Amino acid dipepetide frequency for Catenulispora acidiphila (strain DSM 44928 / JCM 14897 / NBRC 102108 / NRRL B-24433 / ID139908)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.567AlaAla: 23.567 ± 0.133
1.025AlaCys: 1.025 ± 0.02
8.764AlaAsp: 8.764 ± 0.068
8.529AlaGlu: 8.529 ± 0.085
3.783AlaPhe: 3.783 ± 0.033
13.319AlaGly: 13.319 ± 0.086
2.671AlaHis: 2.671 ± 0.031
4.557AlaIle: 4.557 ± 0.041
3.151AlaLys: 3.151 ± 0.038
13.96AlaLeu: 13.96 ± 0.089
2.795AlaMet: 2.795 ± 0.031
2.743AlaAsn: 2.743 ± 0.041
6.861AlaPro: 6.861 ± 0.063
4.109AlaGln: 4.109 ± 0.042
8.673AlaArg: 8.673 ± 0.073
7.347AlaSer: 7.347 ± 0.064
8.018AlaThr: 8.018 ± 0.062
12.38AlaVal: 12.38 ± 0.082
1.967AlaTrp: 1.967 ± 0.028
2.753AlaTyr: 2.753 ± 0.032
0.0AlaXaa: 0.0 ± 0.0
Cys
0.951CysAla: 0.951 ± 0.02
0.106CysCys: 0.106 ± 0.008
0.471CysAsp: 0.471 ± 0.013
0.354CysGlu: 0.354 ± 0.011
0.228CysPhe: 0.228 ± 0.008
0.892CysGly: 0.892 ± 0.017
0.191CysHis: 0.191 ± 0.008
0.165CysIle: 0.165 ± 0.007
0.108CysLys: 0.108 ± 0.006
0.717CysLeu: 0.717 ± 0.017
0.116CysMet: 0.116 ± 0.005
0.169CysAsn: 0.169 ± 0.009
0.434CysPro: 0.434 ± 0.014
0.204CysGln: 0.204 ± 0.009
0.504CysArg: 0.504 ± 0.012
0.485CysSer: 0.485 ± 0.014
0.47CysThr: 0.47 ± 0.014
0.643CysVal: 0.643 ± 0.017
0.118CysTrp: 0.118 ± 0.007
0.184CysTyr: 0.184 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
7.716AspAla: 7.716 ± 0.067
0.43AspCys: 0.43 ± 0.012
3.283AspAsp: 3.283 ± 0.039
3.194AspGlu: 3.194 ± 0.038
1.741AspPhe: 1.741 ± 0.022
5.923AspGly: 5.923 ± 0.05
1.359AspHis: 1.359 ± 0.021
1.964AspIle: 1.964 ± 0.027
1.155AspLys: 1.155 ± 0.024
6.208AspLeu: 6.208 ± 0.055
0.851AspMet: 0.851 ± 0.018
1.075AspAsn: 1.075 ± 0.019
4.596AspPro: 4.596 ± 0.039
1.878AspGln: 1.878 ± 0.027
4.323AspArg: 4.323 ± 0.046
2.92AspSer: 2.92 ± 0.038
3.151AspThr: 3.151 ± 0.038
4.757AspVal: 4.757 ± 0.044
0.944AspTrp: 0.944 ± 0.018
1.33AspTyr: 1.33 ± 0.023
0.0AspXaa: 0.0 ± 0.0
Glu
7.065GluAla: 7.065 ± 0.076
0.326GluCys: 0.326 ± 0.011
2.604GluAsp: 2.604 ± 0.037
2.694GluGlu: 2.694 ± 0.033
1.503GluPhe: 1.503 ± 0.02
3.443GluGly: 3.443 ± 0.039
1.466GluHis: 1.466 ± 0.021
2.204GluIle: 2.204 ± 0.028
1.117GluLys: 1.117 ± 0.022
5.83GluLeu: 5.83 ± 0.061
0.885GluMet: 0.885 ± 0.014
1.102GluAsn: 1.102 ± 0.02
3.155GluPro: 3.155 ± 0.046
2.25GluGln: 2.25 ± 0.029
4.527GluArg: 4.527 ± 0.046
2.541GluSer: 2.541 ± 0.03
2.737GluThr: 2.737 ± 0.031
3.983GluVal: 3.983 ± 0.046
0.656GluTrp: 0.656 ± 0.015
1.138GluTyr: 1.138 ± 0.022
0.0GluXaa: 0.0 ± 0.0
Phe
4.029PheAla: 4.029 ± 0.034
0.261PheCys: 0.261 ± 0.008
2.149PheAsp: 2.149 ± 0.027
1.477PheGlu: 1.477 ± 0.022
0.903PhePhe: 0.903 ± 0.019
3.321PheGly: 3.321 ± 0.038
0.653PheHis: 0.653 ± 0.014
0.822PheIle: 0.822 ± 0.018
0.509PheLys: 0.509 ± 0.013
2.676PheLeu: 2.676 ± 0.031
0.429PheMet: 0.429 ± 0.013
0.632PheAsn: 0.632 ± 0.016
1.433PhePro: 1.433 ± 0.023
0.864PheGln: 0.864 ± 0.018
1.703PheArg: 1.703 ± 0.025
1.649PheSer: 1.649 ± 0.024
2.107PheThr: 2.107 ± 0.028
2.222PheVal: 2.222 ± 0.028
0.447PheTrp: 0.447 ± 0.015
0.664PheTyr: 0.664 ± 0.015
0.0PheXaa: 0.0 ± 0.0
Gly
11.186GlyAla: 11.186 ± 0.074
0.774GlyCys: 0.774 ± 0.017
4.96GlyAsp: 4.96 ± 0.039
4.365GlyGlu: 4.365 ± 0.046
3.073GlyPhe: 3.073 ± 0.039
8.956GlyGly: 8.956 ± 0.094
2.101GlyHis: 2.101 ± 0.026
3.627GlyIle: 3.627 ± 0.037
2.291GlyLys: 2.291 ± 0.033
8.707GlyLeu: 8.707 ± 0.062
2.027GlyMet: 2.027 ± 0.027
2.033GlyAsn: 2.033 ± 0.034
4.676GlyPro: 4.676 ± 0.045
2.9GlyGln: 2.9 ± 0.033
6.347GlyArg: 6.347 ± 0.052
6.34GlySer: 6.34 ± 0.066
6.592GlyThr: 6.592 ± 0.072
7.607GlyVal: 7.607 ± 0.059
1.697GlyTrp: 1.697 ± 0.025
2.491GlyTyr: 2.491 ± 0.031
0.0GlyXaa: 0.0 ± 0.0
His
2.71HisAla: 2.71 ± 0.029
0.195HisCys: 0.195 ± 0.008
1.303HisAsp: 1.303 ± 0.021
1.062HisGlu: 1.062 ± 0.021
0.62HisPhe: 0.62 ± 0.013
2.182HisGly: 2.182 ± 0.027
0.654HisHis: 0.654 ± 0.018
0.724HisIle: 0.724 ± 0.017
0.341HisLys: 0.341 ± 0.011
2.278HisLeu: 2.278 ± 0.03
0.345HisMet: 0.345 ± 0.011
0.422HisAsn: 0.422 ± 0.012
1.619HisPro: 1.619 ± 0.024
0.694HisGln: 0.694 ± 0.014
1.718HisArg: 1.718 ± 0.027
1.134HisSer: 1.134 ± 0.02
1.266HisThr: 1.266 ± 0.019
1.626HisVal: 1.626 ± 0.024
0.358HisTrp: 0.358 ± 0.01
0.513HisTyr: 0.513 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
5.729IleAla: 5.729 ± 0.049
0.29IleCys: 0.29 ± 0.009
2.416IleAsp: 2.416 ± 0.028
2.075IleGlu: 2.075 ± 0.027
0.778IlePhe: 0.778 ± 0.019
3.962IleGly: 3.962 ± 0.04
0.7IleHis: 0.7 ± 0.016
1.069IleIle: 1.069 ± 0.021
0.733IleLys: 0.733 ± 0.015
2.914IleLeu: 2.914 ± 0.034
0.497IleMet: 0.497 ± 0.014
0.763IleAsn: 0.763 ± 0.018
2.137IlePro: 2.137 ± 0.024
0.917IleGln: 0.917 ± 0.02
2.408IleArg: 2.408 ± 0.032
2.055IleSer: 2.055 ± 0.03
2.446IleThr: 2.446 ± 0.03
3.032IleVal: 3.032 ± 0.03
0.449IleTrp: 0.449 ± 0.011
0.632IleTyr: 0.632 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
2.971LysAla: 2.971 ± 0.038
0.129LysCys: 0.129 ± 0.008
1.16LysAsp: 1.16 ± 0.021
0.902LysGlu: 0.902 ± 0.019
0.502LysPhe: 0.502 ± 0.015
1.495LysGly: 1.495 ± 0.028
0.48LysHis: 0.48 ± 0.011
0.854LysIle: 0.854 ± 0.016
0.63LysLys: 0.63 ± 0.019
2.043LysLeu: 2.043 ± 0.026
0.397LysMet: 0.397 ± 0.011
0.58LysAsn: 0.58 ± 0.017
1.451LysPro: 1.451 ± 0.023
0.801LysGln: 0.801 ± 0.018
1.383LysArg: 1.383 ± 0.026
1.231LysSer: 1.231 ± 0.023
1.484LysThr: 1.484 ± 0.028
1.746LysVal: 1.746 ± 0.026
0.275LysTrp: 0.275 ± 0.01
0.489LysTyr: 0.489 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
15.046LeuAla: 15.046 ± 0.1
0.769LeuCys: 0.769 ± 0.016
6.133LeuAsp: 6.133 ± 0.055
4.313LeuGlu: 4.313 ± 0.042
2.633LeuPhe: 2.633 ± 0.031
8.688LeuGly: 8.688 ± 0.053
2.063LeuHis: 2.063 ± 0.025
3.845LeuIle: 3.845 ± 0.041
1.929LeuLys: 1.929 ± 0.028
9.816LeuLeu: 9.816 ± 0.061
1.73LeuMet: 1.73 ± 0.024
2.042LeuAsn: 2.042 ± 0.03
5.972LeuPro: 5.972 ± 0.053
2.256LeuGln: 2.256 ± 0.027
7.499LeuArg: 7.499 ± 0.062
5.654LeuSer: 5.654 ± 0.046
6.73LeuThr: 6.73 ± 0.048
7.996LeuVal: 7.996 ± 0.059
1.274LeuTrp: 1.274 ± 0.021
1.812LeuTyr: 1.812 ± 0.026
0.0LeuXaa: 0.0 ± 0.0
Met
2.49MetAla: 2.49 ± 0.026
0.134MetCys: 0.134 ± 0.007
0.89MetAsp: 0.89 ± 0.017
0.706MetGlu: 0.706 ± 0.016
0.544MetPhe: 0.544 ± 0.013
1.191MetGly: 1.191 ± 0.018
0.346MetHis: 0.346 ± 0.01
0.733MetIle: 0.733 ± 0.016
0.418MetLys: 0.418 ± 0.012
1.848MetLeu: 1.848 ± 0.024
0.35MetMet: 0.35 ± 0.011
0.499MetAsn: 0.499 ± 0.014
1.205MetPro: 1.205 ± 0.019
0.524MetGln: 0.524 ± 0.015
1.399MetArg: 1.399 ± 0.02
1.414MetSer: 1.414 ± 0.022
1.64MetThr: 1.64 ± 0.022
1.398MetVal: 1.398 ± 0.025
0.237MetTrp: 0.237 ± 0.008
0.343MetTyr: 0.343 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
2.767AsnAla: 2.767 ± 0.037
0.171AsnCys: 0.171 ± 0.007
1.103AsnAsp: 1.103 ± 0.02
0.852AsnGlu: 0.852 ± 0.015
0.573AsnPhe: 0.573 ± 0.014
2.453AsnGly: 2.453 ± 0.039
0.467AsnHis: 0.467 ± 0.013
0.733AsnIle: 0.733 ± 0.017
0.429AsnLys: 0.429 ± 0.012
2.029AsnLeu: 2.029 ± 0.03
0.333AsnMet: 0.333 ± 0.012
0.594AsnAsn: 0.594 ± 0.016
1.744AsnPro: 1.744 ± 0.025
0.821AsnGln: 0.821 ± 0.022
1.297AsnArg: 1.297 ± 0.02
1.315AsnSer: 1.315 ± 0.027
1.415AsnThr: 1.415 ± 0.028
1.639AsnVal: 1.639 ± 0.028
0.367AsnTrp: 0.367 ± 0.012
0.526AsnTyr: 0.526 ± 0.014
0.0AsnXaa: 0.0 ± 0.0
Pro
8.592ProAla: 8.592 ± 0.067
0.335ProCys: 0.335 ± 0.011
4.391ProAsp: 4.391 ± 0.042
3.824ProGlu: 3.824 ± 0.044
1.537ProPhe: 1.537 ± 0.022
5.991ProGly: 5.991 ± 0.051
1.274ProHis: 1.274 ± 0.02
1.833ProIle: 1.833 ± 0.029
1.241ProLys: 1.241 ± 0.021
4.896ProLeu: 4.896 ± 0.046
1.038ProMet: 1.038 ± 0.019
1.334ProAsn: 1.334 ± 0.02
3.337ProPro: 3.337 ± 0.043
1.85ProGln: 1.85 ± 0.036
3.276ProArg: 3.276 ± 0.031
3.627ProSer: 3.627 ± 0.049
3.816ProThr: 3.816 ± 0.046
4.788ProVal: 4.788 ± 0.04
0.864ProTrp: 0.864 ± 0.02
1.249ProTyr: 1.249 ± 0.023
0.0ProXaa: 0.0 ± 0.0
Gln
4.29GlnAla: 4.29 ± 0.04
0.195GlnCys: 0.195 ± 0.009
1.571GlnAsp: 1.571 ± 0.024
1.267GlnGlu: 1.267 ± 0.023
0.861GlnPhe: 0.861 ± 0.02
2.268GlnGly: 2.268 ± 0.036
0.732GlnHis: 0.732 ± 0.017
1.482GlnIle: 1.482 ± 0.023
0.625GlnLys: 0.625 ± 0.014
3.06GlnLeu: 3.06 ± 0.031
0.6GlnMet: 0.6 ± 0.014
0.821GlnAsn: 0.821 ± 0.018
1.94GlnPro: 1.94 ± 0.031
1.468GlnGln: 1.468 ± 0.041
2.213GlnArg: 2.213 ± 0.027
1.693GlnSer: 1.693 ± 0.028
1.928GlnThr: 1.928 ± 0.033
2.591GlnVal: 2.591 ± 0.032
0.577GlnTrp: 0.577 ± 0.014
0.738GlnTyr: 0.738 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
8.565ArgAla: 8.565 ± 0.068
0.483ArgCys: 0.483 ± 0.012
3.88ArgAsp: 3.88 ± 0.039
3.928ArgGlu: 3.928 ± 0.04
2.248ArgPhe: 2.248 ± 0.031
4.915ArgGly: 4.915 ± 0.044
1.784ArgHis: 1.784 ± 0.025
3.093ArgIle: 3.093 ± 0.038
1.396ArgLys: 1.396 ± 0.023
7.555ArgLeu: 7.555 ± 0.062
1.612ArgMet: 1.612 ± 0.023
1.302ArgAsn: 1.302 ± 0.021
3.843ArgPro: 3.843 ± 0.04
2.146ArgGln: 2.146 ± 0.032
6.616ArgArg: 6.616 ± 0.067
3.763ArgSer: 3.763 ± 0.037
4.395ArgThr: 4.395 ± 0.04
5.39ArgVal: 5.39 ± 0.042
1.228ArgTrp: 1.228 ± 0.022
1.661ArgTyr: 1.661 ± 0.021
0.0ArgXaa: 0.0 ± 0.0
Ser
8.296SerAla: 8.296 ± 0.071
0.412SerCys: 0.412 ± 0.013
3.114SerAsp: 3.114 ± 0.035
2.616SerGlu: 2.616 ± 0.032
1.714SerPhe: 1.714 ± 0.024
7.02SerGly: 7.02 ± 0.064
1.09SerHis: 1.09 ± 0.018
1.843SerIle: 1.843 ± 0.024
1.156SerLys: 1.156 ± 0.022
4.923SerLeu: 4.923 ± 0.043
1.223SerMet: 1.223 ± 0.021
1.23SerAsn: 1.23 ± 0.025
3.463SerPro: 3.463 ± 0.043
1.793SerGln: 1.793 ± 0.028
3.533SerArg: 3.533 ± 0.032
4.176SerSer: 4.176 ± 0.07
3.935SerThr: 3.935 ± 0.055
4.668SerVal: 4.668 ± 0.04
1.004SerTrp: 1.004 ± 0.019
1.336SerTyr: 1.336 ± 0.025
0.0SerXaa: 0.0 ± 0.0
Thr
9.536ThrAla: 9.536 ± 0.079
0.473ThrCys: 0.473 ± 0.015
3.732ThrAsp: 3.732 ± 0.034
2.982ThrGlu: 2.982 ± 0.032
1.84ThrPhe: 1.84 ± 0.028
6.66ThrGly: 6.66 ± 0.057
1.185ThrHis: 1.185 ± 0.022
2.2ThrIle: 2.2 ± 0.029
1.28ThrLys: 1.28 ± 0.02
5.855ThrLeu: 5.855 ± 0.05
1.101ThrMet: 1.101 ± 0.018
1.396ThrAsn: 1.396 ± 0.029
4.355ThrPro: 4.355 ± 0.05
1.688ThrGln: 1.688 ± 0.03
3.54ThrArg: 3.54 ± 0.037
3.947ThrSer: 3.947 ± 0.051
4.371ThrThr: 4.371 ± 0.057
6.109ThrVal: 6.109 ± 0.056
0.987ThrTrp: 0.987 ± 0.02
1.36ThrTyr: 1.36 ± 0.025
0.0ThrXaa: 0.0 ± 0.0
Val
11.249ValAla: 11.249 ± 0.07
0.675ValCys: 0.675 ± 0.014
4.635ValAsp: 4.635 ± 0.043
4.284ValGlu: 4.284 ± 0.04
2.613ValPhe: 2.613 ± 0.029
6.897ValGly: 6.897 ± 0.053
1.712ValHis: 1.712 ± 0.025
3.023ValIle: 3.023 ± 0.032
1.747ValLys: 1.747 ± 0.025
8.901ValLeu: 8.901 ± 0.06
1.415ValMet: 1.415 ± 0.021
1.847ValAsn: 1.847 ± 0.028
4.911ValPro: 4.911 ± 0.043
2.246ValGln: 2.246 ± 0.026
5.902ValArg: 5.902 ± 0.053
4.849ValSer: 4.849 ± 0.042
5.537ValThr: 5.537 ± 0.053
7.655ValVal: 7.655 ± 0.069
1.108ValTrp: 1.108 ± 0.02
1.65ValTyr: 1.65 ± 0.023
0.0ValXaa: 0.0 ± 0.0
Trp
1.546TrpAla: 1.546 ± 0.024
0.139TrpCys: 0.139 ± 0.007
0.814TrpAsp: 0.814 ± 0.017
0.683TrpGlu: 0.683 ± 0.015
0.522TrpPhe: 0.522 ± 0.013
1.025TrpGly: 1.025 ± 0.018
0.401TrpHis: 0.401 ± 0.011
0.637TrpIle: 0.637 ± 0.016
0.331TrpLys: 0.331 ± 0.011
1.712TrpLeu: 1.712 ± 0.029
0.289TrpMet: 0.289 ± 0.011
0.494TrpAsn: 0.494 ± 0.013
0.818TrpPro: 0.818 ± 0.017
0.638TrpGln: 0.638 ± 0.014
1.263TrpArg: 1.263 ± 0.023
1.108TrpSer: 1.108 ± 0.02
1.191TrpThr: 1.191 ± 0.022
0.961TrpVal: 0.961 ± 0.021
0.337TrpTrp: 0.337 ± 0.012
0.369TrpTyr: 0.369 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.673TyrAla: 2.673 ± 0.032
0.186TyrCys: 0.186 ± 0.008
1.426TyrAsp: 1.426 ± 0.029
1.117TyrGlu: 1.117 ± 0.02
0.733TyrPhe: 0.733 ± 0.015
2.152TyrGly: 2.152 ± 0.029
0.436TyrHis: 0.436 ± 0.013
0.594TyrIle: 0.594 ± 0.015
0.413TyrLys: 0.413 ± 0.011
2.27TyrLeu: 2.27 ± 0.026
0.276TyrMet: 0.276 ± 0.01
0.552TyrAsn: 0.552 ± 0.016
1.145TyrPro: 1.145 ± 0.02
0.872TyrGln: 0.872 ± 0.018
1.676TyrArg: 1.676 ± 0.024
1.296TyrSer: 1.296 ± 0.024
1.368TyrThr: 1.368 ± 0.026
1.667TyrVal: 1.667 ± 0.027
0.384TyrTrp: 0.384 ± 0.012
0.558TyrTyr: 0.558 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8909 proteins (3085666 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski