Amino acid dipepetide frequency for Streptomyces adustus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.584AlaAla: 21.584 ± 0.121	1.085AlaCys: 1.085 ± 0.019	8.6AlaAsp: 8.6 ± 0.065	8.472AlaGlu: 8.472 ± 0.081	3.472AlaPhe: 3.472 ± 0.036	12.903AlaGly: 12.903 ± 0.074	2.986AlaHis: 2.986 ± 0.034	3.35AlaIle: 3.35 ± 0.038	2.703AlaLys: 2.703 ± 0.04	14.559AlaLeu: 14.559 ± 0.101	2.395AlaMet: 2.395 ± 0.03	1.976AlaAsn: 1.976 ± 0.03	6.959AlaPro: 6.959 ± 0.061	4.037AlaGln: 4.037 ± 0.039	10.47AlaArg: 10.47 ± 0.075	6.112AlaSer: 6.112 ± 0.052	7.173AlaThr: 7.173 ± 0.066	12.427AlaVal: 12.427 ± 0.081	1.894AlaTrp: 1.894 ± 0.029	2.797AlaTyr: 2.797 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.149CysAla: 1.149 ± 0.021	0.104CysCys: 0.104 ± 0.007	0.457CysAsp: 0.457 ± 0.014	0.386CysGlu: 0.386 ± 0.012	0.216CysPhe: 0.216 ± 0.01	0.948CysGly: 0.948 ± 0.019	0.195CysHis: 0.195 ± 0.009	0.176CysIle: 0.176 ± 0.008	0.11CysLys: 0.11 ± 0.006	0.783CysLeu: 0.783 ± 0.02	0.119CysMet: 0.119 ± 0.007	0.144CysAsn: 0.144 ± 0.008	0.478CysPro: 0.478 ± 0.014	0.174CysGln: 0.174 ± 0.008	0.597CysArg: 0.597 ± 0.014	0.433CysSer: 0.433 ± 0.015	0.552CysThr: 0.552 ± 0.017	0.674CysVal: 0.674 ± 0.016	0.145CysTrp: 0.145 ± 0.007	0.162CysTyr: 0.162 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.656AspAla: 7.656 ± 0.064	0.433AspCys: 0.433 ± 0.012	3.678AspAsp: 3.678 ± 0.04	3.741AspGlu: 3.741 ± 0.038	1.657AspPhe: 1.657 ± 0.028	6.608AspGly: 6.608 ± 0.058	1.472AspHis: 1.472 ± 0.025	1.944AspIle: 1.944 ± 0.027	1.147AspLys: 1.147 ± 0.025	6.33AspLeu: 6.33 ± 0.049	0.816AspMet: 0.816 ± 0.018	0.994AspAsn: 0.994 ± 0.023	4.495AspPro: 4.495 ± 0.045	1.531AspGln: 1.531 ± 0.024	5.014AspArg: 5.014 ± 0.049	2.689AspSer: 2.689 ± 0.034	3.43AspThr: 3.43 ± 0.036	4.745AspVal: 4.745 ± 0.039	1.023AspTrp: 1.023 ± 0.018	1.167AspTyr: 1.167 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.064GluAla: 7.064 ± 0.071	0.357GluCys: 0.357 ± 0.01	2.722GluAsp: 2.722 ± 0.034	3.266GluGlu: 3.266 ± 0.04	1.425GluPhe: 1.425 ± 0.023	4.038GluGly: 4.038 ± 0.047	1.562GluHis: 1.562 ± 0.025	2.156GluIle: 2.156 ± 0.028	1.305GluLys: 1.305 ± 0.029	6.646GluLeu: 6.646 ± 0.063	0.837GluMet: 0.837 ± 0.017	0.995GluAsn: 0.995 ± 0.02	3.217GluPro: 3.217 ± 0.045	2.236GluGln: 2.236 ± 0.034	5.287GluArg: 5.287 ± 0.062	2.603GluSer: 2.603 ± 0.029	2.854GluThr: 2.854 ± 0.036	4.348GluVal: 4.348 ± 0.049	0.738GluTrp: 0.738 ± 0.017	1.062GluTyr: 1.062 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.683PheAla: 3.683 ± 0.04	0.273PheCys: 0.273 ± 0.009	1.955PheAsp: 1.955 ± 0.027	1.404PheGlu: 1.404 ± 0.023	0.85PhePhe: 0.85 ± 0.02	3.04PheGly: 3.04 ± 0.036	0.63PheHis: 0.63 ± 0.016	0.648PheIle: 0.648 ± 0.016	0.5PheLys: 0.5 ± 0.014	2.555PheLeu: 2.555 ± 0.037	0.403PheMet: 0.403 ± 0.013	0.572PheAsn: 0.572 ± 0.017	1.407PhePro: 1.407 ± 0.025	0.668PheGln: 0.668 ± 0.018	1.849PheArg: 1.849 ± 0.029	1.441PheSer: 1.441 ± 0.024	2.037PheThr: 2.037 ± 0.028	2.279PheVal: 2.279 ± 0.033	0.424PheTrp: 0.424 ± 0.014	0.596PheTyr: 0.596 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.964GlyAla: 10.964 ± 0.072	0.85GlyCys: 0.85 ± 0.017	5.192GlyAsp: 5.192 ± 0.049	4.834GlyGlu: 4.834 ± 0.047	2.935GlyPhe: 2.935 ± 0.034	8.712GlyGly: 8.712 ± 0.098	2.393GlyHis: 2.393 ± 0.033	3.373GlyIle: 3.373 ± 0.034	2.338GlyLys: 2.338 ± 0.037	9.343GlyLeu: 9.343 ± 0.063	1.912GlyMet: 1.912 ± 0.033	1.864GlyAsn: 1.864 ± 0.038	5.221GlyPro: 5.221 ± 0.049	2.705GlyGln: 2.705 ± 0.041	7.866GlyArg: 7.866 ± 0.065	5.549GlySer: 5.549 ± 0.056	6.689GlyThr: 6.689 ± 0.069	7.485GlyVal: 7.485 ± 0.058	1.734GlyTrp: 1.734 ± 0.027	2.308GlyTyr: 2.308 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.72HisAla: 2.72 ± 0.031	0.223HisCys: 0.223 ± 0.01	1.433HisAsp: 1.433 ± 0.025	1.224HisGlu: 1.224 ± 0.026	0.661HisPhe: 0.661 ± 0.015	2.523HisGly: 2.523 ± 0.03	0.724HisHis: 0.724 ± 0.016	0.684HisIle: 0.684 ± 0.017	0.358HisLys: 0.358 ± 0.012	2.458HisLeu: 2.458 ± 0.034	0.334HisMet: 0.334 ± 0.01	0.387HisAsn: 0.387 ± 0.012	1.782HisPro: 1.782 ± 0.029	0.669HisGln: 0.669 ± 0.016	2.184HisArg: 2.184 ± 0.034	1.03HisSer: 1.03 ± 0.02	1.429HisThr: 1.429 ± 0.024	1.734HisVal: 1.734 ± 0.024	0.388HisTrp: 0.388 ± 0.013	0.507HisTyr: 0.507 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.679IleAla: 4.679 ± 0.043	0.286IleCys: 0.286 ± 0.011	2.158IleAsp: 2.158 ± 0.03	1.875IleGlu: 1.875 ± 0.028	0.662IlePhe: 0.662 ± 0.017	3.453IleGly: 3.453 ± 0.039	0.606IleHis: 0.606 ± 0.014	0.775IleIle: 0.775 ± 0.021	0.699IleLys: 0.699 ± 0.018	2.323IleLeu: 2.323 ± 0.028	0.427IleMet: 0.427 ± 0.013	0.664IleAsn: 0.664 ± 0.017	1.752IlePro: 1.752 ± 0.026	0.733IleGln: 0.733 ± 0.019	2.259IleArg: 2.259 ± 0.031	1.618IleSer: 1.618 ± 0.022	2.209IleThr: 2.209 ± 0.028	2.745IleVal: 2.745 ± 0.037	0.387IleTrp: 0.387 ± 0.012	0.534IleTyr: 0.534 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.905LysAla: 2.905 ± 0.044	0.119LysCys: 0.119 ± 0.008	1.349LysAsp: 1.349 ± 0.027	1.103LysGlu: 1.103 ± 0.022	0.46LysPhe: 0.46 ± 0.014	1.725LysGly: 1.725 ± 0.031	0.404LysHis: 0.404 ± 0.012	0.817LysIle: 0.817 ± 0.019	0.801LysLys: 0.801 ± 0.022	1.93LysLeu: 1.93 ± 0.029	0.342LysMet: 0.342 ± 0.013	0.519LysAsn: 0.519 ± 0.017	1.234LysPro: 1.234 ± 0.021	0.704LysGln: 0.704 ± 0.019	1.33LysArg: 1.33 ± 0.023	1.182LysSer: 1.182 ± 0.023	1.293LysThr: 1.293 ± 0.029	1.885LysVal: 1.885 ± 0.031	0.283LysTrp: 0.283 ± 0.01	0.456LysTyr: 0.456 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.161LeuAla: 15.161 ± 0.102	0.876LeuCys: 0.876 ± 0.019	6.682LeuAsp: 6.682 ± 0.062	4.539LeuGlu: 4.539 ± 0.05	2.57LeuPhe: 2.57 ± 0.035	9.224LeuGly: 9.224 ± 0.064	2.321LeuHis: 2.321 ± 0.029	3.127LeuIle: 3.127 ± 0.037	2.047LeuLys: 2.047 ± 0.03	11.328LeuLeu: 11.328 ± 0.102	1.629LeuMet: 1.629 ± 0.024	1.707LeuAsn: 1.707 ± 0.029	6.479LeuPro: 6.479 ± 0.063	2.179LeuGln: 2.179 ± 0.027	8.62LeuArg: 8.62 ± 0.065	5.37LeuSer: 5.37 ± 0.055	7.0LeuThr: 7.0 ± 0.061	8.898LeuVal: 8.898 ± 0.072	1.35LeuTrp: 1.35 ± 0.025	1.947LeuTyr: 1.947 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.152MetAla: 2.152 ± 0.028	0.131MetCys: 0.131 ± 0.007	0.889MetAsp: 0.889 ± 0.021	0.717MetGlu: 0.717 ± 0.017	0.465MetPhe: 0.465 ± 0.014	1.264MetGly: 1.264 ± 0.024	0.37MetHis: 0.37 ± 0.013	0.619MetIle: 0.619 ± 0.016	0.386MetLys: 0.386 ± 0.013	1.621MetLeu: 1.621 ± 0.025	0.294MetMet: 0.294 ± 0.012	0.432MetAsn: 0.432 ± 0.014	1.101MetPro: 1.101 ± 0.02	0.462MetGln: 0.462 ± 0.016	1.384MetArg: 1.384 ± 0.025	1.336MetSer: 1.336 ± 0.022	1.523MetThr: 1.523 ± 0.022	1.227MetVal: 1.227 ± 0.019	0.209MetTrp: 0.209 ± 0.009	0.318MetTyr: 0.318 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.193AsnAla: 2.193 ± 0.031	0.159AsnCys: 0.159 ± 0.008	1.004AsnAsp: 1.004 ± 0.022	0.797AsnGlu: 0.797 ± 0.018	0.493AsnPhe: 0.493 ± 0.016	1.931AsnGly: 1.931 ± 0.032	0.412AsnHis: 0.412 ± 0.012	0.656AsnIle: 0.656 ± 0.016	0.398AsnLys: 0.398 ± 0.014	1.69AsnLeu: 1.69 ± 0.028	0.302AsnMet: 0.302 ± 0.01	0.451AsnAsn: 0.451 ± 0.016	1.367AsnPro: 1.367 ± 0.024	0.528AsnGln: 0.528 ± 0.017	1.295AsnArg: 1.295 ± 0.024	1.001AsnSer: 1.001 ± 0.024	1.21AsnThr: 1.21 ± 0.03	1.368AsnVal: 1.368 ± 0.023	0.313AsnTrp: 0.313 ± 0.012	0.423AsnTyr: 0.423 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.656ProAla: 8.656 ± 0.065	0.336ProCys: 0.336 ± 0.01	4.476ProAsp: 4.476 ± 0.042	4.119ProGlu: 4.119 ± 0.04	1.522ProPhe: 1.522 ± 0.024	6.504ProGly: 6.504 ± 0.065	1.412ProHis: 1.412 ± 0.024	1.251ProIle: 1.251 ± 0.023	1.133ProLys: 1.133 ± 0.022	5.283ProLeu: 5.283 ± 0.055	0.979ProMet: 0.979 ± 0.021	0.898ProAsn: 0.898 ± 0.019	3.338ProPro: 3.338 ± 0.048	1.834ProGln: 1.834 ± 0.038	4.012ProArg: 4.012 ± 0.04	3.183ProSer: 3.183 ± 0.04	3.285ProThr: 3.285 ± 0.043	5.473ProVal: 5.473 ± 0.048	0.902ProTrp: 0.902 ± 0.019	1.425ProTyr: 1.425 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.884GlnAla: 3.884 ± 0.042	0.176GlnCys: 0.176 ± 0.008	1.522GlnAsp: 1.522 ± 0.025	1.505GlnGlu: 1.505 ± 0.022	0.695GlnPhe: 0.695 ± 0.015	2.466GlnGly: 2.466 ± 0.043	0.692GlnHis: 0.692 ± 0.015	1.084GlnIle: 1.084 ± 0.022	0.615GlnLys: 0.615 ± 0.016	3.039GlnLeu: 3.039 ± 0.033	0.479GlnMet: 0.479 ± 0.013	0.536GlnAsn: 0.536 ± 0.015	1.691GlnPro: 1.691 ± 0.038	1.279GlnGln: 1.279 ± 0.033	2.345GlnArg: 2.345 ± 0.032	1.388GlnSer: 1.388 ± 0.022	1.442GlnThr: 1.442 ± 0.025	2.451GlnVal: 2.451 ± 0.037	0.49GlnTrp: 0.49 ± 0.015	0.66GlnTyr: 0.66 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.891ArgAla: 9.891 ± 0.078	0.599ArgCys: 0.599 ± 0.015	4.247ArgAsp: 4.247 ± 0.042	4.575ArgGlu: 4.575 ± 0.05	2.336ArgPhe: 2.336 ± 0.028	5.72ArgGly: 5.72 ± 0.049	2.188ArgHis: 2.188 ± 0.032	3.293ArgIle: 3.293 ± 0.032	1.557ArgLys: 1.557 ± 0.027	9.021ArgLeu: 9.021 ± 0.075	1.674ArgMet: 1.674 ± 0.025	1.353ArgAsn: 1.353 ± 0.025	5.038ArgPro: 5.038 ± 0.052	2.452ArgGln: 2.452 ± 0.034	7.87ArgArg: 7.87 ± 0.069	4.093ArgSer: 4.093 ± 0.042	5.623ArgThr: 5.623 ± 0.048	5.835ArgVal: 5.835 ± 0.049	1.408ArgTrp: 1.408 ± 0.027	1.804ArgTyr: 1.804 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	7.094SerAla: 7.094 ± 0.059	0.427SerCys: 0.427 ± 0.013	2.785SerAsp: 2.785 ± 0.034	2.317SerGlu: 2.317 ± 0.029	1.552SerPhe: 1.552 ± 0.027	6.176SerGly: 6.176 ± 0.064	1.03SerHis: 1.03 ± 0.021	1.397SerIle: 1.397 ± 0.022	1.002SerLys: 1.002 ± 0.022	4.858SerLeu: 4.858 ± 0.049	1.084SerMet: 1.084 ± 0.019	0.899SerAsn: 0.899 ± 0.021	3.181SerPro: 3.181 ± 0.033	1.311SerGln: 1.311 ± 0.025	3.646SerArg: 3.646 ± 0.041	2.962SerSer: 2.962 ± 0.048	3.277SerThr: 3.277 ± 0.041	4.476SerVal: 4.476 ± 0.042	0.953SerTrp: 0.953 ± 0.019	1.302SerTyr: 1.302 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	9.336ThrAla: 9.336 ± 0.067	0.47ThrCys: 0.47 ± 0.013	3.873ThrAsp: 3.873 ± 0.043	3.204ThrGlu: 3.204 ± 0.041	1.633ThrPhe: 1.633 ± 0.027	6.984ThrGly: 6.984 ± 0.064	1.249ThrHis: 1.249 ± 0.022	1.677ThrIle: 1.677 ± 0.028	1.187ThrLys: 1.187 ± 0.022	5.894ThrLeu: 5.894 ± 0.047	0.954ThrMet: 0.954 ± 0.022	1.03ThrAsn: 1.03 ± 0.023	4.143ThrPro: 4.143 ± 0.043	1.453ThrGln: 1.453 ± 0.033	4.021ThrArg: 4.021 ± 0.037	3.379ThrSer: 3.379 ± 0.043	4.084ThrThr: 4.084 ± 0.056	6.371ThrVal: 6.371 ± 0.06	0.951ThrTrp: 0.951 ± 0.019	1.417ThrTyr: 1.417 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.696ValAla: 10.696 ± 0.08	0.767ValCys: 0.767 ± 0.016	5.087ValAsp: 5.087 ± 0.045	4.659ValGlu: 4.659 ± 0.041	2.443ValPhe: 2.443 ± 0.035	6.607ValGly: 6.607 ± 0.058	2.023ValHis: 2.023 ± 0.029	2.726ValIle: 2.726 ± 0.035	1.765ValLys: 1.765 ± 0.032	9.498ValLeu: 9.498 ± 0.073	1.368ValMet: 1.368 ± 0.021	1.681ValAsn: 1.681 ± 0.029	5.263ValPro: 5.263 ± 0.048	2.188ValGln: 2.188 ± 0.027	7.301ValArg: 7.301 ± 0.057	4.35ValSer: 4.35 ± 0.046	5.825ValThr: 5.825 ± 0.054	8.177ValVal: 8.177 ± 0.073	1.175ValTrp: 1.175 ± 0.024	1.63ValTyr: 1.63 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.67TrpAla: 1.67 ± 0.028	0.158TrpCys: 0.158 ± 0.008	0.856TrpAsp: 0.856 ± 0.018	0.727TrpGlu: 0.727 ± 0.016	0.499TrpPhe: 0.499 ± 0.013	1.082TrpGly: 1.082 ± 0.02	0.388TrpHis: 0.388 ± 0.013	0.577TrpIle: 0.577 ± 0.015	0.383TrpLys: 0.383 ± 0.014	1.783TrpLeu: 1.783 ± 0.027	0.29TrpMet: 0.29 ± 0.011	0.449TrpAsn: 0.449 ± 0.014	0.798TrpPro: 0.798 ± 0.016	0.671TrpGln: 0.671 ± 0.017	1.351TrpArg: 1.351 ± 0.023	0.989TrpSer: 0.989 ± 0.021	1.105TrpThr: 1.105 ± 0.022	0.954TrpVal: 0.954 ± 0.019	0.348TrpTrp: 0.348 ± 0.014	0.396TrpTyr: 0.396 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.816TyrAla: 2.816 ± 0.033	0.175TyrCys: 0.175 ± 0.008	1.607TyrAsp: 1.607 ± 0.025	1.253TyrGlu: 1.253 ± 0.022	0.67TyrPhe: 0.67 ± 0.016	2.359TyrGly: 2.359 ± 0.035	0.395TyrHis: 0.395 ± 0.011	0.512TyrIle: 0.512 ± 0.014	0.409TyrLys: 0.409 ± 0.014	2.11TyrLeu: 2.11 ± 0.026	0.261TyrMet: 0.261 ± 0.009	0.438TyrAsn: 0.438 ± 0.014	1.079TyrPro: 1.079 ± 0.021	0.626TyrGln: 0.626 ± 0.016	1.876TyrArg: 1.876 ± 0.027	1.021TyrSer: 1.021 ± 0.022	1.269TyrThr: 1.269 ± 0.027	1.68TyrVal: 1.68 ± 0.026	0.358TyrTrp: 0.358 ± 0.012	0.497TyrTyr: 0.497 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8617 proteins (2795366 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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