Amino acid dipepetide frequency for Desulfitobacterium metallireducens DSM 15288

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.779AlaAla: 5.779 ± 0.123	0.776AlaCys: 0.776 ± 0.039	3.473AlaAsp: 3.473 ± 0.068	5.054AlaGlu: 5.054 ± 0.087	2.915AlaPhe: 2.915 ± 0.057	5.864AlaGly: 5.864 ± 0.096	1.434AlaHis: 1.434 ± 0.04	5.487AlaIle: 5.487 ± 0.088	4.683AlaLys: 4.683 ± 0.083	8.724AlaLeu: 8.724 ± 0.11	2.068AlaMet: 2.068 ± 0.047	2.775AlaAsn: 2.775 ± 0.066	2.307AlaPro: 2.307 ± 0.049	3.692AlaGln: 3.692 ± 0.082	3.387AlaArg: 3.387 ± 0.063	4.226AlaSer: 4.226 ± 0.088	3.79AlaThr: 3.79 ± 0.074	5.434AlaVal: 5.434 ± 0.102	0.739AlaTrp: 0.739 ± 0.03	2.284AlaTyr: 2.284 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.593CysAla: 0.593 ± 0.027	0.14CysCys: 0.14 ± 0.013	0.45CysAsp: 0.45 ± 0.024	0.542CysGlu: 0.542 ± 0.024	0.404CysPhe: 0.404 ± 0.022	0.967CysGly: 0.967 ± 0.038	0.341CysHis: 0.341 ± 0.035	0.618CysIle: 0.618 ± 0.024	0.465CysLys: 0.465 ± 0.024	0.932CysLeu: 0.932 ± 0.034	0.211CysMet: 0.211 ± 0.016	0.39CysAsn: 0.39 ± 0.025	0.661CysPro: 0.661 ± 0.033	0.419CysGln: 0.419 ± 0.021	0.443CysArg: 0.443 ± 0.024	0.644CysSer: 0.644 ± 0.028	0.516CysThr: 0.516 ± 0.024	0.617CysVal: 0.617 ± 0.03	0.1CysTrp: 0.1 ± 0.011	0.299CysTyr: 0.299 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.181AspAla: 3.181 ± 0.062	0.491AspCys: 0.491 ± 0.025	1.846AspAsp: 1.846 ± 0.041	3.478AspGlu: 3.478 ± 0.069	2.408AspPhe: 2.408 ± 0.053	2.996AspGly: 2.996 ± 0.062	0.909AspHis: 0.909 ± 0.028	3.702AspIle: 3.702 ± 0.076	2.944AspLys: 2.944 ± 0.058	5.342AspLeu: 5.342 ± 0.084	1.191AspMet: 1.191 ± 0.039	1.674AspAsn: 1.674 ± 0.044	2.259AspPro: 2.259 ± 0.05	2.027AspGln: 2.027 ± 0.052	2.232AspArg: 2.232 ± 0.049	2.592AspSer: 2.592 ± 0.05	2.26AspThr: 2.26 ± 0.054	3.265AspVal: 3.265 ± 0.063	0.622AspTrp: 0.622 ± 0.028	1.916AspTyr: 1.916 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	5.166GluAla: 5.166 ± 0.081	0.603GluCys: 0.603 ± 0.03	3.427GluAsp: 3.427 ± 0.079	6.127GluGlu: 6.127 ± 0.12	2.738GluPhe: 2.738 ± 0.055	4.581GluGly: 4.581 ± 0.081	1.455GluHis: 1.455 ± 0.042	5.767GluIle: 5.767 ± 0.089	5.437GluLys: 5.437 ± 0.093	7.01GluLeu: 7.01 ± 0.099	2.029GluMet: 2.029 ± 0.053	3.298GluAsn: 3.298 ± 0.068	1.999GluPro: 1.999 ± 0.06	3.202GluGln: 3.202 ± 0.07	3.71GluArg: 3.71 ± 0.065	3.443GluSer: 3.443 ± 0.056	3.22GluThr: 3.22 ± 0.059	5.326GluVal: 5.326 ± 0.098	0.749GluTrp: 0.749 ± 0.028	2.062GluTyr: 2.062 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.028PheAla: 3.028 ± 0.072	0.467PheCys: 0.467 ± 0.022	1.969PheAsp: 1.969 ± 0.049	2.427PheGlu: 2.427 ± 0.063	1.905PhePhe: 1.905 ± 0.061	3.209PheGly: 3.209 ± 0.064	0.779PheHis: 0.779 ± 0.031	3.108PheIle: 3.108 ± 0.072	2.22PheLys: 2.22 ± 0.047	4.487PheLeu: 4.487 ± 0.081	1.059PheMet: 1.059 ± 0.032	1.738PheAsn: 1.738 ± 0.047	1.677PhePro: 1.677 ± 0.042	1.504PheGln: 1.504 ± 0.045	1.692PheArg: 1.692 ± 0.049	2.919PheSer: 2.919 ± 0.062	2.274PheThr: 2.274 ± 0.058	2.664PheVal: 2.664 ± 0.061	0.555PheTrp: 0.555 ± 0.027	1.396PheTyr: 1.396 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.323GlyAla: 5.323 ± 0.092	0.916GlyCys: 0.916 ± 0.036	3.128GlyAsp: 3.128 ± 0.063	4.789GlyGlu: 4.789 ± 0.083	3.297GlyPhe: 3.297 ± 0.067	5.234GlyGly: 5.234 ± 0.09	1.349GlyHis: 1.349 ± 0.037	6.554GlyIle: 6.554 ± 0.104	5.081GlyLys: 5.081 ± 0.079	7.464GlyLeu: 7.464 ± 0.109	2.24GlyMet: 2.24 ± 0.062	2.79GlyAsn: 2.79 ± 0.065	1.964GlyPro: 1.964 ± 0.054	2.932GlyGln: 2.932 ± 0.057	3.134GlyArg: 3.134 ± 0.066	4.023GlySer: 4.023 ± 0.079	4.319GlyThr: 4.319 ± 0.083	5.705GlyVal: 5.705 ± 0.083	0.853GlyTrp: 0.853 ± 0.034	2.669GlyTyr: 2.669 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.256HisAla: 1.256 ± 0.04	0.265HisCys: 0.265 ± 0.015	0.876HisAsp: 0.876 ± 0.034	1.183HisGlu: 1.183 ± 0.037	0.944HisPhe: 0.944 ± 0.032	1.259HisGly: 1.259 ± 0.039	0.506HisHis: 0.506 ± 0.023	1.251HisIle: 1.251 ± 0.037	0.96HisLys: 0.96 ± 0.037	2.019HisLeu: 2.019 ± 0.057	0.433HisMet: 0.433 ± 0.022	0.721HisAsn: 0.721 ± 0.028	1.219HisPro: 1.219 ± 0.041	0.821HisGln: 0.821 ± 0.029	0.902HisArg: 0.902 ± 0.032	1.182HisSer: 1.182 ± 0.036	0.948HisThr: 0.948 ± 0.038	1.217HisVal: 1.217 ± 0.037	0.262HisTrp: 0.262 ± 0.017	0.758HisTyr: 0.758 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.155IleAla: 6.155 ± 0.098	0.725IleCys: 0.725 ± 0.032	3.699IleAsp: 3.699 ± 0.067	4.935IleGlu: 4.935 ± 0.083	2.945IlePhe: 2.945 ± 0.068	5.468IleGly: 5.468 ± 0.096	1.391IleHis: 1.391 ± 0.042	4.919IleIle: 4.919 ± 0.093	3.953IleLys: 3.953 ± 0.08	8.421IleLeu: 8.421 ± 0.121	1.73IleMet: 1.73 ± 0.048	2.926IleAsn: 2.926 ± 0.06	3.705IlePro: 3.705 ± 0.069	3.009IleGln: 3.009 ± 0.057	3.402IleArg: 3.402 ± 0.074	4.902IleSer: 4.902 ± 0.086	4.051IleThr: 4.051 ± 0.068	4.981IleVal: 4.981 ± 0.082	0.612IleTrp: 0.612 ± 0.029	2.2IleTyr: 2.2 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.913LysAla: 4.913 ± 0.09	0.438LysCys: 0.438 ± 0.028	3.252LysAsp: 3.252 ± 0.068	5.094LysGlu: 5.094 ± 0.089	1.782LysPhe: 1.782 ± 0.046	4.273LysGly: 4.273 ± 0.07	0.988LysHis: 0.988 ± 0.033	4.769LysIle: 4.769 ± 0.079	4.173LysLys: 4.173 ± 0.085	5.617LysLeu: 5.617 ± 0.075	1.825LysMet: 1.825 ± 0.043	2.818LysAsn: 2.818 ± 0.068	2.289LysPro: 2.289 ± 0.05	2.233LysGln: 2.233 ± 0.055	2.987LysArg: 2.987 ± 0.067	3.371LysSer: 3.371 ± 0.068	3.453LysThr: 3.453 ± 0.06	4.764LysVal: 4.764 ± 0.081	0.518LysTrp: 0.518 ± 0.025	1.941LysTyr: 1.941 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	8.802LeuAla: 8.802 ± 0.109	0.911LeuCys: 0.911 ± 0.035	5.064LeuAsp: 5.064 ± 0.082	7.478LeuGlu: 7.478 ± 0.104	4.087LeuPhe: 4.087 ± 0.086	8.19LeuGly: 8.19 ± 0.12	1.789LeuHis: 1.789 ± 0.046	7.174LeuIle: 7.174 ± 0.122	6.874LeuLys: 6.874 ± 0.095	10.55LeuLeu: 10.55 ± 0.151	2.546LeuMet: 2.546 ± 0.06	4.648LeuAsn: 4.648 ± 0.074	4.506LeuPro: 4.506 ± 0.064	3.908LeuGln: 3.908 ± 0.081	4.805LeuArg: 4.805 ± 0.077	7.174LeuSer: 7.174 ± 0.1	6.017LeuThr: 6.017 ± 0.098	6.778LeuVal: 6.778 ± 0.097	1.028LeuTrp: 1.028 ± 0.04	2.866LeuTyr: 2.866 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.172MetAla: 2.172 ± 0.052	0.165MetCys: 0.165 ± 0.013	1.406MetAsp: 1.406 ± 0.039	1.751MetGlu: 1.751 ± 0.043	0.828MetPhe: 0.828 ± 0.032	2.133MetGly: 2.133 ± 0.062	0.453MetHis: 0.453 ± 0.024	1.913MetIle: 1.913 ± 0.048	1.837MetLys: 1.837 ± 0.044	2.277MetLeu: 2.277 ± 0.05	0.731MetMet: 0.731 ± 0.033	1.329MetAsn: 1.329 ± 0.037	1.001MetPro: 1.001 ± 0.032	0.891MetGln: 0.891 ± 0.036	1.225MetArg: 1.225 ± 0.034	1.732MetSer: 1.732 ± 0.043	1.424MetThr: 1.424 ± 0.04	1.804MetVal: 1.804 ± 0.05	0.168MetTrp: 0.168 ± 0.016	0.56MetTyr: 0.56 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.759AsnAla: 2.759 ± 0.069	0.446AsnCys: 0.446 ± 0.025	1.77AsnAsp: 1.77 ± 0.045	2.47AsnGlu: 2.47 ± 0.058	1.687AsnPhe: 1.687 ± 0.044	2.828AsnGly: 2.828 ± 0.062	0.798AsnHis: 0.798 ± 0.031	3.047AsnIle: 3.047 ± 0.065	2.31AsnLys: 2.31 ± 0.053	4.598AsnLeu: 4.598 ± 0.063	1.04AsnMet: 1.04 ± 0.032	1.696AsnAsn: 1.696 ± 0.052	2.535AsnPro: 2.535 ± 0.077	1.911AsnGln: 1.911 ± 0.052	1.887AsnArg: 1.887 ± 0.052	2.619AsnSer: 2.619 ± 0.059	2.095AsnThr: 2.095 ± 0.057	2.805AsnVal: 2.805 ± 0.063	0.491AsnTrp: 0.491 ± 0.025	1.533AsnTyr: 1.533 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.701ProAla: 2.701 ± 0.068	0.344ProCys: 0.344 ± 0.023	2.127ProAsp: 2.127 ± 0.056	3.816ProGlu: 3.816 ± 0.078	1.767ProPhe: 1.767 ± 0.044	3.061ProGly: 3.061 ± 0.074	0.814ProHis: 0.814 ± 0.031	2.871ProIle: 2.871 ± 0.054	2.158ProLys: 2.158 ± 0.055	4.036ProLeu: 4.036 ± 0.077	0.932ProMet: 0.932 ± 0.038	1.676ProAsn: 1.676 ± 0.058	1.202ProPro: 1.202 ± 0.046	1.839ProGln: 1.839 ± 0.051	1.462ProArg: 1.462 ± 0.043	2.391ProSer: 2.391 ± 0.052	2.032ProThr: 2.032 ± 0.055	3.08ProVal: 3.08 ± 0.066	0.525ProTrp: 0.525 ± 0.029	1.395ProTyr: 1.395 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.56GlnAla: 3.56 ± 0.078	0.317GlnCys: 0.317 ± 0.02	1.968GlnAsp: 1.968 ± 0.05	3.559GlnGlu: 3.559 ± 0.067	1.419GlnPhe: 1.419 ± 0.041	3.151GlnGly: 3.151 ± 0.064	0.758GlnHis: 0.758 ± 0.027	3.047GlnIle: 3.047 ± 0.067	2.874GlnLys: 2.874 ± 0.056	3.874GlnLeu: 3.874 ± 0.067	1.134GlnMet: 1.134 ± 0.035	1.788GlnAsn: 1.788 ± 0.052	1.334GlnPro: 1.334 ± 0.036	1.681GlnGln: 1.681 ± 0.057	1.942GlnArg: 1.942 ± 0.058	2.318GlnSer: 2.318 ± 0.055	2.252GlnThr: 2.252 ± 0.051	3.071GlnVal: 3.071 ± 0.065	0.425GlnTrp: 0.425 ± 0.022	1.185GlnTyr: 1.185 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.91ArgAla: 2.91 ± 0.051	0.419ArgCys: 0.419 ± 0.023	2.128ArgAsp: 2.128 ± 0.052	3.662ArgGlu: 3.662 ± 0.075	2.048ArgPhe: 2.048 ± 0.05	2.912ArgGly: 2.912 ± 0.057	0.789ArgHis: 0.789 ± 0.031	3.521ArgIle: 3.521 ± 0.071	3.039ArgLys: 3.039 ± 0.056	4.817ArgLeu: 4.817 ± 0.088	1.28ArgMet: 1.28 ± 0.041	1.886ArgAsn: 1.886 ± 0.043	1.745ArgPro: 1.745 ± 0.064	1.97ArgGln: 1.97 ± 0.049	2.246ArgArg: 2.246 ± 0.057	2.44ArgSer: 2.44 ± 0.056	2.274ArgThr: 2.274 ± 0.05	3.392ArgVal: 3.392 ± 0.07	0.573ArgTrp: 0.573 ± 0.028	1.562ArgTyr: 1.562 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.132SerAla: 4.132 ± 0.076	0.632SerCys: 0.632 ± 0.026	2.686SerAsp: 2.686 ± 0.049	3.944SerGlu: 3.944 ± 0.072	2.785SerPhe: 2.785 ± 0.064	4.873SerGly: 4.873 ± 0.084	1.133SerHis: 1.133 ± 0.038	4.394SerIle: 4.394 ± 0.078	3.395SerLys: 3.395 ± 0.072	6.683SerLeu: 6.683 ± 0.087	1.563SerMet: 1.563 ± 0.037	2.391SerAsn: 2.391 ± 0.061	2.477SerPro: 2.477 ± 0.057	2.637SerGln: 2.637 ± 0.057	2.644SerArg: 2.644 ± 0.058	4.22SerSer: 4.22 ± 0.088	3.164SerThr: 3.164 ± 0.062	4.073SerVal: 4.073 ± 0.067	0.661SerTrp: 0.661 ± 0.029	2.002SerTyr: 2.002 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	3.999ThrAla: 3.999 ± 0.084	0.496ThrCys: 0.496 ± 0.025	2.402ThrAsp: 2.402 ± 0.057	3.46ThrGlu: 3.46 ± 0.056	2.237ThrPhe: 2.237 ± 0.053	4.444ThrGly: 4.444 ± 0.086	1.107ThrHis: 1.107 ± 0.039	3.703ThrIle: 3.703 ± 0.075	2.585ThrLys: 2.585 ± 0.056	6.038ThrLeu: 6.038 ± 0.087	1.153ThrMet: 1.153 ± 0.032	1.991ThrAsn: 1.991 ± 0.059	2.653ThrPro: 2.653 ± 0.055	2.239ThrGln: 2.239 ± 0.049	2.291ThrArg: 2.291 ± 0.051	3.187ThrSer: 3.187 ± 0.065	3.011ThrThr: 3.011 ± 0.086	4.126ThrVal: 4.126 ± 0.104	0.535ThrTrp: 0.535 ± 0.027	1.633ThrTyr: 1.633 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	5.536ValAla: 5.536 ± 0.092	0.712ValCys: 0.712 ± 0.032	3.578ValAsp: 3.578 ± 0.071	4.871ValGlu: 4.871 ± 0.087	2.872ValPhe: 2.872 ± 0.056	5.097ValGly: 5.097 ± 0.085	1.25ValHis: 1.25 ± 0.035	5.401ValIle: 5.401 ± 0.097	4.186ValLys: 4.186 ± 0.074	7.77ValLeu: 7.77 ± 0.105	1.739ValMet: 1.739 ± 0.043	3.007ValAsn: 3.007 ± 0.065	2.811ValPro: 2.811 ± 0.073	2.737ValGln: 2.737 ± 0.059	3.076ValArg: 3.076 ± 0.059	4.448ValSer: 4.448 ± 0.085	3.965ValThr: 3.965 ± 0.109	5.28ValVal: 5.28 ± 0.097	0.668ValTrp: 0.668 ± 0.031	2.128ValTyr: 2.128 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.754TrpAla: 0.754 ± 0.03	0.09TrpCys: 0.09 ± 0.01	0.496TrpAsp: 0.496 ± 0.022	0.751TrpGlu: 0.751 ± 0.027	0.405TrpPhe: 0.405 ± 0.023	0.821TrpGly: 0.821 ± 0.032	0.208TrpHis: 0.208 ± 0.015	0.757TrpIle: 0.757 ± 0.033	0.68TrpLys: 0.68 ± 0.03	1.055TrpLeu: 1.055 ± 0.037	0.279TrpMet: 0.279 ± 0.019	0.489TrpAsn: 0.489 ± 0.025	0.372TrpPro: 0.372 ± 0.022	0.515TrpGln: 0.515 ± 0.021	0.549TrpArg: 0.549 ± 0.026	0.606TrpSer: 0.606 ± 0.029	0.501TrpThr: 0.501 ± 0.024	0.824TrpVal: 0.824 ± 0.03	0.12TrpTrp: 0.12 ± 0.012	0.323TrpTyr: 0.323 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.173TyrAla: 2.173 ± 0.051	0.397TyrCys: 0.397 ± 0.022	1.59TyrAsp: 1.59 ± 0.048	1.955TyrGlu: 1.955 ± 0.049	1.604TyrPhe: 1.604 ± 0.044	2.407TyrGly: 2.407 ± 0.056	0.73TyrHis: 0.73 ± 0.031	2.128TyrIle: 2.128 ± 0.05	1.641TyrLys: 1.641 ± 0.047	3.481TyrLeu: 3.481 ± 0.06	0.617TyrMet: 0.617 ± 0.026	1.292TyrAsn: 1.292 ± 0.043	1.516TyrPro: 1.516 ± 0.039	1.491TyrGln: 1.491 ± 0.041	1.599TyrArg: 1.599 ± 0.046	2.049TyrSer: 2.049 ± 0.051	1.727TyrThr: 1.727 ± 0.049	1.926TyrVal: 1.926 ± 0.049	0.39TyrTrp: 0.39 ± 0.02	1.181TyrTyr: 1.181 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3029 proteins (896991 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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