Amino acid dipepetide frequency for Pedobacter hartonius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.131AlaAla: 7.131 ± 0.095	0.645AlaCys: 0.645 ± 0.021	4.662AlaAsp: 4.662 ± 0.059	4.94AlaGlu: 4.94 ± 0.058	3.543AlaPhe: 3.543 ± 0.045	6.25AlaGly: 6.25 ± 0.077	1.264AlaHis: 1.264 ± 0.033	5.324AlaIle: 5.324 ± 0.068	4.557AlaLys: 4.557 ± 0.058	7.105AlaLeu: 7.105 ± 0.077	1.804AlaMet: 1.804 ± 0.042	3.574AlaAsn: 3.574 ± 0.061	2.345AlaPro: 2.345 ± 0.046	2.768AlaGln: 2.768 ± 0.036	2.717AlaArg: 2.717 ± 0.042	4.469AlaSer: 4.469 ± 0.062	3.999AlaThr: 3.999 ± 0.062	5.165AlaVal: 5.165 ± 0.06	0.701AlaTrp: 0.701 ± 0.019	2.851AlaTyr: 2.851 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.516CysAla: 0.516 ± 0.018	0.129CysCys: 0.129 ± 0.008	0.356CysAsp: 0.356 ± 0.016	0.375CysGlu: 0.375 ± 0.015	0.447CysPhe: 0.447 ± 0.019	0.621CysGly: 0.621 ± 0.024	0.187CysHis: 0.187 ± 0.012	0.662CysIle: 0.662 ± 0.02	0.484CysLys: 0.484 ± 0.015	0.798CysLeu: 0.798 ± 0.025	0.183CysMet: 0.183 ± 0.012	0.368CysAsn: 0.368 ± 0.014	0.281CysPro: 0.281 ± 0.015	0.213CysGln: 0.213 ± 0.013	0.327CysArg: 0.327 ± 0.016	0.579CysSer: 0.579 ± 0.021	0.431CysThr: 0.431 ± 0.017	0.438CysVal: 0.438 ± 0.018	0.08CysTrp: 0.08 ± 0.009	0.297CysTyr: 0.297 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.924AspAla: 3.924 ± 0.05	0.356AspCys: 0.356 ± 0.018	2.617AspAsp: 2.617 ± 0.051	3.385AspGlu: 3.385 ± 0.051	3.102AspPhe: 3.102 ± 0.045	3.659AspGly: 3.659 ± 0.059	1.183AspHis: 1.183 ± 0.029	4.015AspIle: 4.015 ± 0.052	3.517AspLys: 3.517 ± 0.054	5.366AspLeu: 5.366 ± 0.059	1.21AspMet: 1.21 ± 0.028	2.521AspAsn: 2.521 ± 0.042	2.204AspPro: 2.204 ± 0.04	2.128AspGln: 2.128 ± 0.038	2.195AspArg: 2.195 ± 0.038	2.745AspSer: 2.745 ± 0.048	2.682AspThr: 2.682 ± 0.037	3.31AspVal: 3.31 ± 0.045	0.741AspTrp: 0.741 ± 0.023	2.452AspTyr: 2.452 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.091GluAla: 4.091 ± 0.057	0.322GluCys: 0.322 ± 0.015	2.876GluAsp: 2.876 ± 0.039	4.073GluGlu: 4.073 ± 0.078	2.443GluPhe: 2.443 ± 0.038	3.447GluGly: 3.447 ± 0.049	1.129GluHis: 1.129 ± 0.028	4.503GluIle: 4.503 ± 0.059	4.708GluLys: 4.708 ± 0.062	5.996GluLeu: 5.996 ± 0.077	1.512GluMet: 1.512 ± 0.033	3.338GluAsn: 3.338 ± 0.055	1.559GluPro: 1.559 ± 0.034	2.508GluGln: 2.508 ± 0.04	2.631GluArg: 2.631 ± 0.043	2.984GluSer: 2.984 ± 0.046	3.015GluThr: 3.015 ± 0.045	3.637GluVal: 3.637 ± 0.053	0.64GluTrp: 0.64 ± 0.022	2.015GluTyr: 2.015 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.373PheAla: 3.373 ± 0.054	0.478PheCys: 0.478 ± 0.018	2.858PheAsp: 2.858 ± 0.043	2.686PheGlu: 2.686 ± 0.043	2.476PhePhe: 2.476 ± 0.046	3.388PheGly: 3.388 ± 0.049	0.897PheHis: 0.897 ± 0.028	3.664PheIle: 3.664 ± 0.057	3.216PheLys: 3.216 ± 0.05	4.438PheLeu: 4.438 ± 0.066	1.106PheMet: 1.106 ± 0.028	2.864PheAsn: 2.864 ± 0.046	1.742PhePro: 1.742 ± 0.034	1.368PheGln: 1.368 ± 0.032	1.957PheArg: 1.957 ± 0.038	3.994PheSer: 3.994 ± 0.051	2.999PheThr: 2.999 ± 0.046	2.806PheVal: 2.806 ± 0.049	0.556PheTrp: 0.556 ± 0.023	2.133PheTyr: 2.133 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	4.72GlyAla: 4.72 ± 0.062	0.596GlyCys: 0.596 ± 0.023	3.2GlyAsp: 3.2 ± 0.049	3.307GlyGlu: 3.307 ± 0.055	3.636GlyPhe: 3.636 ± 0.054	4.908GlyGly: 4.908 ± 0.082	1.271GlyHis: 1.271 ± 0.034	5.63GlyIle: 5.63 ± 0.066	5.273GlyLys: 5.273 ± 0.055	6.695GlyLeu: 6.695 ± 0.071	1.786GlyMet: 1.786 ± 0.034	3.692GlyAsn: 3.692 ± 0.061	1.641GlyPro: 1.641 ± 0.036	2.315GlyGln: 2.315 ± 0.036	2.736GlyArg: 2.736 ± 0.044	4.581GlySer: 4.581 ± 0.074	4.44GlyThr: 4.44 ± 0.087	4.218GlyVal: 4.218 ± 0.065	0.886GlyTrp: 0.886 ± 0.028	3.144GlyTyr: 3.144 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.19HisAla: 1.19 ± 0.028	0.195HisCys: 0.195 ± 0.012	0.903HisAsp: 0.903 ± 0.025	1.005HisGlu: 1.005 ± 0.027	1.084HisPhe: 1.084 ± 0.029	1.14HisGly: 1.14 ± 0.028	0.541HisHis: 0.541 ± 0.021	1.394HisIle: 1.394 ± 0.035	1.045HisLys: 1.045 ± 0.027	1.972HisLeu: 1.972 ± 0.036	0.406HisMet: 0.406 ± 0.016	0.9HisAsn: 0.9 ± 0.022	1.04HisPro: 1.04 ± 0.03	0.82HisGln: 0.82 ± 0.025	0.789HisArg: 0.789 ± 0.023	1.117HisSer: 1.117 ± 0.03	1.072HisThr: 1.072 ± 0.026	1.057HisVal: 1.057 ± 0.028	0.234HisTrp: 0.234 ± 0.015	0.873HisTyr: 0.873 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.962IleAla: 5.962 ± 0.076	0.774IleCys: 0.774 ± 0.021	4.093IleAsp: 4.093 ± 0.05	4.097IleGlu: 4.097 ± 0.061	3.3IlePhe: 3.3 ± 0.048	4.943IleGly: 4.943 ± 0.066	1.341IleHis: 1.341 ± 0.03	5.009IleIle: 5.009 ± 0.072	4.723IleLys: 4.723 ± 0.066	6.651IleLeu: 6.651 ± 0.078	1.407IleMet: 1.407 ± 0.027	4.084IleAsn: 4.084 ± 0.054	3.247IlePro: 3.247 ± 0.044	2.353IleGln: 2.353 ± 0.045	3.332IleArg: 3.332 ± 0.048	5.617IleSer: 5.617 ± 0.062	4.584IleThr: 4.584 ± 0.06	4.276IleVal: 4.276 ± 0.062	0.74IleTrp: 0.74 ± 0.025	2.659IleTyr: 2.659 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.933LysAla: 4.933 ± 0.062	0.32LysCys: 0.32 ± 0.016	4.17LysAsp: 4.17 ± 0.059	4.465LysGlu: 4.465 ± 0.061	2.646LysPhe: 2.646 ± 0.047	4.405LysGly: 4.405 ± 0.055	1.26LysHis: 1.26 ± 0.029	5.049LysIle: 5.049 ± 0.058	5.315LysLys: 5.315 ± 0.064	6.119LysLeu: 6.119 ± 0.076	1.868LysMet: 1.868 ± 0.032	4.102LysAsn: 4.102 ± 0.056	2.55LysPro: 2.55 ± 0.048	2.503LysGln: 2.503 ± 0.045	2.71LysArg: 2.71 ± 0.05	4.031LysSer: 4.031 ± 0.058	4.159LysThr: 4.159 ± 0.056	4.189LysVal: 4.189 ± 0.06	0.757LysTrp: 0.757 ± 0.022	2.757LysTyr: 2.757 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	6.992LeuAla: 6.992 ± 0.067	0.842LeuCys: 0.842 ± 0.023	4.842LeuAsp: 4.842 ± 0.056	5.032LeuGlu: 5.032 ± 0.076	4.61LeuPhe: 4.61 ± 0.06	5.865LeuGly: 5.865 ± 0.071	1.802LeuHis: 1.802 ± 0.036	6.974LeuIle: 6.974 ± 0.077	7.482LeuLys: 7.482 ± 0.078	9.774LeuLeu: 9.774 ± 0.118	2.271LeuMet: 2.271 ± 0.038	5.87LeuAsn: 5.87 ± 0.072	4.202LeuPro: 4.202 ± 0.053	3.591LeuGln: 3.591 ± 0.061	3.975LeuArg: 3.975 ± 0.055	7.675LeuSer: 7.675 ± 0.082	5.697LeuThr: 5.697 ± 0.069	5.529LeuVal: 5.529 ± 0.054	0.889LeuTrp: 0.889 ± 0.028	3.361LeuTyr: 3.361 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	1.869MetAla: 1.869 ± 0.036	0.156MetCys: 0.156 ± 0.011	1.276MetAsp: 1.276 ± 0.027	1.53MetGlu: 1.53 ± 0.034	0.849MetPhe: 0.849 ± 0.022	1.59MetGly: 1.59 ± 0.031	0.447MetHis: 0.447 ± 0.017	1.763MetIle: 1.763 ± 0.034	1.951MetLys: 1.951 ± 0.038	2.243MetLeu: 2.243 ± 0.035	0.663MetMet: 0.663 ± 0.022	1.38MetAsn: 1.38 ± 0.03	1.043MetPro: 1.043 ± 0.026	0.886MetGln: 0.886 ± 0.024	0.922MetArg: 0.922 ± 0.027	1.367MetSer: 1.367 ± 0.032	1.14MetThr: 1.14 ± 0.025	1.514MetVal: 1.514 ± 0.032	0.163MetTrp: 0.163 ± 0.01	0.646MetTyr: 0.646 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.93AsnAla: 3.93 ± 0.053	0.375AsnCys: 0.375 ± 0.017	2.714AsnAsp: 2.714 ± 0.044	2.867AsnGlu: 2.867 ± 0.043	2.718AsnPhe: 2.718 ± 0.043	3.861AsnGly: 3.861 ± 0.055	0.951AsnHis: 0.951 ± 0.023	4.146AsnIle: 4.146 ± 0.063	3.408AsnLys: 3.408 ± 0.046	5.086AsnLeu: 5.086 ± 0.063	1.231AsnMet: 1.231 ± 0.025	2.967AsnAsn: 2.967 ± 0.054	2.672AsnPro: 2.672 ± 0.051	1.985AsnGln: 1.985 ± 0.036	2.312AsnArg: 2.312 ± 0.04	3.44AsnSer: 3.44 ± 0.052	3.349AsnThr: 3.349 ± 0.062	3.075AsnVal: 3.075 ± 0.05	0.684AsnTrp: 0.684 ± 0.023	2.555AsnTyr: 2.555 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	3.517ProAla: 3.517 ± 0.074	0.221ProCys: 0.221 ± 0.013	2.544ProAsp: 2.544 ± 0.04	3.019ProGlu: 3.019 ± 0.046	1.992ProPhe: 1.992 ± 0.037	2.965ProGly: 2.965 ± 0.046	0.631ProHis: 0.631 ± 0.025	2.019ProIle: 2.019 ± 0.036	2.112ProLys: 2.112 ± 0.039	3.618ProLeu: 3.618 ± 0.049	0.765ProMet: 0.765 ± 0.022	1.786ProAsn: 1.786 ± 0.04	1.016ProPro: 1.016 ± 0.031	1.304ProGln: 1.304 ± 0.025	1.106ProArg: 1.106 ± 0.031	2.274ProSer: 2.274 ± 0.04	1.73ProThr: 1.73 ± 0.036	3.427ProVal: 3.427 ± 0.051	0.406ProTrp: 0.406 ± 0.017	1.574ProTyr: 1.574 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.598GlnAla: 2.598 ± 0.046	0.175GlnCys: 0.175 ± 0.01	1.694GlnAsp: 1.694 ± 0.034	2.098GlnGlu: 2.098 ± 0.04	1.636GlnPhe: 1.636 ± 0.032	1.978GlnGly: 1.978 ± 0.037	0.817GlnHis: 0.817 ± 0.022	2.573GlnIle: 2.573 ± 0.042	2.51GlnLys: 2.51 ± 0.046	4.06GlnLeu: 4.06 ± 0.061	0.936GlnMet: 0.936 ± 0.025	1.884GlnAsn: 1.884 ± 0.039	1.434GlnPro: 1.434 ± 0.027	2.045GlnGln: 2.045 ± 0.059	1.571GlnArg: 1.571 ± 0.038	2.238GlnSer: 2.238 ± 0.035	2.05GlnThr: 2.05 ± 0.039	2.307GlnVal: 2.307 ± 0.038	0.411GlnTrp: 0.411 ± 0.017	1.463GlnTyr: 1.463 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.616ArgAla: 2.616 ± 0.047	0.267ArgCys: 0.267 ± 0.013	2.029ArgAsp: 2.029 ± 0.034	2.445ArgGlu: 2.445 ± 0.044	2.136ArgPhe: 2.136 ± 0.038	2.326ArgGly: 2.326 ± 0.046	0.713ArgHis: 0.713 ± 0.022	3.266ArgIle: 3.266 ± 0.054	3.063ArgLys: 3.063 ± 0.05	4.111ArgLeu: 4.111 ± 0.053	1.111ArgMet: 1.111 ± 0.028	2.399ArgAsn: 2.399 ± 0.042	1.44ArgPro: 1.44 ± 0.031	1.562ArgGln: 1.562 ± 0.032	1.719ArgArg: 1.719 ± 0.036	2.579ArgSer: 2.579 ± 0.042	2.164ArgThr: 2.164 ± 0.038	2.346ArgVal: 2.346 ± 0.044	0.511ArgTrp: 0.511 ± 0.018	1.814ArgTyr: 1.814 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.228SerAla: 5.228 ± 0.069	0.582SerCys: 0.582 ± 0.02	3.235SerAsp: 3.235 ± 0.046	3.051SerGlu: 3.051 ± 0.048	3.655SerPhe: 3.655 ± 0.048	5.313SerGly: 5.313 ± 0.056	1.145SerHis: 1.145 ± 0.028	4.67SerIle: 4.67 ± 0.062	3.882SerLys: 3.882 ± 0.052	6.446SerLeu: 6.446 ± 0.068	1.471SerMet: 1.471 ± 0.035	3.213SerAsn: 3.213 ± 0.057	2.528SerPro: 2.528 ± 0.04	2.05SerGln: 2.05 ± 0.038	2.817SerArg: 2.817 ± 0.046	4.501SerSer: 4.501 ± 0.071	3.661SerThr: 3.661 ± 0.055	4.373SerVal: 4.373 ± 0.053	0.815SerTrp: 0.815 ± 0.024	2.93SerTyr: 2.93 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.115ThrAla: 5.115 ± 0.078	0.346ThrCys: 0.346 ± 0.014	3.368ThrAsp: 3.368 ± 0.045	3.219ThrGlu: 3.219 ± 0.049	2.705ThrPhe: 2.705 ± 0.051	5.069ThrGly: 5.069 ± 0.085	0.958ThrHis: 0.958 ± 0.029	4.24ThrIle: 4.24 ± 0.057	3.089ThrLys: 3.089 ± 0.047	5.516ThrLeu: 5.516 ± 0.066	1.035ThrMet: 1.035 ± 0.024	2.734ThrAsn: 2.734 ± 0.056	2.454ThrPro: 2.454 ± 0.047	1.824ThrGln: 1.824 ± 0.034	2.101ThrArg: 2.101 ± 0.037	3.515ThrSer: 3.515 ± 0.057	3.416ThrThr: 3.416 ± 0.065	4.117ThrVal: 4.117 ± 0.072	0.586ThrTrp: 0.586 ± 0.019	2.317ThrTyr: 2.317 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.508ValAla: 4.508 ± 0.057	0.561ValCys: 0.561 ± 0.018	3.114ValAsp: 3.114 ± 0.048	3.27ValGlu: 3.27 ± 0.056	3.212ValPhe: 3.212 ± 0.044	3.498ValGly: 3.498 ± 0.056	1.068ValHis: 1.068 ± 0.025	4.909ValIle: 4.909 ± 0.059	4.567ValLys: 4.567 ± 0.068	6.239ValLeu: 6.239 ± 0.066	1.513ValMet: 1.513 ± 0.035	3.608ValAsn: 3.608 ± 0.054	2.588ValPro: 2.588 ± 0.047	2.081ValGln: 2.081 ± 0.039	2.341ValArg: 2.341 ± 0.042	4.507ValSer: 4.507 ± 0.059	3.928ValThr: 3.928 ± 0.075	4.027ValVal: 4.027 ± 0.059	0.639ValTrp: 0.639 ± 0.02	2.493ValTyr: 2.493 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.729TrpAla: 0.729 ± 0.02	0.099TrpCys: 0.099 ± 0.008	0.609TrpAsp: 0.609 ± 0.023	0.634TrpGlu: 0.634 ± 0.02	0.569TrpPhe: 0.569 ± 0.02	0.713TrpGly: 0.713 ± 0.023	0.235TrpHis: 0.235 ± 0.011	0.756TrpIle: 0.756 ± 0.023	0.817TrpLys: 0.817 ± 0.025	1.142TrpLeu: 1.142 ± 0.031	0.346TrpMet: 0.346 ± 0.016	0.632TrpAsn: 0.632 ± 0.023	0.348TrpPro: 0.348 ± 0.017	0.466TrpGln: 0.466 ± 0.018	0.446TrpArg: 0.446 ± 0.016	0.645TrpSer: 0.645 ± 0.019	0.613TrpThr: 0.613 ± 0.021	0.676TrpVal: 0.676 ± 0.022	0.166TrpTrp: 0.166 ± 0.01	0.439TrpTyr: 0.439 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.873TyrAla: 2.873 ± 0.043	0.334TyrCys: 0.334 ± 0.015	2.152TyrAsp: 2.152 ± 0.037	1.929TyrGlu: 1.929 ± 0.038	2.24TyrPhe: 2.24 ± 0.042	2.734TyrGly: 2.734 ± 0.048	0.933TyrHis: 0.933 ± 0.026	2.625TyrIle: 2.625 ± 0.046	2.589TyrLys: 2.589 ± 0.042	3.901TyrLeu: 3.901 ± 0.059	0.775TyrMet: 0.775 ± 0.024	2.411TyrAsn: 2.411 ± 0.047	1.693TyrPro: 1.693 ± 0.035	1.707TyrGln: 1.707 ± 0.036	1.913TyrArg: 1.913 ± 0.033	2.707TyrSer: 2.707 ± 0.049	2.595TyrThr: 2.595 ± 0.048	2.186TyrVal: 2.186 ± 0.044	0.477TyrTrp: 0.477 ± 0.02	1.787TyrTyr: 1.787 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4634 proteins (1541803 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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