Amino acid dipepetide frequency for Xanthomonadaceae bacterium NML03-0222

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.022AlaAla: 17.022 ± 0.264
1.299AlaCys: 1.299 ± 0.045
6.801AlaAsp: 6.801 ± 0.105
8.407AlaGlu: 8.407 ± 0.159
3.923AlaPhe: 3.923 ± 0.084
9.955AlaGly: 9.955 ± 0.144
2.952AlaHis: 2.952 ± 0.07
5.697AlaIle: 5.697 ± 0.11
3.656AlaLys: 3.656 ± 0.081
15.578AlaLeu: 15.578 ± 0.216
3.154AlaMet: 3.154 ± 0.065
3.176AlaAsn: 3.176 ± 0.088
5.388AlaPro: 5.388 ± 0.1
6.198AlaGln: 6.198 ± 0.109
9.365AlaArg: 9.365 ± 0.152
6.417AlaSer: 6.417 ± 0.1
5.208AlaThr: 5.208 ± 0.104
7.514AlaVal: 7.514 ± 0.136
1.902AlaTrp: 1.902 ± 0.056
2.348AlaTyr: 2.348 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.999CysAla: 0.999 ± 0.04
0.096CysCys: 0.096 ± 0.011
0.503CysAsp: 0.503 ± 0.025
0.478CysGlu: 0.478 ± 0.028
0.296CysPhe: 0.296 ± 0.021
0.837CysGly: 0.837 ± 0.039
0.254CysHis: 0.254 ± 0.021
0.438CysIle: 0.438 ± 0.028
0.256CysLys: 0.256 ± 0.017
0.865CysLeu: 0.865 ± 0.037
0.146CysMet: 0.146 ± 0.015
0.26CysAsn: 0.26 ± 0.021
0.466CysPro: 0.466 ± 0.03
0.394CysGln: 0.394 ± 0.024
0.588CysArg: 0.588 ± 0.027
0.496CysSer: 0.496 ± 0.027
0.409CysThr: 0.409 ± 0.024
0.603CysVal: 0.603 ± 0.031
0.121CysTrp: 0.121 ± 0.014
0.188CysTyr: 0.188 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.933AspAla: 7.933 ± 0.099
0.447AspCys: 0.447 ± 0.026
2.746AspAsp: 2.746 ± 0.068
3.638AspGlu: 3.638 ± 0.081
2.286AspPhe: 2.286 ± 0.069
4.819AspGly: 4.819 ± 0.095
0.919AspHis: 0.919 ± 0.037
2.969AspIle: 2.969 ± 0.067
1.915AspLys: 1.915 ± 0.062
4.738AspLeu: 4.738 ± 0.084
1.355AspMet: 1.355 ± 0.049
1.517AspAsn: 1.517 ± 0.054
2.227AspPro: 2.227 ± 0.059
1.237AspGln: 1.237 ± 0.046
2.857AspArg: 2.857 ± 0.068
2.702AspSer: 2.702 ± 0.063
2.705AspThr: 2.705 ± 0.069
3.716AspVal: 3.716 ± 0.08
1.097AspTrp: 1.097 ± 0.044
1.721AspTyr: 1.721 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
8.028GluAla: 8.028 ± 0.163
0.41GluCys: 0.41 ± 0.024
2.571GluAsp: 2.571 ± 0.065
2.838GluGlu: 2.838 ± 0.084
1.802GluPhe: 1.802 ± 0.05
4.268GluGly: 4.268 ± 0.079
1.467GluHis: 1.467 ± 0.053
3.01GluIle: 3.01 ± 0.081
2.451GluLys: 2.451 ± 0.07
5.875GluLeu: 5.875 ± 0.109
1.39GluMet: 1.39 ± 0.046
1.998GluAsn: 1.998 ± 0.058
2.264GluPro: 2.264 ± 0.066
2.763GluGln: 2.763 ± 0.08
5.015GluArg: 5.015 ± 0.114
2.832GluSer: 2.832 ± 0.062
2.621GluThr: 2.621 ± 0.066
4.412GluVal: 4.412 ± 0.084
0.734GluTrp: 0.734 ± 0.033
1.383GluTyr: 1.383 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
4.487PheAla: 4.487 ± 0.085
0.374PheCys: 0.374 ± 0.02
2.492PheAsp: 2.492 ± 0.066
2.054PheGlu: 2.054 ± 0.054
1.27PhePhe: 1.27 ± 0.052
2.98PheGly: 2.98 ± 0.074
0.808PheHis: 0.808 ± 0.032
1.55PheIle: 1.55 ± 0.054
1.071PheLys: 1.071 ± 0.041
2.91PheLeu: 2.91 ± 0.066
0.78PheMet: 0.78 ± 0.034
1.267PheAsn: 1.267 ± 0.049
1.406PhePro: 1.406 ± 0.048
1.114PheGln: 1.114 ± 0.044
2.051PheArg: 2.051 ± 0.054
2.171PheSer: 2.171 ± 0.053
1.578PheThr: 1.578 ± 0.049
2.371PheVal: 2.371 ± 0.061
0.537PheTrp: 0.537 ± 0.031
0.834PheTyr: 0.834 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
7.648GlyAla: 7.648 ± 0.112
0.8GlyCys: 0.8 ± 0.036
4.163GlyAsp: 4.163 ± 0.089
5.203GlyGlu: 5.203 ± 0.093
3.519GlyPhe: 3.519 ± 0.084
6.284GlyGly: 6.284 ± 0.123
2.052GlyHis: 2.052 ± 0.069
4.497GlyIle: 4.497 ± 0.091
3.769GlyLys: 3.769 ± 0.079
8.479GlyLeu: 8.479 ± 0.126
2.336GlyMet: 2.336 ± 0.071
2.574GlyAsn: 2.574 ± 0.08
2.023GlyPro: 2.023 ± 0.062
3.987GlyGln: 3.987 ± 0.08
5.59GlyArg: 5.59 ± 0.092
4.671GlySer: 4.671 ± 0.093
3.498GlyThr: 3.498 ± 0.087
5.693GlyVal: 5.693 ± 0.105
1.593GlyTrp: 1.593 ± 0.055
2.111GlyTyr: 2.111 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.951HisAla: 2.951 ± 0.077
0.305HisCys: 0.305 ± 0.024
1.349HisAsp: 1.349 ± 0.051
1.315HisGlu: 1.315 ± 0.046
0.883HisPhe: 0.883 ± 0.04
2.374HisGly: 2.374 ± 0.067
0.669HisHis: 0.669 ± 0.032
1.164HisIle: 1.164 ± 0.043
0.619HisLys: 0.619 ± 0.03
2.43HisLeu: 2.43 ± 0.07
0.459HisMet: 0.459 ± 0.024
0.6HisAsn: 0.6 ± 0.032
1.499HisPro: 1.499 ± 0.047
0.984HisGln: 0.984 ± 0.035
1.49HisArg: 1.49 ± 0.053
1.171HisSer: 1.171 ± 0.042
1.114HisThr: 1.114 ± 0.04
1.537HisVal: 1.537 ± 0.054
0.558HisTrp: 0.558 ± 0.034
0.777HisTyr: 0.777 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.817IleAla: 6.817 ± 0.119
0.441IleCys: 0.441 ± 0.025
3.3IleAsp: 3.3 ± 0.071
3.41IleGlu: 3.41 ± 0.075
1.318IlePhe: 1.318 ± 0.048
4.388IleGly: 4.388 ± 0.09
1.125IleHis: 1.125 ± 0.049
1.931IleIle: 1.931 ± 0.06
1.49IleLys: 1.49 ± 0.048
3.631IleLeu: 3.631 ± 0.068
0.663IleMet: 0.663 ± 0.036
1.553IleAsn: 1.553 ± 0.05
2.302IlePro: 2.302 ± 0.06
1.525IleGln: 1.525 ± 0.049
3.047IleArg: 3.047 ± 0.072
2.908IleSer: 2.908 ± 0.07
2.448IleThr: 2.448 ± 0.057
3.089IleVal: 3.089 ± 0.074
0.544IleTrp: 0.544 ± 0.028
0.972IleTyr: 0.972 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.939LysAla: 3.939 ± 0.096
0.144LysCys: 0.144 ± 0.017
1.561LysAsp: 1.561 ± 0.052
1.434LysGlu: 1.434 ± 0.063
0.909LysPhe: 0.909 ± 0.041
2.235LysGly: 2.235 ± 0.062
0.775LysHis: 0.775 ± 0.036
1.595LysIle: 1.595 ± 0.053
1.455LysLys: 1.455 ± 0.055
3.75LysLeu: 3.75 ± 0.074
0.777LysMet: 0.777 ± 0.037
1.031LysAsn: 1.031 ± 0.041
2.232LysPro: 2.232 ± 0.059
1.543LysGln: 1.543 ± 0.048
2.458LysArg: 2.458 ± 0.07
1.856LysSer: 1.856 ± 0.059
1.942LysThr: 1.942 ± 0.054
2.379LysVal: 2.379 ± 0.071
0.362LysTrp: 0.362 ± 0.021
0.727LysTyr: 0.727 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
15.368LeuAla: 15.368 ± 0.2
1.019LeuCys: 1.019 ± 0.041
6.123LeuAsp: 6.123 ± 0.113
5.921LeuGlu: 5.921 ± 0.104
3.338LeuPhe: 3.338 ± 0.071
8.741LeuGly: 8.741 ± 0.138
2.664LeuHis: 2.664 ± 0.074
4.607LeuIle: 4.607 ± 0.09
3.666LeuLys: 3.666 ± 0.073
12.355LeuLeu: 12.355 ± 0.24
2.705LeuMet: 2.705 ± 0.068
2.726LeuAsn: 2.726 ± 0.069
6.912LeuPro: 6.912 ± 0.135
4.977LeuGln: 4.977 ± 0.107
8.081LeuArg: 8.081 ± 0.129
6.077LeuSer: 6.077 ± 0.11
4.716LeuThr: 4.716 ± 0.087
6.502LeuVal: 6.502 ± 0.106
1.525LeuTrp: 1.525 ± 0.061
2.302LeuTyr: 2.302 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.904MetAla: 2.904 ± 0.067
0.153MetCys: 0.153 ± 0.015
1.149MetAsp: 1.149 ± 0.043
1.019MetGlu: 1.019 ± 0.036
0.711MetPhe: 0.711 ± 0.032
1.671MetGly: 1.671 ± 0.051
0.472MetHis: 0.472 ± 0.026
0.849MetIle: 0.849 ± 0.034
1.044MetLys: 1.044 ± 0.042
2.766MetLeu: 2.766 ± 0.068
0.608MetMet: 0.608 ± 0.031
0.881MetAsn: 0.881 ± 0.037
1.545MetPro: 1.545 ± 0.05
1.406MetGln: 1.406 ± 0.048
1.873MetArg: 1.873 ± 0.053
1.787MetSer: 1.787 ± 0.048
1.202MetThr: 1.202 ± 0.04
1.518MetVal: 1.518 ± 0.055
0.215MetTrp: 0.215 ± 0.019
0.41MetTyr: 0.41 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.72AsnAla: 3.72 ± 0.092
0.227AsnCys: 0.227 ± 0.018
1.406AsnAsp: 1.406 ± 0.047
1.377AsnGlu: 1.377 ± 0.047
1.027AsnPhe: 1.027 ± 0.047
2.583AsnGly: 2.583 ± 0.079
0.696AsnHis: 0.696 ± 0.036
1.562AsnIle: 1.562 ± 0.046
0.837AsnLys: 0.837 ± 0.04
2.808AsnLeu: 2.808 ± 0.072
0.581AsnMet: 0.581 ± 0.03
0.897AsnAsn: 0.897 ± 0.041
2.107AsnPro: 2.107 ± 0.065
1.064AsnGln: 1.064 ± 0.037
1.921AsnArg: 1.921 ± 0.06
1.473AsnSer: 1.473 ± 0.052
1.57AsnThr: 1.57 ± 0.051
1.677AsnVal: 1.677 ± 0.058
0.49AsnTrp: 0.49 ± 0.032
0.715AsnTyr: 0.715 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
6.364ProAla: 6.364 ± 0.119
0.325ProCys: 0.325 ± 0.026
3.038ProAsp: 3.038 ± 0.064
3.701ProGlu: 3.701 ± 0.074
1.564ProPhe: 1.564 ± 0.05
4.29ProGly: 4.29 ± 0.089
1.081ProHis: 1.081 ± 0.04
1.799ProIle: 1.799 ± 0.049
1.496ProLys: 1.496 ± 0.052
5.344ProLeu: 5.344 ± 0.106
1.321ProMet: 1.321 ± 0.042
1.253ProAsn: 1.253 ± 0.043
2.435ProPro: 2.435 ± 0.075
2.451ProGln: 2.451 ± 0.06
2.836ProArg: 2.836 ± 0.075
2.421ProSer: 2.421 ± 0.061
1.951ProThr: 1.951 ± 0.059
3.828ProVal: 3.828 ± 0.073
0.839ProTrp: 0.839 ± 0.04
1.165ProTyr: 1.165 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
6.267GlnAla: 6.267 ± 0.118
0.325GlnCys: 0.325 ± 0.02
1.918GlnAsp: 1.918 ± 0.052
1.799GlnGlu: 1.799 ± 0.061
1.245GlnPhe: 1.245 ± 0.038
3.5GlnGly: 3.5 ± 0.074
1.181GlnHis: 1.181 ± 0.046
1.965GlnIle: 1.965 ± 0.055
1.442GlnLys: 1.442 ± 0.053
5.128GlnLeu: 5.128 ± 0.095
1.343GlnMet: 1.343 ± 0.044
1.189GlnAsn: 1.189 ± 0.048
2.449GlnPro: 2.449 ± 0.06
2.902GlnGln: 2.902 ± 0.081
3.825GlnArg: 3.825 ± 0.08
2.299GlnSer: 2.299 ± 0.063
2.057GlnThr: 2.057 ± 0.058
3.094GlnVal: 3.094 ± 0.072
0.833GlnTrp: 0.833 ± 0.034
1.052GlnTyr: 1.052 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
7.776ArgAla: 7.776 ± 0.112
0.527ArgCys: 0.527 ± 0.03
3.975ArgAsp: 3.975 ± 0.084
4.693ArgGlu: 4.693 ± 0.101
2.808ArgPhe: 2.808 ± 0.068
4.678ArgGly: 4.678 ± 0.089
2.002ArgHis: 2.002 ± 0.061
4.157ArgIle: 4.157 ± 0.076
2.18ArgLys: 2.18 ± 0.062
8.416ArgLeu: 8.416 ± 0.138
1.877ArgMet: 1.877 ± 0.056
2.099ArgAsn: 2.099 ± 0.06
3.075ArgPro: 3.075 ± 0.071
3.707ArgGln: 3.707 ± 0.075
5.3ArgArg: 5.3 ± 0.102
3.732ArgSer: 3.732 ± 0.078
2.677ArgThr: 2.677 ± 0.061
4.506ArgVal: 4.506 ± 0.082
1.287ArgTrp: 1.287 ± 0.048
2.214ArgTyr: 2.214 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
6.623SerAla: 6.623 ± 0.105
0.457SerCys: 0.457 ± 0.027
2.646SerAsp: 2.646 ± 0.066
2.814SerGlu: 2.814 ± 0.061
1.887SerPhe: 1.887 ± 0.058
5.238SerGly: 5.238 ± 0.094
1.412SerHis: 1.412 ± 0.047
2.389SerIle: 2.389 ± 0.059
1.614SerLys: 1.614 ± 0.043
5.822SerLeu: 5.822 ± 0.103
1.212SerMet: 1.212 ± 0.042
1.586SerAsn: 1.586 ± 0.067
2.874SerPro: 2.874 ± 0.067
2.36SerGln: 2.36 ± 0.059
4.103SerArg: 4.103 ± 0.089
2.861SerSer: 2.861 ± 0.074
2.514SerThr: 2.514 ± 0.066
3.436SerVal: 3.436 ± 0.078
0.766SerTrp: 0.766 ± 0.039
1.315SerTyr: 1.315 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
5.403ThrAla: 5.403 ± 0.106
0.38ThrCys: 0.38 ± 0.023
2.246ThrAsp: 2.246 ± 0.056
2.168ThrGlu: 2.168 ± 0.062
1.325ThrPhe: 1.325 ± 0.041
4.1ThrGly: 4.1 ± 0.092
1.24ThrHis: 1.24 ± 0.043
1.88ThrIle: 1.88 ± 0.051
0.85ThrLys: 0.85 ± 0.038
6.165ThrLeu: 6.165 ± 0.097
0.802ThrMet: 0.802 ± 0.038
0.897ThrAsn: 0.897 ± 0.044
3.15ThrPro: 3.15 ± 0.07
1.973ThrGln: 1.973 ± 0.06
3.326ThrArg: 3.326 ± 0.082
2.084ThrSer: 2.084 ± 0.067
2.151ThrThr: 2.151 ± 0.077
3.297ThrVal: 3.297 ± 0.075
0.596ThrTrp: 0.596 ± 0.03
0.924ThrTyr: 0.924 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
7.761ValAla: 7.761 ± 0.121
0.605ValCys: 0.605 ± 0.027
3.747ValAsp: 3.747 ± 0.08
4.24ValGlu: 4.24 ± 0.082
2.499ValPhe: 2.499 ± 0.065
4.526ValGly: 4.526 ± 0.096
1.467ValHis: 1.467 ± 0.045
3.344ValIle: 3.344 ± 0.07
2.283ValLys: 2.283 ± 0.073
7.933ValLeu: 7.933 ± 0.128
1.758ValMet: 1.758 ± 0.049
2.102ValAsn: 2.102 ± 0.064
3.142ValPro: 3.142 ± 0.079
2.616ValGln: 2.616 ± 0.065
4.497ValArg: 4.497 ± 0.08
3.875ValSer: 3.875 ± 0.09
2.958ValThr: 2.958 ± 0.07
4.966ValVal: 4.966 ± 0.103
0.875ValTrp: 0.875 ± 0.037
1.408ValTyr: 1.408 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.146TrpAla: 1.146 ± 0.044
0.166TrpCys: 0.166 ± 0.015
0.638TrpAsp: 0.638 ± 0.034
0.527TrpGlu: 0.527 ± 0.028
0.538TrpPhe: 0.538 ± 0.032
0.939TrpGly: 0.939 ± 0.046
0.441TrpHis: 0.441 ± 0.025
0.605TrpIle: 0.605 ± 0.029
0.432TrpLys: 0.432 ± 0.023
2.726TrpLeu: 2.726 ± 0.075
0.477TrpMet: 0.477 ± 0.023
0.463TrpAsn: 0.463 ± 0.026
0.794TrpPro: 0.794 ± 0.035
1.367TrpGln: 1.367 ± 0.043
1.346TrpArg: 1.346 ± 0.049
0.731TrpSer: 0.731 ± 0.038
0.581TrpThr: 0.581 ± 0.029
1.024TrpVal: 1.024 ± 0.042
0.288TrpTrp: 0.288 ± 0.022
0.356TrpTyr: 0.356 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.804TyrAla: 2.804 ± 0.07
0.194TyrCys: 0.194 ± 0.016
1.174TyrAsp: 1.174 ± 0.05
1.094TyrGlu: 1.094 ± 0.047
0.956TyrPhe: 0.956 ± 0.04
2.084TyrGly: 2.084 ± 0.06
0.568TyrHis: 0.568 ± 0.03
0.896TyrIle: 0.896 ± 0.038
0.577TyrLys: 0.577 ± 0.03
2.605TyrLeu: 2.605 ± 0.068
0.438TyrMet: 0.438 ± 0.027
0.666TyrAsn: 0.666 ± 0.04
1.211TyrPro: 1.211 ± 0.044
1.246TyrGln: 1.246 ± 0.044
2.118TyrArg: 2.118 ± 0.066
1.367TyrSer: 1.367 ± 0.051
1.058TyrThr: 1.058 ± 0.038
1.44TyrVal: 1.44 ± 0.051
0.424TyrTrp: 0.424 ± 0.025
0.58TyrTyr: 0.58 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2067 proteins (679785 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski