Amino acid dipepetide frequency for Schistocephalus solidus (Tapeworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.598AlaAla: 8.598 ± 0.067	1.559AlaCys: 1.559 ± 0.017	4.152AlaAsp: 4.152 ± 0.029	4.698AlaGlu: 4.698 ± 0.03	3.134AlaPhe: 3.134 ± 0.02	4.543AlaGly: 4.543 ± 0.033	1.744AlaHis: 1.744 ± 0.015	3.594AlaIle: 3.594 ± 0.026	3.322AlaLys: 3.322 ± 0.027	6.975AlaLeu: 6.975 ± 0.039	1.598AlaMet: 1.598 ± 0.017	2.921AlaAsn: 2.921 ± 0.023	4.565AlaPro: 4.565 ± 0.033	2.609AlaGln: 2.609 ± 0.021	4.505AlaArg: 4.505 ± 0.032	7.104AlaSer: 7.104 ± 0.05	5.227AlaThr: 5.227 ± 0.03	5.232AlaVal: 5.232 ± 0.033	0.953AlaTrp: 0.953 ± 0.013	2.12AlaTyr: 2.12 ± 0.02	0.01AlaXaa: 0.01 ± 0.001
Cys	1.568CysAla: 1.568 ± 0.016	0.628CysCys: 0.628 ± 0.011	1.036CysAsp: 1.036 ± 0.014	0.983CysGlu: 0.983 ± 0.013	0.871CysPhe: 0.871 ± 0.011	1.325CysGly: 1.325 ± 0.017	0.616CysHis: 0.616 ± 0.01	0.983CysIle: 0.983 ± 0.012	0.766CysLys: 0.766 ± 0.011	2.615CysLeu: 2.615 ± 0.023	0.4CysMet: 0.4 ± 0.007	0.706CysAsn: 0.706 ± 0.011	1.534CysPro: 1.534 ± 0.016	0.974CysGln: 0.974 ± 0.013	1.396CysArg: 1.396 ± 0.017	1.905CysSer: 1.905 ± 0.021	1.133CysThr: 1.133 ± 0.011	1.347CysVal: 1.347 ± 0.016	0.265CysTrp: 0.265 ± 0.006	0.495CysTyr: 0.495 ± 0.01	0.003CysXaa: 0.003 ± 0.001
Asp	4.267AspAla: 4.267 ± 0.029	1.137AspCys: 1.137 ± 0.013	5.193AspAsp: 5.193 ± 0.245	3.538AspGlu: 3.538 ± 0.037	2.271AspPhe: 2.271 ± 0.02	3.383AspGly: 3.383 ± 0.04	1.167AspHis: 1.167 ± 0.015	2.456AspIle: 2.456 ± 0.019	1.952AspLys: 1.952 ± 0.02	5.182AspLeu: 5.182 ± 0.028	1.056AspMet: 1.056 ± 0.012	2.102AspAsn: 2.102 ± 0.041	2.458AspPro: 2.458 ± 0.02	1.625AspGln: 1.625 ± 0.018	3.004AspArg: 3.004 ± 0.025	4.14AspSer: 4.14 ± 0.029	2.521AspThr: 2.521 ± 0.02	3.192AspVal: 3.192 ± 0.029	0.679AspTrp: 0.679 ± 0.012	1.474AspTyr: 1.474 ± 0.03	0.007AspXaa: 0.007 ± 0.001
Glu	4.771GluAla: 4.771 ± 0.037	0.949GluCys: 0.949 ± 0.015	3.599GluAsp: 3.599 ± 0.045	5.392GluGlu: 5.392 ± 0.063	1.884GluPhe: 1.884 ± 0.019	2.844GluGly: 2.844 ± 0.026	1.307GluHis: 1.307 ± 0.014	2.575GluIle: 2.575 ± 0.022	3.161GluLys: 3.161 ± 0.029	5.131GluLeu: 5.131 ± 0.04	1.438GluMet: 1.438 ± 0.018	2.338GluAsn: 2.338 ± 0.025	2.457GluPro: 2.457 ± 0.023	2.279GluGln: 2.279 ± 0.02	3.43GluArg: 3.43 ± 0.03	3.838GluSer: 3.838 ± 0.029	3.417GluThr: 3.417 ± 0.026	3.739GluVal: 3.739 ± 0.028	0.528GluTrp: 0.528 ± 0.009	1.306GluTyr: 1.306 ± 0.014	0.004GluXaa: 0.004 ± 0.001
Phe	3.1PheAla: 3.1 ± 0.026	0.992PheCys: 0.992 ± 0.014	1.985PheAsp: 1.985 ± 0.02	1.89PheGlu: 1.89 ± 0.018	2.377PhePhe: 2.377 ± 0.086	2.453PheGly: 2.453 ± 0.026	0.994PheHis: 0.994 ± 0.012	1.784PheIle: 1.784 ± 0.018	1.45PheLys: 1.45 ± 0.016	4.004PheLeu: 4.004 ± 0.029	0.768PheMet: 0.768 ± 0.01	1.485PheAsn: 1.485 ± 0.017	2.035PhePro: 2.035 ± 0.021	1.433PheGln: 1.433 ± 0.018	2.347PheArg: 2.347 ± 0.018	3.745PheSer: 3.745 ± 0.025	2.407PheThr: 2.407 ± 0.019	2.464PheVal: 2.464 ± 0.025	0.531PheTrp: 0.531 ± 0.009	1.269PheTyr: 1.269 ± 0.016	0.005PheXaa: 0.005 ± 0.001
Gly	3.926GlyAla: 3.926 ± 0.031	1.356GlyCys: 1.356 ± 0.018	3.196GlyAsp: 3.196 ± 0.035	3.013GlyGlu: 3.013 ± 0.039	2.203GlyPhe: 2.203 ± 0.021	4.844GlyGly: 4.844 ± 0.056	1.751GlyHis: 1.751 ± 0.016	2.733GlyIle: 2.733 ± 0.026	2.397GlyLys: 2.397 ± 0.022	5.702GlyLeu: 5.702 ± 0.037	1.154GlyMet: 1.154 ± 0.015	1.966GlyAsn: 1.966 ± 0.017	2.857GlyPro: 2.857 ± 0.063	2.288GlyGln: 2.288 ± 0.021	3.793GlyArg: 3.793 ± 0.026	5.054GlySer: 5.054 ± 0.035	3.286GlyThr: 3.286 ± 0.026	3.636GlyVal: 3.636 ± 0.027	0.624GlyTrp: 0.624 ± 0.012	1.511GlyTyr: 1.511 ± 0.016	0.006GlyXaa: 0.006 ± 0.001
His	1.78HisAla: 1.78 ± 0.015	0.789HisCys: 0.789 ± 0.013	1.138HisAsp: 1.138 ± 0.015	1.108HisGlu: 1.108 ± 0.012	1.214HisPhe: 1.214 ± 0.013	1.396HisGly: 1.396 ± 0.017	0.956HisHis: 0.956 ± 0.017	1.144HisIle: 1.144 ± 0.011	0.953HisLys: 0.953 ± 0.012	3.414HisLeu: 3.414 ± 0.028	0.604HisMet: 0.604 ± 0.01	0.843HisAsn: 0.843 ± 0.012	1.724HisPro: 1.724 ± 0.019	1.271HisGln: 1.271 ± 0.014	2.057HisArg: 2.057 ± 0.02	2.19HisSer: 2.19 ± 0.02	1.416HisThr: 1.416 ± 0.016	1.402HisVal: 1.402 ± 0.016	0.334HisTrp: 0.334 ± 0.009	0.651HisTyr: 0.651 ± 0.01	0.003HisXaa: 0.003 ± 0.001
Ile	3.287IleAla: 3.287 ± 0.026	1.09IleCys: 1.09 ± 0.015	2.282IleAsp: 2.282 ± 0.019	2.243IleGlu: 2.243 ± 0.025	2.137IlePhe: 2.137 ± 0.019	2.366IleGly: 2.366 ± 0.024	1.346IleHis: 1.346 ± 0.017	2.375IleIle: 2.375 ± 0.032	1.825IleLys: 1.825 ± 0.02	4.539IleLeu: 4.539 ± 0.029	0.947IleMet: 0.947 ± 0.022	1.978IleAsn: 1.978 ± 0.021	2.547IlePro: 2.547 ± 0.022	1.788IleGln: 1.788 ± 0.017	2.85IleArg: 2.85 ± 0.021	4.256IleSer: 4.256 ± 0.026	2.64IleThr: 2.64 ± 0.024	2.763IleVal: 2.763 ± 0.024	0.485IleTrp: 0.485 ± 0.009	1.356IleTyr: 1.356 ± 0.014	0.005IleXaa: 0.005 ± 0.001
Lys	3.661LysAla: 3.661 ± 0.032	0.808LysCys: 0.808 ± 0.011	2.069LysAsp: 2.069 ± 0.021	2.681LysGlu: 2.681 ± 0.028	1.607LysPhe: 1.607 ± 0.018	1.904LysGly: 1.904 ± 0.029	1.046LysHis: 1.046 ± 0.013	1.973LysIle: 1.973 ± 0.021	3.021LysLys: 3.021 ± 0.065	4.202LysLeu: 4.202 ± 0.032	1.076LysMet: 1.076 ± 0.014	1.74LysAsn: 1.74 ± 0.018	2.445LysPro: 2.445 ± 0.023	1.749LysGln: 1.749 ± 0.018	3.085LysArg: 3.085 ± 0.026	3.308LysSer: 3.308 ± 0.024	2.634LysThr: 2.634 ± 0.023	2.668LysVal: 2.668 ± 0.022	0.423LysTrp: 0.423 ± 0.01	1.04LysTyr: 1.04 ± 0.014	0.006LysXaa: 0.006 ± 0.001
Leu	7.397LeuAla: 7.397 ± 0.043	1.992LeuCys: 1.992 ± 0.019	4.565LeuAsp: 4.565 ± 0.03	5.35LeuGlu: 5.35 ± 0.035	4.029LeuPhe: 4.029 ± 0.033	4.903LeuGly: 4.903 ± 0.029	2.946LeuHis: 2.946 ± 0.019	4.296LeuIle: 4.296 ± 0.034	4.355LeuLys: 4.355 ± 0.034	11.832LeuLeu: 11.832 ± 0.11	2.197LeuMet: 2.197 ± 0.023	3.894LeuAsn: 3.894 ± 0.028	7.247LeuPro: 7.247 ± 0.039	4.558LeuGln: 4.558 ± 0.032	7.102LeuArg: 7.102 ± 0.043	8.793LeuSer: 8.793 ± 0.042	6.138LeuThr: 6.138 ± 0.032	5.961LeuVal: 5.961 ± 0.038	1.065LeuTrp: 1.065 ± 0.012	2.222LeuTyr: 2.222 ± 0.021	0.014LeuXaa: 0.014 ± 0.002
Met	1.658MetAla: 1.658 ± 0.015	0.362MetCys: 0.362 ± 0.008	1.296MetAsp: 1.296 ± 0.015	1.315MetGlu: 1.315 ± 0.016	0.707MetPhe: 0.707 ± 0.011	1.115MetGly: 1.115 ± 0.016	0.65MetHis: 0.65 ± 0.011	0.934MetIle: 0.934 ± 0.019	0.978MetLys: 0.978 ± 0.013	2.046MetLeu: 2.046 ± 0.02	1.21MetMet: 1.21 ± 0.111	0.798MetAsn: 0.798 ± 0.011	1.225MetPro: 1.225 ± 0.015	1.14MetGln: 1.14 ± 0.014	1.49MetArg: 1.49 ± 0.017	1.649MetSer: 1.649 ± 0.014	1.382MetThr: 1.382 ± 0.018	1.273MetVal: 1.273 ± 0.014	0.243MetTrp: 0.243 ± 0.005	0.425MetTyr: 0.425 ± 0.01	0.002MetXaa: 0.002 ± 0.0
Asn	2.962AsnAla: 2.962 ± 0.022	0.912AsnCys: 0.912 ± 0.013	2.137AsnAsp: 2.137 ± 0.039	1.968AsnGlu: 1.968 ± 0.021	1.745AsnPhe: 1.745 ± 0.016	2.435AsnGly: 2.435 ± 0.021	0.936AsnHis: 0.936 ± 0.011	1.753AsnIle: 1.753 ± 0.016	1.391AsnLys: 1.391 ± 0.014	3.759AsnLeu: 3.759 ± 0.028	0.743AsnMet: 0.743 ± 0.012	1.508AsnAsn: 1.508 ± 0.019	2.162AsnPro: 2.162 ± 0.019	1.512AsnGln: 1.512 ± 0.017	2.507AsnArg: 2.507 ± 0.021	3.298AsnSer: 3.298 ± 0.024	2.284AsnThr: 2.284 ± 0.019	2.245AsnVal: 2.245 ± 0.019	0.462AsnTrp: 0.462 ± 0.008	0.992AsnTyr: 0.992 ± 0.013	0.005AsnXaa: 0.005 ± 0.001
Pro	4.651ProAla: 4.651 ± 0.033	1.132ProCys: 1.132 ± 0.013	2.76ProAsp: 2.76 ± 0.025	3.309ProGlu: 3.309 ± 0.023	2.048ProPhe: 2.048 ± 0.02	3.57ProGly: 3.57 ± 0.052	1.606ProHis: 1.606 ± 0.016	2.423ProIle: 2.423 ± 0.02	2.461ProLys: 2.461 ± 0.023	5.681ProLeu: 5.681 ± 0.036	1.128ProMet: 1.128 ± 0.015	2.124ProAsn: 2.124 ± 0.019	6.457ProPro: 6.457 ± 0.073	2.53ProGln: 2.53 ± 0.026	3.6ProArg: 3.6 ± 0.024	6.489ProSer: 6.489 ± 0.044	4.537ProThr: 4.537 ± 0.034	3.881ProVal: 3.881 ± 0.027	0.547ProTrp: 0.547 ± 0.011	1.234ProTyr: 1.234 ± 0.016	0.007ProXaa: 0.007 ± 0.001
Gln	2.994GlnAla: 2.994 ± 0.021	0.852GlnCys: 0.852 ± 0.013	1.677GlnAsp: 1.677 ± 0.016	2.131GlnGlu: 2.131 ± 0.023	1.377GlnPhe: 1.377 ± 0.015	2.08GlnGly: 2.08 ± 0.028	1.256GlnHis: 1.256 ± 0.014	1.802GlnIle: 1.802 ± 0.017	1.92GlnLys: 1.92 ± 0.018	4.789GlnLeu: 4.789 ± 0.034	0.918GlnMet: 0.918 ± 0.012	1.443GlnAsn: 1.443 ± 0.016	2.884GlnPro: 2.884 ± 0.026	2.869GlnGln: 2.869 ± 0.05	2.905GlnArg: 2.905 ± 0.025	3.236GlnSer: 3.236 ± 0.028	2.372GlnThr: 2.372 ± 0.021	2.338GlnVal: 2.338 ± 0.018	0.431GlnTrp: 0.431 ± 0.007	0.87GlnTyr: 0.87 ± 0.014	0.006GlnXaa: 0.006 ± 0.001
Arg	4.143ArgAla: 4.143 ± 0.028	1.452ArgCys: 1.452 ± 0.015	2.721ArgAsp: 2.721 ± 0.024	3.25ArgGlu: 3.25 ± 0.027	2.354ArgPhe: 2.354 ± 0.022	3.193ArgGly: 3.193 ± 0.031	1.872ArgHis: 1.872 ± 0.017	3.424ArgIle: 3.424 ± 0.027	3.045ArgLys: 3.045 ± 0.022	7.469ArgLeu: 7.469 ± 0.043	1.566ArgMet: 1.566 ± 0.019	2.4ArgAsn: 2.4 ± 0.021	3.876ArgPro: 3.876 ± 0.03	3.139ArgGln: 3.139 ± 0.024	5.844ArgArg: 5.844 ± 0.045	5.342ArgSer: 5.342 ± 0.031	3.743ArgThr: 3.743 ± 0.027	3.607ArgVal: 3.607 ± 0.022	0.911ArgTrp: 0.911 ± 0.012	1.55ArgTyr: 1.55 ± 0.016	0.009ArgXaa: 0.009 ± 0.001
Ser	7.314SerAla: 7.314 ± 0.046	1.836SerCys: 1.836 ± 0.02	4.367SerAsp: 4.367 ± 0.028	4.611SerGlu: 4.611 ± 0.031	3.05SerPhe: 3.05 ± 0.024	5.517SerGly: 5.517 ± 0.033	2.13SerHis: 2.13 ± 0.021	3.584SerIle: 3.584 ± 0.024	3.392SerLys: 3.392 ± 0.024	8.545SerLeu: 8.545 ± 0.041	1.722SerMet: 1.722 ± 0.015	3.223SerAsn: 3.223 ± 0.025	6.176SerPro: 6.176 ± 0.045	3.584SerGln: 3.584 ± 0.028	5.352SerArg: 5.352 ± 0.033	10.608SerSer: 10.608 ± 0.091	6.157SerThr: 6.157 ± 0.04	5.574SerVal: 5.574 ± 0.034	0.873SerTrp: 0.873 ± 0.012	1.767SerTyr: 1.767 ± 0.015	0.009SerXaa: 0.009 ± 0.001
Thr	5.606ThrAla: 5.606 ± 0.032	1.338ThrCys: 1.338 ± 0.016	3.174ThrAsp: 3.174 ± 0.026	3.502ThrGlu: 3.502 ± 0.024	2.43ThrPhe: 2.43 ± 0.02	3.736ThrGly: 3.736 ± 0.028	1.455ThrHis: 1.455 ± 0.016	2.806ThrIle: 2.806 ± 0.023	2.475ThrLys: 2.475 ± 0.021	5.282ThrLeu: 5.282 ± 0.03	1.171ThrMet: 1.171 ± 0.017	2.314ThrAsn: 2.314 ± 0.019	4.141ThrPro: 4.141 ± 0.035	2.077ThrGln: 2.077 ± 0.021	3.259ThrArg: 3.259 ± 0.022	5.978ThrSer: 5.978 ± 0.04	5.239ThrThr: 5.239 ± 0.046	4.389ThrVal: 4.389 ± 0.029	0.67ThrTrp: 0.67 ± 0.011	1.401ThrTyr: 1.401 ± 0.013	0.009ThrXaa: 0.009 ± 0.001
Val	4.919ValAla: 4.919 ± 0.029	1.513ValCys: 1.513 ± 0.016	3.639ValAsp: 3.639 ± 0.028	3.477ValGlu: 3.477 ± 0.029	2.49ValPhe: 2.49 ± 0.023	3.797ValGly: 3.797 ± 0.029	1.635ValHis: 1.635 ± 0.016	2.852ValIle: 2.852 ± 0.024	2.57ValLys: 2.57 ± 0.021	5.934ValLeu: 5.934 ± 0.037	1.277ValMet: 1.277 ± 0.016	2.528ValAsn: 2.528 ± 0.023	3.465ValPro: 3.465 ± 0.026	2.26ValGln: 2.26 ± 0.018	3.74ValArg: 3.74 ± 0.025	5.481ValSer: 5.481 ± 0.032	3.823ValThr: 3.823 ± 0.029	4.078ValVal: 4.078 ± 0.037	0.7ValTrp: 0.7 ± 0.011	1.684ValTyr: 1.684 ± 0.018	0.005ValXaa: 0.005 ± 0.001
Trp	0.702TrpAla: 0.702 ± 0.011	0.278TrpCys: 0.278 ± 0.007	0.496TrpAsp: 0.496 ± 0.01	0.534TrpGlu: 0.534 ± 0.01	0.477TrpPhe: 0.477 ± 0.009	0.428TrpGly: 0.428 ± 0.008	0.332TrpHis: 0.332 ± 0.008	0.543TrpIle: 0.543 ± 0.01	0.571TrpLys: 0.571 ± 0.01	1.163TrpLeu: 1.163 ± 0.017	0.364TrpMet: 0.364 ± 0.007	0.516TrpAsn: 0.516 ± 0.01	0.637TrpPro: 0.637 ± 0.012	0.523TrpGln: 0.523 ± 0.01	0.916TrpArg: 0.916 ± 0.011	0.988TrpSer: 0.988 ± 0.013	0.679TrpThr: 0.679 ± 0.01	0.577TrpVal: 0.577 ± 0.01	0.167TrpTrp: 0.167 ± 0.006	0.293TrpTyr: 0.293 ± 0.008	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.853TyrAla: 1.853 ± 0.019	0.569TyrCys: 0.569 ± 0.01	1.316TyrAsp: 1.316 ± 0.027	1.391TyrGlu: 1.391 ± 0.015	1.107TyrPhe: 1.107 ± 0.014	1.457TyrGly: 1.457 ± 0.015	0.637TyrHis: 0.637 ± 0.011	1.066TyrIle: 1.066 ± 0.015	1.134TyrLys: 1.134 ± 0.017	2.581TyrLeu: 2.581 ± 0.022	0.559TyrMet: 0.559 ± 0.009	0.883TyrAsn: 0.883 ± 0.011	1.272TyrPro: 1.272 ± 0.016	0.937TyrGln: 0.937 ± 0.013	1.725TyrArg: 1.725 ± 0.017	1.98TyrSer: 1.98 ± 0.017	1.409TyrThr: 1.409 ± 0.015	1.494TyrVal: 1.494 ± 0.019	0.29TyrTrp: 0.29 ± 0.008	1.165TyrTyr: 1.165 ± 0.06	0.003TyrXaa: 0.003 ± 0.001
Xaa	0.009XaaAla: 0.009 ± 0.001	0.003XaaCys: 0.003 ± 0.001	0.005XaaAsp: 0.005 ± 0.001	0.006XaaGlu: 0.006 ± 0.001	0.006XaaPhe: 0.006 ± 0.001	0.006XaaGly: 0.006 ± 0.001	0.003XaaHis: 0.003 ± 0.001	0.004XaaIle: 0.004 ± 0.001	0.005XaaLys: 0.005 ± 0.001	0.01XaaLeu: 0.01 ± 0.001	0.005XaaMet: 0.005 ± 0.001	0.004XaaAsn: 0.004 ± 0.001	0.011XaaPro: 0.011 ± 0.001	0.005XaaGln: 0.005 ± 0.001	0.008XaaArg: 0.008 ± 0.001	0.009XaaSer: 0.009 ± 0.001	0.008XaaThr: 0.008 ± 0.001	0.006XaaVal: 0.006 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.004XaaTyr: 0.004 ± 0.001	0.095XaaXaa: 0.095 ± 0.032

Statistics based on 20172 proteins (6502664 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---