Amino acid dipepetide frequency for Arcticibacter tournemirensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.158AlaAla: 6.158 ± 0.083	0.647AlaCys: 0.647 ± 0.019	4.258AlaAsp: 4.258 ± 0.059	4.611AlaGlu: 4.611 ± 0.064	3.522AlaPhe: 3.522 ± 0.048	6.155AlaGly: 6.155 ± 0.068	1.029AlaHis: 1.029 ± 0.029	4.911AlaIle: 4.911 ± 0.066	4.03AlaLys: 4.03 ± 0.056	6.629AlaLeu: 6.629 ± 0.074	1.54AlaMet: 1.54 ± 0.033	3.329AlaAsn: 3.329 ± 0.056	2.251AlaPro: 2.251 ± 0.045	2.431AlaGln: 2.431 ± 0.044	3.027AlaArg: 3.027 ± 0.044	4.954AlaSer: 4.954 ± 0.063	3.716AlaThr: 3.716 ± 0.065	5.016AlaVal: 5.016 ± 0.061	0.829AlaTrp: 0.829 ± 0.026	2.806AlaTyr: 2.806 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.491CysAla: 0.491 ± 0.022	0.127CysCys: 0.127 ± 0.01	0.403CysAsp: 0.403 ± 0.016	0.361CysGlu: 0.361 ± 0.016	0.429CysPhe: 0.429 ± 0.018	0.628CysGly: 0.628 ± 0.022	0.175CysHis: 0.175 ± 0.012	0.628CysIle: 0.628 ± 0.018	0.468CysLys: 0.468 ± 0.021	0.806CysLeu: 0.806 ± 0.024	0.17CysMet: 0.17 ± 0.009	0.372CysAsn: 0.372 ± 0.015	0.303CysPro: 0.303 ± 0.016	0.224CysGln: 0.224 ± 0.014	0.402CysArg: 0.402 ± 0.017	0.636CysSer: 0.636 ± 0.02	0.41CysThr: 0.41 ± 0.02	0.447CysVal: 0.447 ± 0.018	0.104CysTrp: 0.104 ± 0.015	0.318CysTyr: 0.318 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.739AspAla: 3.739 ± 0.058	0.395AspCys: 0.395 ± 0.016	2.6AspAsp: 2.6 ± 0.05	3.311AspGlu: 3.311 ± 0.05	3.029AspPhe: 3.029 ± 0.045	3.908AspGly: 3.908 ± 0.069	0.906AspHis: 0.906 ± 0.023	4.11AspIle: 4.11 ± 0.053	3.594AspLys: 3.594 ± 0.047	5.043AspLeu: 5.043 ± 0.063	1.135AspMet: 1.135 ± 0.03	2.683AspAsn: 2.683 ± 0.046	2.419AspPro: 2.419 ± 0.039	1.709AspGln: 1.709 ± 0.036	2.367AspArg: 2.367 ± 0.044	3.088AspSer: 3.088 ± 0.05	2.447AspThr: 2.447 ± 0.044	3.402AspVal: 3.402 ± 0.052	0.826AspTrp: 0.826 ± 0.022	2.563AspTyr: 2.563 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	4.44GluAla: 4.44 ± 0.063	0.364GluCys: 0.364 ± 0.017	2.898GluAsp: 2.898 ± 0.05	4.143GluGlu: 4.143 ± 0.07	2.453GluPhe: 2.453 ± 0.041	3.913GluGly: 3.913 ± 0.053	1.029GluHis: 1.029 ± 0.028	4.351GluIle: 4.351 ± 0.066	4.811GluLys: 4.811 ± 0.072	5.576GluLeu: 5.576 ± 0.065	1.511GluMet: 1.511 ± 0.032	3.352GluAsn: 3.352 ± 0.052	1.768GluPro: 1.768 ± 0.037	2.303GluGln: 2.303 ± 0.043	3.028GluArg: 3.028 ± 0.045	3.361GluSer: 3.361 ± 0.049	3.015GluThr: 3.015 ± 0.045	3.934GluVal: 3.934 ± 0.05	0.76GluTrp: 0.76 ± 0.024	2.253GluTyr: 2.253 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.153PheAla: 3.153 ± 0.048	0.48PheCys: 0.48 ± 0.017	2.871PheAsp: 2.871 ± 0.04	2.652PheGlu: 2.652 ± 0.048	2.527PhePhe: 2.527 ± 0.05	3.363PheGly: 3.363 ± 0.053	0.808PheHis: 0.808 ± 0.026	3.513PheIle: 3.513 ± 0.051	3.036PheLys: 3.036 ± 0.049	4.406PheLeu: 4.406 ± 0.064	1.108PheMet: 1.108 ± 0.026	3.054PheAsn: 3.054 ± 0.047	1.766PhePro: 1.766 ± 0.033	1.388PheGln: 1.388 ± 0.03	2.289PheArg: 2.289 ± 0.038	4.124PheSer: 4.124 ± 0.061	2.983PheThr: 2.983 ± 0.043	2.789PheVal: 2.789 ± 0.05	0.628PheTrp: 0.628 ± 0.021	2.148PheTyr: 2.148 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.584GlyAla: 4.584 ± 0.058	0.665GlyCys: 0.665 ± 0.031	3.504GlyAsp: 3.504 ± 0.052	3.75GlyGlu: 3.75 ± 0.057	3.735GlyPhe: 3.735 ± 0.056	5.103GlyGly: 5.103 ± 0.084	1.163GlyHis: 1.163 ± 0.027	5.42GlyIle: 5.42 ± 0.062	5.357GlyLys: 5.357 ± 0.053	6.386GlyLeu: 6.386 ± 0.079	1.71GlyMet: 1.71 ± 0.031	3.785GlyAsn: 3.785 ± 0.065	1.69GlyPro: 1.69 ± 0.033	2.265GlyGln: 2.265 ± 0.042	3.158GlyArg: 3.158 ± 0.048	5.031GlySer: 5.031 ± 0.072	4.443GlyThr: 4.443 ± 0.074	4.51GlyVal: 4.51 ± 0.059	1.066GlyTrp: 1.066 ± 0.03	3.308GlyTyr: 3.308 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.073HisAla: 1.073 ± 0.027	0.175HisCys: 0.175 ± 0.011	0.837HisAsp: 0.837 ± 0.023	0.986HisGlu: 0.986 ± 0.026	1.032HisPhe: 1.032 ± 0.026	1.101HisGly: 1.101 ± 0.033	0.477HisHis: 0.477 ± 0.021	1.281HisIle: 1.281 ± 0.03	0.881HisLys: 0.881 ± 0.025	1.764HisLeu: 1.764 ± 0.036	0.306HisMet: 0.306 ± 0.013	0.886HisAsn: 0.886 ± 0.023	0.931HisPro: 0.931 ± 0.026	0.669HisGln: 0.669 ± 0.023	0.791HisArg: 0.791 ± 0.022	1.104HisSer: 1.104 ± 0.026	0.964HisThr: 0.964 ± 0.027	0.932HisVal: 0.932 ± 0.024	0.253HisTrp: 0.253 ± 0.014	0.836HisTyr: 0.836 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.456IleAla: 5.456 ± 0.073	0.7IleCys: 0.7 ± 0.025	3.931IleAsp: 3.931 ± 0.05	4.278IleGlu: 4.278 ± 0.06	2.994IlePhe: 2.994 ± 0.049	4.572IleGly: 4.572 ± 0.069	1.288IleHis: 1.288 ± 0.034	4.828IleIle: 4.828 ± 0.073	4.637IleLys: 4.637 ± 0.06	6.132IleLeu: 6.132 ± 0.08	1.313IleMet: 1.313 ± 0.03	3.917IleAsn: 3.917 ± 0.051	3.114IlePro: 3.114 ± 0.05	2.105IleGln: 2.105 ± 0.037	3.498IleArg: 3.498 ± 0.046	5.481IleSer: 5.481 ± 0.064	4.354IleThr: 4.354 ± 0.058	4.203IleVal: 4.203 ± 0.053	0.748IleTrp: 0.748 ± 0.024	2.601IleTyr: 2.601 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	5.026LysAla: 5.026 ± 0.067	0.326LysCys: 0.326 ± 0.014	4.065LysAsp: 4.065 ± 0.055	4.778LysGlu: 4.778 ± 0.06	2.412LysPhe: 2.412 ± 0.038	4.595LysGly: 4.595 ± 0.05	1.14LysHis: 1.14 ± 0.029	4.59LysIle: 4.59 ± 0.056	4.937LysLys: 4.937 ± 0.067	5.793LysLeu: 5.793 ± 0.063	1.666LysMet: 1.666 ± 0.035	3.774LysAsn: 3.774 ± 0.048	2.558LysPro: 2.558 ± 0.043	2.399LysGln: 2.399 ± 0.043	3.046LysArg: 3.046 ± 0.046	3.946LysSer: 3.946 ± 0.053	3.798LysThr: 3.798 ± 0.05	4.418LysVal: 4.418 ± 0.055	0.836LysTrp: 0.836 ± 0.023	2.835LysTyr: 2.835 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	6.416LeuAla: 6.416 ± 0.068	0.784LeuCys: 0.784 ± 0.025	4.52LeuAsp: 4.52 ± 0.056	4.996LeuGlu: 4.996 ± 0.07	4.731LeuPhe: 4.731 ± 0.065	5.685LeuGly: 5.685 ± 0.068	1.6LeuHis: 1.6 ± 0.033	6.451LeuIle: 6.451 ± 0.079	7.136LeuLys: 7.136 ± 0.077	9.236LeuLeu: 9.236 ± 0.107	2.067LeuMet: 2.067 ± 0.038	5.55LeuAsn: 5.55 ± 0.07	4.111LeuPro: 4.111 ± 0.052	3.348LeuGln: 3.348 ± 0.048	4.375LeuArg: 4.375 ± 0.057	7.559LeuSer: 7.559 ± 0.084	5.196LeuThr: 5.196 ± 0.06	5.335LeuVal: 5.335 ± 0.06	1.013LeuTrp: 1.013 ± 0.025	3.474LeuTyr: 3.474 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.609MetAla: 1.609 ± 0.037	0.127MetCys: 0.127 ± 0.009	1.125MetAsp: 1.125 ± 0.027	1.3MetGlu: 1.3 ± 0.031	0.856MetPhe: 0.856 ± 0.026	1.424MetGly: 1.424 ± 0.033	0.386MetHis: 0.386 ± 0.015	1.495MetIle: 1.495 ± 0.031	1.994MetLys: 1.994 ± 0.034	2.056MetLeu: 2.056 ± 0.041	0.561MetMet: 0.561 ± 0.019	1.323MetAsn: 1.323 ± 0.027	1.0MetPro: 1.0 ± 0.027	0.864MetGln: 0.864 ± 0.023	1.043MetArg: 1.043 ± 0.027	1.382MetSer: 1.382 ± 0.03	1.078MetThr: 1.078 ± 0.028	1.331MetVal: 1.331 ± 0.028	0.205MetTrp: 0.205 ± 0.011	0.723MetTyr: 0.723 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.821AsnAla: 3.821 ± 0.055	0.398AsnCys: 0.398 ± 0.019	2.692AsnAsp: 2.692 ± 0.044	3.116AsnGlu: 3.116 ± 0.046	2.502AsnPhe: 2.502 ± 0.046	4.081AsnGly: 4.081 ± 0.062	0.936AsnHis: 0.936 ± 0.028	4.065AsnIle: 4.065 ± 0.056	3.453AsnLys: 3.453 ± 0.044	4.783AsnLeu: 4.783 ± 0.061	1.094AsnMet: 1.094 ± 0.027	3.169AsnAsn: 3.169 ± 0.054	2.747AsnPro: 2.747 ± 0.046	1.804AsnGln: 1.804 ± 0.037	2.582AsnArg: 2.582 ± 0.043	3.542AsnSer: 3.542 ± 0.057	3.29AsnThr: 3.29 ± 0.059	3.257AsnVal: 3.257 ± 0.048	0.784AsnTrp: 0.784 ± 0.025	2.603AsnTyr: 2.603 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	3.307ProAla: 3.307 ± 0.05	0.238ProCys: 0.238 ± 0.012	2.696ProAsp: 2.696 ± 0.045	3.072ProGlu: 3.072 ± 0.047	1.965ProPhe: 1.965 ± 0.035	3.25ProGly: 3.25 ± 0.051	0.684ProHis: 0.684 ± 0.022	1.876ProIle: 1.876 ± 0.039	1.847ProLys: 1.847 ± 0.035	3.597ProLeu: 3.597 ± 0.05	0.711ProMet: 0.711 ± 0.02	1.693ProAsn: 1.693 ± 0.036	1.068ProPro: 1.068 ± 0.03	1.395ProGln: 1.395 ± 0.028	1.379ProArg: 1.379 ± 0.034	2.635ProSer: 2.635 ± 0.043	1.641ProThr: 1.641 ± 0.043	3.641ProVal: 3.641 ± 0.056	0.5ProTrp: 0.5 ± 0.017	1.576ProTyr: 1.576 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.329GlnAla: 2.329 ± 0.042	0.2GlnCys: 0.2 ± 0.012	1.558GlnAsp: 1.558 ± 0.027	1.962GlnGlu: 1.962 ± 0.038	1.556GlnPhe: 1.556 ± 0.031	2.108GlnGly: 2.108 ± 0.034	0.645GlnHis: 0.645 ± 0.022	2.281GlnIle: 2.281 ± 0.039	2.53GlnLys: 2.53 ± 0.042	3.47GlnLeu: 3.47 ± 0.055	0.808GlnMet: 0.808 ± 0.024	1.917GlnAsn: 1.917 ± 0.037	1.306GlnPro: 1.306 ± 0.031	1.721GlnGln: 1.721 ± 0.035	1.607GlnArg: 1.607 ± 0.029	2.195GlnSer: 2.195 ± 0.036	1.935GlnThr: 1.935 ± 0.037	2.127GlnVal: 2.127 ± 0.039	0.477GlnTrp: 0.477 ± 0.019	1.514GlnTyr: 1.514 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.839ArgAla: 2.839 ± 0.038	0.282ArgCys: 0.282 ± 0.014	2.358ArgAsp: 2.358 ± 0.04	2.793ArgGlu: 2.793 ± 0.042	2.486ArgPhe: 2.486 ± 0.04	2.621ArgGly: 2.621 ± 0.047	0.791ArgHis: 0.791 ± 0.023	3.545ArgIle: 3.545 ± 0.047	3.279ArgLys: 3.279 ± 0.047	4.527ArgLeu: 4.527 ± 0.057	1.184ArgMet: 1.184 ± 0.03	2.706ArgAsn: 2.706 ± 0.04	1.651ArgPro: 1.651 ± 0.036	1.735ArgGln: 1.735 ± 0.033	2.209ArgArg: 2.209 ± 0.037	2.811ArgSer: 2.811 ± 0.037	2.371ArgThr: 2.371 ± 0.043	2.755ArgVal: 2.755 ± 0.044	0.667ArgTrp: 0.667 ± 0.02	2.137ArgTyr: 2.137 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.165SerAla: 5.165 ± 0.06	0.603SerCys: 0.603 ± 0.02	3.63SerAsp: 3.63 ± 0.045	3.787SerGlu: 3.787 ± 0.05	3.993SerPhe: 3.993 ± 0.055	5.65SerGly: 5.65 ± 0.076	1.149SerHis: 1.149 ± 0.032	4.627SerIle: 4.627 ± 0.06	3.964SerLys: 3.964 ± 0.053	6.847SerLeu: 6.847 ± 0.072	1.391SerMet: 1.391 ± 0.033	3.376SerAsn: 3.376 ± 0.053	2.703SerPro: 2.703 ± 0.044	2.066SerGln: 2.066 ± 0.039	3.187SerArg: 3.187 ± 0.044	5.05SerSer: 5.05 ± 0.072	3.54SerThr: 3.54 ± 0.06	4.933SerVal: 4.933 ± 0.065	0.912SerTrp: 0.912 ± 0.027	3.122SerTyr: 3.122 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.356ThrAla: 4.356 ± 0.066	0.347ThrCys: 0.347 ± 0.017	3.204ThrAsp: 3.204 ± 0.047	3.153ThrGlu: 3.153 ± 0.044	2.682ThrPhe: 2.682 ± 0.041	5.082ThrGly: 5.082 ± 0.079	0.911ThrHis: 0.911 ± 0.026	3.912ThrIle: 3.912 ± 0.054	2.835ThrLys: 2.835 ± 0.04	5.056ThrLeu: 5.056 ± 0.055	0.979ThrMet: 0.979 ± 0.024	2.637ThrAsn: 2.637 ± 0.057	2.438ThrPro: 2.438 ± 0.046	1.612ThrGln: 1.612 ± 0.032	2.195ThrArg: 2.195 ± 0.034	3.817ThrSer: 3.817 ± 0.066	3.137ThrThr: 3.137 ± 0.06	3.983ThrVal: 3.983 ± 0.059	0.686ThrTrp: 0.686 ± 0.024	2.383ThrTyr: 2.383 ± 0.047	0.001ThrXaa: 0.001 ± 0.001
Val	4.381ValAla: 4.381 ± 0.06	0.575ValCys: 0.575 ± 0.021	3.169ValAsp: 3.169 ± 0.045	3.364ValGlu: 3.364 ± 0.05	3.261ValPhe: 3.261 ± 0.047	3.559ValGly: 3.559 ± 0.057	1.06ValHis: 1.06 ± 0.029	4.816ValIle: 4.816 ± 0.064	4.598ValLys: 4.598 ± 0.063	6.281ValLeu: 6.281 ± 0.068	1.429ValMet: 1.429 ± 0.033	3.717ValAsn: 3.717 ± 0.052	2.685ValPro: 2.685 ± 0.042	2.056ValGln: 2.056 ± 0.039	2.818ValArg: 2.818 ± 0.043	4.966ValSer: 4.966 ± 0.061	3.785ValThr: 3.785 ± 0.057	4.398ValVal: 4.398 ± 0.064	0.768ValTrp: 0.768 ± 0.023	2.661ValTyr: 2.661 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.794TrpAla: 0.794 ± 0.025	0.118TrpCys: 0.118 ± 0.009	0.703TrpAsp: 0.703 ± 0.023	0.733TrpGlu: 0.733 ± 0.02	0.598TrpPhe: 0.598 ± 0.02	0.882TrpGly: 0.882 ± 0.026	0.266TrpHis: 0.266 ± 0.011	0.825TrpIle: 0.825 ± 0.027	0.936TrpLys: 0.936 ± 0.025	1.213TrpLeu: 1.213 ± 0.031	0.385TrpMet: 0.385 ± 0.016	0.785TrpAsn: 0.785 ± 0.022	0.409TrpPro: 0.409 ± 0.016	0.544TrpGln: 0.544 ± 0.019	0.582TrpArg: 0.582 ± 0.02	0.824TrpSer: 0.824 ± 0.026	0.743TrpThr: 0.743 ± 0.021	0.726TrpVal: 0.726 ± 0.024	0.221TrpTrp: 0.221 ± 0.012	0.549TrpTyr: 0.549 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.712TyrAla: 2.712 ± 0.047	0.354TyrCys: 0.354 ± 0.017	2.254TyrAsp: 2.254 ± 0.041	2.117TyrGlu: 2.117 ± 0.043	2.322TyrPhe: 2.322 ± 0.04	2.952TyrGly: 2.952 ± 0.052	0.838TyrHis: 0.838 ± 0.026	2.624TyrIle: 2.624 ± 0.04	2.619TyrLys: 2.619 ± 0.046	3.983TyrLeu: 3.983 ± 0.06	0.813TyrMet: 0.813 ± 0.025	2.693TyrAsn: 2.693 ± 0.047	1.855TyrPro: 1.855 ± 0.034	1.607TyrGln: 1.607 ± 0.032	2.162TyrArg: 2.162 ± 0.036	3.187TyrSer: 3.187 ± 0.046	2.56TyrThr: 2.56 ± 0.043	2.207TyrVal: 2.207 ± 0.042	0.55TyrTrp: 0.55 ± 0.02	1.984TyrTyr: 1.984 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4170 proteins (1573326 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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