Amino acid dipepetide frequency for Arthrobacter phage Melons

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.815AlaAla: 21.815 ± 1.978
0.811AlaCys: 0.811 ± 0.297
7.704AlaAsp: 7.704 ± 0.855
7.623AlaGlu: 7.623 ± 0.665
3.082AlaPhe: 3.082 ± 0.65
15.652AlaGly: 15.652 ± 1.224
1.379AlaHis: 1.379 ± 0.275
4.298AlaIle: 4.298 ± 0.647
2.109AlaLys: 2.109 ± 0.537
11.191AlaLeu: 11.191 ± 0.968
2.838AlaMet: 2.838 ± 0.517
2.595AlaAsn: 2.595 ± 0.43
5.109AlaPro: 5.109 ± 0.731
3.082AlaGln: 3.082 ± 0.432
9.894AlaArg: 9.894 ± 1.053
6.65AlaSer: 6.65 ± 0.803
5.839AlaThr: 5.839 ± 0.667
10.461AlaVal: 10.461 ± 0.959
3.325AlaTrp: 3.325 ± 0.447
1.703AlaTyr: 1.703 ± 0.403
0.0AlaXaa: 0.0 ± 0.0
Cys
0.243CysAla: 0.243 ± 0.168
0.0CysCys: 0.0 ± 0.0
0.405CysAsp: 0.405 ± 0.213
0.73CysGlu: 0.73 ± 0.217
0.0CysPhe: 0.0 ± 0.0
1.703CysGly: 1.703 ± 0.495
0.162CysHis: 0.162 ± 0.116
0.487CysIle: 0.487 ± 0.175
0.405CysLys: 0.405 ± 0.201
0.487CysLeu: 0.487 ± 0.2
0.081CysMet: 0.081 ± 0.083
0.081CysAsn: 0.081 ± 0.09
0.324CysPro: 0.324 ± 0.149
0.568CysGln: 0.568 ± 0.196
0.973CysArg: 0.973 ± 0.274
0.811CysSer: 0.811 ± 0.232
0.324CysThr: 0.324 ± 0.141
0.405CysVal: 0.405 ± 0.184
0.324CysTrp: 0.324 ± 0.171
0.081CysTyr: 0.081 ± 0.09
0.0CysXaa: 0.0 ± 0.0
Asp
5.271AspAla: 5.271 ± 0.575
0.568AspCys: 0.568 ± 0.19
2.433AspAsp: 2.433 ± 0.418
3.325AspGlu: 3.325 ± 0.592
1.865AspPhe: 1.865 ± 0.344
6.893AspGly: 6.893 ± 0.933
1.135AspHis: 1.135 ± 0.278
0.892AspIle: 0.892 ± 0.297
1.622AspLys: 1.622 ± 0.326
6.244AspLeu: 6.244 ± 0.761
0.568AspMet: 0.568 ± 0.217
0.892AspAsn: 0.892 ± 0.306
4.541AspPro: 4.541 ± 0.63
1.298AspGln: 1.298 ± 0.319
3.893AspArg: 3.893 ± 0.657
3.001AspSer: 3.001 ± 0.424
2.19AspThr: 2.19 ± 0.486
4.947AspVal: 4.947 ± 0.776
1.541AspTrp: 1.541 ± 0.305
1.46AspTyr: 1.46 ± 0.37
0.0AspXaa: 0.0 ± 0.0
Glu
6.407GluAla: 6.407 ± 0.901
0.73GluCys: 0.73 ± 0.222
3.487GluAsp: 3.487 ± 0.694
4.866GluGlu: 4.866 ± 0.756
1.541GluPhe: 1.541 ± 0.391
5.109GluGly: 5.109 ± 0.665
0.892GluHis: 0.892 ± 0.36
4.055GluIle: 4.055 ± 0.647
2.433GluLys: 2.433 ± 0.416
6.488GluLeu: 6.488 ± 0.583
0.973GluMet: 0.973 ± 0.27
1.622GluAsn: 1.622 ± 0.286
4.298GluPro: 4.298 ± 0.678
3.244GluGln: 3.244 ± 0.578
4.136GluArg: 4.136 ± 0.509
2.676GluSer: 2.676 ± 0.447
3.244GluThr: 3.244 ± 0.528
6.974GluVal: 6.974 ± 0.696
0.892GluTrp: 0.892 ± 0.243
1.541GluTyr: 1.541 ± 0.383
0.0GluXaa: 0.0 ± 0.0
Phe
2.514PheAla: 2.514 ± 0.349
0.081PheCys: 0.081 ± 0.082
2.027PheAsp: 2.027 ± 0.344
2.595PheGlu: 2.595 ± 0.456
0.568PhePhe: 0.568 ± 0.173
2.19PheGly: 2.19 ± 0.484
0.324PheHis: 0.324 ± 0.19
1.135PheIle: 1.135 ± 0.274
1.622PheLys: 1.622 ± 0.308
2.352PheLeu: 2.352 ± 0.305
0.73PheMet: 0.73 ± 0.24
1.216PheAsn: 1.216 ± 0.332
1.054PhePro: 1.054 ± 0.341
0.243PheGln: 0.243 ± 0.136
2.433PheArg: 2.433 ± 0.479
1.946PheSer: 1.946 ± 0.453
1.054PheThr: 1.054 ± 0.332
1.298PheVal: 1.298 ± 0.325
0.405PheTrp: 0.405 ± 0.176
0.73PheTyr: 0.73 ± 0.243
0.0PheXaa: 0.0 ± 0.0
Gly
10.786GlyAla: 10.786 ± 0.99
0.811GlyCys: 0.811 ± 0.243
5.271GlyAsp: 5.271 ± 0.808
5.758GlyGlu: 5.758 ± 0.638
3.163GlyPhe: 3.163 ± 0.588
9.407GlyGly: 9.407 ± 1.096
1.298GlyHis: 1.298 ± 0.324
3.73GlyIle: 3.73 ± 0.684
3.001GlyLys: 3.001 ± 0.567
7.947GlyLeu: 7.947 ± 1.067
2.919GlyMet: 2.919 ± 0.44
1.541GlyAsn: 1.541 ± 0.391
6.488GlyPro: 6.488 ± 0.721
2.757GlyGln: 2.757 ± 0.457
9.894GlyArg: 9.894 ± 0.676
5.677GlySer: 5.677 ± 0.887
5.352GlyThr: 5.352 ± 0.627
7.704GlyVal: 7.704 ± 1.115
2.676GlyTrp: 2.676 ± 0.412
2.433GlyTyr: 2.433 ± 0.443
0.0GlyXaa: 0.0 ± 0.0
His
1.46HisAla: 1.46 ± 0.314
0.162HisCys: 0.162 ± 0.115
0.811HisAsp: 0.811 ± 0.289
0.73HisGlu: 0.73 ± 0.277
0.568HisPhe: 0.568 ± 0.221
1.541HisGly: 1.541 ± 0.384
0.243HisHis: 0.243 ± 0.127
0.162HisIle: 0.162 ± 0.117
0.568HisLys: 0.568 ± 0.209
1.379HisLeu: 1.379 ± 0.313
0.081HisMet: 0.081 ± 0.079
0.324HisAsn: 0.324 ± 0.158
1.135HisPro: 1.135 ± 0.299
0.811HisGln: 0.811 ± 0.238
1.054HisArg: 1.054 ± 0.308
0.487HisSer: 0.487 ± 0.174
0.405HisThr: 0.405 ± 0.189
1.379HisVal: 1.379 ± 0.397
0.081HisTrp: 0.081 ± 0.08
0.568HisTyr: 0.568 ± 0.188
0.0HisXaa: 0.0 ± 0.0
Ile
4.136IleAla: 4.136 ± 0.634
0.243IleCys: 0.243 ± 0.153
2.027IleAsp: 2.027 ± 0.424
2.433IleGlu: 2.433 ± 0.427
0.568IlePhe: 0.568 ± 0.208
3.244IleGly: 3.244 ± 0.55
0.73IleHis: 0.73 ± 0.253
1.054IleIle: 1.054 ± 0.308
0.811IleLys: 0.811 ± 0.238
3.325IleLeu: 3.325 ± 0.6
0.73IleMet: 0.73 ± 0.236
1.054IleAsn: 1.054 ± 0.3
1.379IlePro: 1.379 ± 0.296
1.054IleGln: 1.054 ± 0.296
3.974IleArg: 3.974 ± 0.553
2.595IleSer: 2.595 ± 0.503
2.595IleThr: 2.595 ± 0.462
2.838IleVal: 2.838 ± 0.425
0.649IleTrp: 0.649 ± 0.198
0.162IleTyr: 0.162 ± 0.114
0.0IleXaa: 0.0 ± 0.0
Lys
5.028LysAla: 5.028 ± 0.754
0.162LysCys: 0.162 ± 0.106
1.46LysAsp: 1.46 ± 0.335
1.946LysGlu: 1.946 ± 0.465
0.892LysPhe: 0.892 ± 0.218
2.676LysGly: 2.676 ± 0.514
0.73LysHis: 0.73 ± 0.274
0.811LysIle: 0.811 ± 0.28
2.109LysLys: 2.109 ± 0.553
2.919LysLeu: 2.919 ± 0.478
1.135LysMet: 1.135 ± 0.343
1.379LysAsn: 1.379 ± 0.359
2.271LysPro: 2.271 ± 0.602
1.865LysGln: 1.865 ± 0.372
2.109LysArg: 2.109 ± 0.406
2.433LysSer: 2.433 ± 0.461
2.676LysThr: 2.676 ± 0.499
2.352LysVal: 2.352 ± 0.38
0.405LysTrp: 0.405 ± 0.206
0.487LysTyr: 0.487 ± 0.212
0.0LysXaa: 0.0 ± 0.0
Leu
11.353LeuAla: 11.353 ± 0.973
1.054LeuCys: 1.054 ± 0.273
5.271LeuAsp: 5.271 ± 0.66
9.083LeuGlu: 9.083 ± 0.88
2.109LeuPhe: 2.109 ± 0.407
9.083LeuGly: 9.083 ± 0.833
0.73LeuHis: 0.73 ± 0.297
3.001LeuIle: 3.001 ± 0.476
3.487LeuLys: 3.487 ± 0.497
7.461LeuLeu: 7.461 ± 1.056
1.784LeuMet: 1.784 ± 0.465
2.514LeuAsn: 2.514 ± 0.454
5.677LeuPro: 5.677 ± 0.623
2.676LeuGln: 2.676 ± 0.481
6.65LeuArg: 6.65 ± 0.755
4.136LeuSer: 4.136 ± 0.627
4.704LeuThr: 4.704 ± 0.74
7.38LeuVal: 7.38 ± 0.917
1.298LeuTrp: 1.298 ± 0.388
1.298LeuTyr: 1.298 ± 0.343
0.0LeuXaa: 0.0 ± 0.0
Met
2.595MetAla: 2.595 ± 0.492
0.243MetCys: 0.243 ± 0.118
1.379MetAsp: 1.379 ± 0.32
0.892MetGlu: 0.892 ± 0.246
0.081MetPhe: 0.081 ± 0.08
2.676MetGly: 2.676 ± 0.498
0.243MetHis: 0.243 ± 0.143
0.568MetIle: 0.568 ± 0.204
1.054MetLys: 1.054 ± 0.271
1.946MetLeu: 1.946 ± 0.398
0.568MetMet: 0.568 ± 0.228
0.568MetAsn: 0.568 ± 0.247
0.73MetPro: 0.73 ± 0.225
0.162MetGln: 0.162 ± 0.104
1.541MetArg: 1.541 ± 0.339
1.946MetSer: 1.946 ± 0.367
1.784MetThr: 1.784 ± 0.342
1.379MetVal: 1.379 ± 0.397
0.243MetTrp: 0.243 ± 0.143
0.162MetTyr: 0.162 ± 0.122
0.0MetXaa: 0.0 ± 0.0
Asn
2.595AsnAla: 2.595 ± 0.739
0.0AsnCys: 0.0 ± 0.0
1.298AsnAsp: 1.298 ± 0.248
1.298AsnGlu: 1.298 ± 0.326
0.73AsnPhe: 0.73 ± 0.262
3.082AsnGly: 3.082 ± 0.522
0.324AsnHis: 0.324 ± 0.191
0.973AsnIle: 0.973 ± 0.278
1.379AsnLys: 1.379 ± 0.44
2.027AsnLeu: 2.027 ± 0.375
0.73AsnMet: 0.73 ± 0.245
0.405AsnAsn: 0.405 ± 0.148
1.216AsnPro: 1.216 ± 0.275
0.892AsnGln: 0.892 ± 0.245
1.784AsnArg: 1.784 ± 0.37
0.811AsnSer: 0.811 ± 0.289
1.135AsnThr: 1.135 ± 0.272
2.109AsnVal: 2.109 ± 0.365
0.487AsnTrp: 0.487 ± 0.193
0.487AsnTyr: 0.487 ± 0.203
0.0AsnXaa: 0.0 ± 0.0
Pro
9.488ProAla: 9.488 ± 0.962
0.405ProCys: 0.405 ± 0.189
3.568ProAsp: 3.568 ± 0.645
5.352ProGlu: 5.352 ± 0.666
1.135ProPhe: 1.135 ± 0.344
5.596ProGly: 5.596 ± 0.879
0.973ProHis: 0.973 ± 0.314
1.622ProIle: 1.622 ± 0.37
1.865ProLys: 1.865 ± 0.403
3.893ProLeu: 3.893 ± 0.498
1.135ProMet: 1.135 ± 0.286
1.054ProAsn: 1.054 ± 0.251
2.838ProPro: 2.838 ± 0.621
0.811ProGln: 0.811 ± 0.238
3.244ProArg: 3.244 ± 0.45
2.919ProSer: 2.919 ± 0.54
2.027ProThr: 2.027 ± 0.417
5.433ProVal: 5.433 ± 0.727
1.703ProTrp: 1.703 ± 0.299
0.892ProTyr: 0.892 ± 0.259
0.0ProXaa: 0.0 ± 0.0
Gln
3.73GlnAla: 3.73 ± 0.473
0.081GlnCys: 0.081 ± 0.087
1.298GlnAsp: 1.298 ± 0.279
1.784GlnGlu: 1.784 ± 0.422
0.973GlnPhe: 0.973 ± 0.303
1.865GlnGly: 1.865 ± 0.403
0.73GlnHis: 0.73 ± 0.218
1.784GlnIle: 1.784 ± 0.396
0.973GlnLys: 0.973 ± 0.229
4.217GlnLeu: 4.217 ± 0.62
0.649GlnMet: 0.649 ± 0.217
1.054GlnAsn: 1.054 ± 0.295
1.865GlnPro: 1.865 ± 0.442
0.973GlnGln: 0.973 ± 0.291
1.865GlnArg: 1.865 ± 0.433
0.892GlnSer: 0.892 ± 0.265
1.379GlnThr: 1.379 ± 0.432
2.514GlnVal: 2.514 ± 0.582
0.487GlnTrp: 0.487 ± 0.173
0.73GlnTyr: 0.73 ± 0.262
0.0GlnXaa: 0.0 ± 0.0
Arg
11.435ArgAla: 11.435 ± 1.321
0.892ArgCys: 0.892 ± 0.285
4.136ArgAsp: 4.136 ± 0.552
3.974ArgGlu: 3.974 ± 0.652
2.514ArgPhe: 2.514 ± 0.427
6.569ArgGly: 6.569 ± 0.783
1.135ArgHis: 1.135 ± 0.317
2.838ArgIle: 2.838 ± 0.44
3.487ArgLys: 3.487 ± 0.627
6.163ArgLeu: 6.163 ± 0.927
1.216ArgMet: 1.216 ± 0.312
1.703ArgAsn: 1.703 ± 0.419
4.785ArgPro: 4.785 ± 0.68
3.001ArgGln: 3.001 ± 0.552
6.65ArgArg: 6.65 ± 0.794
4.136ArgSer: 4.136 ± 0.599
4.947ArgThr: 4.947 ± 0.686
6.731ArgVal: 6.731 ± 0.662
0.811ArgTrp: 0.811 ± 0.263
1.622ArgTyr: 1.622 ± 0.447
0.0ArgXaa: 0.0 ± 0.0
Ser
6.812SerAla: 6.812 ± 0.695
0.324SerCys: 0.324 ± 0.202
2.433SerAsp: 2.433 ± 0.366
2.109SerGlu: 2.109 ± 0.331
1.703SerPhe: 1.703 ± 0.381
6.974SerGly: 6.974 ± 0.891
0.811SerHis: 0.811 ± 0.222
2.109SerIle: 2.109 ± 0.421
2.109SerLys: 2.109 ± 0.444
5.271SerLeu: 5.271 ± 0.729
1.541SerMet: 1.541 ± 0.368
1.216SerAsn: 1.216 ± 0.295
2.352SerPro: 2.352 ± 0.521
1.46SerGln: 1.46 ± 0.304
3.406SerArg: 3.406 ± 0.668
3.649SerSer: 3.649 ± 0.638
2.919SerThr: 2.919 ± 0.54
4.541SerVal: 4.541 ± 0.628
1.622SerTrp: 1.622 ± 0.297
0.973SerTyr: 0.973 ± 0.257
0.0SerXaa: 0.0 ± 0.0
Thr
7.704ThrAla: 7.704 ± 0.788
0.568ThrCys: 0.568 ± 0.213
2.757ThrAsp: 2.757 ± 0.52
2.757ThrGlu: 2.757 ± 0.561
1.946ThrPhe: 1.946 ± 0.531
4.947ThrGly: 4.947 ± 0.962
0.568ThrHis: 0.568 ± 0.222
2.838ThrIle: 2.838 ± 0.568
2.271ThrLys: 2.271 ± 0.413
4.947ThrLeu: 4.947 ± 0.545
0.811ThrMet: 0.811 ± 0.236
1.703ThrAsn: 1.703 ± 0.367
2.271ThrPro: 2.271 ± 0.4
1.216ThrGln: 1.216 ± 0.262
2.919ThrArg: 2.919 ± 0.546
2.027ThrSer: 2.027 ± 0.378
3.325ThrThr: 3.325 ± 0.573
5.433ThrVal: 5.433 ± 0.757
1.135ThrTrp: 1.135 ± 0.284
1.622ThrTyr: 1.622 ± 0.434
0.0ThrXaa: 0.0 ± 0.0
Val
9.65ValAla: 9.65 ± 1.015
0.892ValCys: 0.892 ± 0.348
3.73ValAsp: 3.73 ± 0.491
6.65ValGlu: 6.65 ± 0.679
1.784ValPhe: 1.784 ± 0.33
6.569ValGly: 6.569 ± 1.112
1.135ValHis: 1.135 ± 0.346
2.352ValIle: 2.352 ± 0.373
3.568ValLys: 3.568 ± 0.632
7.542ValLeu: 7.542 ± 0.801
1.379ValMet: 1.379 ± 0.31
1.46ValAsn: 1.46 ± 0.327
5.839ValPro: 5.839 ± 0.681
2.595ValGln: 2.595 ± 0.483
8.11ValArg: 8.11 ± 1.047
4.217ValSer: 4.217 ± 0.705
6.082ValThr: 6.082 ± 0.687
8.029ValVal: 8.029 ± 1.077
1.946ValTrp: 1.946 ± 0.435
1.865ValTyr: 1.865 ± 0.379
0.0ValXaa: 0.0 ± 0.0
Trp
2.352TrpAla: 2.352 ± 0.459
0.162TrpCys: 0.162 ± 0.122
1.298TrpAsp: 1.298 ± 0.354
0.568TrpGlu: 0.568 ± 0.221
0.892TrpPhe: 0.892 ± 0.281
1.379TrpGly: 1.379 ± 0.411
0.324TrpHis: 0.324 ± 0.149
0.649TrpIle: 0.649 ± 0.3
0.568TrpLys: 0.568 ± 0.213
2.027TrpLeu: 2.027 ± 0.496
0.243TrpMet: 0.243 ± 0.125
0.811TrpAsn: 0.811 ± 0.261
1.135TrpPro: 1.135 ± 0.341
0.973TrpGln: 0.973 ± 0.282
1.784TrpArg: 1.784 ± 0.432
1.541TrpSer: 1.541 ± 0.312
1.298TrpThr: 1.298 ± 0.288
1.946TrpVal: 1.946 ± 0.448
0.649TrpTrp: 0.649 ± 0.227
0.324TrpTyr: 0.324 ± 0.139
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.865TyrAla: 1.865 ± 0.424
0.405TyrCys: 0.405 ± 0.17
1.784TyrAsp: 1.784 ± 0.315
1.135TyrGlu: 1.135 ± 0.291
0.405TyrPhe: 0.405 ± 0.147
1.46TyrGly: 1.46 ± 0.36
0.081TyrHis: 0.081 ± 0.08
0.243TyrIle: 0.243 ± 0.129
0.405TyrLys: 0.405 ± 0.177
2.919TyrLeu: 2.919 ± 0.588
0.568TyrMet: 0.568 ± 0.254
0.568TyrAsn: 0.568 ± 0.275
0.649TyrPro: 0.649 ± 0.206
0.162TyrGln: 0.162 ± 0.107
2.433TyrArg: 2.433 ± 0.451
1.784TyrSer: 1.784 ± 0.368
0.487TyrThr: 0.487 ± 0.204
1.541TyrVal: 1.541 ± 0.34
0.243TyrTrp: 0.243 ± 0.134
0.162TyrTyr: 0.162 ± 0.111
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (12332 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski