Amino acid dipepetide frequency for Burkholderia virus phiE125

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.999AlaAla: 17.999 ± 2.439
0.937AlaCys: 0.937 ± 0.285
6.75AlaAsp: 6.75 ± 0.654
7.125AlaGlu: 7.125 ± 0.855
3.937AlaPhe: 3.937 ± 0.411
10.124AlaGly: 10.124 ± 0.937
1.812AlaHis: 1.812 ± 0.31
5.0AlaIle: 5.0 ± 0.532
5.437AlaLys: 5.437 ± 0.624
10.499AlaLeu: 10.499 ± 0.863
2.5AlaMet: 2.5 ± 0.434
3.625AlaAsn: 3.625 ± 0.569
4.25AlaPro: 4.25 ± 0.683
5.125AlaGln: 5.125 ± 1.161
9.687AlaArg: 9.687 ± 1.044
6.5AlaSer: 6.5 ± 0.699
5.875AlaThr: 5.875 ± 0.679
8.687AlaVal: 8.687 ± 0.781
1.75AlaTrp: 1.75 ± 0.272
1.75AlaTyr: 1.75 ± 0.331
0.0AlaXaa: 0.0 ± 0.0
Cys
0.812CysAla: 0.812 ± 0.274
0.25CysCys: 0.25 ± 0.157
1.062CysAsp: 1.062 ± 0.265
1.0CysGlu: 1.0 ± 0.252
0.437CysPhe: 0.437 ± 0.158
0.937CysGly: 0.937 ± 0.225
0.187CysHis: 0.187 ± 0.123
0.437CysIle: 0.437 ± 0.17
0.437CysLys: 0.437 ± 0.143
0.687CysLeu: 0.687 ± 0.207
0.312CysMet: 0.312 ± 0.144
0.25CysAsn: 0.25 ± 0.121
0.437CysPro: 0.437 ± 0.173
0.375CysGln: 0.375 ± 0.133
0.812CysArg: 0.812 ± 0.249
0.812CysSer: 0.812 ± 0.252
0.875CysThr: 0.875 ± 0.199
1.125CysVal: 1.125 ± 0.235
0.125CysTrp: 0.125 ± 0.089
0.437CysTyr: 0.437 ± 0.154
0.0CysXaa: 0.0 ± 0.0
Asp
7.437AspAla: 7.437 ± 0.599
1.125AspCys: 1.125 ± 0.28
4.312AspAsp: 4.312 ± 0.545
4.937AspGlu: 4.937 ± 0.489
1.562AspPhe: 1.562 ± 0.246
7.062AspGly: 7.062 ± 0.766
0.937AspHis: 0.937 ± 0.269
2.437AspIle: 2.437 ± 0.451
2.125AspLys: 2.125 ± 0.308
4.187AspLeu: 4.187 ± 0.554
1.437AspMet: 1.437 ± 0.357
1.437AspAsn: 1.437 ± 0.297
2.75AspPro: 2.75 ± 0.454
2.437AspGln: 2.437 ± 0.348
4.062AspArg: 4.062 ± 0.462
2.437AspSer: 2.437 ± 0.475
2.312AspThr: 2.312 ± 0.378
4.5AspVal: 4.5 ± 0.551
1.562AspTrp: 1.562 ± 0.367
1.562AspTyr: 1.562 ± 0.279
0.0AspXaa: 0.0 ± 0.0
Glu
6.5GluAla: 6.5 ± 0.629
0.75GluCys: 0.75 ± 0.182
2.375GluAsp: 2.375 ± 0.436
2.375GluGlu: 2.375 ± 0.416
1.875GluPhe: 1.875 ± 0.361
3.187GluGly: 3.187 ± 0.54
1.75GluHis: 1.75 ± 0.306
3.187GluIle: 3.187 ± 0.331
2.562GluLys: 2.562 ± 0.358
6.5GluLeu: 6.5 ± 0.764
1.062GluMet: 1.062 ± 0.253
1.937GluAsn: 1.937 ± 0.346
3.437GluPro: 3.437 ± 0.517
3.125GluGln: 3.125 ± 0.431
6.937GluArg: 6.937 ± 0.709
4.187GluSer: 4.187 ± 0.407
3.25GluThr: 3.25 ± 0.318
3.625GluVal: 3.625 ± 0.457
1.375GluTrp: 1.375 ± 0.24
1.437GluTyr: 1.437 ± 0.321
0.0GluXaa: 0.0 ± 0.0
Phe
3.25PheAla: 3.25 ± 0.499
0.375PheCys: 0.375 ± 0.146
2.437PheAsp: 2.437 ± 0.365
2.0PheGlu: 2.0 ± 0.393
0.812PhePhe: 0.812 ± 0.203
3.375PheGly: 3.375 ± 0.505
0.625PheHis: 0.625 ± 0.165
1.5PheIle: 1.5 ± 0.287
1.187PheLys: 1.187 ± 0.262
2.25PheLeu: 2.25 ± 0.355
0.937PheMet: 0.937 ± 0.282
1.375PheAsn: 1.375 ± 0.312
1.437PhePro: 1.437 ± 0.336
1.187PheGln: 1.187 ± 0.262
1.937PheArg: 1.937 ± 0.351
1.75PheSer: 1.75 ± 0.318
1.5PheThr: 1.5 ± 0.29
2.125PheVal: 2.125 ± 0.339
0.625PheTrp: 0.625 ± 0.186
0.875PheTyr: 0.875 ± 0.239
0.0PheXaa: 0.0 ± 0.0
Gly
8.062GlyAla: 8.062 ± 0.742
1.25GlyCys: 1.25 ± 0.277
5.187GlyAsp: 5.187 ± 0.57
4.312GlyGlu: 4.312 ± 0.543
2.25GlyPhe: 2.25 ± 0.34
7.187GlyGly: 7.187 ± 0.921
1.0GlyHis: 1.0 ± 0.278
3.5GlyIle: 3.5 ± 0.532
5.25GlyLys: 5.25 ± 0.743
6.812GlyLeu: 6.812 ± 0.51
2.187GlyMet: 2.187 ± 0.392
2.875GlyAsn: 2.875 ± 0.382
2.375GlyPro: 2.375 ± 0.343
3.375GlyGln: 3.375 ± 0.434
6.312GlyArg: 6.312 ± 0.662
4.625GlySer: 4.625 ± 0.557
3.5GlyThr: 3.5 ± 0.503
6.625GlyVal: 6.625 ± 0.698
1.812GlyTrp: 1.812 ± 0.435
2.375GlyTyr: 2.375 ± 0.313
0.0GlyXaa: 0.0 ± 0.0
His
2.062HisAla: 2.062 ± 0.45
0.25HisCys: 0.25 ± 0.119
1.0HisAsp: 1.0 ± 0.257
1.125HisGlu: 1.125 ± 0.249
0.437HisPhe: 0.437 ± 0.188
1.375HisGly: 1.375 ± 0.286
0.562HisHis: 0.562 ± 0.195
0.687HisIle: 0.687 ± 0.265
0.625HisLys: 0.625 ± 0.177
1.5HisLeu: 1.5 ± 0.341
0.5HisMet: 0.5 ± 0.151
0.25HisAsn: 0.25 ± 0.127
1.125HisPro: 1.125 ± 0.279
0.625HisGln: 0.625 ± 0.186
1.25HisArg: 1.25 ± 0.354
0.875HisSer: 0.875 ± 0.253
1.187HisThr: 1.187 ± 0.285
0.937HisVal: 0.937 ± 0.22
0.187HisTrp: 0.187 ± 0.103
0.375HisTyr: 0.375 ± 0.14
0.0HisXaa: 0.0 ± 0.0
Ile
6.125IleAla: 6.125 ± 0.811
0.625IleCys: 0.625 ± 0.196
5.125IleAsp: 5.125 ± 0.583
4.312IleGlu: 4.312 ± 0.661
0.75IlePhe: 0.75 ± 0.186
3.75IleGly: 3.75 ± 0.417
0.375IleHis: 0.375 ± 0.185
1.5IleIle: 1.5 ± 0.363
2.125IleLys: 2.125 ± 0.338
2.187IleLeu: 2.187 ± 0.335
0.937IleMet: 0.937 ± 0.289
2.187IleAsn: 2.187 ± 0.332
2.25IlePro: 2.25 ± 0.324
1.437IleGln: 1.437 ± 0.378
2.875IleArg: 2.875 ± 0.409
2.562IleSer: 2.562 ± 0.506
2.562IleThr: 2.562 ± 0.504
3.812IleVal: 3.812 ± 0.453
0.562IleTrp: 0.562 ± 0.186
1.0IleTyr: 1.0 ± 0.345
0.0IleXaa: 0.0 ± 0.0
Lys
5.562LysAla: 5.562 ± 0.596
0.312LysCys: 0.312 ± 0.14
2.312LysAsp: 2.312 ± 0.386
1.875LysGlu: 1.875 ± 0.397
1.125LysPhe: 1.125 ± 0.295
2.937LysGly: 2.937 ± 0.445
0.687LysHis: 0.687 ± 0.222
1.562LysIle: 1.562 ± 0.29
1.812LysLys: 1.812 ± 0.348
4.187LysLeu: 4.187 ± 0.444
1.5LysMet: 1.5 ± 0.275
0.937LysAsn: 0.937 ± 0.214
2.062LysPro: 2.062 ± 0.466
1.75LysGln: 1.75 ± 0.236
3.875LysArg: 3.875 ± 0.573
2.687LysSer: 2.687 ± 0.379
2.312LysThr: 2.312 ± 0.349
2.687LysVal: 2.687 ± 0.472
0.562LysTrp: 0.562 ± 0.203
1.75LysTyr: 1.75 ± 0.33
0.0LysXaa: 0.0 ± 0.0
Leu
9.312LeuAla: 9.312 ± 1.033
0.937LeuCys: 0.937 ± 0.276
4.937LeuAsp: 4.937 ± 0.47
5.562LeuGlu: 5.562 ± 0.852
2.125LeuPhe: 2.125 ± 0.383
5.0LeuGly: 5.0 ± 0.643
1.312LeuHis: 1.312 ± 0.332
4.125LeuIle: 4.125 ± 0.532
3.0LeuLys: 3.0 ± 0.425
5.75LeuLeu: 5.75 ± 0.723
1.562LeuMet: 1.562 ± 0.303
2.687LeuAsn: 2.687 ± 0.348
3.687LeuPro: 3.687 ± 0.496
2.937LeuGln: 2.937 ± 0.353
8.0LeuArg: 8.0 ± 0.815
4.937LeuSer: 4.937 ± 0.671
5.062LeuThr: 5.062 ± 0.504
4.875LeuVal: 4.875 ± 0.577
0.937LeuTrp: 0.937 ± 0.239
2.625LeuTyr: 2.625 ± 0.455
0.0LeuXaa: 0.0 ± 0.0
Met
3.312MetAla: 3.312 ± 0.432
0.125MetCys: 0.125 ± 0.095
0.875MetAsp: 0.875 ± 0.239
0.75MetGlu: 0.75 ± 0.217
0.5MetPhe: 0.5 ± 0.207
1.5MetGly: 1.5 ± 0.298
0.437MetHis: 0.437 ± 0.181
1.0MetIle: 1.0 ± 0.243
1.25MetLys: 1.25 ± 0.295
1.625MetLeu: 1.625 ± 0.317
0.625MetMet: 0.625 ± 0.19
1.5MetAsn: 1.5 ± 0.325
1.187MetPro: 1.187 ± 0.186
0.75MetGln: 0.75 ± 0.255
2.25MetArg: 2.25 ± 0.405
2.437MetSer: 2.437 ± 0.401
1.687MetThr: 1.687 ± 0.317
1.375MetVal: 1.375 ± 0.27
0.5MetTrp: 0.5 ± 0.176
0.125MetTyr: 0.125 ± 0.082
0.0MetXaa: 0.0 ± 0.0
Asn
3.875AsnAla: 3.875 ± 0.533
0.25AsnCys: 0.25 ± 0.117
1.937AsnAsp: 1.937 ± 0.335
2.312AsnGlu: 2.312 ± 0.367
0.937AsnPhe: 0.937 ± 0.237
3.437AsnGly: 3.437 ± 0.629
0.812AsnHis: 0.812 ± 0.253
1.5AsnIle: 1.5 ± 0.265
0.625AsnLys: 0.625 ± 0.26
2.875AsnLeu: 2.875 ± 0.373
0.75AsnMet: 0.75 ± 0.222
0.875AsnAsn: 0.875 ± 0.206
2.187AsnPro: 2.187 ± 0.421
1.062AsnGln: 1.062 ± 0.227
2.312AsnArg: 2.312 ± 0.449
2.062AsnSer: 2.062 ± 0.381
1.375AsnThr: 1.375 ± 0.257
2.25AsnVal: 2.25 ± 0.396
0.625AsnTrp: 0.625 ± 0.206
0.812AsnTyr: 0.812 ± 0.238
0.0AsnXaa: 0.0 ± 0.0
Pro
4.75ProAla: 4.75 ± 0.58
1.0ProCys: 1.0 ± 0.257
2.562ProAsp: 2.562 ± 0.465
3.0ProGlu: 3.0 ± 0.526
1.375ProPhe: 1.375 ± 0.278
4.562ProGly: 4.562 ± 0.483
0.687ProHis: 0.687 ± 0.243
2.375ProIle: 2.375 ± 0.442
2.0ProLys: 2.0 ± 0.374
2.875ProLeu: 2.875 ± 0.383
1.562ProMet: 1.562 ± 0.291
1.625ProAsn: 1.625 ± 0.291
3.25ProPro: 3.25 ± 0.692
1.125ProGln: 1.125 ± 0.274
2.937ProArg: 2.937 ± 0.468
2.75ProSer: 2.75 ± 0.468
3.062ProThr: 3.062 ± 0.498
3.75ProVal: 3.75 ± 0.557
0.937ProTrp: 0.937 ± 0.213
1.0ProTyr: 1.0 ± 0.265
0.0ProXaa: 0.0 ± 0.0
Gln
5.375GlnAla: 5.375 ± 0.88
0.5GlnCys: 0.5 ± 0.171
1.687GlnAsp: 1.687 ± 0.355
1.687GlnGlu: 1.687 ± 0.351
1.562GlnPhe: 1.562 ± 0.299
3.0GlnGly: 3.0 ± 0.467
0.5GlnHis: 0.5 ± 0.169
2.375GlnIle: 2.375 ± 0.461
1.562GlnLys: 1.562 ± 0.291
3.562GlnLeu: 3.562 ± 0.619
1.125GlnMet: 1.125 ± 0.256
1.125GlnAsn: 1.125 ± 0.24
1.875GlnPro: 1.875 ± 0.286
2.375GlnGln: 2.375 ± 0.509
3.687GlnArg: 3.687 ± 0.491
2.375GlnSer: 2.375 ± 0.353
1.75GlnThr: 1.75 ± 0.343
2.437GlnVal: 2.437 ± 0.459
0.687GlnTrp: 0.687 ± 0.175
1.312GlnTyr: 1.312 ± 0.331
0.0GlnXaa: 0.0 ± 0.0
Arg
10.187ArgAla: 10.187 ± 0.943
0.75ArgCys: 0.75 ± 0.264
4.437ArgAsp: 4.437 ± 0.59
5.562ArgGlu: 5.562 ± 0.666
3.625ArgPhe: 3.625 ± 0.42
5.25ArgGly: 5.25 ± 0.589
1.5ArgHis: 1.5 ± 0.307
3.937ArgIle: 3.937 ± 0.498
2.875ArgLys: 2.875 ± 0.418
6.25ArgLeu: 6.25 ± 0.713
1.687ArgMet: 1.687 ± 0.374
2.312ArgAsn: 2.312 ± 0.377
3.187ArgPro: 3.187 ± 0.497
3.875ArgGln: 3.875 ± 0.443
5.625ArgArg: 5.625 ± 0.585
4.125ArgSer: 4.125 ± 0.5
3.562ArgThr: 3.562 ± 0.501
6.125ArgVal: 6.125 ± 0.689
1.187ArgTrp: 1.187 ± 0.301
2.125ArgTyr: 2.125 ± 0.328
0.0ArgXaa: 0.0 ± 0.0
Ser
6.875SerAla: 6.875 ± 0.695
0.75SerCys: 0.75 ± 0.224
3.812SerAsp: 3.812 ± 0.489
3.312SerGlu: 3.312 ± 0.528
1.687SerPhe: 1.687 ± 0.346
4.75SerGly: 4.75 ± 0.518
0.812SerHis: 0.812 ± 0.206
2.875SerIle: 2.875 ± 0.469
2.812SerLys: 2.812 ± 0.403
3.875SerLeu: 3.875 ± 0.59
2.312SerMet: 2.312 ± 0.369
2.812SerAsn: 2.812 ± 0.492
2.75SerPro: 2.75 ± 0.654
1.687SerGln: 1.687 ± 0.322
3.75SerArg: 3.75 ± 0.498
3.625SerSer: 3.625 ± 0.436
3.25SerThr: 3.25 ± 0.409
4.562SerVal: 4.562 ± 0.592
0.687SerTrp: 0.687 ± 0.189
1.812SerTyr: 1.812 ± 0.5
0.0SerXaa: 0.0 ± 0.0
Thr
6.312ThrAla: 6.312 ± 1.036
0.312ThrCys: 0.312 ± 0.124
3.062ThrAsp: 3.062 ± 0.413
2.687ThrGlu: 2.687 ± 0.392
2.562ThrPhe: 2.562 ± 0.395
3.875ThrGly: 3.875 ± 0.493
0.687ThrHis: 0.687 ± 0.268
2.812ThrIle: 2.812 ± 0.447
2.062ThrLys: 2.062 ± 0.331
4.375ThrLeu: 4.375 ± 0.544
0.875ThrMet: 0.875 ± 0.231
1.625ThrAsn: 1.625 ± 0.29
3.187ThrPro: 3.187 ± 0.411
2.5ThrGln: 2.5 ± 0.355
2.187ThrArg: 2.187 ± 0.428
3.0ThrSer: 3.0 ± 0.583
2.625ThrThr: 2.625 ± 0.361
4.687ThrVal: 4.687 ± 0.475
0.562ThrTrp: 0.562 ± 0.194
1.625ThrTyr: 1.625 ± 0.286
0.0ThrXaa: 0.0 ± 0.0
Val
6.812ValAla: 6.812 ± 0.585
0.625ValCys: 0.625 ± 0.223
4.562ValAsp: 4.562 ± 0.615
5.0ValGlu: 5.0 ± 0.677
2.312ValPhe: 2.312 ± 0.374
6.75ValGly: 6.75 ± 0.549
1.437ValHis: 1.437 ± 0.334
3.875ValIle: 3.875 ± 0.604
3.375ValLys: 3.375 ± 0.487
5.0ValLeu: 5.0 ± 0.618
1.187ValMet: 1.187 ± 0.228
2.562ValAsn: 2.562 ± 0.44
3.812ValPro: 3.812 ± 0.513
2.812ValGln: 2.812 ± 0.55
6.062ValArg: 6.062 ± 0.605
4.75ValSer: 4.75 ± 0.611
3.625ValThr: 3.625 ± 0.427
5.125ValVal: 5.125 ± 0.695
1.062ValTrp: 1.062 ± 0.218
2.062ValTyr: 2.062 ± 0.404
0.0ValXaa: 0.0 ± 0.0
Trp
1.625TrpAla: 1.625 ± 0.304
0.312TrpCys: 0.312 ± 0.121
0.937TrpAsp: 0.937 ± 0.285
0.875TrpGlu: 0.875 ± 0.263
0.312TrpPhe: 0.312 ± 0.133
0.875TrpGly: 0.875 ± 0.203
0.5TrpHis: 0.5 ± 0.191
1.437TrpIle: 1.437 ± 0.265
0.687TrpLys: 0.687 ± 0.238
1.937TrpLeu: 1.937 ± 0.381
0.312TrpMet: 0.312 ± 0.194
0.312TrpAsn: 0.312 ± 0.135
0.75TrpPro: 0.75 ± 0.252
0.687TrpGln: 0.687 ± 0.221
1.437TrpArg: 1.437 ± 0.304
0.812TrpSer: 0.812 ± 0.281
0.812TrpThr: 0.812 ± 0.231
1.5TrpVal: 1.5 ± 0.315
0.312TrpTrp: 0.312 ± 0.144
0.312TrpTyr: 0.312 ± 0.131
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.125TyrAla: 3.125 ± 0.33
0.375TyrCys: 0.375 ± 0.143
1.25TyrAsp: 1.25 ± 0.218
1.625TyrGlu: 1.625 ± 0.307
1.375TyrPhe: 1.375 ± 0.275
1.937TyrGly: 1.937 ± 0.423
0.312TyrHis: 0.312 ± 0.132
0.937TyrIle: 0.937 ± 0.245
0.75TyrLys: 0.75 ± 0.152
2.437TyrLeu: 2.437 ± 0.459
0.375TyrMet: 0.375 ± 0.146
0.562TyrAsn: 0.562 ± 0.149
1.187TyrPro: 1.187 ± 0.33
1.312TyrGln: 1.312 ± 0.256
2.187TyrArg: 2.187 ± 0.36
1.5TyrSer: 1.5 ± 0.329
1.437TyrThr: 1.437 ± 0.332
2.0TyrVal: 2.0 ± 0.363
0.687TyrTrp: 0.687 ± 0.158
0.5TyrTyr: 0.5 ± 0.192
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 72 proteins (16002 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski