Amino acid dipepetide frequency for Aquamicrobium defluvii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.006AlaAla: 17.006 ± 0.165
1.059AlaCys: 1.059 ± 0.029
6.942AlaAsp: 6.942 ± 0.071
7.661AlaGlu: 7.661 ± 0.093
4.463AlaPhe: 4.463 ± 0.066
11.603AlaGly: 11.603 ± 0.115
2.19AlaHis: 2.19 ± 0.048
6.685AlaIle: 6.685 ± 0.078
3.47AlaLys: 3.47 ± 0.066
13.042AlaLeu: 13.042 ± 0.119
3.653AlaMet: 3.653 ± 0.053
2.911AlaAsn: 2.911 ± 0.049
5.202AlaPro: 5.202 ± 0.073
3.796AlaGln: 3.796 ± 0.063
9.452AlaArg: 9.452 ± 0.106
6.531AlaSer: 6.531 ± 0.08
5.778AlaThr: 5.778 ± 0.071
8.671AlaVal: 8.671 ± 0.093
1.39AlaTrp: 1.39 ± 0.037
2.532AlaTyr: 2.532 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.942CysAla: 0.942 ± 0.028
0.098CysCys: 0.098 ± 0.008
0.524CysAsp: 0.524 ± 0.02
0.451CysGlu: 0.451 ± 0.019
0.315CysPhe: 0.315 ± 0.016
0.907CysGly: 0.907 ± 0.027
0.223CysHis: 0.223 ± 0.014
0.395CysIle: 0.395 ± 0.017
0.191CysLys: 0.191 ± 0.013
0.74CysLeu: 0.74 ± 0.024
0.15CysMet: 0.15 ± 0.01
0.201CysAsn: 0.201 ± 0.012
0.449CysPro: 0.449 ± 0.02
0.22CysGln: 0.22 ± 0.014
0.626CysArg: 0.626 ± 0.023
0.423CysSer: 0.423 ± 0.018
0.387CysThr: 0.387 ± 0.02
0.572CysVal: 0.572 ± 0.02
0.11CysTrp: 0.11 ± 0.01
0.191CysTyr: 0.191 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.738AspAla: 6.738 ± 0.087
0.472AspCys: 0.472 ± 0.02
3.239AspAsp: 3.239 ± 0.061
3.747AspGlu: 3.747 ± 0.061
2.208AspPhe: 2.208 ± 0.049
5.223AspGly: 5.223 ± 0.075
1.297AspHis: 1.297 ± 0.036
3.255AspIle: 3.255 ± 0.052
1.745AspLys: 1.745 ± 0.042
5.655AspLeu: 5.655 ± 0.068
1.516AspMet: 1.516 ± 0.041
1.334AspAsn: 1.334 ± 0.029
3.236AspPro: 3.236 ± 0.047
1.51AspGln: 1.51 ± 0.037
4.371AspArg: 4.371 ± 0.063
2.185AspSer: 2.185 ± 0.04
2.645AspThr: 2.645 ± 0.048
3.98AspVal: 3.98 ± 0.053
0.915AspTrp: 0.915 ± 0.028
1.489AspTyr: 1.489 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
8.026GluAla: 8.026 ± 0.102
0.344GluCys: 0.344 ± 0.016
2.838GluAsp: 2.838 ± 0.054
3.489GluGlu: 3.489 ± 0.058
1.817GluPhe: 1.817 ± 0.038
4.562GluGly: 4.562 ± 0.056
1.195GluHis: 1.195 ± 0.033
3.679GluIle: 3.679 ± 0.061
2.631GluLys: 2.631 ± 0.057
5.545GluLeu: 5.545 ± 0.074
1.587GluMet: 1.587 ± 0.038
1.692GluAsn: 1.692 ± 0.032
2.808GluPro: 2.808 ± 0.051
2.175GluGln: 2.175 ± 0.045
5.328GluArg: 5.328 ± 0.069
2.415GluSer: 2.415 ± 0.046
3.502GluThr: 3.502 ± 0.053
4.023GluVal: 4.023 ± 0.053
0.734GluTrp: 0.734 ± 0.024
1.007GluTyr: 1.007 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.554PheAla: 4.554 ± 0.059
0.378PheCys: 0.378 ± 0.016
2.619PheAsp: 2.619 ± 0.046
2.23PheGlu: 2.23 ± 0.036
1.449PhePhe: 1.449 ± 0.043
3.85PheGly: 3.85 ± 0.062
0.793PheHis: 0.793 ± 0.023
1.826PheIle: 1.826 ± 0.041
0.813PheLys: 0.813 ± 0.028
3.343PheLeu: 3.343 ± 0.056
0.927PheMet: 0.927 ± 0.027
1.004PheAsn: 1.004 ± 0.025
1.583PhePro: 1.583 ± 0.037
1.043PheGln: 1.043 ± 0.026
2.584PheArg: 2.584 ± 0.047
2.35PheSer: 2.35 ± 0.04
1.94PheThr: 1.94 ± 0.037
2.847PheVal: 2.847 ± 0.05
0.542PheTrp: 0.542 ± 0.023
0.952PheTyr: 0.952 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
9.169GlyAla: 9.169 ± 0.112
0.797GlyCys: 0.797 ± 0.028
4.544GlyAsp: 4.544 ± 0.072
5.166GlyGlu: 5.166 ± 0.067
3.753GlyPhe: 3.753 ± 0.058
7.472GlyGly: 7.472 ± 0.269
1.964GlyHis: 1.964 ± 0.041
5.093GlyIle: 5.093 ± 0.074
3.655GlyLys: 3.655 ± 0.055
8.668GlyLeu: 8.668 ± 0.091
2.495GlyMet: 2.495 ± 0.046
2.36GlyAsn: 2.36 ± 0.049
3.469GlyPro: 3.469 ± 0.052
2.838GlyGln: 2.838 ± 0.046
6.6GlyArg: 6.6 ± 0.073
4.819GlySer: 4.819 ± 0.076
4.644GlyThr: 4.644 ± 0.071
6.126GlyVal: 6.126 ± 0.085
1.392GlyTrp: 1.392 ± 0.038
2.29GlyTyr: 2.29 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.321HisAla: 2.321 ± 0.049
0.232HisCys: 0.232 ± 0.014
1.24HisAsp: 1.24 ± 0.035
1.204HisGlu: 1.204 ± 0.03
0.86HisPhe: 0.86 ± 0.022
1.97HisGly: 1.97 ± 0.042
0.544HisHis: 0.544 ± 0.023
1.023HisIle: 1.023 ± 0.03
0.507HisLys: 0.507 ± 0.021
1.969HisLeu: 1.969 ± 0.041
0.561HisMet: 0.561 ± 0.02
0.463HisAsn: 0.463 ± 0.018
1.258HisPro: 1.258 ± 0.034
0.554HisGln: 0.554 ± 0.023
1.516HisArg: 1.516 ± 0.04
0.961HisSer: 0.961 ± 0.031
0.828HisThr: 0.828 ± 0.025
1.516HisVal: 1.516 ± 0.034
0.303HisTrp: 0.303 ± 0.014
0.558HisTyr: 0.558 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
7.623IleAla: 7.623 ± 0.077
0.5IleCys: 0.5 ± 0.019
3.735IleAsp: 3.735 ± 0.056
3.699IleGlu: 3.699 ± 0.05
1.783IlePhe: 1.783 ± 0.045
5.235IleGly: 5.235 ± 0.071
0.993IleHis: 0.993 ± 0.026
2.345IleIle: 2.345 ± 0.052
1.136IleLys: 1.136 ± 0.031
4.662IleLeu: 4.662 ± 0.065
1.109IleMet: 1.109 ± 0.028
1.392IleAsn: 1.392 ± 0.032
2.279IlePro: 2.279 ± 0.039
1.149IleGln: 1.149 ± 0.028
3.699IleArg: 3.699 ± 0.05
3.081IleSer: 3.081 ± 0.055
2.571IleThr: 2.571 ± 0.046
4.771IleVal: 4.771 ± 0.058
0.632IleTrp: 0.632 ± 0.023
1.171IleTyr: 1.171 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.27LysAla: 4.27 ± 0.07
0.163LysCys: 0.163 ± 0.01
1.643LysAsp: 1.643 ± 0.041
1.679LysGlu: 1.679 ± 0.039
0.862LysPhe: 0.862 ± 0.024
2.661LysGly: 2.661 ± 0.05
0.573LysHis: 0.573 ± 0.021
1.65LysIle: 1.65 ± 0.037
1.343LysLys: 1.343 ± 0.036
3.236LysLeu: 3.236 ± 0.057
0.812LysMet: 0.812 ± 0.025
0.843LysAsn: 0.843 ± 0.028
2.044LysPro: 2.044 ± 0.046
1.039LysGln: 1.039 ± 0.029
2.314LysArg: 2.314 ± 0.045
1.818LysSer: 1.818 ± 0.04
1.798LysThr: 1.798 ± 0.039
2.478LysVal: 2.478 ± 0.049
0.398LysTrp: 0.398 ± 0.019
0.602LysTyr: 0.602 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
13.412LeuAla: 13.412 ± 0.122
0.88LeuCys: 0.88 ± 0.025
5.947LeuAsp: 5.947 ± 0.071
5.42LeuGlu: 5.42 ± 0.069
3.661LeuPhe: 3.661 ± 0.062
8.058LeuGly: 8.058 ± 0.083
1.849LeuHis: 1.849 ± 0.041
5.008LeuIle: 5.008 ± 0.066
3.425LeuLys: 3.425 ± 0.053
9.29LeuLeu: 9.29 ± 0.119
2.408LeuMet: 2.408 ± 0.045
2.484LeuAsn: 2.484 ± 0.051
5.326LeuPro: 5.326 ± 0.07
2.586LeuGln: 2.586 ± 0.049
6.805LeuArg: 6.805 ± 0.075
6.446LeuSer: 6.446 ± 0.084
5.176LeuThr: 5.176 ± 0.07
7.526LeuVal: 7.526 ± 0.086
1.11LeuTrp: 1.11 ± 0.038
2.043LeuTyr: 2.043 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.4MetAla: 3.4 ± 0.055
0.177MetCys: 0.177 ± 0.012
1.205MetAsp: 1.205 ± 0.028
1.318MetGlu: 1.318 ± 0.029
0.722MetPhe: 0.722 ± 0.023
1.907MetGly: 1.907 ± 0.037
0.45MetHis: 0.45 ± 0.019
1.4MetIle: 1.4 ± 0.032
1.083MetLys: 1.083 ± 0.031
2.684MetLeu: 2.684 ± 0.045
0.713MetMet: 0.713 ± 0.027
0.878MetAsn: 0.878 ± 0.03
1.523MetPro: 1.523 ± 0.03
0.877MetGln: 0.877 ± 0.026
1.966MetArg: 1.966 ± 0.038
1.751MetSer: 1.751 ± 0.041
1.801MetThr: 1.801 ± 0.041
1.846MetVal: 1.846 ± 0.037
0.231MetTrp: 0.231 ± 0.012
0.313MetTyr: 0.313 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.17AsnAla: 3.17 ± 0.05
0.228AsnCys: 0.228 ± 0.013
1.386AsnAsp: 1.386 ± 0.034
1.359AsnGlu: 1.359 ± 0.036
0.949AsnPhe: 0.949 ± 0.028
2.508AsnGly: 2.508 ± 0.054
0.513AsnHis: 0.513 ± 0.019
1.385AsnIle: 1.385 ± 0.03
0.652AsnLys: 0.652 ± 0.023
2.478AsnLeu: 2.478 ± 0.044
0.668AsnMet: 0.668 ± 0.022
0.67AsnAsn: 0.67 ± 0.025
1.81AsnPro: 1.81 ± 0.039
0.725AsnGln: 0.725 ± 0.024
1.987AsnArg: 1.987 ± 0.038
1.195AsnSer: 1.195 ± 0.035
1.231AsnThr: 1.231 ± 0.033
1.918AsnVal: 1.918 ± 0.044
0.442AsnTrp: 0.442 ± 0.02
0.659AsnTyr: 0.659 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
6.341ProAla: 6.341 ± 0.079
0.338ProCys: 0.338 ± 0.018
3.545ProAsp: 3.545 ± 0.051
3.748ProGlu: 3.748 ± 0.065
1.987ProPhe: 1.987 ± 0.04
4.485ProGly: 4.485 ± 0.062
1.061ProHis: 1.061 ± 0.029
2.086ProIle: 2.086 ± 0.041
1.525ProLys: 1.525 ± 0.034
4.553ProLeu: 4.553 ± 0.067
1.166ProMet: 1.166 ± 0.027
1.208ProAsn: 1.208 ± 0.031
2.242ProPro: 2.242 ± 0.053
1.821ProGln: 1.821 ± 0.039
2.918ProArg: 2.918 ± 0.047
2.614ProSer: 2.614 ± 0.051
2.076ProThr: 2.076 ± 0.04
4.478ProVal: 4.478 ± 0.061
0.654ProTrp: 0.654 ± 0.023
1.175ProTyr: 1.175 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.001GlnAla: 4.001 ± 0.062
0.182GlnCys: 0.182 ± 0.011
1.456GlnAsp: 1.456 ± 0.031
1.664GlnGlu: 1.664 ± 0.042
1.069GlnPhe: 1.069 ± 0.032
2.334GlnGly: 2.334 ± 0.044
0.617GlnHis: 0.617 ± 0.022
1.808GlnIle: 1.808 ± 0.04
1.176GlnLys: 1.176 ± 0.032
2.682GlnLeu: 2.682 ± 0.05
0.872GlnMet: 0.872 ± 0.026
0.872GlnAsn: 0.872 ± 0.026
1.846GlnPro: 1.846 ± 0.041
1.158GlnGln: 1.158 ± 0.039
2.372GlnArg: 2.372 ± 0.045
1.713GlnSer: 1.713 ± 0.04
1.632GlnThr: 1.632 ± 0.038
2.144GlnVal: 2.144 ± 0.047
0.384GlnTrp: 0.384 ± 0.016
0.56GlnTyr: 0.56 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
7.98ArgAla: 7.98 ± 0.084
0.496ArgCys: 0.496 ± 0.021
4.19ArgAsp: 4.19 ± 0.061
4.472ArgGlu: 4.472 ± 0.059
3.09ArgPhe: 3.09 ± 0.049
4.906ArgGly: 4.906 ± 0.058
1.877ArgHis: 1.877 ± 0.038
4.527ArgIle: 4.527 ± 0.063
2.715ArgLys: 2.715 ± 0.05
8.19ArgLeu: 8.19 ± 0.08
2.088ArgMet: 2.088 ± 0.035
2.122ArgAsn: 2.122 ± 0.038
3.632ArgPro: 3.632 ± 0.062
2.824ArgGln: 2.824 ± 0.049
6.031ArgArg: 6.031 ± 0.093
3.957ArgSer: 3.957 ± 0.057
3.493ArgThr: 3.493 ± 0.061
4.644ArgVal: 4.644 ± 0.059
0.955ArgTrp: 0.955 ± 0.027
1.783ArgTyr: 1.783 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.261SerAla: 6.261 ± 0.075
0.433SerCys: 0.433 ± 0.019
2.938SerAsp: 2.938 ± 0.049
2.831SerGlu: 2.831 ± 0.049
2.387SerPhe: 2.387 ± 0.048
5.96SerGly: 5.96 ± 0.084
1.138SerHis: 1.138 ± 0.031
2.852SerIle: 2.852 ± 0.051
1.507SerLys: 1.507 ± 0.035
5.313SerLeu: 5.313 ± 0.074
1.435SerMet: 1.435 ± 0.035
1.302SerAsn: 1.302 ± 0.031
2.757SerPro: 2.757 ± 0.052
1.6SerGln: 1.6 ± 0.037
3.914SerArg: 3.914 ± 0.063
2.966SerSer: 2.966 ± 0.053
2.704SerThr: 2.704 ± 0.046
4.094SerVal: 4.094 ± 0.064
0.732SerTrp: 0.732 ± 0.025
1.292SerTyr: 1.292 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
5.931ThrAla: 5.931 ± 0.06
0.382ThrCys: 0.382 ± 0.018
2.692ThrAsp: 2.692 ± 0.051
2.53ThrGlu: 2.53 ± 0.045
1.997ThrPhe: 1.997 ± 0.042
5.193ThrGly: 5.193 ± 0.07
0.964ThrHis: 0.964 ± 0.026
2.938ThrIle: 2.938 ± 0.057
1.249ThrLys: 1.249 ± 0.032
5.475ThrLeu: 5.475 ± 0.065
1.294ThrMet: 1.294 ± 0.029
1.201ThrAsn: 1.201 ± 0.031
2.971ThrPro: 2.971 ± 0.048
1.36ThrGln: 1.36 ± 0.032
3.299ThrArg: 3.299 ± 0.053
2.656ThrSer: 2.656 ± 0.048
2.641ThrThr: 2.641 ± 0.051
4.46ThrVal: 4.46 ± 0.07
0.608ThrTrp: 0.608 ± 0.023
1.128ThrTyr: 1.128 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
9.3ValAla: 9.3 ± 0.093
0.588ValCys: 0.588 ± 0.021
4.072ValAsp: 4.072 ± 0.057
4.901ValGlu: 4.901 ± 0.064
2.828ValPhe: 2.828 ± 0.043
5.512ValGly: 5.512 ± 0.078
1.365ValHis: 1.365 ± 0.031
4.002ValIle: 4.002 ± 0.061
2.308ValLys: 2.308 ± 0.05
7.422ValLeu: 7.422 ± 0.086
1.917ValMet: 1.917 ± 0.035
1.945ValAsn: 1.945 ± 0.037
3.857ValPro: 3.857 ± 0.061
2.038ValGln: 2.038 ± 0.043
5.192ValArg: 5.192 ± 0.066
4.551ValSer: 4.551 ± 0.063
4.294ValThr: 4.294 ± 0.062
6.047ValVal: 6.047 ± 0.081
0.906ValTrp: 0.906 ± 0.027
1.484ValTyr: 1.484 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.191TrpAla: 1.191 ± 0.033
0.117TrpCys: 0.117 ± 0.01
0.556TrpAsp: 0.556 ± 0.022
0.55TrpGlu: 0.55 ± 0.022
0.584TrpPhe: 0.584 ± 0.021
0.85TrpGly: 0.85 ± 0.027
0.312TrpHis: 0.312 ± 0.015
0.654TrpIle: 0.654 ± 0.02
0.5TrpLys: 0.5 ± 0.019
1.632TrpLeu: 1.632 ± 0.041
0.399TrpMet: 0.399 ± 0.019
0.467TrpAsn: 0.467 ± 0.021
0.708TrpPro: 0.708 ± 0.024
0.554TrpGln: 0.554 ± 0.019
1.155TrpArg: 1.155 ± 0.031
0.774TrpSer: 0.774 ± 0.025
0.725TrpThr: 0.725 ± 0.022
0.751TrpVal: 0.751 ± 0.024
0.209TrpTrp: 0.209 ± 0.013
0.297TrpTyr: 0.297 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.404TyrAla: 2.404 ± 0.043
0.251TyrCys: 0.251 ± 0.014
1.446TyrAsp: 1.446 ± 0.035
1.28TyrGlu: 1.28 ± 0.03
0.844TyrPhe: 0.844 ± 0.027
2.118TyrGly: 2.118 ± 0.039
0.473TyrHis: 0.473 ± 0.019
0.953TyrIle: 0.953 ± 0.026
0.594TyrLys: 0.594 ± 0.02
2.277TyrLeu: 2.277 ± 0.051
0.473TyrMet: 0.473 ± 0.022
0.587TyrAsn: 0.587 ± 0.021
1.021TyrPro: 1.021 ± 0.025
0.674TyrGln: 0.674 ± 0.024
1.841TyrArg: 1.841 ± 0.036
1.211TyrSer: 1.211 ± 0.032
1.104TyrThr: 1.104 ± 0.029
1.639TyrVal: 1.639 ± 0.037
0.336TyrTrp: 0.336 ± 0.017
0.581TyrTyr: 0.581 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4454 proteins (1348077 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski