Amino acid dipepetide frequency for Paracoccus halophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.614AlaAla: 18.614 ± 0.208	1.089AlaCys: 1.089 ± 0.033	7.254AlaAsp: 7.254 ± 0.091	8.86AlaGlu: 8.86 ± 0.129	3.961AlaPhe: 3.961 ± 0.066	12.02AlaGly: 12.02 ± 0.133	2.306AlaHis: 2.306 ± 0.053	6.577AlaIle: 6.577 ± 0.102	2.917AlaLys: 2.917 ± 0.07	14.334AlaLeu: 14.334 ± 0.15	4.066AlaMet: 4.066 ± 0.074	2.63AlaAsn: 2.63 ± 0.049	6.255AlaPro: 6.255 ± 0.101	4.546AlaGln: 4.546 ± 0.081	10.947AlaArg: 10.947 ± 0.141	5.777AlaSer: 5.777 ± 0.079	5.977AlaThr: 5.977 ± 0.077	8.317AlaVal: 8.317 ± 0.089	1.516AlaTrp: 1.516 ± 0.039	2.363AlaTyr: 2.363 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.026CysAla: 1.026 ± 0.031	0.104CysCys: 0.104 ± 0.01	0.562CysAsp: 0.562 ± 0.023	0.407CysGlu: 0.407 ± 0.022	0.287CysPhe: 0.287 ± 0.016	0.9CysGly: 0.9 ± 0.033	0.273CysHis: 0.273 ± 0.017	0.418CysIle: 0.418 ± 0.02	0.171CysLys: 0.171 ± 0.012	0.784CysLeu: 0.784 ± 0.026	0.168CysMet: 0.168 ± 0.012	0.202CysAsn: 0.202 ± 0.013	0.496CysPro: 0.496 ± 0.024	0.246CysGln: 0.246 ± 0.015	0.619CysArg: 0.619 ± 0.025	0.422CysSer: 0.422 ± 0.02	0.385CysThr: 0.385 ± 0.017	0.522CysVal: 0.522 ± 0.023	0.125CysTrp: 0.125 ± 0.011	0.174CysTyr: 0.174 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.185AspAla: 7.185 ± 0.087	0.498AspCys: 0.498 ± 0.025	3.324AspAsp: 3.324 ± 0.07	3.661AspGlu: 3.661 ± 0.055	2.233AspPhe: 2.233 ± 0.047	5.376AspGly: 5.376 ± 0.076	1.359AspHis: 1.359 ± 0.038	2.954AspIle: 2.954 ± 0.046	1.514AspLys: 1.514 ± 0.038	6.543AspLeu: 6.543 ± 0.089	1.602AspMet: 1.602 ± 0.04	1.222AspAsn: 1.222 ± 0.034	3.97AspPro: 3.97 ± 0.059	1.959AspGln: 1.959 ± 0.043	4.977AspArg: 4.977 ± 0.068	2.42AspSer: 2.42 ± 0.046	2.46AspThr: 2.46 ± 0.052	3.232AspVal: 3.232 ± 0.056	1.228AspTrp: 1.228 ± 0.036	1.552AspTyr: 1.552 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.881GluAla: 7.881 ± 0.105	0.363GluCys: 0.363 ± 0.022	3.072GluAsp: 3.072 ± 0.056	2.997GluGlu: 2.997 ± 0.073	1.91GluPhe: 1.91 ± 0.04	4.634GluGly: 4.634 ± 0.078	1.145GluHis: 1.145 ± 0.033	3.706GluIle: 3.706 ± 0.068	1.891GluLys: 1.891 ± 0.047	5.496GluLeu: 5.496 ± 0.085	1.735GluMet: 1.735 ± 0.042	1.694GluAsn: 1.694 ± 0.04	2.588GluPro: 2.588 ± 0.057	2.009GluGln: 2.009 ± 0.053	4.568GluArg: 4.568 ± 0.071	2.429GluSer: 2.429 ± 0.049	3.516GluThr: 3.516 ± 0.055	3.814GluVal: 3.814 ± 0.068	0.802GluTrp: 0.802 ± 0.028	1.144GluTyr: 1.144 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.427PheAla: 4.427 ± 0.065	0.372PheCys: 0.372 ± 0.017	2.612PheAsp: 2.612 ± 0.049	1.838PheGlu: 1.838 ± 0.047	1.296PhePhe: 1.296 ± 0.042	3.488PheGly: 3.488 ± 0.065	0.778PheHis: 0.778 ± 0.028	1.662PheIle: 1.662 ± 0.049	0.68PheLys: 0.68 ± 0.028	3.465PheLeu: 3.465 ± 0.076	0.875PheMet: 0.875 ± 0.029	0.887PheAsn: 0.887 ± 0.033	1.568PhePro: 1.568 ± 0.042	0.998PheGln: 0.998 ± 0.038	2.438PheArg: 2.438 ± 0.054	2.011PheSer: 2.011 ± 0.038	1.901PheThr: 1.901 ± 0.042	2.488PheVal: 2.488 ± 0.049	0.592PheTrp: 0.592 ± 0.027	0.798PheTyr: 0.798 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.718GlyAla: 10.718 ± 0.106	0.848GlyCys: 0.848 ± 0.033	4.886GlyAsp: 4.886 ± 0.077	4.777GlyGlu: 4.777 ± 0.067	3.723GlyPhe: 3.723 ± 0.065	7.48GlyGly: 7.48 ± 0.116	1.925GlyHis: 1.925 ± 0.048	4.874GlyIle: 4.874 ± 0.075	2.924GlyLys: 2.924 ± 0.055	9.569GlyLeu: 9.569 ± 0.109	2.854GlyMet: 2.854 ± 0.052	2.145GlyAsn: 2.145 ± 0.053	3.977GlyPro: 3.977 ± 0.069	3.441GlyGln: 3.441 ± 0.058	7.008GlyArg: 7.008 ± 0.094	4.244GlySer: 4.244 ± 0.066	4.405GlyThr: 4.405 ± 0.073	6.079GlyVal: 6.079 ± 0.093	1.639GlyTrp: 1.639 ± 0.043	2.218GlyTyr: 2.218 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.379HisAla: 2.379 ± 0.055	0.239HisCys: 0.239 ± 0.015	1.376HisAsp: 1.376 ± 0.039	1.124HisGlu: 1.124 ± 0.034	0.784HisPhe: 0.784 ± 0.028	1.998HisGly: 1.998 ± 0.041	0.524HisHis: 0.524 ± 0.026	0.955HisIle: 0.955 ± 0.03	0.419HisLys: 0.419 ± 0.021	2.103HisLeu: 2.103 ± 0.054	0.526HisMet: 0.526 ± 0.022	0.393HisAsn: 0.393 ± 0.019	1.42HisPro: 1.42 ± 0.036	0.54HisGln: 0.54 ± 0.026	1.541HisArg: 1.541 ± 0.036	0.875HisSer: 0.875 ± 0.032	0.638HisThr: 0.638 ± 0.028	1.492HisVal: 1.492 ± 0.04	0.311HisTrp: 0.311 ± 0.016	0.533HisTyr: 0.533 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.782IleAla: 7.782 ± 0.102	0.583IleCys: 0.583 ± 0.024	3.451IleAsp: 3.451 ± 0.05	3.578IleGlu: 3.578 ± 0.056	1.786IlePhe: 1.786 ± 0.046	5.34IleGly: 5.34 ± 0.069	0.978IleHis: 0.978 ± 0.031	2.198IleIle: 2.198 ± 0.053	1.155IleLys: 1.155 ± 0.035	4.933IleLeu: 4.933 ± 0.079	1.163IleMet: 1.163 ± 0.037	1.214IleAsn: 1.214 ± 0.035	2.474IlePro: 2.474 ± 0.054	1.173IleGln: 1.173 ± 0.034	4.081IleArg: 4.081 ± 0.066	2.926IleSer: 2.926 ± 0.052	2.715IleThr: 2.715 ± 0.053	3.857IleVal: 3.857 ± 0.062	0.789IleTrp: 0.789 ± 0.026	1.12IleTyr: 1.12 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.339LysAla: 3.339 ± 0.065	0.146LysCys: 0.146 ± 0.011	1.32LysAsp: 1.32 ± 0.038	1.2LysGlu: 1.2 ± 0.043	0.788LysPhe: 0.788 ± 0.031	2.362LysGly: 2.362 ± 0.053	0.484LysHis: 0.484 ± 0.022	1.308LysIle: 1.308 ± 0.042	0.854LysLys: 0.854 ± 0.037	2.527LysLeu: 2.527 ± 0.053	0.683LysMet: 0.683 ± 0.029	0.637LysAsn: 0.637 ± 0.027	1.644LysPro: 1.644 ± 0.039	0.819LysGln: 0.819 ± 0.026	1.894LysArg: 1.894 ± 0.052	1.541LysSer: 1.541 ± 0.043	1.583LysThr: 1.583 ± 0.04	1.811LysVal: 1.811 ± 0.048	0.353LysTrp: 0.353 ± 0.018	0.579LysTyr: 0.579 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.479LeuAla: 14.479 ± 0.156	0.84LeuCys: 0.84 ± 0.029	6.098LeuAsp: 6.098 ± 0.083	4.875LeuGlu: 4.875 ± 0.071	3.369LeuPhe: 3.369 ± 0.067	8.837LeuGly: 8.837 ± 0.095	1.818LeuHis: 1.818 ± 0.038	5.693LeuIle: 5.693 ± 0.078	2.682LeuLys: 2.682 ± 0.058	9.264LeuLeu: 9.264 ± 0.131	2.641LeuMet: 2.641 ± 0.048	2.626LeuAsn: 2.626 ± 0.05	6.27LeuPro: 6.27 ± 0.092	2.772LeuGln: 2.772 ± 0.053	8.159LeuArg: 8.159 ± 0.1	6.252LeuSer: 6.252 ± 0.071	6.034LeuThr: 6.034 ± 0.083	6.801LeuVal: 6.801 ± 0.088	1.3LeuTrp: 1.3 ± 0.037	1.95LeuTyr: 1.95 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.819MetAla: 3.819 ± 0.063	0.168MetCys: 0.168 ± 0.013	1.367MetAsp: 1.367 ± 0.037	1.221MetGlu: 1.221 ± 0.034	0.791MetPhe: 0.791 ± 0.024	2.244MetGly: 2.244 ± 0.054	0.42MetHis: 0.42 ± 0.019	1.69MetIle: 1.69 ± 0.042	0.968MetLys: 0.968 ± 0.029	2.854MetLeu: 2.854 ± 0.057	0.737MetMet: 0.737 ± 0.03	0.85MetAsn: 0.85 ± 0.03	1.619MetPro: 1.619 ± 0.038	0.998MetGln: 0.998 ± 0.027	2.186MetArg: 2.186 ± 0.05	1.596MetSer: 1.596 ± 0.042	2.005MetThr: 2.005 ± 0.048	1.838MetVal: 1.838 ± 0.043	0.212MetTrp: 0.212 ± 0.016	0.267MetTyr: 0.267 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.955AsnAla: 2.955 ± 0.056	0.25AsnCys: 0.25 ± 0.016	1.388AsnAsp: 1.388 ± 0.04	1.097AsnGlu: 1.097 ± 0.032	0.895AsnPhe: 0.895 ± 0.028	2.187AsnGly: 2.187 ± 0.052	0.473AsnHis: 0.473 ± 0.02	1.322AsnIle: 1.322 ± 0.036	0.567AsnLys: 0.567 ± 0.029	2.509AsnLeu: 2.509 ± 0.053	0.691AsnMet: 0.691 ± 0.026	0.582AsnAsn: 0.582 ± 0.029	1.762AsnPro: 1.762 ± 0.04	0.669AsnGln: 0.669 ± 0.026	1.895AsnArg: 1.895 ± 0.049	1.111AsnSer: 1.111 ± 0.039	1.091AsnThr: 1.091 ± 0.031	1.589AsnVal: 1.589 ± 0.041	0.435AsnTrp: 0.435 ± 0.022	0.576AsnTyr: 0.576 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.109ProAla: 7.109 ± 0.107	0.35ProCys: 0.35 ± 0.017	4.075ProAsp: 4.075 ± 0.06	4.422ProGlu: 4.422 ± 0.076	1.889ProPhe: 1.889 ± 0.044	5.489ProGly: 5.489 ± 0.074	1.093ProHis: 1.093 ± 0.033	2.211ProIle: 2.211 ± 0.048	1.243ProLys: 1.243 ± 0.04	4.875ProLeu: 4.875 ± 0.07	1.406ProMet: 1.406 ± 0.037	1.123ProAsn: 1.123 ± 0.027	2.641ProPro: 2.641 ± 0.061	1.825ProGln: 1.825 ± 0.043	3.41ProArg: 3.41 ± 0.06	2.307ProSer: 2.307 ± 0.051	2.096ProThr: 2.096 ± 0.041	4.419ProVal: 4.419 ± 0.069	0.732ProTrp: 0.732 ± 0.03	1.074ProTyr: 1.074 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.437GlnAla: 4.437 ± 0.073	0.213GlnCys: 0.213 ± 0.012	1.748GlnAsp: 1.748 ± 0.045	1.602GlnGlu: 1.602 ± 0.038	1.018GlnPhe: 1.018 ± 0.029	3.032GlnGly: 3.032 ± 0.057	0.534GlnHis: 0.534 ± 0.023	2.133GlnIle: 2.133 ± 0.049	0.969GlnLys: 0.969 ± 0.031	2.8GlnLeu: 2.8 ± 0.054	1.036GlnMet: 1.036 ± 0.034	0.865GlnAsn: 0.865 ± 0.03	1.899GlnPro: 1.899 ± 0.045	1.102GlnGln: 1.102 ± 0.033	2.367GlnArg: 2.367 ± 0.05	1.63GlnSer: 1.63 ± 0.04	1.619GlnThr: 1.619 ± 0.042	2.385GlnVal: 2.385 ± 0.047	0.369GlnTrp: 0.369 ± 0.018	0.55GlnTyr: 0.55 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.702ArgAla: 9.702 ± 0.117	0.487ArgCys: 0.487 ± 0.025	4.984ArgAsp: 4.984 ± 0.088	4.469ArgGlu: 4.469 ± 0.073	2.879ArgPhe: 2.879 ± 0.049	5.566ArgGly: 5.566 ± 0.08	1.919ArgHis: 1.919 ± 0.047	4.75ArgIle: 4.75 ± 0.081	2.118ArgLys: 2.118 ± 0.048	8.846ArgLeu: 8.846 ± 0.127	2.254ArgMet: 2.254 ± 0.043	1.96ArgAsn: 1.96 ± 0.042	4.086ArgPro: 4.086 ± 0.067	2.833ArgGln: 2.833 ± 0.054	6.262ArgArg: 6.262 ± 0.096	3.339ArgSer: 3.339 ± 0.057	2.879ArgThr: 2.879 ± 0.058	5.041ArgVal: 5.041 ± 0.077	1.022ArgTrp: 1.022 ± 0.033	1.592ArgTyr: 1.592 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.883SerAla: 5.883 ± 0.091	0.433SerCys: 0.433 ± 0.021	3.115SerAsp: 3.115 ± 0.048	2.59SerGlu: 2.59 ± 0.051	2.079SerPhe: 2.079 ± 0.043	5.431SerGly: 5.431 ± 0.073	1.044SerHis: 1.044 ± 0.031	2.36SerIle: 2.36 ± 0.045	1.112SerLys: 1.112 ± 0.035	5.056SerLeu: 5.056 ± 0.077	1.294SerMet: 1.294 ± 0.035	1.148SerAsn: 1.148 ± 0.031	2.592SerPro: 2.592 ± 0.05	1.527SerGln: 1.527 ± 0.035	3.69SerArg: 3.69 ± 0.062	2.401SerSer: 2.401 ± 0.054	2.211SerThr: 2.211 ± 0.046	3.485SerVal: 3.485 ± 0.067	0.758SerTrp: 0.758 ± 0.03	1.176SerTyr: 1.176 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.817ThrAla: 5.817 ± 0.063	0.439ThrCys: 0.439 ± 0.023	2.825ThrAsp: 2.825 ± 0.051	2.857ThrGlu: 2.857 ± 0.044	1.625ThrPhe: 1.625 ± 0.041	5.467ThrGly: 5.467 ± 0.078	1.048ThrHis: 1.048 ± 0.033	2.633ThrIle: 2.633 ± 0.049	1.038ThrLys: 1.038 ± 0.029	5.261ThrLeu: 5.261 ± 0.083	1.186ThrMet: 1.186 ± 0.035	1.089ThrAsn: 1.089 ± 0.04	3.242ThrPro: 3.242 ± 0.062	1.368ThrGln: 1.368 ± 0.041	3.816ThrArg: 3.816 ± 0.06	2.363ThrSer: 2.363 ± 0.048	2.307ThrThr: 2.307 ± 0.052	3.926ThrVal: 3.926 ± 0.064	0.569ThrTrp: 0.569 ± 0.026	1.044ThrTyr: 1.044 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.897ValAla: 8.897 ± 0.093	0.515ValCys: 0.515 ± 0.023	3.525ValAsp: 3.525 ± 0.059	4.104ValGlu: 4.104 ± 0.063	2.49ValPhe: 2.49 ± 0.055	4.849ValGly: 4.849 ± 0.079	1.229ValHis: 1.229 ± 0.035	4.258ValIle: 4.258 ± 0.065	1.779ValLys: 1.779 ± 0.047	7.431ValLeu: 7.431 ± 0.086	2.117ValMet: 2.117 ± 0.043	1.824ValAsn: 1.824 ± 0.05	3.518ValPro: 3.518 ± 0.056	2.087ValGln: 2.087 ± 0.044	4.124ValArg: 4.124 ± 0.066	3.864ValSer: 3.864 ± 0.058	4.493ValThr: 4.493 ± 0.077	5.058ValVal: 5.058 ± 0.084	0.918ValTrp: 0.918 ± 0.03	1.289ValTyr: 1.289 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.436TrpAla: 1.436 ± 0.035	0.118TrpCys: 0.118 ± 0.01	0.729TrpAsp: 0.729 ± 0.03	0.538TrpGlu: 0.538 ± 0.021	0.544TrpPhe: 0.544 ± 0.023	1.035TrpGly: 1.035 ± 0.033	0.354TrpHis: 0.354 ± 0.019	0.756TrpIle: 0.756 ± 0.031	0.418TrpLys: 0.418 ± 0.022	1.936TrpLeu: 1.936 ± 0.05	0.386TrpMet: 0.386 ± 0.018	0.424TrpAsn: 0.424 ± 0.023	0.736TrpPro: 0.736 ± 0.028	0.755TrpGln: 0.755 ± 0.029	1.271TrpArg: 1.271 ± 0.039	0.806TrpSer: 0.806 ± 0.029	0.715TrpThr: 0.715 ± 0.025	0.801TrpVal: 0.801 ± 0.029	0.237TrpTrp: 0.237 ± 0.014	0.262TrpTyr: 0.262 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.442TyrAla: 2.442 ± 0.053	0.239TyrCys: 0.239 ± 0.014	1.557TyrAsp: 1.557 ± 0.048	1.177TyrGlu: 1.177 ± 0.036	0.827TyrPhe: 0.827 ± 0.029	2.0TyrGly: 2.0 ± 0.054	0.461TyrHis: 0.461 ± 0.022	0.841TyrIle: 0.841 ± 0.025	0.451TyrLys: 0.451 ± 0.021	2.173TyrLeu: 2.173 ± 0.049	0.43TyrMet: 0.43 ± 0.021	0.53TyrAsn: 0.53 ± 0.024	1.032TyrPro: 1.032 ± 0.031	0.644TyrGln: 0.644 ± 0.025	1.731TyrArg: 1.731 ± 0.046	1.072TyrSer: 1.072 ± 0.034	0.891TyrThr: 0.891 ± 0.031	1.414TyrVal: 1.414 ± 0.037	0.35TyrTrp: 0.35 ± 0.02	0.548TyrTyr: 0.548 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3457 proteins (1072070 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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