Amino acid dipepetide frequency for Pelagibacterium halotolerans (strain DSM 22347 / JCM 15775 / CGMCC 1.7692 / B2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.344AlaAla: 15.344 ± 0.154
0.802AlaCys: 0.802 ± 0.029
6.996AlaAsp: 6.996 ± 0.08
7.671AlaGlu: 7.671 ± 0.112
4.603AlaPhe: 4.603 ± 0.067
10.361AlaGly: 10.361 ± 0.112
2.178AlaHis: 2.178 ± 0.046
7.491AlaIle: 7.491 ± 0.083
3.284AlaLys: 3.284 ± 0.068
13.78AlaLeu: 13.78 ± 0.117
3.721AlaMet: 3.721 ± 0.061
3.154AlaAsn: 3.154 ± 0.062
5.407AlaPro: 5.407 ± 0.08
4.418AlaGln: 4.418 ± 0.069
8.31AlaArg: 8.31 ± 0.094
6.134AlaSer: 6.134 ± 0.087
5.939AlaThr: 5.939 ± 0.073
8.496AlaVal: 8.496 ± 0.088
1.32AlaTrp: 1.32 ± 0.031
2.618AlaTyr: 2.618 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.858CysAla: 0.858 ± 0.026
0.082CysCys: 0.082 ± 0.009
0.475CysAsp: 0.475 ± 0.021
0.387CysGlu: 0.387 ± 0.018
0.27CysPhe: 0.27 ± 0.015
0.771CysGly: 0.771 ± 0.028
0.22CysHis: 0.22 ± 0.015
0.359CysIle: 0.359 ± 0.019
0.134CysLys: 0.134 ± 0.009
0.636CysLeu: 0.636 ± 0.026
0.146CysMet: 0.146 ± 0.011
0.193CysAsn: 0.193 ± 0.014
0.374CysPro: 0.374 ± 0.022
0.19CysGln: 0.19 ± 0.014
0.454CysArg: 0.454 ± 0.024
0.373CysSer: 0.373 ± 0.017
0.325CysThr: 0.325 ± 0.018
0.52CysVal: 0.52 ± 0.022
0.104CysTrp: 0.104 ± 0.009
0.184CysTyr: 0.184 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.025AspAla: 7.025 ± 0.088
0.433AspCys: 0.433 ± 0.018
3.301AspAsp: 3.301 ± 0.063
3.671AspGlu: 3.671 ± 0.064
2.405AspPhe: 2.405 ± 0.046
5.452AspGly: 5.452 ± 0.085
1.191AspHis: 1.191 ± 0.035
3.803AspIle: 3.803 ± 0.058
1.632AspLys: 1.632 ± 0.036
5.942AspLeu: 5.942 ± 0.086
1.498AspMet: 1.498 ± 0.035
1.498AspAsn: 1.498 ± 0.032
3.532AspPro: 3.532 ± 0.054
1.709AspGln: 1.709 ± 0.033
3.98AspArg: 3.98 ± 0.061
2.156AspSer: 2.156 ± 0.051
2.986AspThr: 2.986 ± 0.058
3.992AspVal: 3.992 ± 0.063
1.008AspTrp: 1.008 ± 0.033
1.578AspTyr: 1.578 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
7.574GluAla: 7.574 ± 0.094
0.293GluCys: 0.293 ± 0.017
3.242GluAsp: 3.242 ± 0.063
3.291GluGlu: 3.291 ± 0.059
1.808GluPhe: 1.808 ± 0.042
4.713GluGly: 4.713 ± 0.082
1.201GluHis: 1.201 ± 0.031
4.164GluIle: 4.164 ± 0.066
2.397GluLys: 2.397 ± 0.056
5.344GluLeu: 5.344 ± 0.08
1.81GluMet: 1.81 ± 0.037
1.906GluAsn: 1.906 ± 0.043
2.959GluPro: 2.959 ± 0.063
2.058GluGln: 2.058 ± 0.04
4.747GluArg: 4.747 ± 0.072
2.509GluSer: 2.509 ± 0.048
4.061GluThr: 4.061 ± 0.066
3.879GluVal: 3.879 ± 0.065
0.689GluTrp: 0.689 ± 0.025
1.065GluTyr: 1.065 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
5.023PheAla: 5.023 ± 0.07
0.348PheCys: 0.348 ± 0.016
2.744PheAsp: 2.744 ± 0.044
2.486PheGlu: 2.486 ± 0.043
1.586PhePhe: 1.586 ± 0.042
3.952PheGly: 3.952 ± 0.06
0.659PheHis: 0.659 ± 0.027
1.909PheIle: 1.909 ± 0.045
0.935PheLys: 0.935 ± 0.032
3.377PheLeu: 3.377 ± 0.064
0.92PheMet: 0.92 ± 0.029
1.085PheAsn: 1.085 ± 0.037
1.661PhePro: 1.661 ± 0.038
1.009PheGln: 1.009 ± 0.026
2.02PheArg: 2.02 ± 0.043
2.601PheSer: 2.601 ± 0.047
2.135PheThr: 2.135 ± 0.046
3.097PheVal: 3.097 ± 0.058
0.625PheTrp: 0.625 ± 0.025
0.971PheTyr: 0.971 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
9.42GlyAla: 9.42 ± 0.1
0.699GlyCys: 0.699 ± 0.024
4.527GlyAsp: 4.527 ± 0.08
5.272GlyGlu: 5.272 ± 0.073
3.883GlyPhe: 3.883 ± 0.06
7.179GlyGly: 7.179 ± 0.117
1.88GlyHis: 1.88 ± 0.045
4.94GlyIle: 4.94 ± 0.069
3.02GlyLys: 3.02 ± 0.058
9.289GlyLeu: 9.289 ± 0.099
2.462GlyMet: 2.462 ± 0.047
2.346GlyAsn: 2.346 ± 0.059
3.527GlyPro: 3.527 ± 0.059
3.102GlyGln: 3.102 ± 0.06
5.633GlyArg: 5.633 ± 0.075
4.524GlySer: 4.524 ± 0.054
4.909GlyThr: 4.909 ± 0.074
6.334GlyVal: 6.334 ± 0.078
1.347GlyTrp: 1.347 ± 0.036
2.293GlyTyr: 2.293 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.088HisAla: 2.088 ± 0.048
0.206HisCys: 0.206 ± 0.014
1.127HisAsp: 1.127 ± 0.03
1.067HisGlu: 1.067 ± 0.029
0.907HisPhe: 0.907 ± 0.031
1.737HisGly: 1.737 ± 0.039
0.549HisHis: 0.549 ± 0.022
1.091HisIle: 1.091 ± 0.031
0.562HisLys: 0.562 ± 0.025
1.999HisLeu: 1.999 ± 0.042
0.559HisMet: 0.559 ± 0.022
0.49HisAsn: 0.49 ± 0.021
1.208HisPro: 1.208 ± 0.034
0.586HisGln: 0.586 ± 0.025
1.259HisArg: 1.259 ± 0.031
0.885HisSer: 0.885 ± 0.03
0.883HisThr: 0.883 ± 0.031
1.412HisVal: 1.412 ± 0.04
0.279HisTrp: 0.279 ± 0.018
0.519HisTyr: 0.519 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
8.469IleAla: 8.469 ± 0.092
0.493IleCys: 0.493 ± 0.021
4.032IleAsp: 4.032 ± 0.064
4.351IleGlu: 4.351 ± 0.057
2.084IlePhe: 2.084 ± 0.044
5.45IleGly: 5.45 ± 0.065
0.937IleHis: 0.937 ± 0.027
2.792IleIle: 2.792 ± 0.06
1.424IleLys: 1.424 ± 0.036
5.062IleLeu: 5.062 ± 0.073
1.167IleMet: 1.167 ± 0.034
1.529IleAsn: 1.529 ± 0.043
2.493IlePro: 2.493 ± 0.05
1.245IleGln: 1.245 ± 0.032
3.043IleArg: 3.043 ± 0.052
3.398IleSer: 3.398 ± 0.062
2.928IleThr: 2.928 ± 0.047
5.12IleVal: 5.12 ± 0.072
0.675IleTrp: 0.675 ± 0.028
1.208IleTyr: 1.208 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.578LysAla: 3.578 ± 0.066
0.148LysCys: 0.148 ± 0.012
1.555LysAsp: 1.555 ± 0.037
1.238LysGlu: 1.238 ± 0.037
0.922LysPhe: 0.922 ± 0.029
2.445LysGly: 2.445 ± 0.051
0.584LysHis: 0.584 ± 0.024
1.658LysIle: 1.658 ± 0.038
1.149LysLys: 1.149 ± 0.04
2.93LysLeu: 2.93 ± 0.054
0.672LysMet: 0.672 ± 0.025
0.697LysAsn: 0.697 ± 0.02
1.77LysPro: 1.77 ± 0.042
0.806LysGln: 0.806 ± 0.027
2.145LysArg: 2.145 ± 0.048
1.989LysSer: 1.989 ± 0.05
1.866LysThr: 1.866 ± 0.045
2.078LysVal: 2.078 ± 0.049
0.343LysTrp: 0.343 ± 0.02
0.502LysTyr: 0.502 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
13.588LeuAla: 13.588 ± 0.126
0.73LeuCys: 0.73 ± 0.027
6.4LeuAsp: 6.4 ± 0.084
5.882LeuGlu: 5.882 ± 0.071
3.754LeuPhe: 3.754 ± 0.061
8.677LeuGly: 8.677 ± 0.09
1.641LeuHis: 1.641 ± 0.041
5.526LeuIle: 5.526 ± 0.071
3.183LeuLys: 3.183 ± 0.065
8.975LeuLeu: 8.975 ± 0.104
2.488LeuMet: 2.488 ± 0.046
2.682LeuAsn: 2.682 ± 0.048
5.211LeuPro: 5.211 ± 0.07
2.357LeuGln: 2.357 ± 0.051
5.971LeuArg: 5.971 ± 0.072
6.727LeuSer: 6.727 ± 0.092
5.526LeuThr: 5.526 ± 0.079
7.915LeuVal: 7.915 ± 0.092
1.103LeuTrp: 1.103 ± 0.033
2.194LeuTyr: 2.194 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.472MetAla: 3.472 ± 0.056
0.137MetCys: 0.137 ± 0.01
1.296MetAsp: 1.296 ± 0.032
1.225MetGlu: 1.225 ± 0.036
0.854MetPhe: 0.854 ± 0.031
2.218MetGly: 2.218 ± 0.058
0.429MetHis: 0.429 ± 0.02
1.582MetIle: 1.582 ± 0.04
0.811MetLys: 0.811 ± 0.025
2.632MetLeu: 2.632 ± 0.054
0.701MetMet: 0.701 ± 0.026
0.758MetAsn: 0.758 ± 0.026
1.531MetPro: 1.531 ± 0.042
0.749MetGln: 0.749 ± 0.027
1.744MetArg: 1.744 ± 0.042
1.836MetSer: 1.836 ± 0.044
1.966MetThr: 1.966 ± 0.041
2.011MetVal: 2.011 ± 0.045
0.204MetTrp: 0.204 ± 0.013
0.349MetTyr: 0.349 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.368AsnAla: 3.368 ± 0.06
0.207AsnCys: 0.207 ± 0.012
1.465AsnAsp: 1.465 ± 0.05
1.324AsnGlu: 1.324 ± 0.036
1.144AsnPhe: 1.144 ± 0.029
2.53AsnGly: 2.53 ± 0.052
0.5AsnHis: 0.5 ± 0.023
1.498AsnIle: 1.498 ± 0.034
0.618AsnLys: 0.618 ± 0.023
2.642AsnLeu: 2.642 ± 0.048
0.666AsnMet: 0.666 ± 0.024
0.675AsnAsn: 0.675 ± 0.027
1.854AsnPro: 1.854 ± 0.036
0.824AsnGln: 0.824 ± 0.026
1.847AsnArg: 1.847 ± 0.039
1.361AsnSer: 1.361 ± 0.033
1.4AsnThr: 1.4 ± 0.033
1.933AsnVal: 1.933 ± 0.047
0.485AsnTrp: 0.485 ± 0.024
0.729AsnTyr: 0.729 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
5.811ProAla: 5.811 ± 0.08
0.26ProCys: 0.26 ± 0.015
3.808ProAsp: 3.808 ± 0.057
3.832ProGlu: 3.832 ± 0.068
2.031ProPhe: 2.031 ± 0.047
4.258ProGly: 4.258 ± 0.065
1.085ProHis: 1.085 ± 0.032
2.629ProIle: 2.629 ± 0.045
1.396ProLys: 1.396 ± 0.035
4.606ProLeu: 4.606 ± 0.063
1.253ProMet: 1.253 ± 0.032
1.401ProAsn: 1.401 ± 0.037
2.03ProPro: 2.03 ± 0.05
1.793ProGln: 1.793 ± 0.041
2.684ProArg: 2.684 ± 0.054
2.609ProSer: 2.609 ± 0.047
2.44ProThr: 2.44 ± 0.046
4.161ProVal: 4.161 ± 0.068
0.636ProTrp: 0.636 ± 0.025
1.208ProTyr: 1.208 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.771GlnAla: 3.771 ± 0.059
0.178GlnCys: 0.178 ± 0.012
1.462GlnAsp: 1.462 ± 0.038
1.422GlnGlu: 1.422 ± 0.037
1.161GlnPhe: 1.161 ± 0.032
2.327GlnGly: 2.327 ± 0.041
0.57GlnHis: 0.57 ± 0.02
2.019GlnIle: 2.019 ± 0.043
0.936GlnLys: 0.936 ± 0.027
2.915GlnLeu: 2.915 ± 0.051
1.087GlnMet: 1.087 ± 0.03
0.811GlnAsn: 0.811 ± 0.028
1.666GlnPro: 1.666 ± 0.043
1.117GlnGln: 1.117 ± 0.034
2.293GlnArg: 2.293 ± 0.047
2.017GlnSer: 2.017 ± 0.04
1.948GlnThr: 1.948 ± 0.044
2.181GlnVal: 2.181 ± 0.046
0.446GlnTrp: 0.446 ± 0.018
0.679GlnTyr: 0.679 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
7.404ArgAla: 7.404 ± 0.082
0.447ArgCys: 0.447 ± 0.022
3.798ArgAsp: 3.798 ± 0.061
3.855ArgGlu: 3.855 ± 0.064
2.814ArgPhe: 2.814 ± 0.053
4.316ArgGly: 4.316 ± 0.064
1.537ArgHis: 1.537 ± 0.042
3.864ArgIle: 3.864 ± 0.06
2.142ArgLys: 2.142 ± 0.045
7.043ArgLeu: 7.043 ± 0.099
1.799ArgMet: 1.799 ± 0.038
1.876ArgAsn: 1.876 ± 0.041
3.118ArgPro: 3.118 ± 0.062
2.49ArgGln: 2.49 ± 0.047
4.808ArgArg: 4.808 ± 0.069
3.469ArgSer: 3.469 ± 0.058
3.497ArgThr: 3.497 ± 0.059
4.361ArgVal: 4.361 ± 0.067
0.871ArgTrp: 0.871 ± 0.026
1.655ArgTyr: 1.655 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.397SerAla: 6.397 ± 0.1
0.325SerCys: 0.325 ± 0.017
3.176SerAsp: 3.176 ± 0.049
3.124SerGlu: 3.124 ± 0.058
2.307SerPhe: 2.307 ± 0.036
5.779SerGly: 5.779 ± 0.08
1.107SerHis: 1.107 ± 0.035
3.126SerIle: 3.126 ± 0.055
1.414SerLys: 1.414 ± 0.04
5.324SerLeu: 5.324 ± 0.076
1.469SerMet: 1.469 ± 0.032
1.508SerAsn: 1.508 ± 0.037
2.651SerPro: 2.651 ± 0.048
1.864SerGln: 1.864 ± 0.043
3.496SerArg: 3.496 ± 0.057
3.02SerSer: 3.02 ± 0.06
2.769SerThr: 2.769 ± 0.052
4.276SerVal: 4.276 ± 0.063
0.704SerTrp: 0.704 ± 0.023
1.298SerTyr: 1.298 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
6.088ThrAla: 6.088 ± 0.075
0.357ThrCys: 0.357 ± 0.018
3.149ThrAsp: 3.149 ± 0.057
2.986ThrGlu: 2.986 ± 0.052
2.012ThrPhe: 2.012 ± 0.047
5.351ThrGly: 5.351 ± 0.07
1.096ThrHis: 1.096 ± 0.029
3.529ThrIle: 3.529 ± 0.061
1.282ThrLys: 1.282 ± 0.039
6.245ThrLeu: 6.245 ± 0.079
1.326ThrMet: 1.326 ± 0.038
1.441ThrAsn: 1.441 ± 0.042
3.327ThrPro: 3.327 ± 0.06
1.52ThrGln: 1.52 ± 0.031
3.399ThrArg: 3.399 ± 0.057
2.797ThrSer: 2.797 ± 0.048
2.848ThrThr: 2.848 ± 0.057
4.244ThrVal: 4.244 ± 0.063
0.553ThrTrp: 0.553 ± 0.022
1.262ThrTyr: 1.262 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.964ValAla: 8.964 ± 0.088
0.554ValCys: 0.554 ± 0.023
4.136ValAsp: 4.136 ± 0.067
4.7ValGlu: 4.7 ± 0.074
3.083ValPhe: 3.083 ± 0.054
5.974ValGly: 5.974 ± 0.07
1.298ValHis: 1.298 ± 0.032
4.275ValIle: 4.275 ± 0.071
1.851ValLys: 1.851 ± 0.048
7.91ValLeu: 7.91 ± 0.095
1.96ValMet: 1.96 ± 0.042
1.95ValAsn: 1.95 ± 0.034
3.772ValPro: 3.772 ± 0.058
1.958ValGln: 1.958 ± 0.043
4.623ValArg: 4.623 ± 0.071
4.693ValSer: 4.693 ± 0.057
4.479ValThr: 4.479 ± 0.065
5.828ValVal: 5.828 ± 0.085
0.922ValTrp: 0.922 ± 0.03
1.544ValTyr: 1.544 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.228TrpAla: 1.228 ± 0.032
0.128TrpCys: 0.128 ± 0.01
0.657TrpAsp: 0.657 ± 0.024
0.558TrpGlu: 0.558 ± 0.024
0.535TrpPhe: 0.535 ± 0.021
0.932TrpGly: 0.932 ± 0.031
0.308TrpHis: 0.308 ± 0.016
0.671TrpIle: 0.671 ± 0.025
0.335TrpLys: 0.335 ± 0.018
1.567TrpLeu: 1.567 ± 0.041
0.334TrpMet: 0.334 ± 0.019
0.437TrpAsn: 0.437 ± 0.019
0.72TrpPro: 0.72 ± 0.025
0.519TrpGln: 0.519 ± 0.02
1.008TrpArg: 1.008 ± 0.033
0.795TrpSer: 0.795 ± 0.027
0.753TrpThr: 0.753 ± 0.023
0.898TrpVal: 0.898 ± 0.029
0.219TrpTrp: 0.219 ± 0.014
0.303TrpTyr: 0.303 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.557TyrAla: 2.557 ± 0.05
0.228TyrCys: 0.228 ± 0.014
1.448TyrAsp: 1.448 ± 0.036
1.371TyrGlu: 1.371 ± 0.037
0.978TyrPhe: 0.978 ± 0.029
2.165TyrGly: 2.165 ± 0.048
0.443TyrHis: 0.443 ± 0.02
0.972TyrIle: 0.972 ± 0.024
0.572TyrLys: 0.572 ± 0.024
2.31TyrLeu: 2.31 ± 0.04
0.466TyrMet: 0.466 ± 0.022
0.633TyrAsn: 0.633 ± 0.024
1.12TyrPro: 1.12 ± 0.031
0.691TyrGln: 0.691 ± 0.024
1.703TyrArg: 1.703 ± 0.033
1.241TyrSer: 1.241 ± 0.031
1.154TyrThr: 1.154 ± 0.032
1.737TyrVal: 1.737 ± 0.043
0.372TyrTrp: 0.372 ± 0.017
0.611TyrTyr: 0.611 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3875 proteins (1168210 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski