Amino acid dipepetide frequency for Diporeia-associated CRESS-DNA virus LH481

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.038AlaAla: 4.038 ± 0.166
1.346AlaCys: 1.346 ± 1.328
5.384AlaAsp: 5.384 ± 0.913
4.038AlaGlu: 4.038 ± 1.909
1.346AlaPhe: 1.346 ± 0.747
6.729AlaGly: 6.729 ± 1.661
0.0AlaHis: 0.0 ± 0.0
4.038AlaIle: 4.038 ± 3.985
2.692AlaLys: 2.692 ± 0.581
2.692AlaLeu: 2.692 ± 0.581
1.346AlaMet: 1.346 ± 1.233
2.692AlaAsn: 2.692 ± 1.494
0.0AlaPro: 0.0 ± 0.0
1.346AlaGln: 1.346 ± 0.747
2.692AlaArg: 2.692 ± 1.494
8.075AlaSer: 8.075 ± 0.332
9.421AlaThr: 9.421 ± 3.155
5.384AlaVal: 5.384 ± 0.913
1.346AlaTrp: 1.346 ± 0.747
8.075AlaTyr: 8.075 ± 1.743
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.346CysAsp: 1.346 ± 1.328
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
2.692CysGly: 2.692 ± 0.581
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
1.346CysLys: 1.346 ± 0.747
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
1.346CysAsn: 1.346 ± 0.747
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.346CysSer: 1.346 ± 1.328
1.346CysThr: 1.346 ± 1.328
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
2.692CysTyr: 2.692 ± 0.581
0.0CysXaa: 0.0 ± 0.0
Asp
5.384AspAla: 5.384 ± 3.238
0.0AspCys: 0.0 ± 0.0
4.038AspAsp: 4.038 ± 2.242
2.692AspGlu: 2.692 ± 2.657
2.692AspPhe: 2.692 ± 1.494
1.346AspGly: 1.346 ± 0.747
0.0AspHis: 0.0 ± 0.0
6.729AspIle: 6.729 ± 0.415
1.346AspLys: 1.346 ± 0.747
4.038AspLeu: 4.038 ± 2.242
0.0AspMet: 0.0 ± 0.0
2.692AspAsn: 2.692 ± 1.494
1.346AspPro: 1.346 ± 1.328
1.346AspGln: 1.346 ± 0.747
5.384AspArg: 5.384 ± 1.162
5.384AspSer: 5.384 ± 2.989
2.692AspThr: 2.692 ± 1.494
2.692AspVal: 2.692 ± 0.581
1.346AspTrp: 1.346 ± 1.328
1.346AspTyr: 1.346 ± 1.328
0.0AspXaa: 0.0 ± 0.0
Glu
1.346GluAla: 1.346 ± 1.328
0.0GluCys: 0.0 ± 0.0
0.0GluAsp: 0.0 ± 0.0
0.0GluGlu: 0.0 ± 0.0
5.384GluPhe: 5.384 ± 0.913
1.346GluGly: 1.346 ± 0.747
2.692GluHis: 2.692 ± 0.581
4.038GluIle: 4.038 ± 1.909
4.038GluLys: 4.038 ± 2.242
4.038GluLeu: 4.038 ± 3.985
2.692GluMet: 2.692 ± 1.494
0.0GluAsn: 0.0 ± 0.0
5.384GluPro: 5.384 ± 0.913
1.346GluGln: 1.346 ± 1.328
1.346GluArg: 1.346 ± 1.328
1.346GluSer: 1.346 ± 1.328
4.038GluThr: 4.038 ± 0.166
1.346GluVal: 1.346 ± 0.747
1.346GluTrp: 1.346 ± 1.328
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
1.346PheAla: 1.346 ± 0.747
1.346PheCys: 1.346 ± 0.747
1.346PheAsp: 1.346 ± 0.747
4.038PheGlu: 4.038 ± 0.166
2.692PhePhe: 2.692 ± 1.494
5.384PheGly: 5.384 ± 0.913
1.346PheHis: 1.346 ± 1.328
2.692PheIle: 2.692 ± 1.494
0.0PheLys: 0.0 ± 0.0
1.346PheLeu: 1.346 ± 0.747
0.0PheMet: 0.0 ± 0.0
2.692PheAsn: 2.692 ± 1.494
4.038PhePro: 4.038 ± 0.166
0.0PheGln: 0.0 ± 0.0
5.384PheArg: 5.384 ± 0.913
0.0PheSer: 0.0 ± 0.0
1.346PheThr: 1.346 ± 0.747
2.692PheVal: 2.692 ± 0.581
2.692PheTrp: 2.692 ± 2.657
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
13.459GlyAla: 13.459 ± 3.321
0.0GlyCys: 0.0 ± 0.0
4.038GlyAsp: 4.038 ± 0.166
0.0GlyGlu: 0.0 ± 0.0
4.038GlyPhe: 4.038 ± 2.242
2.692GlyGly: 2.692 ± 1.494
0.0GlyHis: 0.0 ± 0.0
6.729GlyIle: 6.729 ± 1.661
5.384GlyLys: 5.384 ± 1.162
6.729GlyLeu: 6.729 ± 1.661
0.0GlyMet: 0.0 ± 0.0
5.384GlyAsn: 5.384 ± 0.913
1.346GlyPro: 1.346 ± 1.328
6.729GlyGln: 6.729 ± 2.49
0.0GlyArg: 0.0 ± 0.0
4.038GlySer: 4.038 ± 0.166
6.729GlyThr: 6.729 ± 2.49
5.384GlyVal: 5.384 ± 2.989
1.346GlyTrp: 1.346 ± 0.747
5.384GlyTyr: 5.384 ± 1.162
0.0GlyXaa: 0.0 ± 0.0
His
1.346HisAla: 1.346 ± 1.328
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
1.346HisIle: 1.346 ± 0.747
0.0HisLys: 0.0 ± 0.0
1.346HisLeu: 1.346 ± 1.328
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
1.346HisPro: 1.346 ± 1.328
1.346HisGln: 1.346 ± 0.747
1.346HisArg: 1.346 ± 0.747
0.0HisSer: 0.0 ± 0.0
1.346HisThr: 1.346 ± 0.747
4.038HisVal: 4.038 ± 0.166
2.692HisTrp: 2.692 ± 0.581
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.384IleAla: 5.384 ± 1.162
1.346IleCys: 1.346 ± 1.328
8.075IleAsp: 8.075 ± 1.743
1.346IleGlu: 1.346 ± 0.747
2.692IlePhe: 2.692 ± 0.581
2.692IleGly: 2.692 ± 0.581
0.0IleHis: 0.0 ± 0.0
4.038IleIle: 4.038 ± 1.909
5.384IleLys: 5.384 ± 1.162
5.384IleLeu: 5.384 ± 1.162
0.0IleMet: 0.0 ± 0.0
4.038IleAsn: 4.038 ± 0.166
5.384IlePro: 5.384 ± 1.162
0.0IleGln: 0.0 ± 0.0
6.729IleArg: 6.729 ± 4.566
2.692IleSer: 2.692 ± 0.581
2.692IleThr: 2.692 ± 2.657
2.692IleVal: 2.692 ± 1.494
1.346IleTrp: 1.346 ± 1.328
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
5.384LysAla: 5.384 ± 2.989
0.0LysCys: 0.0 ± 0.0
6.729LysAsp: 6.729 ± 2.49
1.346LysGlu: 1.346 ± 0.747
1.346LysPhe: 1.346 ± 1.328
2.692LysGly: 2.692 ± 2.657
0.0LysHis: 0.0 ± 0.0
4.038LysIle: 4.038 ± 0.166
6.729LysLys: 6.729 ± 1.661
2.692LysLeu: 2.692 ± 1.494
4.038LysMet: 4.038 ± 0.166
2.692LysAsn: 2.692 ± 1.494
4.038LysPro: 4.038 ± 0.166
2.692LysGln: 2.692 ± 1.494
8.075LysArg: 8.075 ± 2.408
5.384LysSer: 5.384 ± 0.913
0.0LysThr: 0.0 ± 0.0
6.729LysVal: 6.729 ± 3.736
1.346LysTrp: 1.346 ± 0.747
8.075LysTyr: 8.075 ± 2.408
0.0LysXaa: 0.0 ± 0.0
Leu
2.692LeuAla: 2.692 ± 0.581
0.0LeuCys: 0.0 ± 0.0
4.038LeuAsp: 4.038 ± 0.166
4.038LeuGlu: 4.038 ± 1.909
1.346LeuPhe: 1.346 ± 0.747
8.075LeuGly: 8.075 ± 2.408
2.692LeuHis: 2.692 ± 0.581
0.0LeuIle: 0.0 ± 0.0
9.421LeuLys: 9.421 ± 1.08
4.038LeuLeu: 4.038 ± 0.166
1.346LeuMet: 1.346 ± 1.328
1.346LeuAsn: 1.346 ± 1.328
4.038LeuPro: 4.038 ± 0.166
2.692LeuGln: 2.692 ± 0.581
2.692LeuArg: 2.692 ± 0.581
1.346LeuSer: 1.346 ± 1.328
5.384LeuThr: 5.384 ± 1.162
0.0LeuVal: 0.0 ± 0.0
0.0LeuTrp: 0.0 ± 0.0
4.038LeuTyr: 4.038 ± 2.242
0.0LeuXaa: 0.0 ± 0.0
Met
1.346MetAla: 1.346 ± 1.328
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
1.346MetGlu: 1.346 ± 1.328
0.0MetPhe: 0.0 ± 0.0
4.038MetGly: 4.038 ± 2.242
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.346MetLys: 1.346 ± 0.747
1.346MetLeu: 1.346 ± 0.747
0.0MetMet: 0.0 ± 0.0
1.346MetAsn: 1.346 ± 0.747
2.692MetPro: 2.692 ± 1.494
2.692MetGln: 2.692 ± 0.581
4.038MetArg: 4.038 ± 0.166
0.0MetSer: 0.0 ± 0.0
4.038MetThr: 4.038 ± 0.166
1.346MetVal: 1.346 ± 1.328
1.346MetTrp: 1.346 ± 0.747
1.346MetTyr: 1.346 ± 0.747
0.0MetXaa: 0.0 ± 0.0
Asn
4.038AsnAla: 4.038 ± 0.166
0.0AsnCys: 0.0 ± 0.0
0.0AsnAsp: 0.0 ± 0.0
2.692AsnGlu: 2.692 ± 0.581
5.384AsnPhe: 5.384 ± 0.913
6.729AsnGly: 6.729 ± 1.661
1.346AsnHis: 1.346 ± 1.328
6.729AsnIle: 6.729 ± 0.415
2.692AsnLys: 2.692 ± 1.494
2.692AsnLeu: 2.692 ± 0.581
4.038AsnMet: 4.038 ± 2.242
4.038AsnAsn: 4.038 ± 2.242
2.692AsnPro: 2.692 ± 1.494
4.038AsnGln: 4.038 ± 2.242
0.0AsnArg: 0.0 ± 0.0
1.346AsnSer: 1.346 ± 0.747
2.692AsnThr: 2.692 ± 0.581
4.038AsnVal: 4.038 ± 2.242
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
6.729ProAla: 6.729 ± 3.736
0.0ProCys: 0.0 ± 0.0
1.346ProAsp: 1.346 ± 0.747
5.384ProGlu: 5.384 ± 0.913
0.0ProPhe: 0.0 ± 0.0
4.038ProGly: 4.038 ± 0.166
0.0ProHis: 0.0 ± 0.0
2.692ProIle: 2.692 ± 0.581
2.692ProLys: 2.692 ± 0.581
1.346ProLeu: 1.346 ± 1.328
1.346ProMet: 1.346 ± 0.747
4.038ProAsn: 4.038 ± 0.166
2.692ProPro: 2.692 ± 0.581
1.346ProGln: 1.346 ± 0.747
2.692ProArg: 2.692 ± 2.657
1.346ProSer: 1.346 ± 1.328
4.038ProThr: 4.038 ± 0.166
4.038ProVal: 4.038 ± 1.909
0.0ProTrp: 0.0 ± 0.0
2.692ProTyr: 2.692 ± 0.581
0.0ProXaa: 0.0 ± 0.0
Gln
4.038GlnAla: 4.038 ± 0.166
0.0GlnCys: 0.0 ± 0.0
1.346GlnAsp: 1.346 ± 0.747
2.692GlnGlu: 2.692 ± 0.581
2.692GlnPhe: 2.692 ± 1.494
2.692GlnGly: 2.692 ± 0.581
0.0GlnHis: 0.0 ± 0.0
1.346GlnIle: 1.346 ± 1.328
1.346GlnLys: 1.346 ± 0.747
0.0GlnLeu: 0.0 ± 0.0
2.692GlnMet: 2.692 ± 0.581
2.692GlnAsn: 2.692 ± 0.581
1.346GlnPro: 1.346 ± 0.747
0.0GlnGln: 0.0 ± 0.0
1.346GlnArg: 1.346 ± 0.747
1.346GlnSer: 1.346 ± 0.747
4.038GlnThr: 4.038 ± 2.242
0.0GlnVal: 0.0 ± 0.0
2.692GlnTrp: 2.692 ± 1.494
1.346GlnTyr: 1.346 ± 1.328
0.0GlnXaa: 0.0 ± 0.0
Arg
1.346ArgAla: 1.346 ± 1.328
2.692ArgCys: 2.692 ± 0.581
1.346ArgAsp: 1.346 ± 0.747
4.038ArgGlu: 4.038 ± 1.909
1.346ArgPhe: 1.346 ± 1.328
1.346ArgGly: 1.346 ± 1.328
2.692ArgHis: 2.692 ± 1.494
2.692ArgIle: 2.692 ± 2.657
8.075ArgLys: 8.075 ± 4.483
5.384ArgLeu: 5.384 ± 1.162
2.692ArgMet: 2.692 ± 1.494
2.692ArgAsn: 2.692 ± 0.581
0.0ArgPro: 0.0 ± 0.0
1.346ArgGln: 1.346 ± 0.747
6.729ArgArg: 6.729 ± 2.49
8.075ArgSer: 8.075 ± 5.894
5.384ArgThr: 5.384 ± 2.989
4.038ArgVal: 4.038 ± 0.166
1.346ArgTrp: 1.346 ± 1.328
1.346ArgTyr: 1.346 ± 1.328
0.0ArgXaa: 0.0 ± 0.0
Ser
5.384SerAla: 5.384 ± 0.913
1.346SerCys: 1.346 ± 1.328
4.038SerAsp: 4.038 ± 0.166
0.0SerGlu: 0.0 ± 0.0
2.692SerPhe: 2.692 ± 2.657
12.113SerGly: 12.113 ± 0.499
1.346SerHis: 1.346 ± 1.328
1.346SerIle: 1.346 ± 1.328
6.729SerLys: 6.729 ± 1.661
2.692SerLeu: 2.692 ± 1.494
2.692SerMet: 2.692 ± 2.657
2.692SerAsn: 2.692 ± 0.581
1.346SerPro: 1.346 ± 0.747
0.0SerGln: 0.0 ± 0.0
2.692SerArg: 2.692 ± 0.581
2.692SerSer: 2.692 ± 0.581
2.692SerThr: 2.692 ± 0.581
5.384SerVal: 5.384 ± 0.913
4.038SerTrp: 4.038 ± 1.909
1.346SerTyr: 1.346 ± 0.747
0.0SerXaa: 0.0 ± 0.0
Thr
5.384ThrAla: 5.384 ± 0.913
0.0ThrCys: 0.0 ± 0.0
2.692ThrAsp: 2.692 ± 1.494
2.692ThrGlu: 2.692 ± 1.494
1.346ThrPhe: 1.346 ± 0.747
5.384ThrGly: 5.384 ± 1.162
1.346ThrHis: 1.346 ± 0.747
4.038ThrIle: 4.038 ± 1.909
5.384ThrLys: 5.384 ± 1.162
6.729ThrLeu: 6.729 ± 1.661
1.346ThrMet: 1.346 ± 0.832
6.729ThrAsn: 6.729 ± 3.736
2.692ThrPro: 2.692 ± 1.494
1.346ThrGln: 1.346 ± 0.747
4.038ThrArg: 4.038 ± 1.909
4.038ThrSer: 4.038 ± 0.166
0.0ThrThr: 0.0 ± 0.0
2.692ThrVal: 2.692 ± 0.581
0.0ThrTrp: 0.0 ± 0.0
4.038ThrTyr: 4.038 ± 1.909
0.0ThrXaa: 0.0 ± 0.0
Val
4.038ValAla: 4.038 ± 0.166
1.346ValCys: 1.346 ± 0.747
1.346ValAsp: 1.346 ± 0.747
2.692ValGlu: 2.692 ± 0.581
5.384ValPhe: 5.384 ± 0.913
5.384ValGly: 5.384 ± 0.913
2.692ValHis: 2.692 ± 1.494
4.038ValIle: 4.038 ± 0.166
1.346ValLys: 1.346 ± 0.747
1.346ValLeu: 1.346 ± 0.747
1.346ValMet: 1.346 ± 0.747
2.692ValAsn: 2.692 ± 1.494
1.346ValPro: 1.346 ± 1.328
2.692ValGln: 2.692 ± 1.494
9.421ValArg: 9.421 ± 0.996
8.075ValSer: 8.075 ± 2.408
1.346ValThr: 1.346 ± 0.747
6.729ValVal: 6.729 ± 0.415
1.346ValTrp: 1.346 ± 1.328
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
1.346TrpAla: 1.346 ± 0.747
1.346TrpCys: 1.346 ± 1.328
1.346TrpAsp: 1.346 ± 1.328
1.346TrpGlu: 1.346 ± 0.747
0.0TrpPhe: 0.0 ± 0.0
1.346TrpGly: 1.346 ± 1.328
0.0TrpHis: 0.0 ± 0.0
4.038TrpIle: 4.038 ± 3.985
4.038TrpLys: 4.038 ± 0.166
1.346TrpLeu: 1.346 ± 1.328
0.0TrpMet: 0.0 ± 0.0
2.692TrpAsn: 2.692 ± 0.581
1.346TrpPro: 1.346 ± 0.747
1.346TrpGln: 1.346 ± 1.328
0.0TrpArg: 0.0 ± 0.0
1.346TrpSer: 1.346 ± 1.328
1.346TrpThr: 1.346 ± 0.747
1.346TrpVal: 1.346 ± 0.747
0.0TrpTrp: 0.0 ± 0.0
1.346TrpTyr: 1.346 ± 1.328
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
1.346TyrCys: 1.346 ± 0.747
4.038TyrAsp: 4.038 ± 0.166
1.346TyrGlu: 1.346 ± 0.747
0.0TyrPhe: 0.0 ± 0.0
2.692TyrGly: 2.692 ± 1.494
0.0TyrHis: 0.0 ± 0.0
1.346TyrIle: 1.346 ± 1.328
4.038TyrLys: 4.038 ± 2.242
4.038TyrLeu: 4.038 ± 1.909
1.346TyrMet: 1.346 ± 0.747
2.692TyrAsn: 2.692 ± 0.581
5.384TyrPro: 5.384 ± 3.238
1.346TyrGln: 1.346 ± 0.747
0.0TyrArg: 0.0 ± 0.0
5.384TyrSer: 5.384 ± 1.162
1.346TyrThr: 1.346 ± 1.328
4.038TyrVal: 4.038 ± 0.166
2.692TyrTrp: 2.692 ± 2.657
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (744 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski