Amino acid dipepetide frequency for Thalassotalea sp. ND16A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.555AlaAla: 7.555 ± 0.115	0.917AlaCys: 0.917 ± 0.031	4.837AlaAsp: 4.837 ± 0.09	5.646AlaGlu: 5.646 ± 0.075	3.392AlaPhe: 3.392 ± 0.063	5.962AlaGly: 5.962 ± 0.088	1.569AlaHis: 1.569 ± 0.038	6.485AlaIle: 6.485 ± 0.08	5.564AlaLys: 5.564 ± 0.089	8.79AlaLeu: 8.79 ± 0.096	2.402AlaMet: 2.402 ± 0.042	4.423AlaAsn: 4.423 ± 0.061	2.692AlaPro: 2.692 ± 0.052	3.763AlaGln: 3.763 ± 0.068	3.091AlaArg: 3.091 ± 0.053	5.457AlaSer: 5.457 ± 0.073	4.839AlaThr: 4.839 ± 0.1	5.574AlaVal: 5.574 ± 0.086	0.921AlaTrp: 0.921 ± 0.031	2.344AlaTyr: 2.344 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.81CysAla: 0.81 ± 0.028	0.169CysCys: 0.169 ± 0.012	0.61CysAsp: 0.61 ± 0.024	0.52CysGlu: 0.52 ± 0.024	0.448CysPhe: 0.448 ± 0.022	0.834CysGly: 0.834 ± 0.033	0.423CysHis: 0.423 ± 0.049	0.649CysIle: 0.649 ± 0.026	0.473CysLys: 0.473 ± 0.017	0.995CysLeu: 0.995 ± 0.028	0.227CysMet: 0.227 ± 0.012	0.386CysAsn: 0.386 ± 0.015	0.441CysPro: 0.441 ± 0.018	0.555CysGln: 0.555 ± 0.02	0.416CysArg: 0.416 ± 0.019	0.768CysSer: 0.768 ± 0.028	0.484CysThr: 0.484 ± 0.021	0.576CysVal: 0.576 ± 0.021	0.119CysTrp: 0.119 ± 0.009	0.321CysTyr: 0.321 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.311AspAla: 4.311 ± 0.077	0.641AspCys: 0.641 ± 0.027	3.682AspAsp: 3.682 ± 0.085	3.745AspGlu: 3.745 ± 0.063	2.682AspPhe: 2.682 ± 0.049	4.061AspGly: 4.061 ± 0.12	1.119AspHis: 1.119 ± 0.037	4.552AspIle: 4.552 ± 0.06	3.585AspLys: 3.585 ± 0.059	5.153AspLeu: 5.153 ± 0.067	1.355AspMet: 1.355 ± 0.028	3.276AspAsn: 3.276 ± 0.073	1.891AspPro: 1.891 ± 0.049	1.822AspGln: 1.822 ± 0.035	1.95AspArg: 1.95 ± 0.045	3.586AspSer: 3.586 ± 0.062	2.633AspThr: 2.633 ± 0.063	3.863AspVal: 3.863 ± 0.059	0.802AspTrp: 0.802 ± 0.023	2.227AspTyr: 2.227 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	3.935GluAla: 3.935 ± 0.065	0.453GluCys: 0.453 ± 0.018	2.78GluAsp: 2.78 ± 0.049	3.048GluGlu: 3.048 ± 0.06	2.651GluPhe: 2.651 ± 0.046	3.018GluGly: 3.018 ± 0.061	1.612GluHis: 1.612 ± 0.035	3.978GluIle: 3.978 ± 0.062	3.572GluLys: 3.572 ± 0.058	6.714GluLeu: 6.714 ± 0.072	1.538GluMet: 1.538 ± 0.038	3.064GluAsn: 3.064 ± 0.046	1.843GluPro: 1.843 ± 0.05	4.78GluGln: 4.78 ± 0.067	2.554GluArg: 2.554 ± 0.044	3.275GluSer: 3.275 ± 0.055	2.852GluThr: 2.852 ± 0.051	3.906GluVal: 3.906 ± 0.063	0.552GluTrp: 0.552 ± 0.019	1.785GluTyr: 1.785 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.005PheAla: 4.005 ± 0.053	0.515PheCys: 0.515 ± 0.021	3.041PheAsp: 3.041 ± 0.058	2.366PheGlu: 2.366 ± 0.043	1.801PhePhe: 1.801 ± 0.043	3.052PheGly: 3.052 ± 0.052	0.874PheHis: 0.874 ± 0.027	3.342PheIle: 3.342 ± 0.062	2.282PheLys: 2.282 ± 0.047	3.453PheLeu: 3.453 ± 0.064	0.954PheMet: 0.954 ± 0.028	2.462PheAsn: 2.462 ± 0.041	1.423PhePro: 1.423 ± 0.035	1.283PheGln: 1.283 ± 0.03	1.415PheArg: 1.415 ± 0.03	3.758PheSer: 3.758 ± 0.054	2.54PheThr: 2.54 ± 0.048	2.762PheVal: 2.762 ± 0.049	0.524PheTrp: 0.524 ± 0.019	1.588PheTyr: 1.588 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.059GlyAla: 5.059 ± 0.082	0.817GlyCys: 0.817 ± 0.029	3.836GlyAsp: 3.836 ± 0.079	4.031GlyGlu: 4.031 ± 0.064	3.423GlyPhe: 3.423 ± 0.055	4.547GlyGly: 4.547 ± 0.082	1.406GlyHis: 1.406 ± 0.039	4.715GlyIle: 4.715 ± 0.058	4.133GlyLys: 4.133 ± 0.075	6.457GlyLeu: 6.457 ± 0.072	1.84GlyMet: 1.84 ± 0.045	3.146GlyAsn: 3.146 ± 0.07	1.601GlyPro: 1.601 ± 0.043	2.677GlyGln: 2.677 ± 0.057	2.588GlyArg: 2.588 ± 0.045	4.222GlySer: 4.222 ± 0.066	3.299GlyThr: 3.299 ± 0.067	4.77GlyVal: 4.77 ± 0.058	0.872GlyTrp: 0.872 ± 0.029	2.492GlyTyr: 2.492 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.485HisAla: 1.485 ± 0.033	0.345HisCys: 0.345 ± 0.02	1.106HisAsp: 1.106 ± 0.03	1.001HisGlu: 1.001 ± 0.028	1.113HisPhe: 1.113 ± 0.029	1.544HisGly: 1.544 ± 0.041	0.686HisHis: 0.686 ± 0.025	1.448HisIle: 1.448 ± 0.039	1.168HisLys: 1.168 ± 0.032	2.266HisLeu: 2.266 ± 0.046	0.474HisMet: 0.474 ± 0.019	1.034HisAsn: 1.034 ± 0.028	1.035HisPro: 1.035 ± 0.031	1.318HisGln: 1.318 ± 0.036	0.966HisArg: 0.966 ± 0.03	1.491HisSer: 1.491 ± 0.033	0.978HisThr: 0.978 ± 0.028	1.192HisVal: 1.192 ± 0.032	0.372HisTrp: 0.372 ± 0.016	0.884HisTyr: 0.884 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.859IleAla: 6.859 ± 0.091	0.773IleCys: 0.773 ± 0.026	4.703IleAsp: 4.703 ± 0.057	4.804IleGlu: 4.804 ± 0.055	2.63IlePhe: 2.63 ± 0.051	4.651IleGly: 4.651 ± 0.063	1.26IleHis: 1.26 ± 0.03	4.468IleIle: 4.468 ± 0.067	4.097IleLys: 4.097 ± 0.059	5.46IleLeu: 5.46 ± 0.08	1.332IleMet: 1.332 ± 0.031	3.974IleAsn: 3.974 ± 0.053	2.524IlePro: 2.524 ± 0.047	2.033IleGln: 2.033 ± 0.04	2.571IleArg: 2.571 ± 0.043	5.369IleSer: 5.369 ± 0.065	4.208IleThr: 4.208 ± 0.07	4.224IleVal: 4.224 ± 0.068	0.68IleTrp: 0.68 ± 0.023	1.865IleTyr: 1.865 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	5.204LysAla: 5.204 ± 0.087	0.365LysCys: 0.365 ± 0.021	2.928LysAsp: 2.928 ± 0.048	3.083LysGlu: 3.083 ± 0.06	2.113LysPhe: 2.113 ± 0.043	3.163LysGly: 3.163 ± 0.05	1.404LysHis: 1.404 ± 0.037	3.542LysIle: 3.542 ± 0.064	3.26LysLys: 3.26 ± 0.063	5.736LysLeu: 5.736 ± 0.075	1.45LysMet: 1.45 ± 0.031	2.77LysAsn: 2.77 ± 0.054	2.418LysPro: 2.418 ± 0.052	3.572LysGln: 3.572 ± 0.068	2.53LysArg: 2.53 ± 0.042	3.482LysSer: 3.482 ± 0.056	3.229LysThr: 3.229 ± 0.054	4.063LysVal: 4.063 ± 0.06	0.561LysTrp: 0.561 ± 0.022	1.681LysTyr: 1.681 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	10.241LeuAla: 10.241 ± 0.103	0.946LeuCys: 0.946 ± 0.025	5.269LeuAsp: 5.269 ± 0.071	5.214LeuGlu: 5.214 ± 0.068	4.323LeuPhe: 4.323 ± 0.065	6.182LeuGly: 6.182 ± 0.084	1.956LeuHis: 1.956 ± 0.045	6.637LeuIle: 6.637 ± 0.093	5.423LeuLys: 5.423 ± 0.072	10.59LeuLeu: 10.59 ± 0.148	2.502LeuMet: 2.502 ± 0.046	5.011LeuAsn: 5.011 ± 0.061	4.467LeuPro: 4.467 ± 0.062	3.895LeuGln: 3.895 ± 0.068	3.698LeuArg: 3.698 ± 0.059	7.803LeuSer: 7.803 ± 0.094	6.678LeuThr: 6.678 ± 0.083	6.502LeuVal: 6.502 ± 0.083	1.013LeuTrp: 1.013 ± 0.031	2.634LeuTyr: 2.634 ± 0.043	0.001LeuXaa: 0.001 ± 0.0
Met	2.424MetAla: 2.424 ± 0.048	0.191MetCys: 0.191 ± 0.01	1.108MetAsp: 1.108 ± 0.032	1.123MetGlu: 1.123 ± 0.031	0.965MetPhe: 0.965 ± 0.029	1.504MetGly: 1.504 ± 0.039	0.5MetHis: 0.5 ± 0.02	1.462MetIle: 1.462 ± 0.04	1.396MetLys: 1.396 ± 0.034	2.621MetLeu: 2.621 ± 0.051	0.697MetMet: 0.697 ± 0.028	1.166MetAsn: 1.166 ± 0.032	1.191MetPro: 1.191 ± 0.031	1.213MetGln: 1.213 ± 0.035	0.998MetArg: 0.998 ± 0.03	1.811MetSer: 1.811 ± 0.042	1.453MetThr: 1.453 ± 0.033	1.677MetVal: 1.677 ± 0.037	0.232MetTrp: 0.232 ± 0.013	0.534MetTyr: 0.534 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.851AsnAla: 3.851 ± 0.069	0.519AsnCys: 0.519 ± 0.022	2.932AsnAsp: 2.932 ± 0.071	2.834AsnGlu: 2.834 ± 0.053	2.068AsnPhe: 2.068 ± 0.042	3.439AsnGly: 3.439 ± 0.069	1.086AsnHis: 1.086 ± 0.031	3.67AsnIle: 3.67 ± 0.059	3.0AsnLys: 3.0 ± 0.06	4.657AsnLeu: 4.657 ± 0.062	1.092AsnMet: 1.092 ± 0.031	2.926AsnAsn: 2.926 ± 0.053	2.138AsnPro: 2.138 ± 0.04	2.235AsnGln: 2.235 ± 0.042	2.026AsnArg: 2.026 ± 0.037	3.381AsnSer: 3.381 ± 0.066	2.748AsnThr: 2.748 ± 0.054	3.112AsnVal: 3.112 ± 0.054	0.692AsnTrp: 0.692 ± 0.024	1.727AsnTyr: 1.727 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	3.006ProAla: 3.006 ± 0.056	0.323ProCys: 0.323 ± 0.018	2.15ProAsp: 2.15 ± 0.042	2.852ProGlu: 2.852 ± 0.059	1.655ProPhe: 1.655 ± 0.037	2.537ProGly: 2.537 ± 0.051	0.76ProHis: 0.76 ± 0.028	2.323ProIle: 2.323 ± 0.046	2.02ProLys: 2.02 ± 0.044	3.851ProLeu: 3.851 ± 0.06	0.932ProMet: 0.932 ± 0.025	1.708ProAsn: 1.708 ± 0.038	1.007ProPro: 1.007 ± 0.031	1.58ProGln: 1.58 ± 0.036	1.161ProArg: 1.161 ± 0.034	2.189ProSer: 2.189 ± 0.037	1.988ProThr: 1.988 ± 0.04	2.961ProVal: 2.961 ± 0.052	0.468ProTrp: 0.468 ± 0.019	1.175ProTyr: 1.175 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.389GlnAla: 4.389 ± 0.069	0.421GlnCys: 0.421 ± 0.018	2.104GlnAsp: 2.104 ± 0.042	2.14GlnGlu: 2.14 ± 0.046	1.813GlnPhe: 1.813 ± 0.034	3.016GlnGly: 3.016 ± 0.044	1.418GlnHis: 1.418 ± 0.038	2.904GlnIle: 2.904 ± 0.048	2.201GlnLys: 2.201 ± 0.049	5.663GlnLeu: 5.663 ± 0.079	1.088GlnMet: 1.088 ± 0.029	1.859GlnAsn: 1.859 ± 0.04	1.679GlnPro: 1.679 ± 0.034	4.426GlnGln: 4.426 ± 0.103	2.153GlnArg: 2.153 ± 0.047	2.862GlnSer: 2.862 ± 0.051	2.306GlnThr: 2.306 ± 0.048	3.282GlnVal: 3.282 ± 0.058	0.644GlnTrp: 0.644 ± 0.027	1.479GlnTyr: 1.479 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.977ArgAla: 2.977 ± 0.05	0.394ArgCys: 0.394 ± 0.017	2.094ArgAsp: 2.094 ± 0.041	2.37ArgGlu: 2.37 ± 0.047	1.981ArgPhe: 1.981 ± 0.041	2.299ArgGly: 2.299 ± 0.05	0.908ArgHis: 0.908 ± 0.023	2.718ArgIle: 2.718 ± 0.052	2.272ArgLys: 2.272 ± 0.042	4.24ArgLeu: 4.24 ± 0.06	1.021ArgMet: 1.021 ± 0.028	1.801ArgAsn: 1.801 ± 0.031	1.289ArgPro: 1.289 ± 0.034	1.982ArgGln: 1.982 ± 0.041	1.891ArgArg: 1.891 ± 0.04	2.244ArgSer: 2.244 ± 0.042	1.896ArgThr: 1.896 ± 0.04	2.807ArgVal: 2.807 ± 0.047	0.538ArgTrp: 0.538 ± 0.021	1.518ArgTyr: 1.518 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.88SerAla: 5.88 ± 0.071	0.707SerCys: 0.707 ± 0.031	3.925SerAsp: 3.925 ± 0.072	3.805SerGlu: 3.805 ± 0.059	3.179SerPhe: 3.179 ± 0.05	4.935SerGly: 4.935 ± 0.071	1.457SerHis: 1.457 ± 0.031	4.485SerIle: 4.485 ± 0.058	3.861SerLys: 3.861 ± 0.063	6.876SerLeu: 6.876 ± 0.086	1.608SerMet: 1.608 ± 0.04	3.321SerAsn: 3.321 ± 0.061	2.341SerPro: 2.341 ± 0.04	2.86SerGln: 2.86 ± 0.049	2.63SerArg: 2.63 ± 0.045	4.65SerSer: 4.65 ± 0.072	3.613SerThr: 3.613 ± 0.07	4.532SerVal: 4.532 ± 0.073	0.86SerTrp: 0.86 ± 0.027	2.358SerTyr: 2.358 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.097ThrAla: 5.097 ± 0.089	0.484ThrCys: 0.484 ± 0.022	3.278ThrAsp: 3.278 ± 0.083	3.225ThrGlu: 3.225 ± 0.051	2.236ThrPhe: 2.236 ± 0.051	4.125ThrGly: 4.125 ± 0.065	1.023ThrHis: 1.023 ± 0.027	3.87ThrIle: 3.87 ± 0.066	2.554ThrLys: 2.554 ± 0.049	5.91ThrLeu: 5.91 ± 0.089	1.186ThrMet: 1.186 ± 0.03	2.421ThrAsn: 2.421 ± 0.043	2.514ThrPro: 2.514 ± 0.046	2.026ThrGln: 2.026 ± 0.042	1.985ThrArg: 1.985 ± 0.039	3.652ThrSer: 3.652 ± 0.076	3.153ThrThr: 3.153 ± 0.074	3.99ThrVal: 3.99 ± 0.08	0.64ThrTrp: 0.64 ± 0.023	1.53ThrTyr: 1.53 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	6.108ValAla: 6.108 ± 0.074	0.722ValCys: 0.722 ± 0.026	4.249ValAsp: 4.249 ± 0.068	4.258ValGlu: 4.258 ± 0.054	2.836ValPhe: 2.836 ± 0.045	4.245ValGly: 4.245 ± 0.063	1.228ValHis: 1.228 ± 0.029	4.88ValIle: 4.88 ± 0.062	3.756ValLys: 3.756 ± 0.055	6.299ValLeu: 6.299 ± 0.068	1.659ValMet: 1.659 ± 0.041	3.586ValAsn: 3.586 ± 0.058	2.309ValPro: 2.309 ± 0.045	2.248ValGln: 2.248 ± 0.042	2.401ValArg: 2.401 ± 0.044	4.871ValSer: 4.871 ± 0.071	3.993ValThr: 3.993 ± 0.087	4.789ValVal: 4.789 ± 0.074	0.72ValTrp: 0.72 ± 0.025	1.911ValTyr: 1.911 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.751TrpAla: 0.751 ± 0.028	0.135TrpCys: 0.135 ± 0.01	0.613TrpAsp: 0.613 ± 0.027	0.403TrpGlu: 0.403 ± 0.019	0.568TrpPhe: 0.568 ± 0.024	0.728TrpGly: 0.728 ± 0.025	0.412TrpHis: 0.412 ± 0.019	0.561TrpIle: 0.561 ± 0.023	0.423TrpLys: 0.423 ± 0.017	1.734TrpLeu: 1.734 ± 0.037	0.288TrpMet: 0.288 ± 0.017	0.465TrpAsn: 0.465 ± 0.02	0.476TrpPro: 0.476 ± 0.02	1.223TrpGln: 1.223 ± 0.035	0.599TrpArg: 0.599 ± 0.02	0.731TrpSer: 0.731 ± 0.026	0.505TrpThr: 0.505 ± 0.022	0.735TrpVal: 0.735 ± 0.029	0.163TrpTrp: 0.163 ± 0.012	0.363TrpTyr: 0.363 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.277TyrAla: 2.277 ± 0.047	0.382TyrCys: 0.382 ± 0.018	1.692TyrAsp: 1.692 ± 0.04	1.441TyrGlu: 1.441 ± 0.033	1.563TyrPhe: 1.563 ± 0.036	2.087TyrGly: 2.087 ± 0.041	0.807TyrHis: 0.807 ± 0.022	1.795TyrIle: 1.795 ± 0.036	1.512TyrLys: 1.512 ± 0.036	3.522TyrLeu: 3.522 ± 0.057	0.621TyrMet: 0.621 ± 0.022	1.335TyrAsn: 1.335 ± 0.039	1.367TyrPro: 1.367 ± 0.032	2.357TyrGln: 2.357 ± 0.047	1.618TyrArg: 1.618 ± 0.04	2.281TyrSer: 2.281 ± 0.053	1.507TyrThr: 1.507 ± 0.04	1.751TyrVal: 1.751 ± 0.037	0.504TyrTrp: 0.504 ± 0.022	1.129TyrTyr: 1.129 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3946 proteins (1311202 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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