Amino acid dipepetide frequency for Paracoccus phage vB_PsuS_Psul1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.082AlaAla: 20.082 ± 1.883
1.121AlaCys: 1.121 ± 0.411
7.379AlaAsp: 7.379 ± 1.11
7.659AlaGlu: 7.659 ± 1.058
4.483AlaPhe: 4.483 ± 0.65
9.714AlaGly: 9.714 ± 1.098
1.868AlaHis: 1.868 ± 0.367
5.791AlaIle: 5.791 ± 0.759
4.95AlaLys: 4.95 ± 0.672
11.209AlaLeu: 11.209 ± 1.192
5.231AlaMet: 5.231 ± 0.793
3.456AlaAsn: 3.456 ± 0.596
6.258AlaPro: 6.258 ± 0.757
4.39AlaGln: 4.39 ± 0.658
9.901AlaArg: 9.901 ± 0.972
6.258AlaSer: 6.258 ± 0.773
6.071AlaThr: 6.071 ± 0.778
7.099AlaVal: 7.099 ± 0.739
2.522AlaTrp: 2.522 ± 0.536
2.522AlaTyr: 2.522 ± 0.527
0.0AlaXaa: 0.0 ± 0.0
Cys
0.467CysAla: 0.467 ± 0.247
0.0CysCys: 0.0 ± 0.0
0.467CysAsp: 0.467 ± 0.237
0.934CysGlu: 0.934 ± 0.365
0.374CysPhe: 0.374 ± 0.178
1.214CysGly: 1.214 ± 0.331
0.187CysHis: 0.187 ± 0.15
0.56CysIle: 0.56 ± 0.262
0.187CysLys: 0.187 ± 0.137
0.56CysLeu: 0.56 ± 0.262
0.093CysMet: 0.093 ± 0.111
0.56CysAsn: 0.56 ± 0.327
0.467CysPro: 0.467 ± 0.272
0.0CysGln: 0.0 ± 0.0
0.934CysArg: 0.934 ± 0.303
0.374CysSer: 0.374 ± 0.19
0.467CysThr: 0.467 ± 0.229
0.56CysVal: 0.56 ± 0.237
0.467CysTrp: 0.467 ± 0.19
0.093CysTyr: 0.093 ± 0.099
0.0CysXaa: 0.0 ± 0.0
Asp
8.687AspAla: 8.687 ± 1.058
0.747AspCys: 0.747 ± 0.379
2.896AspAsp: 2.896 ± 0.659
3.082AspGlu: 3.082 ± 0.648
2.335AspPhe: 2.335 ± 0.464
5.418AspGly: 5.418 ± 0.653
1.214AspHis: 1.214 ± 0.305
1.775AspIle: 1.775 ± 0.439
2.148AspLys: 2.148 ± 0.552
6.071AspLeu: 6.071 ± 0.848
2.242AspMet: 2.242 ± 0.438
0.934AspAsn: 0.934 ± 0.255
3.176AspPro: 3.176 ± 0.57
1.868AspGln: 1.868 ± 0.302
4.95AspArg: 4.95 ± 0.654
2.896AspSer: 2.896 ± 0.474
2.148AspThr: 2.148 ± 0.473
3.363AspVal: 3.363 ± 0.519
1.401AspTrp: 1.401 ± 0.346
1.401AspTyr: 1.401 ± 0.329
0.0AspXaa: 0.0 ± 0.0
Glu
7.286GluAla: 7.286 ± 0.998
0.56GluCys: 0.56 ± 0.268
3.456GluAsp: 3.456 ± 0.814
5.791GluGlu: 5.791 ± 1.209
2.429GluPhe: 2.429 ± 0.431
3.643GluGly: 3.643 ± 0.644
0.841GluHis: 0.841 ± 0.283
4.11GluIle: 4.11 ± 0.565
2.709GluLys: 2.709 ± 0.417
4.577GluLeu: 4.577 ± 0.738
2.055GluMet: 2.055 ± 0.434
1.681GluAsn: 1.681 ± 0.477
2.709GluPro: 2.709 ± 0.54
2.055GluGln: 2.055 ± 0.518
5.324GluArg: 5.324 ± 0.772
2.709GluSer: 2.709 ± 0.639
2.242GluThr: 2.242 ± 0.439
3.549GluVal: 3.549 ± 0.556
1.308GluTrp: 1.308 ± 0.338
1.214GluTyr: 1.214 ± 0.301
0.0GluXaa: 0.0 ± 0.0
Phe
2.802PheAla: 2.802 ± 0.483
0.374PheCys: 0.374 ± 0.163
2.335PheAsp: 2.335 ± 0.476
1.962PheGlu: 1.962 ± 0.465
1.494PhePhe: 1.494 ± 0.411
3.643PheGly: 3.643 ± 0.535
0.841PheHis: 0.841 ± 0.348
1.214PheIle: 1.214 ± 0.369
0.747PheLys: 0.747 ± 0.281
2.335PheLeu: 2.335 ± 0.415
0.841PheMet: 0.841 ± 0.267
0.934PheAsn: 0.934 ± 0.315
1.308PhePro: 1.308 ± 0.334
1.214PheGln: 1.214 ± 0.25
2.615PheArg: 2.615 ± 0.494
2.335PheSer: 2.335 ± 0.545
2.522PheThr: 2.522 ± 0.356
2.148PheVal: 2.148 ± 0.599
0.467PheTrp: 0.467 ± 0.236
0.56PheTyr: 0.56 ± 0.168
0.0PheXaa: 0.0 ± 0.0
Gly
8.967GlyAla: 8.967 ± 1.134
0.747GlyCys: 0.747 ± 0.232
5.885GlyAsp: 5.885 ± 0.666
4.67GlyGlu: 4.67 ± 0.613
3.082GlyPhe: 3.082 ± 0.545
8.126GlyGly: 8.126 ± 1.059
2.242GlyHis: 2.242 ± 0.378
4.577GlyIle: 4.577 ± 0.568
3.082GlyLys: 3.082 ± 0.547
7.286GlyLeu: 7.286 ± 0.851
2.615GlyMet: 2.615 ± 0.564
2.335GlyAsn: 2.335 ± 0.57
3.363GlyPro: 3.363 ± 0.463
2.896GlyGln: 2.896 ± 0.545
6.632GlyArg: 6.632 ± 0.99
4.577GlySer: 4.577 ± 0.684
5.044GlyThr: 5.044 ± 0.741
4.67GlyVal: 4.67 ± 0.541
1.868GlyTrp: 1.868 ± 0.477
1.308GlyTyr: 1.308 ± 0.369
0.0GlyXaa: 0.0 ± 0.0
His
1.681HisAla: 1.681 ± 0.392
0.467HisCys: 0.467 ± 0.234
1.494HisAsp: 1.494 ± 0.458
1.214HisGlu: 1.214 ± 0.372
1.308HisPhe: 1.308 ± 0.401
1.775HisGly: 1.775 ± 0.571
0.374HisHis: 0.374 ± 0.195
1.401HisIle: 1.401 ± 0.338
0.467HisLys: 0.467 ± 0.227
1.494HisLeu: 1.494 ± 0.407
0.654HisMet: 0.654 ± 0.251
0.56HisAsn: 0.56 ± 0.222
1.588HisPro: 1.588 ± 0.504
0.747HisGln: 0.747 ± 0.295
1.588HisArg: 1.588 ± 0.457
0.654HisSer: 0.654 ± 0.268
0.654HisThr: 0.654 ± 0.177
0.747HisVal: 0.747 ± 0.307
0.56HisTrp: 0.56 ± 0.236
0.654HisTyr: 0.654 ± 0.237
0.0HisXaa: 0.0 ± 0.0
Ile
6.725IleAla: 6.725 ± 0.665
0.56IleCys: 0.56 ± 0.266
3.269IleAsp: 3.269 ± 0.42
3.736IleGlu: 3.736 ± 0.646
0.934IlePhe: 0.934 ± 0.238
4.11IleGly: 4.11 ± 0.638
1.027IleHis: 1.027 ± 0.346
1.681IleIle: 1.681 ± 0.383
1.494IleLys: 1.494 ± 0.337
3.456IleLeu: 3.456 ± 0.407
1.401IleMet: 1.401 ± 0.358
1.775IleAsn: 1.775 ± 0.388
2.335IlePro: 2.335 ± 0.425
1.214IleGln: 1.214 ± 0.328
4.577IleArg: 4.577 ± 0.742
3.923IleSer: 3.923 ± 0.653
3.643IleThr: 3.643 ± 0.557
2.896IleVal: 2.896 ± 0.611
0.747IleTrp: 0.747 ± 0.255
1.027IleTyr: 1.027 ± 0.288
0.0IleXaa: 0.0 ± 0.0
Lys
5.418LysAla: 5.418 ± 0.716
0.28LysCys: 0.28 ± 0.201
2.242LysAsp: 2.242 ± 0.452
1.962LysGlu: 1.962 ± 0.516
0.654LysPhe: 0.654 ± 0.276
3.176LysGly: 3.176 ± 0.532
0.467LysHis: 0.467 ± 0.204
1.401LysIle: 1.401 ± 0.247
1.027LysLys: 1.027 ± 0.429
3.83LysLeu: 3.83 ± 0.627
1.308LysMet: 1.308 ± 0.297
1.681LysAsn: 1.681 ± 0.372
1.681LysPro: 1.681 ± 0.441
1.027LysGln: 1.027 ± 0.397
3.269LysArg: 3.269 ± 0.771
1.868LysSer: 1.868 ± 0.393
1.868LysThr: 1.868 ± 0.401
2.429LysVal: 2.429 ± 0.471
0.841LysTrp: 0.841 ± 0.228
0.56LysTyr: 0.56 ± 0.219
0.0LysXaa: 0.0 ± 0.0
Leu
11.582LeuAla: 11.582 ± 1.208
0.841LeuCys: 0.841 ± 0.287
4.95LeuAsp: 4.95 ± 0.777
4.67LeuGlu: 4.67 ± 0.662
1.588LeuPhe: 1.588 ± 0.283
6.819LeuGly: 6.819 ± 0.935
1.775LeuHis: 1.775 ± 0.417
3.549LeuIle: 3.549 ± 0.579
4.67LeuLys: 4.67 ± 0.715
7.379LeuLeu: 7.379 ± 1.031
2.242LeuMet: 2.242 ± 0.501
1.962LeuAsn: 1.962 ± 0.383
6.071LeuPro: 6.071 ± 0.732
4.297LeuGln: 4.297 ± 0.645
5.604LeuArg: 5.604 ± 0.754
5.978LeuSer: 5.978 ± 0.838
5.137LeuThr: 5.137 ± 0.555
4.203LeuVal: 4.203 ± 0.449
0.56LeuTrp: 0.56 ± 0.218
1.121LeuTyr: 1.121 ± 0.271
0.0LeuXaa: 0.0 ± 0.0
Met
3.736MetAla: 3.736 ± 0.766
0.0MetCys: 0.0 ± 0.0
0.654MetAsp: 0.654 ± 0.27
1.494MetGlu: 1.494 ± 0.458
0.187MetPhe: 0.187 ± 0.14
1.775MetGly: 1.775 ± 0.37
0.934MetHis: 0.934 ± 0.296
1.868MetIle: 1.868 ± 0.338
1.308MetLys: 1.308 ± 0.387
2.615MetLeu: 2.615 ± 0.504
0.467MetMet: 0.467 ± 0.233
1.121MetAsn: 1.121 ± 0.276
1.401MetPro: 1.401 ± 0.399
1.027MetGln: 1.027 ± 0.333
3.83MetArg: 3.83 ± 0.433
2.709MetSer: 2.709 ± 0.539
2.429MetThr: 2.429 ± 0.34
1.308MetVal: 1.308 ± 0.388
0.187MetTrp: 0.187 ± 0.141
0.28MetTyr: 0.28 ± 0.164
0.0MetXaa: 0.0 ± 0.0
Asn
3.643AsnAla: 3.643 ± 0.469
0.187AsnCys: 0.187 ± 0.129
1.681AsnAsp: 1.681 ± 0.361
1.401AsnGlu: 1.401 ± 0.294
0.841AsnPhe: 0.841 ± 0.301
2.148AsnGly: 2.148 ± 0.468
0.56AsnHis: 0.56 ± 0.215
1.027AsnIle: 1.027 ± 0.299
0.747AsnLys: 0.747 ± 0.228
2.429AsnLeu: 2.429 ± 0.493
0.467AsnMet: 0.467 ± 0.214
0.28AsnAsn: 0.28 ± 0.149
1.962AsnPro: 1.962 ± 0.373
0.56AsnGln: 0.56 ± 0.272
1.588AsnArg: 1.588 ± 0.385
2.148AsnSer: 2.148 ± 0.43
1.588AsnThr: 1.588 ± 0.381
1.308AsnVal: 1.308 ± 0.296
0.841AsnTrp: 0.841 ± 0.227
0.28AsnTyr: 0.28 ± 0.15
0.0AsnXaa: 0.0 ± 0.0
Pro
6.632ProAla: 6.632 ± 0.727
0.467ProCys: 0.467 ± 0.209
3.082ProAsp: 3.082 ± 0.498
4.203ProGlu: 4.203 ± 0.647
1.681ProPhe: 1.681 ± 0.443
4.764ProGly: 4.764 ± 0.765
1.214ProHis: 1.214 ± 0.419
2.335ProIle: 2.335 ± 0.435
2.335ProLys: 2.335 ± 0.44
3.83ProLeu: 3.83 ± 0.517
2.148ProMet: 2.148 ± 0.436
0.934ProAsn: 0.934 ± 0.254
2.709ProPro: 2.709 ± 0.606
1.308ProGln: 1.308 ± 0.36
2.989ProArg: 2.989 ± 0.417
2.615ProSer: 2.615 ± 0.558
2.709ProThr: 2.709 ± 0.495
5.511ProVal: 5.511 ± 0.724
0.56ProTrp: 0.56 ± 0.207
0.841ProTyr: 0.841 ± 0.287
0.0ProXaa: 0.0 ± 0.0
Gln
4.11GlnAla: 4.11 ± 0.854
0.467GlnCys: 0.467 ± 0.2
1.775GlnAsp: 1.775 ± 0.445
1.681GlnGlu: 1.681 ± 0.445
0.934GlnPhe: 0.934 ± 0.334
2.242GlnGly: 2.242 ± 0.403
0.747GlnHis: 0.747 ± 0.239
2.615GlnIle: 2.615 ± 0.632
1.494GlnLys: 1.494 ± 0.324
3.082GlnLeu: 3.082 ± 0.49
1.027GlnMet: 1.027 ± 0.33
0.747GlnAsn: 0.747 ± 0.219
2.522GlnPro: 2.522 ± 0.527
1.027GlnGln: 1.027 ± 0.342
2.989GlnArg: 2.989 ± 0.501
2.429GlnSer: 2.429 ± 0.647
1.121GlnThr: 1.121 ± 0.276
2.148GlnVal: 2.148 ± 0.529
0.56GlnTrp: 0.56 ± 0.199
0.841GlnTyr: 0.841 ± 0.258
0.0GlnXaa: 0.0 ± 0.0
Arg
9.341ArgAla: 9.341 ± 0.766
0.654ArgCys: 0.654 ± 0.23
4.764ArgAsp: 4.764 ± 0.646
4.483ArgGlu: 4.483 ± 0.73
2.802ArgPhe: 2.802 ± 0.526
6.445ArgGly: 6.445 ± 1.056
1.775ArgHis: 1.775 ± 0.428
4.016ArgIle: 4.016 ± 0.517
2.989ArgLys: 2.989 ± 0.564
7.753ArgLeu: 7.753 ± 0.878
2.148ArgMet: 2.148 ± 0.476
2.429ArgAsn: 2.429 ± 0.502
3.269ArgPro: 3.269 ± 0.601
3.363ArgGln: 3.363 ± 0.619
8.78ArgArg: 8.78 ± 1.158
4.67ArgSer: 4.67 ± 0.773
2.989ArgThr: 2.989 ± 0.526
5.044ArgVal: 5.044 ± 0.767
2.055ArgTrp: 2.055 ± 0.423
1.775ArgTyr: 1.775 ± 0.355
0.0ArgXaa: 0.0 ± 0.0
Ser
7.286SerAla: 7.286 ± 0.907
0.747SerCys: 0.747 ± 0.279
4.297SerAsp: 4.297 ± 0.544
3.456SerGlu: 3.456 ± 0.613
2.522SerPhe: 2.522 ± 0.426
6.632SerGly: 6.632 ± 0.908
0.654SerHis: 0.654 ± 0.293
2.802SerIle: 2.802 ± 0.445
1.588SerLys: 1.588 ± 0.377
4.764SerLeu: 4.764 ± 0.851
1.681SerMet: 1.681 ± 0.431
1.308SerAsn: 1.308 ± 0.35
3.176SerPro: 3.176 ± 0.681
1.681SerGln: 1.681 ± 0.348
4.11SerArg: 4.11 ± 0.721
3.269SerSer: 3.269 ± 0.657
3.082SerThr: 3.082 ± 0.685
3.363SerVal: 3.363 ± 0.643
1.308SerTrp: 1.308 ± 0.306
1.401SerTyr: 1.401 ± 0.332
0.0SerXaa: 0.0 ± 0.0
Thr
7.566ThrAla: 7.566 ± 0.782
0.187ThrCys: 0.187 ± 0.118
3.082ThrAsp: 3.082 ± 0.468
3.363ThrGlu: 3.363 ± 0.7
2.055ThrPhe: 2.055 ± 0.403
4.67ThrGly: 4.67 ± 0.615
1.588ThrHis: 1.588 ± 0.469
3.456ThrIle: 3.456 ± 0.724
1.681ThrLys: 1.681 ± 0.402
3.176ThrLeu: 3.176 ± 0.662
0.841ThrMet: 0.841 ± 0.328
0.654ThrAsn: 0.654 ± 0.237
4.11ThrPro: 4.11 ± 0.705
1.588ThrGln: 1.588 ± 0.338
3.83ThrArg: 3.83 ± 0.661
2.896ThrSer: 2.896 ± 0.446
2.522ThrThr: 2.522 ± 0.4
4.11ThrVal: 4.11 ± 0.579
0.841ThrTrp: 0.841 ± 0.315
1.121ThrTyr: 1.121 ± 0.341
0.0ThrXaa: 0.0 ± 0.0
Val
8.407ValAla: 8.407 ± 0.853
0.28ValCys: 0.28 ± 0.165
2.989ValAsp: 2.989 ± 0.743
2.802ValGlu: 2.802 ± 0.519
1.494ValPhe: 1.494 ± 0.336
5.044ValGly: 5.044 ± 0.927
0.934ValHis: 0.934 ± 0.296
4.11ValIle: 4.11 ± 0.676
1.681ValLys: 1.681 ± 0.334
5.791ValLeu: 5.791 ± 0.668
1.027ValMet: 1.027 ± 0.295
1.588ValAsn: 1.588 ± 0.394
2.148ValPro: 2.148 ± 0.398
2.896ValGln: 2.896 ± 0.651
4.11ValArg: 4.11 ± 0.569
4.67ValSer: 4.67 ± 0.614
4.203ValThr: 4.203 ± 0.662
3.456ValVal: 3.456 ± 0.456
1.588ValTrp: 1.588 ± 0.371
0.841ValTyr: 0.841 ± 0.299
0.0ValXaa: 0.0 ± 0.0
Trp
1.681TrpAla: 1.681 ± 0.365
0.093TrpCys: 0.093 ± 0.091
0.467TrpAsp: 0.467 ± 0.175
0.654TrpGlu: 0.654 ± 0.221
0.934TrpPhe: 0.934 ± 0.285
1.214TrpGly: 1.214 ± 0.316
0.56TrpHis: 0.56 ± 0.248
1.214TrpIle: 1.214 ± 0.246
1.027TrpLys: 1.027 ± 0.292
1.401TrpLeu: 1.401 ± 0.49
0.28TrpMet: 0.28 ± 0.192
0.374TrpAsn: 0.374 ± 0.184
1.121TrpPro: 1.121 ± 0.363
0.747TrpGln: 0.747 ± 0.266
1.962TrpArg: 1.962 ± 0.461
1.588TrpSer: 1.588 ± 0.308
2.148TrpThr: 2.148 ± 0.444
1.214TrpVal: 1.214 ± 0.389
0.093TrpTrp: 0.093 ± 0.095
0.467TrpTyr: 0.467 ± 0.22
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.868TyrAla: 1.868 ± 0.424
0.187TyrCys: 0.187 ± 0.129
1.588TyrAsp: 1.588 ± 0.422
1.027TyrGlu: 1.027 ± 0.334
0.56TyrPhe: 0.56 ± 0.261
1.401TyrGly: 1.401 ± 0.312
0.28TyrHis: 0.28 ± 0.188
1.027TyrIle: 1.027 ± 0.421
0.654TyrLys: 0.654 ± 0.2
1.962TyrLeu: 1.962 ± 0.345
0.467TyrMet: 0.467 ± 0.235
0.374TyrAsn: 0.374 ± 0.187
1.494TyrPro: 1.494 ± 0.413
0.654TyrGln: 0.654 ± 0.217
1.962TyrArg: 1.962 ± 0.399
0.56TyrSer: 0.56 ± 0.15
0.747TyrThr: 0.747 ± 0.249
0.934TyrVal: 0.934 ± 0.31
0.56TyrTrp: 0.56 ± 0.254
0.747TyrTyr: 0.747 ± 0.29
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (10707 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski