Amino acid dipepetide frequency for Thaumarchaeota archaeon SCGC AC-337_F14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.095AlaAla: 4.095 ± 0.216
0.717AlaCys: 0.717 ± 0.06
3.019AlaAsp: 3.019 ± 0.134
4.088AlaGlu: 4.088 ± 0.185
2.424AlaPhe: 2.424 ± 0.143
3.816AlaGly: 3.816 ± 0.171
0.983AlaHis: 0.983 ± 0.081
5.164AlaIle: 5.164 ± 0.188
5.429AlaLys: 5.429 ± 0.213
4.992AlaLeu: 4.992 ± 0.227
1.463AlaMet: 1.463 ± 0.122
2.532AlaAsn: 2.532 ± 0.123
1.549AlaPro: 1.549 ± 0.119
1.585AlaGln: 1.585 ± 0.113
2.446AlaArg: 2.446 ± 0.143
3.787AlaSer: 3.787 ± 0.187
3.149AlaThr: 3.149 ± 0.126
3.866AlaVal: 3.866 ± 0.168
0.509AlaTrp: 0.509 ± 0.062
1.757AlaTyr: 1.757 ± 0.096
0.0AlaXaa: 0.0 ± 0.0
Cys
0.502CysAla: 0.502 ± 0.059
0.158CysCys: 0.158 ± 0.03
0.71CysAsp: 0.71 ± 0.076
0.631CysGlu: 0.631 ± 0.068
0.495CysPhe: 0.495 ± 0.062
1.104CysGly: 1.104 ± 0.095
0.273CysHis: 0.273 ± 0.045
1.004CysIle: 1.004 ± 0.082
1.076CysLys: 1.076 ± 0.079
0.746CysLeu: 0.746 ± 0.065
0.265CysMet: 0.265 ± 0.044
0.524CysAsn: 0.524 ± 0.068
0.588CysPro: 0.588 ± 0.07
0.23CysGln: 0.23 ± 0.041
0.366CysArg: 0.366 ± 0.051
0.846CysSer: 0.846 ± 0.08
0.588CysThr: 0.588 ± 0.065
0.595CysVal: 0.595 ± 0.061
0.115CysTrp: 0.115 ± 0.03
0.287CysTyr: 0.287 ± 0.042
0.0CysXaa: 0.0 ± 0.0
Asp
3.773AspAla: 3.773 ± 0.19
0.746AspCys: 0.746 ± 0.075
3.672AspAsp: 3.672 ± 0.179
4.647AspGlu: 4.647 ± 0.181
2.611AspPhe: 2.611 ± 0.151
3.873AspGly: 3.873 ± 0.17
0.975AspHis: 0.975 ± 0.083
5.013AspIle: 5.013 ± 0.156
4.769AspLys: 4.769 ± 0.219
5.365AspLeu: 5.365 ± 0.25
1.377AspMet: 1.377 ± 0.097
2.697AspAsn: 2.697 ± 0.146
2.274AspPro: 2.274 ± 0.103
1.42AspGln: 1.42 ± 0.102
1.979AspArg: 1.979 ± 0.112
3.78AspSer: 3.78 ± 0.162
2.611AspThr: 2.611 ± 0.144
4.353AspVal: 4.353 ± 0.178
0.674AspTrp: 0.674 ± 0.073
2.374AspTyr: 2.374 ± 0.131
0.0AspXaa: 0.0 ± 0.0
Glu
3.83GluAla: 3.83 ± 0.17
0.638GluCys: 0.638 ± 0.081
3.22GluAsp: 3.22 ± 0.169
4.891GluGlu: 4.891 ± 0.22
2.89GluPhe: 2.89 ± 0.159
2.898GluGly: 2.898 ± 0.149
1.219GluHis: 1.219 ± 0.108
7.208GluIle: 7.208 ± 0.225
8.513GluLys: 8.513 ± 0.286
6.821GluLeu: 6.821 ± 0.213
1.8GluMet: 1.8 ± 0.108
4.138GluAsn: 4.138 ± 0.16
2.338GluPro: 2.338 ± 0.142
2.302GluGln: 2.302 ± 0.128
2.976GluArg: 2.976 ± 0.154
4.619GluSer: 4.619 ± 0.192
3.299GluThr: 3.299 ± 0.16
3.407GluVal: 3.407 ± 0.204
0.524GluTrp: 0.524 ± 0.053
2.338GluTyr: 2.338 ± 0.129
0.0GluXaa: 0.0 ± 0.0
Phe
2.539PheAla: 2.539 ± 0.162
0.674PheCys: 0.674 ± 0.065
3.313PheAsp: 3.313 ± 0.159
3.192PheGlu: 3.192 ± 0.153
1.721PhePhe: 1.721 ± 0.145
3.062PheGly: 3.062 ± 0.144
0.861PheHis: 0.861 ± 0.076
2.596PheIle: 2.596 ± 0.18
2.654PheLys: 2.654 ± 0.141
4.052PheLeu: 4.052 ± 0.216
0.868PheMet: 0.868 ± 0.079
1.936PheAsn: 1.936 ± 0.114
1.571PhePro: 1.571 ± 0.099
1.255PheGln: 1.255 ± 0.116
1.37PheArg: 1.37 ± 0.098
3.565PheSer: 3.565 ± 0.175
2.231PheThr: 2.231 ± 0.132
3.256PheVal: 3.256 ± 0.153
0.387PheTrp: 0.387 ± 0.056
1.664PheTyr: 1.664 ± 0.111
0.0PheXaa: 0.0 ± 0.0
Gly
3.615GlyAla: 3.615 ± 0.169
0.717GlyCys: 0.717 ± 0.073
3.091GlyAsp: 3.091 ± 0.146
3.392GlyGlu: 3.392 ± 0.175
3.106GlyPhe: 3.106 ± 0.157
4.511GlyGly: 4.511 ± 0.217
1.277GlyHis: 1.277 ± 0.104
6.311GlyIle: 6.311 ± 0.226
6.161GlyLys: 6.161 ± 0.201
5.343GlyLeu: 5.343 ± 0.211
1.886GlyMet: 1.886 ± 0.11
2.675GlyAsn: 2.675 ± 0.153
1.657GlyPro: 1.657 ± 0.125
1.807GlyGln: 1.807 ± 0.11
2.56GlyArg: 2.56 ± 0.141
4.561GlySer: 4.561 ± 0.186
3.529GlyThr: 3.529 ± 0.188
4.224GlyVal: 4.224 ± 0.195
0.71GlyTrp: 0.71 ± 0.068
2.266GlyTyr: 2.266 ± 0.136
0.007GlyXaa: 0.007 ± 0.008
His
1.212HisAla: 1.212 ± 0.096
0.23HisCys: 0.23 ± 0.043
1.026HisAsp: 1.026 ± 0.084
1.162HisGlu: 1.162 ± 0.088
0.897HisPhe: 0.897 ± 0.082
1.391HisGly: 1.391 ± 0.091
0.459HisHis: 0.459 ± 0.056
1.327HisIle: 1.327 ± 0.094
1.305HisLys: 1.305 ± 0.087
1.65HisLeu: 1.65 ± 0.115
0.452HisMet: 0.452 ± 0.066
0.81HisAsn: 0.81 ± 0.073
1.004HisPro: 1.004 ± 0.099
0.559HisGln: 0.559 ± 0.064
0.789HisArg: 0.789 ± 0.071
1.234HisSer: 1.234 ± 0.09
1.033HisThr: 1.033 ± 0.087
1.434HisVal: 1.434 ± 0.097
0.208HisTrp: 0.208 ± 0.035
0.516HisTyr: 0.516 ± 0.06
0.0HisXaa: 0.0 ± 0.0
Ile
5.279IleAla: 5.279 ± 0.21
0.81IleCys: 0.81 ± 0.069
5.365IleAsp: 5.365 ± 0.181
6.197IleGlu: 6.197 ± 0.251
3.78IlePhe: 3.78 ± 0.229
5.745IleGly: 5.745 ± 0.208
1.757IleHis: 1.757 ± 0.108
7.122IleIle: 7.122 ± 0.27
7.287IleLys: 7.287 ± 0.231
8.054IleLeu: 8.054 ± 0.242
1.743IleMet: 1.743 ± 0.112
4.009IleAsn: 4.009 ± 0.173
4.124IlePro: 4.124 ± 0.173
2.926IleGln: 2.926 ± 0.16
3.643IleArg: 3.643 ± 0.166
6.648IleSer: 6.648 ± 0.213
5.279IleThr: 5.279 ± 0.185
5.386IleVal: 5.386 ± 0.175
0.624IleTrp: 0.624 ± 0.063
2.058IleTyr: 2.058 ± 0.135
0.0IleXaa: 0.0 ± 0.0
Lys
4.181LysAla: 4.181 ± 0.22
0.94LysCys: 0.94 ± 0.083
4.604LysAsp: 4.604 ± 0.152
6.397LysGlu: 6.397 ± 0.282
4.131LysPhe: 4.131 ± 0.178
4.332LysGly: 4.332 ± 0.206
1.786LysHis: 1.786 ± 0.121
10.557LysIle: 10.557 ± 0.237
10.679LysLys: 10.679 ± 0.408
8.069LysLeu: 8.069 ± 0.253
2.424LysMet: 2.424 ± 0.135
6.268LysAsn: 6.268 ± 0.243
2.912LysPro: 2.912 ± 0.14
3.12LysGln: 3.12 ± 0.142
3.443LysArg: 3.443 ± 0.187
5.702LysSer: 5.702 ± 0.205
5.092LysThr: 5.092 ± 0.203
4.483LysVal: 4.483 ± 0.193
0.782LysTrp: 0.782 ± 0.082
2.955LysTyr: 2.955 ± 0.153
0.0LysXaa: 0.0 ± 0.0
Leu
5.3LeuAla: 5.3 ± 0.192
0.818LeuCys: 0.818 ± 0.075
5.96LeuAsp: 5.96 ± 0.199
7.021LeuGlu: 7.021 ± 0.247
3.306LeuPhe: 3.306 ± 0.168
5.723LeuGly: 5.723 ± 0.21
1.685LeuHis: 1.685 ± 0.128
6.39LeuIle: 6.39 ± 0.216
8.011LeuLys: 8.011 ± 0.232
7.28LeuLeu: 7.28 ± 0.241
1.922LeuMet: 1.922 ± 0.111
4.024LeuAsn: 4.024 ± 0.152
3.414LeuPro: 3.414 ± 0.129
2.611LeuGln: 2.611 ± 0.149
3.651LeuArg: 3.651 ± 0.15
6.67LeuSer: 6.67 ± 0.249
4.712LeuThr: 4.712 ± 0.22
5.845LeuVal: 5.845 ± 0.238
0.617LeuTrp: 0.617 ± 0.077
2.568LeuTyr: 2.568 ± 0.125
0.0LeuXaa: 0.0 ± 0.0
Met
1.578MetAla: 1.578 ± 0.119
0.251MetCys: 0.251 ± 0.043
1.291MetAsp: 1.291 ± 0.096
1.391MetGlu: 1.391 ± 0.104
0.681MetPhe: 0.681 ± 0.076
1.736MetGly: 1.736 ± 0.115
0.416MetHis: 0.416 ± 0.06
2.209MetIle: 2.209 ± 0.133
2.216MetLys: 2.216 ± 0.127
2.288MetLeu: 2.288 ± 0.131
0.717MetMet: 0.717 ± 0.08
1.269MetAsn: 1.269 ± 0.089
0.904MetPro: 0.904 ± 0.082
0.76MetGln: 0.76 ± 0.078
0.99MetArg: 0.99 ± 0.085
1.958MetSer: 1.958 ± 0.124
1.477MetThr: 1.477 ± 0.094
1.477MetVal: 1.477 ± 0.102
0.201MetTrp: 0.201 ± 0.038
0.732MetTyr: 0.732 ± 0.063
0.0MetXaa: 0.0 ± 0.0
Asn
2.962AsnAla: 2.962 ± 0.177
0.631AsnCys: 0.631 ± 0.07
2.912AsnAsp: 2.912 ± 0.139
3.565AsnGlu: 3.565 ± 0.152
2.546AsnPhe: 2.546 ± 0.146
2.768AsnGly: 2.768 ± 0.137
0.918AsnHis: 0.918 ± 0.072
4.16AsnIle: 4.16 ± 0.192
3.737AsnLys: 3.737 ± 0.2
4.483AsnLeu: 4.483 ± 0.19
1.384AsnMet: 1.384 ± 0.112
2.374AsnAsn: 2.374 ± 0.122
2.424AsnPro: 2.424 ± 0.127
1.621AsnGln: 1.621 ± 0.108
1.836AsnArg: 1.836 ± 0.126
3.894AsnSer: 3.894 ± 0.167
2.682AsnThr: 2.682 ± 0.144
3.887AsnVal: 3.887 ± 0.191
0.552AsnTrp: 0.552 ± 0.057
1.75AsnTyr: 1.75 ± 0.122
0.0AsnXaa: 0.0 ± 0.0
Pro
1.757ProAla: 1.757 ± 0.121
0.244ProCys: 0.244 ± 0.047
2.654ProAsp: 2.654 ± 0.15
3.156ProGlu: 3.156 ± 0.143
1.449ProPhe: 1.449 ± 0.114
2.252ProGly: 2.252 ± 0.13
0.753ProHis: 0.753 ± 0.071
3.091ProIle: 3.091 ± 0.143
3.435ProLys: 3.435 ± 0.187
2.603ProLeu: 2.603 ± 0.154
0.904ProMet: 0.904 ± 0.073
2.187ProAsn: 2.187 ± 0.121
1.277ProPro: 1.277 ± 0.103
1.04ProGln: 1.04 ± 0.074
1.327ProArg: 1.327 ± 0.11
2.352ProSer: 2.352 ± 0.11
2.152ProThr: 2.152 ± 0.114
2.388ProVal: 2.388 ± 0.121
0.409ProTrp: 0.409 ± 0.05
1.241ProTyr: 1.241 ± 0.091
0.0ProXaa: 0.0 ± 0.0
Gln
1.52GlnAla: 1.52 ± 0.122
0.151GlnCys: 0.151 ± 0.037
1.528GlnAsp: 1.528 ± 0.106
1.979GlnGlu: 1.979 ± 0.127
1.434GlnPhe: 1.434 ± 0.117
1.442GlnGly: 1.442 ± 0.109
0.631GlnHis: 0.631 ± 0.076
3.421GlnIle: 3.421 ± 0.167
3.478GlnLys: 3.478 ± 0.157
2.496GlnLeu: 2.496 ± 0.121
0.724GlnMet: 0.724 ± 0.078
1.908GlnAsn: 1.908 ± 0.129
0.947GlnPro: 0.947 ± 0.078
1.04GlnGln: 1.04 ± 0.094
1.262GlnArg: 1.262 ± 0.095
1.843GlnSer: 1.843 ± 0.112
1.635GlnThr: 1.635 ± 0.127
1.764GlnVal: 1.764 ± 0.121
0.273GlnTrp: 0.273 ± 0.047
0.897GlnTyr: 0.897 ± 0.074
0.0GlnXaa: 0.0 ± 0.0
Arg
2.173ArgAla: 2.173 ± 0.148
0.445ArgCys: 0.445 ± 0.065
2.331ArgAsp: 2.331 ± 0.139
2.754ArgGlu: 2.754 ± 0.142
1.671ArgPhe: 1.671 ± 0.122
2.467ArgGly: 2.467 ± 0.159
0.66ArgHis: 0.66 ± 0.062
3.478ArgIle: 3.478 ± 0.152
3.744ArgLys: 3.744 ± 0.187
3.751ArgLeu: 3.751 ± 0.18
1.09ArgMet: 1.09 ± 0.092
2.288ArgAsn: 2.288 ± 0.127
1.291ArgPro: 1.291 ± 0.096
1.191ArgGln: 1.191 ± 0.092
1.793ArgArg: 1.793 ± 0.117
1.893ArgSer: 1.893 ± 0.117
1.994ArgThr: 1.994 ± 0.136
2.453ArgVal: 2.453 ± 0.152
0.402ArgTrp: 0.402 ± 0.053
1.37ArgTyr: 1.37 ± 0.09
0.0ArgXaa: 0.0 ± 0.0
Ser
3.816SerAla: 3.816 ± 0.179
0.882SerCys: 0.882 ± 0.086
4.296SerAsp: 4.296 ± 0.181
4.748SerGlu: 4.748 ± 0.18
3.027SerPhe: 3.027 ± 0.152
5.049SerGly: 5.049 ± 0.195
1.219SerHis: 1.219 ± 0.096
5.795SerIle: 5.795 ± 0.225
6.749SerLys: 6.749 ± 0.246
6.139SerLeu: 6.139 ± 0.237
1.815SerMet: 1.815 ± 0.105
3.464SerAsn: 3.464 ± 0.156
2.109SerPro: 2.109 ± 0.118
2.195SerGln: 2.195 ± 0.143
2.489SerArg: 2.489 ± 0.135
4.626SerSer: 4.626 ± 0.19
3.844SerThr: 3.844 ± 0.157
4.095SerVal: 4.095 ± 0.175
0.71SerTrp: 0.71 ± 0.068
2.023SerTyr: 2.023 ± 0.11
0.0SerXaa: 0.0 ± 0.0
Thr
3.256ThrAla: 3.256 ± 0.149
0.631ThrCys: 0.631 ± 0.062
3.005ThrAsp: 3.005 ± 0.146
3.6ThrGlu: 3.6 ± 0.148
1.908ThrPhe: 1.908 ± 0.124
3.923ThrGly: 3.923 ± 0.202
0.782ThrHis: 0.782 ± 0.077
4.949ThrIle: 4.949 ± 0.216
5.013ThrLys: 5.013 ± 0.229
4.583ThrLeu: 4.583 ± 0.175
1.183ThrMet: 1.183 ± 0.088
2.718ThrAsn: 2.718 ± 0.143
2.209ThrPro: 2.209 ± 0.124
1.657ThrGln: 1.657 ± 0.104
2.008ThrArg: 2.008 ± 0.133
3.88ThrSer: 3.88 ± 0.165
2.84ThrThr: 2.84 ± 0.161
3.744ThrVal: 3.744 ± 0.193
0.373ThrTrp: 0.373 ± 0.06
1.628ThrTyr: 1.628 ± 0.115
0.0ThrXaa: 0.0 ± 0.0
Val
3.665ValAla: 3.665 ± 0.184
0.897ValCys: 0.897 ± 0.078
4.11ValAsp: 4.11 ± 0.199
4.454ValGlu: 4.454 ± 0.214
2.625ValPhe: 2.625 ± 0.146
4.275ValGly: 4.275 ± 0.19
1.183ValHis: 1.183 ± 0.096
5.479ValIle: 5.479 ± 0.22
5.422ValLys: 5.422 ± 0.226
5.178ValLeu: 5.178 ± 0.195
1.571ValMet: 1.571 ± 0.1
2.991ValAsn: 2.991 ± 0.145
2.36ValPro: 2.36 ± 0.13
1.671ValGln: 1.671 ± 0.116
2.575ValArg: 2.575 ± 0.148
4.483ValSer: 4.483 ± 0.187
3.701ValThr: 3.701 ± 0.174
4.246ValVal: 4.246 ± 0.195
0.61ValTrp: 0.61 ± 0.065
1.965ValTyr: 1.965 ± 0.118
0.0ValXaa: 0.0 ± 0.0
Trp
0.567TrpAla: 0.567 ± 0.07
0.108TrpCys: 0.108 ± 0.027
0.473TrpAsp: 0.473 ± 0.058
0.624TrpGlu: 0.624 ± 0.078
0.459TrpPhe: 0.459 ± 0.058
0.617TrpGly: 0.617 ± 0.072
0.201TrpHis: 0.201 ± 0.038
0.638TrpIle: 0.638 ± 0.077
0.968TrpLys: 0.968 ± 0.079
0.753TrpLeu: 0.753 ± 0.08
0.28TrpMet: 0.28 ± 0.046
0.645TrpAsn: 0.645 ± 0.073
0.323TrpPro: 0.323 ± 0.051
0.258TrpGln: 0.258 ± 0.043
0.409TrpArg: 0.409 ± 0.05
0.481TrpSer: 0.481 ± 0.056
0.402TrpThr: 0.402 ± 0.06
0.574TrpVal: 0.574 ± 0.068
0.136TrpTrp: 0.136 ± 0.034
0.366TrpTyr: 0.366 ± 0.056
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.757TyrAla: 1.757 ± 0.106
0.416TyrCys: 0.416 ± 0.06
2.403TyrAsp: 2.403 ± 0.138
1.979TyrGlu: 1.979 ± 0.1
1.607TyrPhe: 1.607 ± 0.112
2.417TyrGly: 2.417 ± 0.144
0.66TyrHis: 0.66 ± 0.068
1.922TyrIle: 1.922 ± 0.109
2.209TyrLys: 2.209 ± 0.125
2.883TyrLeu: 2.883 ± 0.15
0.667TyrMet: 0.667 ± 0.06
1.628TyrAsn: 1.628 ± 0.106
1.399TyrPro: 1.399 ± 0.099
1.126TyrGln: 1.126 ± 0.093
1.327TyrArg: 1.327 ± 0.104
2.266TyrSer: 2.266 ± 0.122
1.642TyrThr: 1.642 ± 0.1
1.979TyrVal: 1.979 ± 0.105
0.466TyrTrp: 0.466 ± 0.055
1.169TyrTyr: 1.169 ± 0.105
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.007XaaGly: 0.007 ± 0.008
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.022XaaXaa: 0.022 ± 0.023
Statistics based on 560 proteins (139431 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski