17 ± 0.075	1.149ValLys: 1.149 ± 0.04	7.888ValLeu: 7.888 ± 0.116	1.285ValMet: 1.285 ± 0.041	1.704ValAsn: 1.704 ± 0.045	4.244ValPro: 4.244 ± 0.07	1.858ValGln: 1.858 ± 0.051	5.224ValArg: 5.224 ± 0.074	5.41ValSer: 5.41 ± 0.076	6.556ValThr: 6.556 ± 0.103	8.749ValVal: 8.749 ± 0.134	0.789ValTrp: 0.789 ± 0.032	2.085ValTyr: 2.085 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.985TrpAla: 0.985 ± 0.037	0.094TrpCys: 0.094 ± 0.01	0.852TrpAsp: 0.852 ± 0.033	0.81TrpGlu: 0.81 ± 0.029	0.422TrpPhe: 0.422 ± 0.021	0.847TrpGly: 0.847 ± 0.028	0.252TrpHis: 0.252 ± 0.018	0.581TrpIle: 0.581 ± 0.027	0.247TrpLys: 0.247 ± 0.015	1.197TrpLeu: 1.197 ± 0.036	0.226TrpMet: 0.226 ± 0.015	0.374TrpAsn: 0.374 ± 0.022	0.462TrpPro: 0.462 ± 0.021	0.295TrpGln: 0.295 ± 0.017	0.82TrpArg: 0.82 ± 0.037	0.608TrpSer: 0.608 ± 0.029	0.734TrpThr: 0.734 ± 0.033	0.829TrpVal: 0.829 ± 0.028	0.189TrpTrp: 0.189 ± 0.017	0.35TrpTyr: 0.35 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.765TyrAla: 2.765 ± 0.057	0.255TyrCys: 0.255 ± 0.016	2.642TyrAsp: 2.642 ± 0.055	2.435TyrGlu: 2.435 ± 0.059	0.782TyrPhe: 0.782 ± 0.031	2.291TyrGly: 2.291 ± 0.05	0.587TyrHis: 0.587 ± 0.026	0.651TyrIle: 0.651 ± 0.029	0.359TyrLys: 0.359 ± 0.021	2.302TyrLeu: 2.302 ± 0.049	0.34TyrMet: 0.34 ± 0.019	0.551TyrAsn: 0.551 ± 0.023	1.266TyrPro: 1.266 ± 0.035	0.668TyrGln: 0.668 ± 0.026	1.997TyrArg: 1.997 ± 0.052	1.134TyrSer: 1.134 ± 0.031	1.493TyrThr: 1.493 ± 0.04	2.393TyrVal: 2.393 ± 0.053	0.328TyrTrp: 0.328 ± 0.02	0.776TyrTyr: 0.776 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3099 proteins (914088 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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