Amino acid dipepetide frequency for Dyadobacter psychrotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.238AlaAla: 6.238 ± 0.06	0.6AlaCys: 0.6 ± 0.018	4.217AlaAsp: 4.217 ± 0.051	4.362AlaGlu: 4.362 ± 0.047	3.453AlaPhe: 3.453 ± 0.042	5.855AlaGly: 5.855 ± 0.059	1.183AlaHis: 1.183 ± 0.026	4.927AlaIle: 4.927 ± 0.042	4.339AlaLys: 4.339 ± 0.044	6.901AlaLeu: 6.901 ± 0.066	1.698AlaMet: 1.698 ± 0.026	3.434AlaAsn: 3.434 ± 0.041	2.343AlaPro: 2.343 ± 0.039	2.901AlaGln: 2.901 ± 0.038	2.815AlaArg: 2.815 ± 0.038	4.854AlaSer: 4.854 ± 0.046	3.933AlaThr: 3.933 ± 0.044	5.075AlaVal: 5.075 ± 0.063	0.839AlaTrp: 0.839 ± 0.021	2.677AlaTyr: 2.677 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.453CysAla: 0.453 ± 0.015	0.124CysCys: 0.124 ± 0.007	0.369CysAsp: 0.369 ± 0.012	0.416CysGlu: 0.416 ± 0.015	0.403CysPhe: 0.403 ± 0.014	0.584CysGly: 0.584 ± 0.016	0.187CysHis: 0.187 ± 0.011	0.543CysIle: 0.543 ± 0.016	0.411CysLys: 0.411 ± 0.014	0.713CysLeu: 0.713 ± 0.018	0.172CysMet: 0.172 ± 0.008	0.321CysAsn: 0.321 ± 0.012	0.289CysPro: 0.289 ± 0.012	0.255CysGln: 0.255 ± 0.012	0.306CysArg: 0.306 ± 0.012	0.515CysSer: 0.515 ± 0.015	0.406CysThr: 0.406 ± 0.016	0.431CysVal: 0.431 ± 0.013	0.089CysTrp: 0.089 ± 0.006	0.282CysTyr: 0.282 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.679AspAla: 3.679 ± 0.046	0.36AspCys: 0.36 ± 0.012	2.452AspAsp: 2.452 ± 0.038	3.197AspGlu: 3.197 ± 0.041	3.128AspPhe: 3.128 ± 0.035	3.933AspGly: 3.933 ± 0.05	1.022AspHis: 1.022 ± 0.023	3.744AspIle: 3.744 ± 0.042	3.692AspLys: 3.692 ± 0.044	5.356AspLeu: 5.356 ± 0.045	1.164AspMet: 1.164 ± 0.02	2.456AspAsn: 2.456 ± 0.033	2.225AspPro: 2.225 ± 0.031	2.078AspGln: 2.078 ± 0.032	2.333AspArg: 2.333 ± 0.038	3.203AspSer: 3.203 ± 0.041	2.477AspThr: 2.477 ± 0.034	3.42AspVal: 3.42 ± 0.045	0.83AspTrp: 0.83 ± 0.018	2.4AspTyr: 2.4 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	4.127GluAla: 4.127 ± 0.053	0.312GluCys: 0.312 ± 0.011	2.79GluAsp: 2.79 ± 0.04	3.731GluGlu: 3.731 ± 0.054	2.51GluPhe: 2.51 ± 0.034	3.505GluGly: 3.505 ± 0.044	1.034GluHis: 1.034 ± 0.023	4.632GluIle: 4.632 ± 0.042	5.162GluLys: 5.162 ± 0.052	5.752GluLeu: 5.752 ± 0.055	1.568GluMet: 1.568 ± 0.029	3.707GluAsn: 3.707 ± 0.044	1.739GluPro: 1.739 ± 0.03	2.363GluGln: 2.363 ± 0.031	2.659GluArg: 2.659 ± 0.04	3.381GluSer: 3.381 ± 0.038	3.249GluThr: 3.249 ± 0.038	3.856GluVal: 3.856 ± 0.054	0.747GluTrp: 0.747 ± 0.018	2.085GluTyr: 2.085 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.428PheAla: 3.428 ± 0.035	0.472PheCys: 0.472 ± 0.012	2.869PheAsp: 2.869 ± 0.035	2.892PheGlu: 2.892 ± 0.034	2.516PhePhe: 2.516 ± 0.043	3.536PheGly: 3.536 ± 0.043	0.831PheHis: 0.831 ± 0.018	3.201PheIle: 3.201 ± 0.042	2.926PheLys: 2.926 ± 0.039	4.707PheLeu: 4.707 ± 0.047	1.077PheMet: 1.077 ± 0.023	2.55PheAsn: 2.55 ± 0.039	1.913PhePro: 1.913 ± 0.028	1.707PheGln: 1.707 ± 0.032	2.165PheArg: 2.165 ± 0.029	4.015PheSer: 4.015 ± 0.044	2.997PheThr: 2.997 ± 0.034	3.1PheVal: 3.1 ± 0.037	0.649PheTrp: 0.649 ± 0.017	2.064PheTyr: 2.064 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	4.641GlyAla: 4.641 ± 0.054	0.587GlyCys: 0.587 ± 0.017	3.284GlyAsp: 3.284 ± 0.048	3.584GlyGlu: 3.584 ± 0.041	3.777GlyPhe: 3.777 ± 0.046	4.877GlyGly: 4.877 ± 0.062	1.197GlyHis: 1.197 ± 0.023	5.409GlyIle: 5.409 ± 0.057	5.473GlyLys: 5.473 ± 0.057	6.512GlyLeu: 6.512 ± 0.063	1.728GlyMet: 1.728 ± 0.03	3.701GlyAsn: 3.701 ± 0.048	1.727GlyPro: 1.727 ± 0.027	2.502GlyGln: 2.502 ± 0.031	2.831GlyArg: 2.831 ± 0.037	4.827GlySer: 4.827 ± 0.051	4.254GlyThr: 4.254 ± 0.062	4.472GlyVal: 4.472 ± 0.049	1.026GlyTrp: 1.026 ± 0.021	3.1GlyTyr: 3.1 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.188HisAla: 1.188 ± 0.026	0.173HisCys: 0.173 ± 0.009	0.864HisAsp: 0.864 ± 0.022	0.975HisGlu: 0.975 ± 0.021	1.098HisPhe: 1.098 ± 0.022	1.159HisGly: 1.159 ± 0.023	0.498HisHis: 0.498 ± 0.017	1.262HisIle: 1.262 ± 0.027	0.938HisLys: 0.938 ± 0.018	1.776HisLeu: 1.776 ± 0.034	0.343HisMet: 0.343 ± 0.012	0.808HisAsn: 0.808 ± 0.02	0.939HisPro: 0.939 ± 0.02	0.767HisGln: 0.767 ± 0.019	0.79HisArg: 0.79 ± 0.019	1.083HisSer: 1.083 ± 0.022	0.92HisThr: 0.92 ± 0.02	1.019HisVal: 1.019 ± 0.021	0.265HisTrp: 0.265 ± 0.012	0.838HisTyr: 0.838 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.294IleAla: 5.294 ± 0.048	0.622IleCys: 0.622 ± 0.018	3.834IleAsp: 3.834 ± 0.04	4.217IleGlu: 4.217 ± 0.051	3.26IlePhe: 3.26 ± 0.032	4.744IleGly: 4.744 ± 0.058	1.302IleHis: 1.302 ± 0.024	4.549IleIle: 4.549 ± 0.048	4.358IleLys: 4.358 ± 0.045	6.555IleLeu: 6.555 ± 0.066	1.343IleMet: 1.343 ± 0.023	3.668IleAsn: 3.668 ± 0.041	3.225IlePro: 3.225 ± 0.037	2.467IleGln: 2.467 ± 0.036	3.377IleArg: 3.377 ± 0.04	5.496IleSer: 5.496 ± 0.057	4.228IleThr: 4.228 ± 0.038	4.295IleVal: 4.295 ± 0.046	0.782IleTrp: 0.782 ± 0.018	2.505IleTyr: 2.505 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.838LysAla: 4.838 ± 0.045	0.289LysCys: 0.289 ± 0.014	3.821LysAsp: 3.821 ± 0.047	4.499LysGlu: 4.499 ± 0.056	2.479LysPhe: 2.479 ± 0.032	4.488LysGly: 4.488 ± 0.047	1.106LysHis: 1.106 ± 0.024	4.974LysIle: 4.974 ± 0.044	5.075LysLys: 5.075 ± 0.058	5.925LysLeu: 5.925 ± 0.054	1.877LysMet: 1.877 ± 0.031	4.06LysAsn: 4.06 ± 0.045	2.747LysPro: 2.747 ± 0.038	2.635LysGln: 2.635 ± 0.035	2.811LysArg: 2.811 ± 0.038	4.387LysSer: 4.387 ± 0.044	4.195LysThr: 4.195 ± 0.044	4.231LysVal: 4.231 ± 0.048	0.832LysTrp: 0.832 ± 0.019	2.562LysTyr: 2.562 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	7.17LeuAla: 7.17 ± 0.065	0.727LeuCys: 0.727 ± 0.019	4.842LeuAsp: 4.842 ± 0.047	5.151LeuGlu: 5.151 ± 0.052	4.718LeuPhe: 4.718 ± 0.063	6.015LeuGly: 6.015 ± 0.051	1.715LeuHis: 1.715 ± 0.028	6.755LeuIle: 6.755 ± 0.071	6.787LeuLys: 6.787 ± 0.059	9.702LeuLeu: 9.702 ± 0.088	2.181LeuMet: 2.181 ± 0.032	5.08LeuAsn: 5.08 ± 0.046	4.348LeuPro: 4.348 ± 0.046	3.361LeuGln: 3.361 ± 0.039	4.177LeuArg: 4.177 ± 0.039	7.366LeuSer: 7.366 ± 0.066	5.909LeuThr: 5.909 ± 0.044	5.665LeuVal: 5.665 ± 0.054	1.008LeuTrp: 1.008 ± 0.024	3.273LeuTyr: 3.273 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.79MetAla: 1.79 ± 0.033	0.122MetCys: 0.122 ± 0.007	1.27MetAsp: 1.27 ± 0.025	1.361MetGlu: 1.361 ± 0.022	0.844MetPhe: 0.844 ± 0.021	1.507MetGly: 1.507 ± 0.028	0.423MetHis: 0.423 ± 0.014	1.534MetIle: 1.534 ± 0.025	1.969MetLys: 1.969 ± 0.026	2.174MetLeu: 2.174 ± 0.03	0.594MetMet: 0.594 ± 0.016	1.303MetAsn: 1.303 ± 0.024	1.043MetPro: 1.043 ± 0.019	0.951MetGln: 0.951 ± 0.02	0.963MetArg: 0.963 ± 0.024	1.441MetSer: 1.441 ± 0.026	1.258MetThr: 1.258 ± 0.024	1.421MetVal: 1.421 ± 0.028	0.21MetTrp: 0.21 ± 0.011	0.653MetTyr: 0.653 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.636AsnAla: 3.636 ± 0.042	0.338AsnCys: 0.338 ± 0.012	2.527AsnAsp: 2.527 ± 0.036	2.866AsnGlu: 2.866 ± 0.035	2.582AsnPhe: 2.582 ± 0.034	3.959AsnGly: 3.959 ± 0.057	0.946AsnHis: 0.946 ± 0.021	3.694AsnIle: 3.694 ± 0.042	3.137AsnLys: 3.137 ± 0.039	5.024AsnLeu: 5.024 ± 0.053	1.144AsnMet: 1.144 ± 0.021	2.77AsnAsn: 2.77 ± 0.035	2.721AsnPro: 2.721 ± 0.039	2.166AsnGln: 2.166 ± 0.033	2.418AsnArg: 2.418 ± 0.031	3.528AsnSer: 3.528 ± 0.048	2.957AsnThr: 2.957 ± 0.038	3.192AsnVal: 3.192 ± 0.044	0.761AsnTrp: 0.761 ± 0.019	2.335AsnTyr: 2.335 ± 0.031	0.001AsnXaa: 0.001 ± 0.001
Pro	3.263ProAla: 3.263 ± 0.04	0.196ProCys: 0.196 ± 0.009	2.746ProAsp: 2.746 ± 0.037	3.068ProGlu: 3.068 ± 0.04	2.005ProPhe: 2.005 ± 0.031	2.943ProGly: 2.943 ± 0.042	0.622ProHis: 0.622 ± 0.018	2.243ProIle: 2.243 ± 0.034	2.237ProLys: 2.237 ± 0.037	3.432ProLeu: 3.432 ± 0.044	0.83ProMet: 0.83 ± 0.02	1.858ProAsn: 1.858 ± 0.032	1.03ProPro: 1.03 ± 0.022	1.318ProGln: 1.318 ± 0.026	1.204ProArg: 1.204 ± 0.027	2.45ProSer: 2.45 ± 0.034	1.952ProThr: 1.952 ± 0.035	3.467ProVal: 3.467 ± 0.042	0.46ProTrp: 0.46 ± 0.015	1.526ProTyr: 1.526 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	2.627GlnAla: 2.627 ± 0.038	0.194GlnCys: 0.194 ± 0.01	1.744GlnAsp: 1.744 ± 0.03	2.212GlnGlu: 2.212 ± 0.034	1.704GlnPhe: 1.704 ± 0.029	2.096GlnGly: 2.096 ± 0.033	0.707GlnHis: 0.707 ± 0.018	2.843GlnIle: 2.843 ± 0.033	2.914GlnLys: 2.914 ± 0.038	3.76GlnLeu: 3.76 ± 0.036	0.939GlnMet: 0.939 ± 0.019	2.241GlnAsn: 2.241 ± 0.032	1.47GlnPro: 1.47 ± 0.025	1.919GlnGln: 1.919 ± 0.034	1.624GlnArg: 1.624 ± 0.026	2.433GlnSer: 2.433 ± 0.039	2.313GlnThr: 2.313 ± 0.034	2.447GlnVal: 2.447 ± 0.037	0.474GlnTrp: 0.474 ± 0.015	1.435GlnTyr: 1.435 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	2.631ArgAla: 2.631 ± 0.035	0.263ArgCys: 0.263 ± 0.011	2.101ArgAsp: 2.101 ± 0.034	2.632ArgGlu: 2.632 ± 0.039	2.4ArgPhe: 2.4 ± 0.031	2.309ArgGly: 2.309 ± 0.033	0.715ArgHis: 0.715 ± 0.019	3.4ArgIle: 3.4 ± 0.039	3.069ArgLys: 3.069 ± 0.033	4.224ArgLeu: 4.224 ± 0.046	1.127ArgMet: 1.127 ± 0.023	2.433ArgAsn: 2.433 ± 0.031	1.549ArgPro: 1.549 ± 0.032	1.755ArgGln: 1.755 ± 0.03	1.889ArgArg: 1.889 ± 0.033	2.699ArgSer: 2.699 ± 0.038	2.319ArgThr: 2.319 ± 0.026	2.543ArgVal: 2.543 ± 0.034	0.594ArgTrp: 0.594 ± 0.016	1.908ArgTyr: 1.908 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	4.969SerAla: 4.969 ± 0.05	0.581SerCys: 0.581 ± 0.015	3.688SerAsp: 3.688 ± 0.042	4.081SerGlu: 4.081 ± 0.047	3.866SerPhe: 3.866 ± 0.044	5.559SerGly: 5.559 ± 0.053	1.189SerHis: 1.189 ± 0.024	4.483SerIle: 4.483 ± 0.048	4.228SerLys: 4.228 ± 0.044	6.705SerLeu: 6.705 ± 0.057	1.372SerMet: 1.372 ± 0.025	3.167SerAsn: 3.167 ± 0.041	2.526SerPro: 2.526 ± 0.036	2.548SerGln: 2.548 ± 0.033	2.879SerArg: 2.879 ± 0.037	4.581SerSer: 4.581 ± 0.049	3.565SerThr: 3.565 ± 0.046	4.821SerVal: 4.821 ± 0.046	0.914SerTrp: 0.914 ± 0.021	2.791SerTyr: 2.791 ± 0.036	0.001SerXaa: 0.001 ± 0.001
Thr	4.554ThrAla: 4.554 ± 0.05	0.344ThrCys: 0.344 ± 0.014	3.448ThrAsp: 3.448 ± 0.044	3.314ThrGlu: 3.314 ± 0.04	2.814ThrPhe: 2.814 ± 0.038	4.872ThrGly: 4.872 ± 0.055	0.919ThrHis: 0.919 ± 0.022	3.999ThrIle: 3.999 ± 0.048	3.2ThrLys: 3.2 ± 0.042	5.363ThrLeu: 5.363 ± 0.052	1.059ThrMet: 1.059 ± 0.026	2.78ThrAsn: 2.78 ± 0.037	2.51ThrPro: 2.51 ± 0.037	1.889ThrGln: 1.889 ± 0.033	2.105ThrArg: 2.105 ± 0.029	3.82ThrSer: 3.82 ± 0.04	3.291ThrThr: 3.291 ± 0.052	3.92ThrVal: 3.92 ± 0.045	0.668ThrTrp: 0.668 ± 0.017	2.238ThrTyr: 2.238 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	4.641ValAla: 4.641 ± 0.047	0.543ValCys: 0.543 ± 0.016	3.329ValAsp: 3.329 ± 0.035	3.562ValGlu: 3.562 ± 0.038	3.206ValPhe: 3.206 ± 0.039	3.993ValGly: 3.993 ± 0.049	1.071ValHis: 1.071 ± 0.021	4.755ValIle: 4.755 ± 0.051	4.477ValLys: 4.477 ± 0.053	6.201ValLeu: 6.201 ± 0.066	1.508ValMet: 1.508 ± 0.026	3.454ValAsn: 3.454 ± 0.04	2.497ValPro: 2.497 ± 0.04	2.159ValGln: 2.159 ± 0.033	2.752ValArg: 2.752 ± 0.034	5.005ValSer: 5.005 ± 0.053	4.017ValThr: 4.017 ± 0.046	4.438ValVal: 4.438 ± 0.05	0.77ValTrp: 0.77 ± 0.018	2.365ValTyr: 2.365 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.821TrpAla: 0.821 ± 0.018	0.103TrpCys: 0.103 ± 0.006	0.698TrpAsp: 0.698 ± 0.02	0.747TrpGlu: 0.747 ± 0.018	0.634TrpPhe: 0.634 ± 0.018	0.822TrpGly: 0.822 ± 0.022	0.259TrpHis: 0.259 ± 0.011	0.863TrpIle: 0.863 ± 0.022	0.947TrpLys: 0.947 ± 0.02	1.301TrpLeu: 1.301 ± 0.024	0.368TrpMet: 0.368 ± 0.013	0.739TrpAsn: 0.739 ± 0.018	0.376TrpPro: 0.376 ± 0.013	0.593TrpGln: 0.593 ± 0.015	0.539TrpArg: 0.539 ± 0.015	0.7TrpSer: 0.7 ± 0.018	0.699TrpThr: 0.699 ± 0.018	0.746TrpVal: 0.746 ± 0.018	0.201TrpTrp: 0.201 ± 0.009	0.501TrpTyr: 0.501 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.658TyrAla: 2.658 ± 0.038	0.316TyrCys: 0.316 ± 0.013	2.257TyrAsp: 2.257 ± 0.037	2.041TyrGlu: 2.041 ± 0.027	2.216TyrPhe: 2.216 ± 0.036	2.751TyrGly: 2.751 ± 0.034	0.779TyrHis: 0.779 ± 0.016	2.311TyrIle: 2.311 ± 0.034	2.491TyrLys: 2.491 ± 0.032	3.869TyrLeu: 3.869 ± 0.044	0.739TyrMet: 0.739 ± 0.016	2.174TyrAsn: 2.174 ± 0.038	1.632TyrPro: 1.632 ± 0.027	1.762TyrGln: 1.762 ± 0.027	1.924TyrArg: 1.924 ± 0.029	2.728TyrSer: 2.728 ± 0.036	2.166TyrThr: 2.166 ± 0.033	2.186TyrVal: 2.186 ± 0.027	0.538TyrTrp: 0.538 ± 0.017	1.694TyrTyr: 1.694 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6512 proteins (2294528 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---