Amino acid dipepetide frequency for Fulvivirga sp. M361

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.425AlaAla: 4.425 ± 0.058
0.596AlaCys: 0.596 ± 0.016
3.667AlaAsp: 3.667 ± 0.046
3.934AlaGlu: 3.934 ± 0.046
3.297AlaPhe: 3.297 ± 0.035
4.725AlaGly: 4.725 ± 0.054
1.152AlaHis: 1.152 ± 0.024
4.755AlaIle: 4.755 ± 0.053
3.507AlaLys: 3.507 ± 0.047
6.54AlaLeu: 6.54 ± 0.065
1.489AlaMet: 1.489 ± 0.029
3.143AlaAsn: 3.143 ± 0.043
2.09AlaPro: 2.09 ± 0.034
2.372AlaGln: 2.372 ± 0.037
2.633AlaArg: 2.633 ± 0.038
4.44AlaSer: 4.44 ± 0.052
3.667AlaThr: 3.667 ± 0.051
4.061AlaVal: 4.061 ± 0.045
0.789AlaTrp: 0.789 ± 0.019
2.618AlaTyr: 2.618 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.427CysAla: 0.427 ± 0.015
0.12CysCys: 0.12 ± 0.008
0.457CysAsp: 0.457 ± 0.017
0.453CysGlu: 0.453 ± 0.015
0.364CysPhe: 0.364 ± 0.015
0.558CysGly: 0.558 ± 0.018
0.201CysHis: 0.201 ± 0.01
0.532CysIle: 0.532 ± 0.016
0.382CysLys: 0.382 ± 0.013
0.71CysLeu: 0.71 ± 0.016
0.168CysMet: 0.168 ± 0.009
0.351CysAsn: 0.351 ± 0.013
0.294CysPro: 0.294 ± 0.012
0.276CysGln: 0.276 ± 0.01
0.285CysArg: 0.285 ± 0.012
0.564CysSer: 0.564 ± 0.022
0.429CysThr: 0.429 ± 0.017
0.409CysVal: 0.409 ± 0.013
0.098CysTrp: 0.098 ± 0.007
0.287CysTyr: 0.287 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
3.57AspAla: 3.57 ± 0.048
0.383AspCys: 0.383 ± 0.012
3.269AspAsp: 3.269 ± 0.052
3.842AspGlu: 3.842 ± 0.047
3.534AspPhe: 3.534 ± 0.038
4.175AspGly: 4.175 ± 0.066
1.398AspHis: 1.398 ± 0.024
4.497AspIle: 4.497 ± 0.043
3.574AspLys: 3.574 ± 0.047
5.871AspLeu: 5.871 ± 0.06
1.22AspMet: 1.22 ± 0.025
3.201AspAsn: 3.201 ± 0.041
2.622AspPro: 2.622 ± 0.039
2.417AspGln: 2.417 ± 0.037
2.497AspArg: 2.497 ± 0.035
3.169AspSer: 3.169 ± 0.051
2.814AspThr: 2.814 ± 0.036
3.614AspVal: 3.614 ± 0.051
0.889AspTrp: 0.889 ± 0.019
2.694AspTyr: 2.694 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
4.405GluAla: 4.405 ± 0.051
0.362GluCys: 0.362 ± 0.015
3.654GluAsp: 3.654 ± 0.046
4.917GluGlu: 4.917 ± 0.061
2.755GluPhe: 2.755 ± 0.038
4.255GluGly: 4.255 ± 0.047
1.233GluHis: 1.233 ± 0.027
4.856GluIle: 4.856 ± 0.05
4.957GluLys: 4.957 ± 0.063
6.433GluLeu: 6.433 ± 0.057
1.607GluMet: 1.607 ± 0.024
3.896GluAsn: 3.896 ± 0.046
1.846GluPro: 1.846 ± 0.029
2.432GluGln: 2.432 ± 0.036
2.871GluArg: 2.871 ± 0.038
3.608GluSer: 3.608 ± 0.042
3.233GluThr: 3.233 ± 0.042
4.871GluVal: 4.871 ± 0.05
0.777GluTrp: 0.777 ± 0.018
2.419GluTyr: 2.419 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
2.637PheAla: 2.637 ± 0.036
0.405PheCys: 0.405 ± 0.013
3.484PheAsp: 3.484 ± 0.041
3.327PheGlu: 3.327 ± 0.041
2.687PhePhe: 2.687 ± 0.043
3.44PheGly: 3.44 ± 0.047
0.951PheHis: 0.951 ± 0.021
3.544PheIle: 3.544 ± 0.046
2.949PheLys: 2.949 ± 0.042
4.466PheLeu: 4.466 ± 0.052
1.087PheMet: 1.087 ± 0.024
3.105PheAsn: 3.105 ± 0.044
1.718PhePro: 1.718 ± 0.029
1.672PheGln: 1.672 ± 0.028
2.084PheArg: 2.084 ± 0.031
4.053PheSer: 4.053 ± 0.047
3.072PheThr: 3.072 ± 0.038
2.812PheVal: 2.812 ± 0.04
0.627PheTrp: 0.627 ± 0.019
2.116PheTyr: 2.116 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
4.383GlyAla: 4.383 ± 0.057
0.644GlyCys: 0.644 ± 0.021
3.825GlyAsp: 3.825 ± 0.057
4.042GlyGlu: 4.042 ± 0.041
3.642GlyPhe: 3.642 ± 0.042
4.903GlyGly: 4.903 ± 0.06
1.257GlyHis: 1.257 ± 0.026
5.277GlyIle: 5.277 ± 0.049
4.579GlyLys: 4.579 ± 0.056
6.307GlyLeu: 6.307 ± 0.057
1.609GlyMet: 1.609 ± 0.029
3.82GlyAsn: 3.82 ± 0.053
1.806GlyPro: 1.806 ± 0.035
2.505GlyGln: 2.505 ± 0.036
2.806GlyArg: 2.806 ± 0.035
4.598GlySer: 4.598 ± 0.057
4.38GlyThr: 4.38 ± 0.07
4.584GlyVal: 4.584 ± 0.051
0.966GlyTrp: 0.966 ± 0.021
2.983GlyTyr: 2.983 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
1.093HisAla: 1.093 ± 0.026
0.165HisCys: 0.165 ± 0.008
1.028HisAsp: 1.028 ± 0.022
1.169HisGlu: 1.169 ± 0.025
1.239HisPhe: 1.239 ± 0.025
1.223HisGly: 1.223 ± 0.022
0.587HisHis: 0.587 ± 0.017
1.34HisIle: 1.34 ± 0.023
1.088HisLys: 1.088 ± 0.024
2.044HisLeu: 2.044 ± 0.036
0.411HisMet: 0.411 ± 0.014
0.881HisAsn: 0.881 ± 0.021
0.98HisPro: 0.98 ± 0.022
0.802HisGln: 0.802 ± 0.017
0.868HisArg: 0.868 ± 0.019
1.225HisSer: 1.225 ± 0.023
1.05HisThr: 1.05 ± 0.02
1.085HisVal: 1.085 ± 0.021
0.32HisTrp: 0.32 ± 0.011
0.957HisTyr: 0.957 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
4.781IleAla: 4.781 ± 0.046
0.587IleCys: 0.587 ± 0.017
4.58IleAsp: 4.58 ± 0.049
4.806IleGlu: 4.806 ± 0.052
3.089IlePhe: 3.089 ± 0.04
4.904IleGly: 4.904 ± 0.05
1.489IleHis: 1.489 ± 0.025
4.813IleIle: 4.813 ± 0.065
4.523IleLys: 4.523 ± 0.058
6.077IleLeu: 6.077 ± 0.058
1.351IleMet: 1.351 ± 0.023
4.028IleAsn: 4.028 ± 0.045
2.934IlePro: 2.934 ± 0.041
2.431IleGln: 2.431 ± 0.032
3.215IleArg: 3.215 ± 0.035
5.374IleSer: 5.374 ± 0.052
4.715IleThr: 4.715 ± 0.06
4.182IleVal: 4.182 ± 0.045
0.718IleTrp: 0.718 ± 0.02
2.593IleTyr: 2.593 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.311LysAla: 4.311 ± 0.051
0.324LysCys: 0.324 ± 0.012
3.667LysAsp: 3.667 ± 0.043
5.051LysGlu: 5.051 ± 0.063
2.253LysPhe: 2.253 ± 0.031
4.151LysGly: 4.151 ± 0.051
1.165LysHis: 1.165 ± 0.024
4.452LysIle: 4.452 ± 0.053
5.197LysLys: 5.197 ± 0.066
5.548LysLeu: 5.548 ± 0.061
1.642LysMet: 1.642 ± 0.031
3.58LysAsn: 3.58 ± 0.045
2.167LysPro: 2.167 ± 0.034
2.133LysGln: 2.133 ± 0.032
2.821LysArg: 2.821 ± 0.039
3.893LysSer: 3.893 ± 0.043
3.507LysThr: 3.507 ± 0.04
4.446LysVal: 4.446 ± 0.05
0.798LysTrp: 0.798 ± 0.019
2.555LysTyr: 2.555 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
6.113LeuAla: 6.113 ± 0.058
0.689LeuCys: 0.689 ± 0.017
5.336LeuAsp: 5.336 ± 0.052
6.101LeuGlu: 6.101 ± 0.054
4.677LeuPhe: 4.677 ± 0.058
5.945LeuGly: 5.945 ± 0.059
1.614LeuHis: 1.614 ± 0.028
6.603LeuIle: 6.603 ± 0.068
6.767LeuLys: 6.767 ± 0.064
8.984LeuLeu: 8.984 ± 0.091
2.14LeuMet: 2.14 ± 0.034
5.396LeuAsn: 5.396 ± 0.054
3.864LeuPro: 3.864 ± 0.04
3.183LeuGln: 3.183 ± 0.044
3.787LeuArg: 3.787 ± 0.038
7.509LeuSer: 7.509 ± 0.06
5.768LeuThr: 5.768 ± 0.055
5.569LeuVal: 5.569 ± 0.056
1.018LeuTrp: 1.018 ± 0.025
3.337LeuTyr: 3.337 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
1.707MetAla: 1.707 ± 0.028
0.125MetCys: 0.125 ± 0.008
1.359MetAsp: 1.359 ± 0.024
1.485MetGlu: 1.485 ± 0.027
0.774MetPhe: 0.774 ± 0.019
1.439MetGly: 1.439 ± 0.028
0.421MetHis: 0.421 ± 0.012
1.508MetIle: 1.508 ± 0.025
1.936MetLys: 1.936 ± 0.03
1.926MetLeu: 1.926 ± 0.035
0.562MetMet: 0.562 ± 0.017
1.2MetAsn: 1.2 ± 0.024
0.857MetPro: 0.857 ± 0.017
0.736MetGln: 0.736 ± 0.019
0.957MetArg: 0.957 ± 0.021
1.415MetSer: 1.415 ± 0.026
1.236MetThr: 1.236 ± 0.024
1.485MetVal: 1.485 ± 0.024
0.166MetTrp: 0.166 ± 0.007
0.644MetTyr: 0.644 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.544AsnAla: 3.544 ± 0.042
0.372AsnCys: 0.372 ± 0.015
3.303AsnAsp: 3.303 ± 0.047
3.46AsnGlu: 3.46 ± 0.04
2.6AsnPhe: 2.6 ± 0.035
4.157AsnGly: 4.157 ± 0.06
1.046AsnHis: 1.046 ± 0.022
3.931AsnIle: 3.931 ± 0.044
3.049AsnLys: 3.049 ± 0.036
4.786AsnLeu: 4.786 ± 0.049
1.093AsnMet: 1.093 ± 0.021
3.097AsnAsn: 3.097 ± 0.052
2.599AsnPro: 2.599 ± 0.039
1.967AsnGln: 1.967 ± 0.029
2.385AsnArg: 2.385 ± 0.032
3.439AsnSer: 3.439 ± 0.044
3.47AsnThr: 3.47 ± 0.044
3.469AsnVal: 3.469 ± 0.047
0.772AsnTrp: 0.772 ± 0.018
2.497AsnTyr: 2.497 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
2.434ProAla: 2.434 ± 0.04
0.199ProCys: 0.199 ± 0.01
2.827ProAsp: 2.827 ± 0.042
3.095ProGlu: 3.095 ± 0.039
1.972ProPhe: 1.972 ± 0.033
3.008ProGly: 3.008 ± 0.038
0.702ProHis: 0.702 ± 0.021
2.28ProIle: 2.28 ± 0.035
1.926ProLys: 1.926 ± 0.032
3.237ProLeu: 3.237 ± 0.037
0.728ProMet: 0.728 ± 0.018
1.976ProAsn: 1.976 ± 0.032
1.131ProPro: 1.131 ± 0.025
1.177ProGln: 1.177 ± 0.024
1.212ProArg: 1.212 ± 0.024
2.461ProSer: 2.461 ± 0.034
1.948ProThr: 1.948 ± 0.034
2.99ProVal: 2.99 ± 0.042
0.471ProTrp: 0.471 ± 0.016
1.42ProTyr: 1.42 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
2.304GlnAla: 2.304 ± 0.036
0.216GlnCys: 0.216 ± 0.009
1.865GlnAsp: 1.865 ± 0.029
2.332GlnGlu: 2.332 ± 0.034
1.679GlnPhe: 1.679 ± 0.028
2.196GlnGly: 2.196 ± 0.03
0.729GlnHis: 0.729 ± 0.016
2.257GlnIle: 2.257 ± 0.031
2.45GlnLys: 2.45 ± 0.04
3.782GlnLeu: 3.782 ± 0.043
0.847GlnMet: 0.847 ± 0.018
2.001GlnAsn: 2.001 ± 0.032
1.287GlnPro: 1.287 ± 0.025
1.538GlnGln: 1.538 ± 0.032
1.594GlnArg: 1.594 ± 0.029
2.266GlnSer: 2.266 ± 0.032
1.862GlnThr: 1.862 ± 0.029
2.447GlnVal: 2.447 ± 0.031
0.566GlnTrp: 0.566 ± 0.014
1.449GlnTyr: 1.449 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
2.439ArgAla: 2.439 ± 0.034
0.233ArgCys: 0.233 ± 0.009
2.234ArgAsp: 2.234 ± 0.032
2.639ArgGlu: 2.639 ± 0.039
2.348ArgPhe: 2.348 ± 0.035
2.282ArgGly: 2.282 ± 0.032
0.835ArgHis: 0.835 ± 0.017
3.162ArgIle: 3.162 ± 0.043
3.005ArgLys: 3.005 ± 0.043
4.274ArgLeu: 4.274 ± 0.046
1.047ArgMet: 1.047 ± 0.023
2.28ArgAsn: 2.28 ± 0.033
1.488ArgPro: 1.488 ± 0.024
1.582ArgGln: 1.582 ± 0.028
1.825ArgArg: 1.825 ± 0.032
2.881ArgSer: 2.881 ± 0.033
2.252ArgThr: 2.252 ± 0.033
2.651ArgVal: 2.651 ± 0.035
0.607ArgTrp: 0.607 ± 0.017
1.994ArgTyr: 1.994 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
4.235SerAla: 4.235 ± 0.048
0.615SerCys: 0.615 ± 0.019
4.029SerAsp: 4.029 ± 0.043
4.102SerGlu: 4.102 ± 0.04
3.984SerPhe: 3.984 ± 0.054
5.559SerGly: 5.559 ± 0.069
1.279SerHis: 1.279 ± 0.028
5.051SerIle: 5.051 ± 0.051
3.808SerLys: 3.808 ± 0.045
6.523SerLeu: 6.523 ± 0.061
1.424SerMet: 1.424 ± 0.027
3.539SerAsn: 3.539 ± 0.044
2.506SerPro: 2.506 ± 0.036
2.183SerGln: 2.183 ± 0.031
2.73SerArg: 2.73 ± 0.039
4.73SerSer: 4.73 ± 0.054
3.769SerThr: 3.769 ± 0.055
4.436SerVal: 4.436 ± 0.052
0.928SerTrp: 0.928 ± 0.021
2.876SerTyr: 2.876 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
3.799ThrAla: 3.799 ± 0.053
0.39ThrCys: 0.39 ± 0.015
3.562ThrAsp: 3.562 ± 0.048
3.378ThrGlu: 3.378 ± 0.042
3.108ThrPhe: 3.108 ± 0.041
4.59ThrGly: 4.59 ± 0.054
1.088ThrHis: 1.088 ± 0.023
4.303ThrIle: 4.303 ± 0.057
2.807ThrLys: 2.807 ± 0.036
5.67ThrLeu: 5.67 ± 0.053
0.987ThrMet: 0.987 ± 0.023
2.834ThrAsn: 2.834 ± 0.044
2.556ThrPro: 2.556 ± 0.038
1.875ThrGln: 1.875 ± 0.026
2.185ThrArg: 2.185 ± 0.029
4.188ThrSer: 4.188 ± 0.052
3.457ThrThr: 3.457 ± 0.052
4.0ThrVal: 4.0 ± 0.057
0.709ThrTrp: 0.709 ± 0.018
2.441ThrTyr: 2.441 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
4.065ValAla: 4.065 ± 0.042
0.501ValCys: 0.501 ± 0.016
3.722ValAsp: 3.722 ± 0.041
3.954ValGlu: 3.954 ± 0.04
3.353ValPhe: 3.353 ± 0.042
3.898ValGly: 3.898 ± 0.046
1.13ValHis: 1.13 ± 0.021
4.874ValIle: 4.874 ± 0.052
4.024ValLys: 4.024 ± 0.048
6.104ValLeu: 6.104 ± 0.061
1.412ValMet: 1.412 ± 0.026
3.726ValAsn: 3.726 ± 0.045
2.467ValPro: 2.467 ± 0.032
2.02ValGln: 2.02 ± 0.03
2.719ValArg: 2.719 ± 0.036
4.871ValSer: 4.871 ± 0.058
4.176ValThr: 4.176 ± 0.064
4.333ValVal: 4.333 ± 0.06
0.741ValTrp: 0.741 ± 0.019
2.417ValTyr: 2.417 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
0.708TrpAla: 0.708 ± 0.019
0.111TrpCys: 0.111 ± 0.007
0.776TrpAsp: 0.776 ± 0.02
0.832TrpGlu: 0.832 ± 0.019
0.566TrpPhe: 0.566 ± 0.015
0.832TrpGly: 0.832 ± 0.021
0.298TrpHis: 0.298 ± 0.012
0.807TrpIle: 0.807 ± 0.024
0.848TrpLys: 0.848 ± 0.022
1.193TrpLeu: 1.193 ± 0.027
0.359TrpMet: 0.359 ± 0.013
0.726TrpAsn: 0.726 ± 0.017
0.385TrpPro: 0.385 ± 0.012
0.564TrpGln: 0.564 ± 0.018
0.545TrpArg: 0.545 ± 0.014
0.874TrpSer: 0.874 ± 0.021
0.736TrpThr: 0.736 ± 0.022
0.832TrpVal: 0.832 ± 0.017
0.197TrpTrp: 0.197 ± 0.01
0.519TrpTyr: 0.519 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.522TyrAla: 2.522 ± 0.035
0.328TyrCys: 0.328 ± 0.012
2.604TyrAsp: 2.604 ± 0.045
2.467TyrGlu: 2.467 ± 0.033
2.313TyrPhe: 2.313 ± 0.037
2.677TyrGly: 2.677 ± 0.037
0.978TyrHis: 0.978 ± 0.022
2.351TyrIle: 2.351 ± 0.033
2.285TyrLys: 2.285 ± 0.03
3.924TyrLeu: 3.924 ± 0.043
0.756TyrMet: 0.756 ± 0.016
2.256TyrAsn: 2.256 ± 0.035
1.599TyrPro: 1.599 ± 0.03
1.803TyrGln: 1.803 ± 0.031
2.037TyrArg: 2.037 ± 0.033
2.747TyrSer: 2.747 ± 0.042
2.385TyrThr: 2.385 ± 0.033
2.234TyrVal: 2.234 ± 0.03
0.55TyrTrp: 0.55 ± 0.017
1.976TyrTyr: 1.976 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.001XaaPhe: 0.001 ± 0.001
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6272 proteins (2376036 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski