Amino acid dipepetide frequency for Streptococcus satellite phage Javan216

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.494AlaAla: 0.494 ± 0.503
0.0AlaCys: 0.0 ± 0.0
3.949AlaAsp: 3.949 ± 1.155
3.455AlaGlu: 3.455 ± 1.663
2.962AlaPhe: 2.962 ± 1.282
1.974AlaGly: 1.974 ± 0.91
0.0AlaHis: 0.0 ± 0.0
3.455AlaIle: 3.455 ± 1.226
2.962AlaLys: 2.962 ± 1.034
4.442AlaLeu: 4.442 ± 1.6
0.987AlaMet: 0.987 ± 0.541
2.468AlaAsn: 2.468 ± 1.909
0.494AlaPro: 0.494 ± 0.577
0.494AlaGln: 0.494 ± 0.503
2.962AlaArg: 2.962 ± 0.771
2.468AlaSer: 2.468 ± 0.838
6.417AlaThr: 6.417 ± 1.511
1.481AlaVal: 1.481 ± 0.847
0.987AlaTrp: 0.987 ± 0.604
2.962AlaTyr: 2.962 ± 0.926
0.0AlaXaa: 0.0 ± 0.0
Cys
0.494CysAla: 0.494 ± 0.577
0.0CysCys: 0.0 ± 0.0
0.494CysAsp: 0.494 ± 0.469
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.494CysIle: 0.494 ± 0.589
0.0CysLys: 0.0 ± 0.0
1.481CysLeu: 1.481 ± 0.684
0.0CysMet: 0.0 ± 0.0
0.494CysAsn: 0.494 ± 0.503
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.494CysVal: 0.494 ± 0.593
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.494AspAla: 0.494 ± 0.404
0.987AspCys: 0.987 ± 0.79
5.429AspAsp: 5.429 ± 1.705
5.923AspGlu: 5.923 ± 2.206
2.962AspPhe: 2.962 ± 1.19
2.962AspGly: 2.962 ± 1.106
0.987AspHis: 0.987 ± 0.765
3.949AspIle: 3.949 ± 1.351
4.936AspLys: 4.936 ± 1.782
5.429AspLeu: 5.429 ± 0.912
0.987AspMet: 0.987 ± 0.532
5.923AspAsn: 5.923 ± 1.385
1.481AspPro: 1.481 ± 0.738
0.987AspGln: 0.987 ± 0.808
3.455AspArg: 3.455 ± 1.402
2.962AspSer: 2.962 ± 1.334
3.949AspThr: 3.949 ± 1.642
6.417AspVal: 6.417 ± 0.959
0.0AspTrp: 0.0 ± 0.0
6.417AspTyr: 6.417 ± 2.235
0.0AspXaa: 0.0 ± 0.0
Glu
4.442GluAla: 4.442 ± 1.657
1.974GluCys: 1.974 ± 1.226
3.949GluAsp: 3.949 ± 1.781
6.91GluGlu: 6.91 ± 2.35
4.936GluPhe: 4.936 ± 1.852
1.481GluGly: 1.481 ± 0.738
0.987GluHis: 0.987 ± 0.604
5.923GluIle: 5.923 ± 1.112
7.404GluLys: 7.404 ± 1.069
8.885GluLeu: 8.885 ± 2.481
3.455GluMet: 3.455 ± 1.063
4.442GluAsn: 4.442 ± 1.377
1.974GluPro: 1.974 ± 0.942
2.962GluGln: 2.962 ± 1.195
4.442GluArg: 4.442 ± 1.78
0.987GluSer: 0.987 ± 0.806
2.468GluThr: 2.468 ± 0.887
4.442GluVal: 4.442 ± 1.404
1.974GluTrp: 1.974 ± 0.87
4.442GluTyr: 4.442 ± 1.165
0.0GluXaa: 0.0 ± 0.0
Phe
1.481PheAla: 1.481 ± 0.785
0.0PheCys: 0.0 ± 0.0
2.962PheAsp: 2.962 ± 0.844
3.949PheGlu: 3.949 ± 1.336
2.962PhePhe: 2.962 ± 1.05
2.468PheGly: 2.468 ± 1.147
0.494PheHis: 0.494 ± 0.443
1.481PheIle: 1.481 ± 0.922
5.429PheLys: 5.429 ± 1.731
3.949PheLeu: 3.949 ± 1.181
0.987PheMet: 0.987 ± 0.54
2.962PheAsn: 2.962 ± 1.318
1.481PhePro: 1.481 ± 0.813
0.494PheGln: 0.494 ± 0.46
1.481PheArg: 1.481 ± 0.8
4.442PheSer: 4.442 ± 1.395
2.468PheThr: 2.468 ± 1.387
1.974PheVal: 1.974 ± 0.759
0.0PheTrp: 0.0 ± 0.0
3.455PheTyr: 3.455 ± 1.427
0.0PheXaa: 0.0 ± 0.0
Gly
2.468GlyAla: 2.468 ± 0.81
0.0GlyCys: 0.0 ± 0.0
2.468GlyAsp: 2.468 ± 0.961
1.481GlyGlu: 1.481 ± 0.954
1.481GlyPhe: 1.481 ± 0.766
1.481GlyGly: 1.481 ± 1.139
1.974GlyHis: 1.974 ± 0.647
3.949GlyIle: 3.949 ± 1.376
6.417GlyLys: 6.417 ± 1.768
4.442GlyLeu: 4.442 ± 1.124
0.987GlyMet: 0.987 ± 0.763
1.481GlyAsn: 1.481 ± 0.52
0.494GlyPro: 0.494 ± 0.46
0.987GlyGln: 0.987 ± 0.651
1.481GlyArg: 1.481 ± 0.709
2.468GlySer: 2.468 ± 0.992
2.468GlyThr: 2.468 ± 1.1
4.936GlyVal: 4.936 ± 1.409
0.494GlyTrp: 0.494 ± 0.469
2.468GlyTyr: 2.468 ± 0.921
0.0GlyXaa: 0.0 ± 0.0
His
3.455HisAla: 3.455 ± 1.05
0.0HisCys: 0.0 ± 0.0
0.494HisAsp: 0.494 ± 0.577
0.987HisGlu: 0.987 ± 0.82
0.494HisPhe: 0.494 ± 0.443
0.494HisGly: 0.494 ± 0.443
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.974HisLys: 1.974 ± 1.052
1.481HisLeu: 1.481 ± 0.655
0.0HisMet: 0.0 ± 0.0
0.494HisAsn: 0.494 ± 0.443
0.0HisPro: 0.0 ± 0.0
0.494HisGln: 0.494 ± 0.46
0.494HisArg: 0.494 ± 0.443
0.494HisSer: 0.494 ± 0.443
0.494HisThr: 0.494 ± 0.443
1.481HisVal: 1.481 ± 0.805
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.949IleAla: 3.949 ± 1.09
0.494IleCys: 0.494 ± 0.503
6.417IleAsp: 6.417 ± 1.834
5.429IleGlu: 5.429 ± 1.344
1.974IlePhe: 1.974 ± 0.602
1.974IleGly: 1.974 ± 0.66
0.0IleHis: 0.0 ± 0.0
1.974IleIle: 1.974 ± 0.909
7.404IleLys: 7.404 ± 1.572
4.442IleLeu: 4.442 ± 1.387
0.987IleMet: 0.987 ± 0.647
6.417IleAsn: 6.417 ± 1.284
1.974IlePro: 1.974 ± 0.85
3.455IleGln: 3.455 ± 1.214
5.923IleArg: 5.923 ± 2.123
3.949IleSer: 3.949 ± 0.739
5.923IleThr: 5.923 ± 1.081
4.936IleVal: 4.936 ± 1.566
0.987IleTrp: 0.987 ± 0.742
3.455IleTyr: 3.455 ± 1.181
0.0IleXaa: 0.0 ± 0.0
Lys
5.429LysAla: 5.429 ± 1.251
0.0LysCys: 0.0 ± 0.0
6.91LysAsp: 6.91 ± 1.792
7.404LysGlu: 7.404 ± 2.016
2.468LysPhe: 2.468 ± 1.094
3.949LysGly: 3.949 ± 1.093
1.481LysHis: 1.481 ± 0.57
7.404LysIle: 7.404 ± 1.342
7.897LysLys: 7.897 ± 2.944
9.378LysLeu: 9.378 ± 2.428
1.974LysMet: 1.974 ± 1.231
9.872LysAsn: 9.872 ± 1.856
2.962LysPro: 2.962 ± 1.38
8.391LysGln: 8.391 ± 2.585
4.442LysArg: 4.442 ± 0.922
4.442LysSer: 4.442 ± 1.042
4.442LysThr: 4.442 ± 2.299
7.404LysVal: 7.404 ± 1.873
0.987LysTrp: 0.987 ± 0.644
4.442LysTyr: 4.442 ± 1.225
0.0LysXaa: 0.0 ± 0.0
Leu
3.949LeuAla: 3.949 ± 1.486
0.0LeuCys: 0.0 ± 0.0
8.391LeuAsp: 8.391 ± 1.469
7.897LeuGlu: 7.897 ± 1.821
3.455LeuPhe: 3.455 ± 0.843
3.949LeuGly: 3.949 ± 1.304
0.0LeuHis: 0.0 ± 0.0
7.404LeuIle: 7.404 ± 2.381
6.91LeuLys: 6.91 ± 1.142
9.378LeuLeu: 9.378 ± 2.158
3.455LeuMet: 3.455 ± 1.078
8.391LeuAsn: 8.391 ± 1.921
3.455LeuPro: 3.455 ± 0.978
4.442LeuGln: 4.442 ± 1.539
1.974LeuArg: 1.974 ± 0.91
7.897LeuSer: 7.897 ± 2.44
4.442LeuThr: 4.442 ± 0.793
3.455LeuVal: 3.455 ± 1.236
0.987LeuTrp: 0.987 ± 0.455
3.949LeuTyr: 3.949 ± 1.163
0.0LeuXaa: 0.0 ± 0.0
Met
2.962MetAla: 2.962 ± 1.571
0.0MetCys: 0.0 ± 0.0
0.494MetAsp: 0.494 ± 0.469
2.962MetGlu: 2.962 ± 1.279
0.987MetPhe: 0.987 ± 0.528
0.494MetGly: 0.494 ± 0.589
0.0MetHis: 0.0 ± 0.0
1.481MetIle: 1.481 ± 0.929
0.987MetLys: 0.987 ± 0.598
2.468MetLeu: 2.468 ± 0.923
0.0MetMet: 0.0 ± 0.0
2.468MetAsn: 2.468 ± 0.817
0.0MetPro: 0.0 ± 0.0
0.494MetGln: 0.494 ± 0.517
0.494MetArg: 0.494 ± 0.577
1.481MetSer: 1.481 ± 0.522
2.468MetThr: 2.468 ± 1.275
0.987MetVal: 0.987 ± 0.651
0.494MetTrp: 0.494 ± 0.46
0.494MetTyr: 0.494 ± 0.469
0.0MetXaa: 0.0 ± 0.0
Asn
4.442AsnAla: 4.442 ± 1.643
0.0AsnCys: 0.0 ± 0.0
3.455AsnAsp: 3.455 ± 1.555
4.442AsnGlu: 4.442 ± 0.998
2.962AsnPhe: 2.962 ± 1.189
4.936AsnGly: 4.936 ± 1.404
1.481AsnHis: 1.481 ± 0.991
5.429AsnIle: 5.429 ± 1.516
10.365AsnLys: 10.365 ± 1.831
5.429AsnLeu: 5.429 ± 1.442
2.962AsnMet: 2.962 ± 1.317
3.455AsnAsn: 3.455 ± 0.949
1.974AsnPro: 1.974 ± 0.591
3.455AsnGln: 3.455 ± 0.914
3.455AsnArg: 3.455 ± 0.994
3.455AsnSer: 3.455 ± 1.267
5.923AsnThr: 5.923 ± 1.508
1.974AsnVal: 1.974 ± 0.96
0.987AsnTrp: 0.987 ± 0.809
1.974AsnTyr: 1.974 ± 0.915
0.0AsnXaa: 0.0 ± 0.0
Pro
0.987ProAla: 0.987 ± 0.886
0.0ProCys: 0.0 ± 0.0
1.481ProAsp: 1.481 ± 0.595
0.987ProGlu: 0.987 ± 0.646
1.974ProPhe: 1.974 ± 0.909
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
0.987ProIle: 0.987 ± 0.533
2.962ProLys: 2.962 ± 1.068
1.481ProLeu: 1.481 ± 0.813
0.494ProMet: 0.494 ± 0.46
2.962ProAsn: 2.962 ± 1.248
0.494ProPro: 0.494 ± 0.469
0.0ProGln: 0.0 ± 0.0
2.468ProArg: 2.468 ± 0.842
0.987ProSer: 0.987 ± 0.729
0.987ProThr: 0.987 ± 0.661
3.949ProVal: 3.949 ± 0.93
0.0ProTrp: 0.0 ± 0.0
1.481ProTyr: 1.481 ± 0.82
0.0ProXaa: 0.0 ± 0.0
Gln
2.468GlnAla: 2.468 ± 1.405
0.0GlnCys: 0.0 ± 0.0
1.481GlnAsp: 1.481 ± 0.996
3.455GlnGlu: 3.455 ± 1.233
0.987GlnPhe: 0.987 ± 0.455
1.481GlnGly: 1.481 ± 0.698
0.987GlnHis: 0.987 ± 0.669
4.442GlnIle: 4.442 ± 1.914
3.949GlnLys: 3.949 ± 1.554
4.936GlnLeu: 4.936 ± 1.13
1.481GlnMet: 1.481 ± 0.681
1.481GlnAsn: 1.481 ± 0.595
0.987GlnPro: 0.987 ± 0.808
1.481GlnGln: 1.481 ± 0.829
0.494GlnArg: 0.494 ± 0.577
2.962GlnSer: 2.962 ± 0.855
0.0GlnThr: 0.0 ± 0.0
2.468GlnVal: 2.468 ± 1.254
0.494GlnTrp: 0.494 ± 0.404
1.974GlnTyr: 1.974 ± 0.721
0.0GlnXaa: 0.0 ± 0.0
Arg
0.494ArgAla: 0.494 ± 0.577
0.0ArgCys: 0.0 ± 0.0
3.455ArgAsp: 3.455 ± 1.365
5.429ArgGlu: 5.429 ± 1.197
2.962ArgPhe: 2.962 ± 1.081
2.468ArgGly: 2.468 ± 1.291
0.494ArgHis: 0.494 ± 0.443
4.936ArgIle: 4.936 ± 1.432
3.949ArgLys: 3.949 ± 1.288
5.429ArgLeu: 5.429 ± 1.387
0.0ArgMet: 0.0 ± 0.0
3.455ArgAsn: 3.455 ± 0.912
1.481ArgPro: 1.481 ± 0.679
2.962ArgGln: 2.962 ± 1.4
1.481ArgArg: 1.481 ± 1.212
0.494ArgSer: 0.494 ± 0.443
2.962ArgThr: 2.962 ± 1.041
1.481ArgVal: 1.481 ± 0.819
0.0ArgTrp: 0.0 ± 0.0
1.481ArgTyr: 1.481 ± 1.288
0.0ArgXaa: 0.0 ± 0.0
Ser
0.987SerAla: 0.987 ± 0.857
0.0SerCys: 0.0 ± 0.0
4.442SerAsp: 4.442 ± 1.099
5.429SerGlu: 5.429 ± 1.381
1.481SerPhe: 1.481 ± 0.689
0.987SerGly: 0.987 ± 1.006
0.0SerHis: 0.0 ± 0.0
0.987SerIle: 0.987 ± 0.539
7.404SerLys: 7.404 ± 2.264
3.949SerLeu: 3.949 ± 1.353
0.987SerMet: 0.987 ± 0.763
6.417SerAsn: 6.417 ± 1.51
2.468SerPro: 2.468 ± 0.841
0.987SerGln: 0.987 ± 0.594
1.974SerArg: 1.974 ± 0.915
1.481SerSer: 1.481 ± 1.065
2.468SerThr: 2.468 ± 0.556
2.468SerVal: 2.468 ± 1.005
0.494SerTrp: 0.494 ± 0.404
5.429SerTyr: 5.429 ± 1.746
0.0SerXaa: 0.0 ± 0.0
Thr
2.468ThrAla: 2.468 ± 1.095
0.0ThrCys: 0.0 ± 0.0
2.468ThrAsp: 2.468 ± 1.087
4.442ThrGlu: 4.442 ± 1.41
1.974ThrPhe: 1.974 ± 1.065
4.442ThrGly: 4.442 ± 1.017
1.974ThrHis: 1.974 ± 0.827
4.936ThrIle: 4.936 ± 1.256
4.936ThrLys: 4.936 ± 1.139
5.923ThrLeu: 5.923 ± 1.841
0.987ThrMet: 0.987 ± 0.604
2.962ThrAsn: 2.962 ± 1.437
1.481ThrPro: 1.481 ± 0.983
0.987ThrGln: 0.987 ± 0.598
1.481ThrArg: 1.481 ± 0.83
3.949ThrSer: 3.949 ± 1.314
4.442ThrThr: 4.442 ± 1.786
7.404ThrVal: 7.404 ± 1.349
0.0ThrTrp: 0.0 ± 0.0
1.481ThrTyr: 1.481 ± 0.627
0.0ThrXaa: 0.0 ± 0.0
Val
2.468ValAla: 2.468 ± 0.924
0.0ValCys: 0.0 ± 0.0
3.455ValAsp: 3.455 ± 1.305
2.962ValGlu: 2.962 ± 1.267
4.936ValPhe: 4.936 ± 0.954
2.962ValGly: 2.962 ± 1.074
0.987ValHis: 0.987 ± 0.604
8.885ValIle: 8.885 ± 1.655
9.378ValLys: 9.378 ± 2.504
4.936ValLeu: 4.936 ± 1.606
0.494ValMet: 0.494 ± 0.404
3.455ValAsn: 3.455 ± 1.292
1.481ValPro: 1.481 ± 0.522
2.468ValGln: 2.468 ± 1.196
2.468ValArg: 2.468 ± 1.229
3.455ValSer: 3.455 ± 1.011
2.962ValThr: 2.962 ± 1.072
0.987ValVal: 0.987 ± 0.676
0.494ValTrp: 0.494 ± 0.5
2.962ValTyr: 2.962 ± 0.831
0.0ValXaa: 0.0 ± 0.0
Trp
0.987TrpAla: 0.987 ± 0.455
0.0TrpCys: 0.0 ± 0.0
0.987TrpAsp: 0.987 ± 0.644
0.987TrpGlu: 0.987 ± 0.455
0.0TrpPhe: 0.0 ± 0.0
0.987TrpGly: 0.987 ± 0.651
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.494TrpLys: 0.494 ± 0.46
0.987TrpLeu: 0.987 ± 0.528
0.494TrpMet: 0.494 ± 0.587
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.494TrpGln: 0.494 ± 0.469
0.494TrpArg: 0.494 ± 0.66
0.494TrpSer: 0.494 ± 0.443
0.0TrpThr: 0.0 ± 0.0
1.481TrpVal: 1.481 ± 0.83
0.494TrpTrp: 0.494 ± 0.443
0.494TrpTyr: 0.494 ± 0.404
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.494TyrAla: 0.494 ± 0.46
0.494TyrCys: 0.494 ± 0.404
3.455TyrAsp: 3.455 ± 1.31
3.949TyrGlu: 3.949 ± 1.516
2.962TyrPhe: 2.962 ± 0.873
4.936TyrGly: 4.936 ± 1.365
1.481TyrHis: 1.481 ± 0.57
3.949TyrIle: 3.949 ± 1.543
5.923TyrLys: 5.923 ± 1.919
5.429TyrLeu: 5.429 ± 1.007
0.0TyrMet: 0.0 ± 0.0
2.962TyrAsn: 2.962 ± 1.32
0.0TyrPro: 0.0 ± 0.0
1.974TyrGln: 1.974 ± 0.814
3.949TyrArg: 3.949 ± 1.443
1.974TyrSer: 1.974 ± 0.759
3.455TyrThr: 3.455 ± 1.029
1.974TyrVal: 1.974 ± 0.685
0.0TyrTrp: 0.0 ± 0.0
1.481TyrTyr: 1.481 ± 0.944
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (2027 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski