Amino acid dipepetide frequency for Ilyomonas limi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.763AlaAla: 7.763 ± 0.082	0.826AlaCys: 0.826 ± 0.024	4.371AlaAsp: 4.371 ± 0.053	3.967AlaGlu: 3.967 ± 0.057	3.778AlaPhe: 3.778 ± 0.047	5.936AlaGly: 5.936 ± 0.068	1.433AlaHis: 1.433 ± 0.033	5.827AlaIle: 5.827 ± 0.076	4.608AlaLys: 4.608 ± 0.057	7.296AlaLeu: 7.296 ± 0.08	1.901AlaMet: 1.901 ± 0.035	3.982AlaAsn: 3.982 ± 0.052	2.637AlaPro: 2.637 ± 0.04	3.257AlaGln: 3.257 ± 0.049	2.515AlaArg: 2.515 ± 0.049	4.513AlaSer: 4.513 ± 0.058	4.81AlaThr: 4.81 ± 0.064	5.487AlaVal: 5.487 ± 0.065	0.938AlaTrp: 0.938 ± 0.027	3.194AlaTyr: 3.194 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.59CysAla: 0.59 ± 0.022	0.212CysCys: 0.212 ± 0.013	0.395CysAsp: 0.395 ± 0.016	0.399CysGlu: 0.399 ± 0.019	0.532CysPhe: 0.532 ± 0.02	0.689CysGly: 0.689 ± 0.027	0.225CysHis: 0.225 ± 0.014	0.867CysIle: 0.867 ± 0.024	0.574CysLys: 0.574 ± 0.018	0.869CysLeu: 0.869 ± 0.023	0.238CysMet: 0.238 ± 0.012	0.516CysAsn: 0.516 ± 0.018	0.367CysPro: 0.367 ± 0.017	0.241CysGln: 0.241 ± 0.013	0.351CysArg: 0.351 ± 0.013	0.616CysSer: 0.616 ± 0.021	0.613CysThr: 0.613 ± 0.023	0.518CysVal: 0.518 ± 0.019	0.114CysTrp: 0.114 ± 0.008	0.388CysTyr: 0.388 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.401AspAla: 4.401 ± 0.05	0.421AspCys: 0.421 ± 0.016	2.487AspAsp: 2.487 ± 0.052	3.285AspGlu: 3.285 ± 0.053	2.812AspPhe: 2.812 ± 0.052	3.641AspGly: 3.641 ± 0.067	0.822AspHis: 0.822 ± 0.024	4.026AspIle: 4.026 ± 0.05	3.902AspLys: 3.902 ± 0.063	4.169AspLeu: 4.169 ± 0.058	1.226AspMet: 1.226 ± 0.033	2.926AspAsn: 2.926 ± 0.048	1.769AspPro: 1.769 ± 0.034	1.273AspGln: 1.273 ± 0.033	1.753AspArg: 1.753 ± 0.035	3.317AspSer: 3.317 ± 0.058	3.05AspThr: 3.05 ± 0.048	3.684AspVal: 3.684 ± 0.052	0.895AspTrp: 0.895 ± 0.022	2.566AspTyr: 2.566 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.257GluAla: 4.257 ± 0.065	0.388GluCys: 0.388 ± 0.016	2.735GluAsp: 2.735 ± 0.047	3.746GluGlu: 3.746 ± 0.068	1.95GluPhe: 1.95 ± 0.037	3.319GluGly: 3.319 ± 0.046	1.185GluHis: 1.185 ± 0.03	3.591GluIle: 3.591 ± 0.057	4.192GluLys: 4.192 ± 0.06	4.874GluLeu: 4.874 ± 0.07	1.505GluMet: 1.505 ± 0.035	3.038GluAsn: 3.038 ± 0.041	1.724GluPro: 1.724 ± 0.031	2.624GluGln: 2.624 ± 0.046	2.374GluArg: 2.374 ± 0.044	2.407GluSer: 2.407 ± 0.04	2.648GluThr: 2.648 ± 0.041	3.729GluVal: 3.729 ± 0.052	0.781GluTrp: 0.781 ± 0.024	2.092GluTyr: 2.092 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.621PheAla: 3.621 ± 0.047	0.528PheCys: 0.528 ± 0.018	2.702PheAsp: 2.702 ± 0.042	2.35PheGlu: 2.35 ± 0.037	2.504PhePhe: 2.504 ± 0.044	3.257PheGly: 3.257 ± 0.042	0.89PheHis: 0.89 ± 0.023	3.81PheIle: 3.81 ± 0.054	2.856PheLys: 2.856 ± 0.044	4.157PheLeu: 4.157 ± 0.052	1.046PheMet: 1.046 ± 0.025	2.867PheAsn: 2.867 ± 0.048	1.737PhePro: 1.737 ± 0.038	1.385PheGln: 1.385 ± 0.029	1.708PheArg: 1.708 ± 0.034	3.33PheSer: 3.33 ± 0.049	3.411PheThr: 3.411 ± 0.046	2.804PheVal: 2.804 ± 0.041	0.635PheTrp: 0.635 ± 0.023	2.191PheTyr: 2.191 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.765GlyAla: 4.765 ± 0.06	0.72GlyCys: 0.72 ± 0.026	3.498GlyAsp: 3.498 ± 0.06	3.349GlyGlu: 3.349 ± 0.049	3.32GlyPhe: 3.32 ± 0.048	4.84GlyGly: 4.84 ± 0.082	1.151GlyHis: 1.151 ± 0.028	5.31GlyIle: 5.31 ± 0.071	5.177GlyLys: 5.177 ± 0.061	5.59GlyLeu: 5.59 ± 0.064	1.757GlyMet: 1.757 ± 0.033	4.182GlyAsn: 4.182 ± 0.067	1.482GlyPro: 1.482 ± 0.031	1.957GlyGln: 1.957 ± 0.035	2.421GlyArg: 2.421 ± 0.038	4.206GlySer: 4.206 ± 0.06	4.228GlyThr: 4.228 ± 0.066	4.26GlyVal: 4.26 ± 0.055	1.077GlyTrp: 1.077 ± 0.029	3.192GlyTyr: 3.192 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.423HisAla: 1.423 ± 0.029	0.244HisCys: 0.244 ± 0.013	0.909HisAsp: 0.909 ± 0.022	0.999HisGlu: 0.999 ± 0.025	1.338HisPhe: 1.338 ± 0.029	1.198HisGly: 1.198 ± 0.03	0.611HisHis: 0.611 ± 0.019	1.551HisIle: 1.551 ± 0.031	1.059HisLys: 1.059 ± 0.032	2.067HisLeu: 2.067 ± 0.037	0.363HisMet: 0.363 ± 0.016	1.075HisAsn: 1.075 ± 0.022	1.176HisPro: 1.176 ± 0.028	0.862HisGln: 0.862 ± 0.021	0.766HisArg: 0.766 ± 0.021	1.118HisSer: 1.118 ± 0.024	1.275HisThr: 1.275 ± 0.025	1.099HisVal: 1.099 ± 0.028	0.329HisTrp: 0.329 ± 0.014	1.058HisTyr: 1.058 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.421IleAla: 6.421 ± 0.084	0.758IleCys: 0.758 ± 0.024	4.077IleAsp: 4.077 ± 0.055	3.851IleGlu: 3.851 ± 0.051	2.933IlePhe: 2.933 ± 0.049	4.699IleGly: 4.699 ± 0.055	1.557IleHis: 1.557 ± 0.029	5.401IleIle: 5.401 ± 0.072	4.595IleLys: 4.595 ± 0.062	5.695IleLeu: 5.695 ± 0.067	1.335IleMet: 1.335 ± 0.033	4.363IleAsn: 4.363 ± 0.059	3.048IlePro: 3.048 ± 0.045	2.719IleGln: 2.719 ± 0.045	2.724IleArg: 2.724 ± 0.036	4.671IleSer: 4.671 ± 0.057	4.933IleThr: 4.933 ± 0.057	4.564IleVal: 4.564 ± 0.052	0.699IleTrp: 0.699 ± 0.019	2.624IleTyr: 2.624 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	5.207LysAla: 5.207 ± 0.063	0.355LysCys: 0.355 ± 0.015	4.076LysAsp: 4.076 ± 0.058	4.819LysGlu: 4.819 ± 0.072	1.935LysPhe: 1.935 ± 0.042	4.425LysGly: 4.425 ± 0.056	1.29LysHis: 1.29 ± 0.029	4.29LysIle: 4.29 ± 0.061	4.965LysLys: 4.965 ± 0.076	5.558LysLeu: 5.558 ± 0.067	1.868LysMet: 1.868 ± 0.037	3.974LysAsn: 3.974 ± 0.052	2.68LysPro: 2.68 ± 0.043	3.17LysGln: 3.17 ± 0.045	2.726LysArg: 2.726 ± 0.043	3.375LysSer: 3.375 ± 0.05	3.869LysThr: 3.869 ± 0.05	4.121LysVal: 4.121 ± 0.057	0.852LysTrp: 0.852 ± 0.024	2.725LysTyr: 2.725 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	6.455LeuAla: 6.455 ± 0.068	0.933LeuCys: 0.933 ± 0.027	4.18LeuAsp: 4.18 ± 0.056	4.079LeuGlu: 4.079 ± 0.067	4.907LeuPhe: 4.907 ± 0.059	5.15LeuGly: 5.15 ± 0.062	2.211LeuHis: 2.211 ± 0.043	6.141LeuIle: 6.141 ± 0.072	6.037LeuLys: 6.037 ± 0.064	9.97LeuLeu: 9.97 ± 0.108	2.134LeuMet: 2.134 ± 0.037	5.009LeuAsn: 5.009 ± 0.058	4.342LeuPro: 4.342 ± 0.052	5.131LeuGln: 5.131 ± 0.066	3.626LeuArg: 3.626 ± 0.05	6.297LeuSer: 6.297 ± 0.079	5.212LeuThr: 5.212 ± 0.059	5.167LeuVal: 5.167 ± 0.059	1.04LeuTrp: 1.04 ± 0.027	3.74LeuTyr: 3.74 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.732MetAla: 1.732 ± 0.033	0.17MetCys: 0.17 ± 0.01	1.238MetAsp: 1.238 ± 0.027	1.263MetGlu: 1.263 ± 0.03	0.83MetPhe: 0.83 ± 0.024	1.372MetGly: 1.372 ± 0.031	0.582MetHis: 0.582 ± 0.02	1.413MetIle: 1.413 ± 0.032	1.933MetLys: 1.933 ± 0.039	2.326MetLeu: 2.326 ± 0.045	0.705MetMet: 0.705 ± 0.021	1.426MetAsn: 1.426 ± 0.035	1.189MetPro: 1.189 ± 0.028	1.489MetGln: 1.489 ± 0.034	1.042MetArg: 1.042 ± 0.027	1.259MetSer: 1.259 ± 0.025	1.08MetThr: 1.08 ± 0.027	1.434MetVal: 1.434 ± 0.029	0.231MetTrp: 0.231 ± 0.011	0.917MetTyr: 0.917 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.491AsnAla: 4.491 ± 0.058	0.459AsnCys: 0.459 ± 0.018	3.089AsnAsp: 3.089 ± 0.052	3.231AsnGlu: 3.231 ± 0.053	2.53AsnPhe: 2.53 ± 0.048	4.334AsnGly: 4.334 ± 0.069	1.046AsnHis: 1.046 ± 0.026	4.457AsnIle: 4.457 ± 0.058	4.023AsnLys: 4.023 ± 0.049	4.425AsnLeu: 4.425 ± 0.062	1.24AsnMet: 1.24 ± 0.025	4.107AsnAsn: 4.107 ± 0.061	2.65AsnPro: 2.65 ± 0.04	1.842AsnGln: 1.842 ± 0.037	2.257AsnArg: 2.257 ± 0.036	3.37AsnSer: 3.37 ± 0.057	3.726AsnThr: 3.726 ± 0.059	3.437AsnVal: 3.437 ± 0.048	0.831AsnTrp: 0.831 ± 0.02	2.675AsnTyr: 2.675 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	3.7ProAla: 3.7 ± 0.05	0.244ProCys: 0.244 ± 0.013	2.598ProAsp: 2.598 ± 0.042	2.597ProGlu: 2.597 ± 0.043	2.076ProPhe: 2.076 ± 0.036	2.732ProGly: 2.732 ± 0.044	0.813ProHis: 0.813 ± 0.025	2.116ProIle: 2.116 ± 0.041	1.911ProLys: 1.911 ± 0.038	3.522ProLeu: 3.522 ± 0.044	0.832ProMet: 0.832 ± 0.026	2.052ProAsn: 2.052 ± 0.031	1.35ProPro: 1.35 ± 0.036	1.706ProGln: 1.706 ± 0.033	1.072ProArg: 1.072 ± 0.029	2.182ProSer: 2.182 ± 0.038	2.024ProThr: 2.024 ± 0.033	3.498ProVal: 3.498 ± 0.051	0.523ProTrp: 0.523 ± 0.019	1.753ProTyr: 1.753 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.818GlnAla: 2.818 ± 0.042	0.303GlnCys: 0.303 ± 0.015	1.67GlnAsp: 1.67 ± 0.032	1.938GlnGlu: 1.938 ± 0.035	1.959GlnPhe: 1.959 ± 0.04	2.041GlnGly: 2.041 ± 0.037	1.133GlnHis: 1.133 ± 0.028	2.32GlnIle: 2.32 ± 0.042	2.782GlnLys: 2.782 ± 0.046	4.597GlnLeu: 4.597 ± 0.063	1.114GlnMet: 1.114 ± 0.027	2.175GlnAsn: 2.175 ± 0.038	1.997GlnPro: 1.997 ± 0.035	3.218GlnGln: 3.218 ± 0.068	1.783GlnArg: 1.783 ± 0.036	2.451GlnSer: 2.451 ± 0.045	2.345GlnThr: 2.345 ± 0.045	2.313GlnVal: 2.313 ± 0.037	0.633GlnTrp: 0.633 ± 0.02	1.96GlnTyr: 1.96 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.379ArgAla: 2.379 ± 0.042	0.315ArgCys: 0.315 ± 0.013	1.815ArgAsp: 1.815 ± 0.034	1.977ArgGlu: 1.977 ± 0.039	1.999ArgPhe: 1.999 ± 0.035	2.136ArgGly: 2.136 ± 0.044	0.733ArgHis: 0.733 ± 0.019	2.983ArgIle: 2.983 ± 0.05	2.732ArgLys: 2.732 ± 0.04	3.721ArgLeu: 3.721 ± 0.045	1.098ArgMet: 1.098 ± 0.027	2.365ArgAsn: 2.365 ± 0.038	1.259ArgPro: 1.259 ± 0.029	1.678ArgGln: 1.678 ± 0.032	1.717ArgArg: 1.717 ± 0.035	2.075ArgSer: 2.075 ± 0.036	2.133ArgThr: 2.133 ± 0.034	2.135ArgVal: 2.135 ± 0.038	0.583ArgTrp: 0.583 ± 0.018	1.852ArgTyr: 1.852 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.506SerAla: 4.506 ± 0.058	0.642SerCys: 0.642 ± 0.021	2.987SerAsp: 2.987 ± 0.046	2.663SerGlu: 2.663 ± 0.046	3.544SerPhe: 3.544 ± 0.047	4.593SerGly: 4.593 ± 0.06	1.072SerHis: 1.072 ± 0.023	4.571SerIle: 4.571 ± 0.058	3.659SerLys: 3.659 ± 0.052	5.923SerLeu: 5.923 ± 0.061	1.314SerMet: 1.314 ± 0.028	3.548SerAsn: 3.548 ± 0.052	2.288SerPro: 2.288 ± 0.041	1.879SerGln: 1.879 ± 0.031	2.179SerArg: 2.179 ± 0.037	3.941SerSer: 3.941 ± 0.062	3.517SerThr: 3.517 ± 0.056	3.84SerVal: 3.84 ± 0.062	0.803SerTrp: 0.803 ± 0.026	2.728SerTyr: 2.728 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.412ThrAla: 5.412 ± 0.065	0.484ThrCys: 0.484 ± 0.019	3.383ThrAsp: 3.383 ± 0.049	2.796ThrGlu: 2.796 ± 0.041	2.802ThrPhe: 2.802 ± 0.043	4.826ThrGly: 4.826 ± 0.058	1.112ThrHis: 1.112 ± 0.025	4.741ThrIle: 4.741 ± 0.054	3.314ThrLys: 3.314 ± 0.045	5.452ThrLeu: 5.452 ± 0.06	1.083ThrMet: 1.083 ± 0.026	3.216ThrAsn: 3.216 ± 0.057	2.779ThrPro: 2.779 ± 0.041	1.964ThrGln: 1.964 ± 0.033	1.832ThrArg: 1.832 ± 0.035	3.54ThrSer: 3.54 ± 0.052	4.115ThrThr: 4.115 ± 0.057	4.076ThrVal: 4.076 ± 0.053	0.73ThrTrp: 0.73 ± 0.022	2.568ThrTyr: 2.568 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	5.113ValAla: 5.113 ± 0.071	0.74ValCys: 0.74 ± 0.023	3.064ValAsp: 3.064 ± 0.043	3.116ValGlu: 3.116 ± 0.049	3.048ValPhe: 3.048 ± 0.04	3.537ValGly: 3.537 ± 0.056	1.355ValHis: 1.355 ± 0.033	4.603ValIle: 4.603 ± 0.057	4.15ValLys: 4.15 ± 0.057	6.307ValLeu: 6.307 ± 0.063	1.569ValMet: 1.569 ± 0.038	3.601ValAsn: 3.601 ± 0.049	2.59ValPro: 2.59 ± 0.039	2.713ValGln: 2.713 ± 0.045	2.334ValArg: 2.334 ± 0.041	4.038ValSer: 4.038 ± 0.053	3.775ValThr: 3.775 ± 0.055	4.466ValVal: 4.466 ± 0.057	0.774ValTrp: 0.774 ± 0.02	2.765ValTyr: 2.765 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.807TrpAla: 0.807 ± 0.021	0.128TrpCys: 0.128 ± 0.008	0.757TrpAsp: 0.757 ± 0.021	0.626TrpGlu: 0.626 ± 0.02	0.609TrpPhe: 0.609 ± 0.024	0.864TrpGly: 0.864 ± 0.022	0.35TrpHis: 0.35 ± 0.017	0.878TrpIle: 0.878 ± 0.027	0.911TrpLys: 0.911 ± 0.026	1.415TrpLeu: 1.415 ± 0.032	0.433TrpMet: 0.433 ± 0.017	0.877TrpAsn: 0.877 ± 0.027	0.356TrpPro: 0.356 ± 0.015	0.737TrpGln: 0.737 ± 0.025	0.602TrpArg: 0.602 ± 0.017	0.764TrpSer: 0.764 ± 0.021	0.662TrpThr: 0.662 ± 0.018	0.724TrpVal: 0.724 ± 0.021	0.28TrpTrp: 0.28 ± 0.014	0.598TrpTyr: 0.598 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.179TyrAla: 3.179 ± 0.054	0.444TyrCys: 0.444 ± 0.016	2.394TyrAsp: 2.394 ± 0.048	2.108TyrGlu: 2.108 ± 0.04	2.382TyrPhe: 2.382 ± 0.04	2.896TyrGly: 2.896 ± 0.049	0.948TyrHis: 0.948 ± 0.026	2.771TyrIle: 2.771 ± 0.043	2.901TyrLys: 2.901 ± 0.046	3.828TyrLeu: 3.828 ± 0.05	0.871TyrMet: 0.871 ± 0.024	2.918TyrAsn: 2.918 ± 0.049	1.881TyrPro: 1.881 ± 0.04	1.705TyrGln: 1.705 ± 0.032	1.903TyrArg: 1.903 ± 0.035	2.729TyrSer: 2.729 ± 0.052	2.798TyrThr: 2.798 ± 0.045	2.303TyrVal: 2.303 ± 0.038	0.628TyrTrp: 0.628 ± 0.02	2.116TyrTyr: 2.116 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4606 proteins (1624473 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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