Amino acid dipepetide frequency for Planctomycetaceae bacterium SCGC AG-212-D15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.172AlaAla: 13.172 ± 0.264
1.489AlaCys: 1.489 ± 0.064
5.996AlaAsp: 5.996 ± 0.121
6.646AlaGlu: 6.646 ± 0.17
3.863AlaPhe: 3.863 ± 0.103
9.089AlaGly: 9.089 ± 0.153
2.009AlaHis: 2.009 ± 0.074
4.918AlaIle: 4.918 ± 0.142
4.375AlaLys: 4.375 ± 0.144
11.178AlaLeu: 11.178 ± 0.217
2.384AlaMet: 2.384 ± 0.089
2.831AlaAsn: 2.831 ± 0.104
5.234AlaPro: 5.234 ± 0.139
3.263AlaGln: 3.263 ± 0.107
7.92AlaArg: 7.92 ± 0.163
5.466AlaSer: 5.466 ± 0.137
5.443AlaThr: 5.443 ± 0.12
8.218AlaVal: 8.218 ± 0.187
1.701AlaTrp: 1.701 ± 0.079
2.387AlaTyr: 2.387 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
1.133CysAla: 1.133 ± 0.058
0.31CysCys: 0.31 ± 0.032
0.688CysAsp: 0.688 ± 0.04
0.68CysGlu: 0.68 ± 0.044
0.512CysPhe: 0.512 ± 0.036
1.161CysGly: 1.161 ± 0.061
0.409CysHis: 0.409 ± 0.037
0.525CysIle: 0.525 ± 0.037
0.398CysLys: 0.398 ± 0.033
1.476CysLeu: 1.476 ± 0.069
0.251CysMet: 0.251 ± 0.024
0.357CysAsn: 0.357 ± 0.028
0.833CysPro: 0.833 ± 0.058
0.515CysGln: 0.515 ± 0.035
1.096CysArg: 1.096 ± 0.057
0.621CysSer: 0.621 ± 0.041
0.613CysThr: 0.613 ± 0.04
0.864CysVal: 0.864 ± 0.049
0.308CysTrp: 0.308 ± 0.034
0.401CysTyr: 0.401 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
5.826AspAla: 5.826 ± 0.129
0.649AspCys: 0.649 ± 0.043
3.196AspAsp: 3.196 ± 0.108
3.354AspGlu: 3.354 ± 0.1
2.082AspPhe: 2.082 ± 0.079
5.425AspGly: 5.425 ± 0.168
1.342AspHis: 1.342 ± 0.066
2.169AspIle: 2.169 ± 0.071
2.307AspLys: 2.307 ± 0.113
5.885AspLeu: 5.885 ± 0.13
1.114AspMet: 1.114 ± 0.057
1.345AspAsn: 1.345 ± 0.059
3.524AspPro: 3.524 ± 0.108
1.743AspGln: 1.743 ± 0.075
4.106AspArg: 4.106 ± 0.103
2.42AspSer: 2.42 ± 0.085
2.167AspThr: 2.167 ± 0.076
3.992AspVal: 3.992 ± 0.103
0.98AspTrp: 0.98 ± 0.048
1.575AspTyr: 1.575 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
6.547GluAla: 6.547 ± 0.157
0.641GluCys: 0.641 ± 0.042
2.692GluAsp: 2.692 ± 0.092
3.77GluGlu: 3.77 ± 0.118
1.937GluPhe: 1.937 ± 0.071
4.052GluGly: 4.052 ± 0.107
1.339GluHis: 1.339 ± 0.063
2.694GluIle: 2.694 ± 0.095
3.087GluLys: 3.087 ± 0.117
6.234GluLeu: 6.234 ± 0.135
1.515GluMet: 1.515 ± 0.058
1.412GluAsn: 1.412 ± 0.062
3.007GluPro: 3.007 ± 0.105
2.529GluGln: 2.529 ± 0.091
5.151GluArg: 5.151 ± 0.138
2.775GluSer: 2.775 ± 0.084
2.873GluThr: 2.873 ± 0.091
4.401GluVal: 4.401 ± 0.111
0.936GluTrp: 0.936 ± 0.057
1.376GluTyr: 1.376 ± 0.061
0.0GluXaa: 0.0 ± 0.0
Phe
3.791PheAla: 3.791 ± 0.109
0.509PheCys: 0.509 ± 0.043
2.34PheAsp: 2.34 ± 0.08
1.976PheGlu: 1.976 ± 0.074
1.466PhePhe: 1.466 ± 0.063
3.268PheGly: 3.268 ± 0.105
0.84PheHis: 0.84 ± 0.048
1.332PheIle: 1.332 ± 0.064
1.143PheLys: 1.143 ± 0.05
3.755PheLeu: 3.755 ± 0.103
0.649PheMet: 0.649 ± 0.042
1.055PheAsn: 1.055 ± 0.056
1.67PhePro: 1.67 ± 0.065
1.264PheGln: 1.264 ± 0.052
2.669PheArg: 2.669 ± 0.078
2.082PheSer: 2.082 ± 0.093
2.012PheThr: 2.012 ± 0.079
2.821PheVal: 2.821 ± 0.102
0.613PheTrp: 0.613 ± 0.043
0.908PheTyr: 0.908 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
7.253GlyAla: 7.253 ± 0.154
1.381GlyCys: 1.381 ± 0.06
4.083GlyAsp: 4.083 ± 0.112
4.479GlyGlu: 4.479 ± 0.107
3.041GlyPhe: 3.041 ± 0.085
6.609GlyGly: 6.609 ± 0.197
1.97GlyHis: 1.97 ± 0.081
3.687GlyIle: 3.687 ± 0.102
4.724GlyLys: 4.724 ± 0.171
7.863GlyLeu: 7.863 ± 0.182
1.996GlyMet: 1.996 ± 0.074
2.49GlyAsn: 2.49 ± 0.16
3.788GlyPro: 3.788 ± 0.106
2.855GlyGln: 2.855 ± 0.08
5.89GlyArg: 5.89 ± 0.119
4.634GlySer: 4.634 ± 0.132
4.398GlyThr: 4.398 ± 0.145
5.51GlyVal: 5.51 ± 0.117
1.626GlyTrp: 1.626 ± 0.07
2.219GlyTyr: 2.219 ± 0.087
0.0GlyXaa: 0.0 ± 0.0
His
2.224HisAla: 2.224 ± 0.087
0.406HisCys: 0.406 ± 0.035
1.44HisAsp: 1.44 ± 0.058
1.275HisGlu: 1.275 ± 0.053
1.019HisPhe: 1.019 ± 0.048
2.069HisGly: 2.069 ± 0.072
0.809HisHis: 0.809 ± 0.069
0.884HisIle: 0.884 ± 0.044
0.677HisLys: 0.677 ± 0.048
2.503HisLeu: 2.503 ± 0.094
0.321HisMet: 0.321 ± 0.029
0.546HisAsn: 0.546 ± 0.038
1.523HisPro: 1.523 ± 0.057
0.721HisGln: 0.721 ± 0.045
1.694HisArg: 1.694 ± 0.074
1.138HisSer: 1.138 ± 0.056
1.058HisThr: 1.058 ± 0.059
1.681HisVal: 1.681 ± 0.067
0.385HisTrp: 0.385 ± 0.028
0.693HisTyr: 0.693 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
4.903IleAla: 4.903 ± 0.126
0.608IleCys: 0.608 ± 0.045
2.873IleAsp: 2.873 ± 0.09
2.79IleGlu: 2.79 ± 0.09
1.44IlePhe: 1.44 ± 0.056
3.788IleGly: 3.788 ± 0.103
1.073IleHis: 1.073 ± 0.051
1.722IleIle: 1.722 ± 0.077
1.626IleLys: 1.626 ± 0.077
4.375IleLeu: 4.375 ± 0.121
0.758IleMet: 0.758 ± 0.049
1.14IleAsn: 1.14 ± 0.065
2.369IlePro: 2.369 ± 0.08
1.365IleGln: 1.365 ± 0.06
3.168IleArg: 3.168 ± 0.093
2.144IleSer: 2.144 ± 0.094
2.221IleThr: 2.221 ± 0.104
3.486IleVal: 3.486 ± 0.107
0.667IleTrp: 0.667 ± 0.041
1.091IleTyr: 1.091 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.264LysAla: 4.264 ± 0.152
0.424LysCys: 0.424 ± 0.033
2.563LysAsp: 2.563 ± 0.124
2.79LysGlu: 2.79 ± 0.12
1.068LysPhe: 1.068 ± 0.055
2.961LysGly: 2.961 ± 0.112
0.959LysHis: 0.959 ± 0.056
1.895LysIle: 1.895 ± 0.085
2.237LysLys: 2.237 ± 0.108
3.918LysLeu: 3.918 ± 0.126
1.213LysMet: 1.213 ± 0.069
1.272LysAsn: 1.272 ± 0.063
2.873LysPro: 2.873 ± 0.107
1.601LysGln: 1.601 ± 0.068
2.829LysArg: 2.829 ± 0.096
1.97LysSer: 1.97 ± 0.075
2.172LysThr: 2.172 ± 0.097
2.966LysVal: 2.966 ± 0.106
0.577LysTrp: 0.577 ± 0.038
0.996LysTyr: 0.996 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
13.043LeuAla: 13.043 ± 0.251
1.378LeuCys: 1.378 ± 0.062
5.769LeuAsp: 5.769 ± 0.137
5.867LeuGlu: 5.867 ± 0.13
3.543LeuPhe: 3.543 ± 0.096
7.894LeuGly: 7.894 ± 0.167
2.195LeuHis: 2.195 ± 0.07
4.435LeuIle: 4.435 ± 0.111
4.096LeuLys: 4.096 ± 0.108
11.212LeuLeu: 11.212 ± 0.24
1.888LeuMet: 1.888 ± 0.066
2.666LeuAsn: 2.666 ± 0.079
6.017LeuPro: 6.017 ± 0.123
3.442LeuGln: 3.442 ± 0.11
7.701LeuArg: 7.701 ± 0.172
5.606LeuSer: 5.606 ± 0.121
5.658LeuThr: 5.658 ± 0.137
7.732LeuVal: 7.732 ± 0.138
1.505LeuTrp: 1.505 ± 0.066
2.198LeuTyr: 2.198 ± 0.082
0.0LeuXaa: 0.0 ± 0.0
Met
2.322MetAla: 2.322 ± 0.078
0.246MetCys: 0.246 ± 0.024
1.058MetAsp: 1.058 ± 0.057
1.073MetGlu: 1.073 ± 0.048
0.649MetPhe: 0.649 ± 0.039
1.469MetGly: 1.469 ± 0.07
0.473MetHis: 0.473 ± 0.037
1.042MetIle: 1.042 ± 0.057
0.998MetLys: 0.998 ± 0.053
2.149MetLeu: 2.149 ± 0.072
0.551MetMet: 0.551 ± 0.04
0.874MetAsn: 0.874 ± 0.049
1.513MetPro: 1.513 ± 0.065
0.711MetGln: 0.711 ± 0.043
1.518MetArg: 1.518 ± 0.063
1.345MetSer: 1.345 ± 0.055
1.339MetThr: 1.339 ± 0.058
1.588MetVal: 1.588 ± 0.076
0.243MetTrp: 0.243 ± 0.023
0.349MetTyr: 0.349 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.632AsnAla: 2.632 ± 0.078
0.339AsnCys: 0.339 ± 0.027
1.484AsnAsp: 1.484 ± 0.076
1.337AsnGlu: 1.337 ± 0.063
1.068AsnPhe: 1.068 ± 0.058
2.586AsnGly: 2.586 ± 0.11
0.693AsnHis: 0.693 ± 0.046
1.257AsnIle: 1.257 ± 0.06
0.921AsnLys: 0.921 ± 0.048
2.808AsnLeu: 2.808 ± 0.108
0.486AsnMet: 0.486 ± 0.035
0.957AsnAsn: 0.957 ± 0.063
2.082AsnPro: 2.082 ± 0.084
1.091AsnGln: 1.091 ± 0.055
2.097AsnArg: 2.097 ± 0.077
1.293AsnSer: 1.293 ± 0.057
1.319AsnThr: 1.319 ± 0.097
1.957AsnVal: 1.957 ± 0.095
0.504AsnTrp: 0.504 ± 0.037
0.84AsnTyr: 0.84 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
6.912ProAla: 6.912 ± 0.168
0.546ProCys: 0.546 ± 0.044
3.729ProAsp: 3.729 ± 0.11
4.016ProGlu: 4.016 ± 0.12
1.815ProPhe: 1.815 ± 0.072
4.657ProGly: 4.657 ± 0.124
1.107ProHis: 1.107 ± 0.05
2.351ProIle: 2.351 ± 0.09
2.389ProLys: 2.389 ± 0.114
5.071ProLeu: 5.071 ± 0.125
1.171ProMet: 1.171 ± 0.05
1.642ProAsn: 1.642 ± 0.073
3.91ProPro: 3.91 ± 0.149
1.676ProGln: 1.676 ± 0.069
3.501ProArg: 3.501 ± 0.09
3.343ProSer: 3.343 ± 0.089
3.137ProThr: 3.137 ± 0.099
4.101ProVal: 4.101 ± 0.119
0.918ProTrp: 0.918 ± 0.053
1.239ProTyr: 1.239 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
4.28GlnAla: 4.28 ± 0.118
0.37GlnCys: 0.37 ± 0.034
1.564GlnAsp: 1.564 ± 0.07
2.012GlnGlu: 2.012 ± 0.084
1.246GlnPhe: 1.246 ± 0.049
2.389GlnGly: 2.389 ± 0.073
0.939GlnHis: 0.939 ± 0.058
1.536GlnIle: 1.536 ± 0.059
1.471GlnLys: 1.471 ± 0.06
3.385GlnLeu: 3.385 ± 0.105
0.861GlnMet: 0.861 ± 0.05
0.817GlnAsn: 0.817 ± 0.044
2.079GlnPro: 2.079 ± 0.082
1.368GlnGln: 1.368 ± 0.087
2.775GlnArg: 2.775 ± 0.086
1.82GlnSer: 1.82 ± 0.07
1.774GlnThr: 1.774 ± 0.07
2.645GlnVal: 2.645 ± 0.081
0.528GlnTrp: 0.528 ± 0.036
0.752GlnTyr: 0.752 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
6.93ArgAla: 6.93 ± 0.161
0.913ArgCys: 0.913 ± 0.046
3.987ArgAsp: 3.987 ± 0.104
4.644ArgGlu: 4.644 ± 0.128
3.124ArgPhe: 3.124 ± 0.096
5.042ArgGly: 5.042 ± 0.108
1.924ArgHis: 1.924 ± 0.081
3.452ArgIle: 3.452 ± 0.09
3.077ArgLys: 3.077 ± 0.081
8.502ArgLeu: 8.502 ± 0.147
1.756ArgMet: 1.756 ± 0.062
1.88ArgAsn: 1.88 ± 0.071
3.907ArgPro: 3.907 ± 0.102
3.002ArgGln: 3.002 ± 0.1
6.689ArgArg: 6.689 ± 0.161
4.106ArgSer: 4.106 ± 0.101
3.47ArgThr: 3.47 ± 0.098
5.089ArgVal: 5.089 ± 0.12
1.42ArgTrp: 1.42 ± 0.065
2.014ArgTyr: 2.014 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
5.459SerAla: 5.459 ± 0.134
0.724SerCys: 0.724 ± 0.048
2.813SerAsp: 2.813 ± 0.083
2.8SerGlu: 2.8 ± 0.086
1.963SerPhe: 1.963 ± 0.076
5.009SerGly: 5.009 ± 0.136
1.13SerHis: 1.13 ± 0.047
2.451SerIle: 2.451 ± 0.088
1.841SerLys: 1.841 ± 0.074
5.428SerLeu: 5.428 ± 0.117
1.257SerMet: 1.257 ± 0.056
1.611SerAsn: 1.611 ± 0.079
3.369SerPro: 3.369 ± 0.111
1.655SerGln: 1.655 ± 0.065
3.698SerArg: 3.698 ± 0.091
3.514SerSer: 3.514 ± 0.209
2.614SerThr: 2.614 ± 0.073
4.005SerVal: 4.005 ± 0.118
0.946SerTrp: 0.946 ± 0.052
1.293SerTyr: 1.293 ± 0.086
0.0SerXaa: 0.0 ± 0.0
Thr
5.216ThrAla: 5.216 ± 0.115
0.631ThrCys: 0.631 ± 0.039
2.728ThrAsp: 2.728 ± 0.091
2.656ThrGlu: 2.656 ± 0.077
2.084ThrPhe: 2.084 ± 0.077
4.61ThrGly: 4.61 ± 0.123
1.14ThrHis: 1.14 ± 0.052
2.389ThrIle: 2.389 ± 0.081
1.802ThrLys: 1.802 ± 0.083
5.353ThrLeu: 5.353 ± 0.108
1.05ThrMet: 1.05 ± 0.045
1.433ThrAsn: 1.433 ± 0.079
3.385ThrPro: 3.385 ± 0.1
1.629ThrGln: 1.629 ± 0.083
3.356ThrArg: 3.356 ± 0.115
2.95ThrSer: 2.95 ± 0.12
2.901ThrThr: 2.901 ± 0.148
3.93ThrVal: 3.93 ± 0.101
0.696ThrTrp: 0.696 ± 0.043
1.474ThrTyr: 1.474 ± 0.094
0.0ThrXaa: 0.0 ± 0.0
Val
8.13ValAla: 8.13 ± 0.161
1.024ValCys: 1.024 ± 0.057
3.602ValAsp: 3.602 ± 0.112
4.636ValGlu: 4.636 ± 0.116
2.609ValPhe: 2.609 ± 0.076
5.451ValGly: 5.451 ± 0.126
1.598ValHis: 1.598 ± 0.061
3.362ValIle: 3.362 ± 0.093
2.857ValLys: 2.857 ± 0.101
7.949ValLeu: 7.949 ± 0.177
1.492ValMet: 1.492 ± 0.056
1.999ValAsn: 1.999 ± 0.083
4.104ValPro: 4.104 ± 0.108
2.433ValGln: 2.433 ± 0.085
5.616ValArg: 5.616 ± 0.122
3.925ValSer: 3.925 ± 0.112
4.083ValThr: 4.083 ± 0.113
6.258ValVal: 6.258 ± 0.152
1.151ValTrp: 1.151 ± 0.061
1.761ValTyr: 1.761 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
1.272TrpAla: 1.272 ± 0.059
0.217TrpCys: 0.217 ± 0.022
1.058TrpAsp: 1.058 ± 0.069
0.846TrpGlu: 0.846 ± 0.045
0.621TrpPhe: 0.621 ± 0.043
1.034TrpGly: 1.034 ± 0.053
0.463TrpHis: 0.463 ± 0.035
0.685TrpIle: 0.685 ± 0.041
0.729TrpLys: 0.729 ± 0.044
2.051TrpLeu: 2.051 ± 0.088
0.421TrpMet: 0.421 ± 0.031
0.631TrpAsn: 0.631 ± 0.034
0.817TrpPro: 0.817 ± 0.048
0.763TrpGln: 0.763 ± 0.055
1.226TrpArg: 1.226 ± 0.069
0.946TrpSer: 0.946 ± 0.053
0.931TrpThr: 0.931 ± 0.058
1.068TrpVal: 1.068 ± 0.053
0.303TrpTrp: 0.303 ± 0.03
0.424TrpTyr: 0.424 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.278TyrAla: 2.278 ± 0.074
0.344TyrCys: 0.344 ± 0.029
1.539TyrAsp: 1.539 ± 0.137
1.324TyrGlu: 1.324 ± 0.061
1.014TyrPhe: 1.014 ± 0.049
1.937TyrGly: 1.937 ± 0.069
0.652TyrHis: 0.652 ± 0.04
0.82TyrIle: 0.82 ± 0.042
0.789TyrLys: 0.789 ± 0.052
2.749TyrLeu: 2.749 ± 0.078
0.372TyrMet: 0.372 ± 0.029
0.794TyrAsn: 0.794 ± 0.065
1.226TyrPro: 1.226 ± 0.054
0.985TyrGln: 0.985 ± 0.064
2.229TyrArg: 2.229 ± 0.087
1.482TyrSer: 1.482 ± 0.072
1.231TyrThr: 1.231 ± 0.07
1.727TyrVal: 1.727 ± 0.066
0.499TyrTrp: 0.499 ± 0.036
0.815TyrTyr: 0.815 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1256 proteins (386727 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski