Amino acid dipepetide frequency for Coriobacterium glomerans (strain ATCC 49209 / DSM 20642 / JCM 10262 / PW2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.145AlaAla: 14.145 ± 0.226
2.048AlaCys: 2.048 ± 0.067
6.958AlaAsp: 6.958 ± 0.115
6.191AlaGlu: 6.191 ± 0.104
3.816AlaPhe: 3.816 ± 0.086
9.309AlaGly: 9.309 ± 0.146
2.372AlaHis: 2.372 ± 0.065
6.572AlaIle: 6.572 ± 0.113
3.372AlaLys: 3.372 ± 0.097
11.939AlaLeu: 11.939 ± 0.192
2.75AlaMet: 2.75 ± 0.065
2.478AlaAsn: 2.478 ± 0.069
4.298AlaPro: 4.298 ± 0.09
3.39AlaGln: 3.39 ± 0.073
8.749AlaArg: 8.749 ± 0.16
7.322AlaSer: 7.322 ± 0.118
5.368AlaThr: 5.368 ± 0.105
7.83AlaVal: 7.83 ± 0.114
1.155AlaTrp: 1.155 ± 0.05
2.574AlaTyr: 2.574 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
2.23CysAla: 2.23 ± 0.066
0.306CysCys: 0.306 ± 0.023
1.201CysAsp: 1.201 ± 0.05
1.048CysGlu: 1.048 ± 0.042
0.492CysPhe: 0.492 ± 0.024
1.714CysGly: 1.714 ± 0.06
0.269CysHis: 0.269 ± 0.023
0.795CysIle: 0.795 ± 0.039
0.358CysLys: 0.358 ± 0.02
1.224CysLeu: 1.224 ± 0.046
0.375CysMet: 0.375 ± 0.023
0.381CysAsn: 0.381 ± 0.024
0.741CysPro: 0.741 ± 0.041
0.326CysGln: 0.326 ± 0.024
1.015CysArg: 1.015 ± 0.042
0.987CysSer: 0.987 ± 0.044
0.764CysThr: 0.764 ± 0.035
1.113CysVal: 1.113 ± 0.042
0.189CysTrp: 0.189 ± 0.016
0.433CysTyr: 0.433 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
7.84AspAla: 7.84 ± 0.122
0.727AspCys: 0.727 ± 0.036
3.819AspAsp: 3.819 ± 0.096
4.804AspGlu: 4.804 ± 0.104
2.279AspPhe: 2.279 ± 0.069
5.026AspGly: 5.026 ± 0.105
1.209AspHis: 1.209 ± 0.047
3.817AspIle: 3.817 ± 0.083
1.657AspLys: 1.657 ± 0.075
6.018AspLeu: 6.018 ± 0.11
1.618AspMet: 1.618 ± 0.049
1.308AspAsn: 1.308 ± 0.053
3.301AspPro: 3.301 ± 0.087
1.698AspGln: 1.698 ± 0.054
4.552AspArg: 4.552 ± 0.107
3.322AspSer: 3.322 ± 0.07
2.757AspThr: 2.757 ± 0.083
4.76AspVal: 4.76 ± 0.087
0.6AspTrp: 0.6 ± 0.033
1.753AspTyr: 1.753 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
5.945GluAla: 5.945 ± 0.099
0.745GluCys: 0.745 ± 0.038
3.231GluAsp: 3.231 ± 0.075
3.444GluGlu: 3.444 ± 0.093
1.911GluPhe: 1.911 ± 0.061
4.089GluGly: 4.089 ± 0.082
1.621GluHis: 1.621 ± 0.061
3.882GluIle: 3.882 ± 0.086
2.108GluLys: 2.108 ± 0.062
6.404GluLeu: 6.404 ± 0.109
1.701GluMet: 1.701 ± 0.051
1.743GluAsn: 1.743 ± 0.055
2.586GluPro: 2.586 ± 0.073
2.501GluGln: 2.501 ± 0.069
6.227GluArg: 6.227 ± 0.131
3.337GluSer: 3.337 ± 0.073
3.102GluThr: 3.102 ± 0.07
4.081GluVal: 4.081 ± 0.095
0.459GluTrp: 0.459 ± 0.029
1.206GluTyr: 1.206 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.876PheAla: 3.876 ± 0.08
0.655PheCys: 0.655 ± 0.033
2.783PheAsp: 2.783 ± 0.062
2.232PheGlu: 2.232 ± 0.066
1.486PhePhe: 1.486 ± 0.06
3.359PheGly: 3.359 ± 0.077
0.686PheHis: 0.686 ± 0.034
2.193PheIle: 2.193 ± 0.066
1.191PheLys: 1.191 ± 0.054
3.007PheLeu: 3.007 ± 0.086
0.973PheMet: 0.973 ± 0.04
1.176PheAsn: 1.176 ± 0.044
1.241PhePro: 1.241 ± 0.047
0.846PheGln: 0.846 ± 0.035
1.895PheArg: 1.895 ± 0.063
2.791PheSer: 2.791 ± 0.058
2.128PheThr: 2.128 ± 0.06
2.66PheVal: 2.66 ± 0.075
0.433PheTrp: 0.433 ± 0.029
1.012PheTyr: 1.012 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
8.635GlyAla: 8.635 ± 0.149
1.652GlyCys: 1.652 ± 0.056
4.604GlyAsp: 4.604 ± 0.089
4.555GlyGlu: 4.555 ± 0.087
3.438GlyPhe: 3.438 ± 0.08
6.388GlyGly: 6.388 ± 0.164
1.564GlyHis: 1.564 ± 0.057
5.538GlyIle: 5.538 ± 0.1
2.853GlyLys: 2.853 ± 0.082
7.155GlyLeu: 7.155 ± 0.115
2.305GlyMet: 2.305 ± 0.064
2.012GlyAsn: 2.012 ± 0.057
2.483GlyPro: 2.483 ± 0.071
2.012GlyGln: 2.012 ± 0.059
5.557GlyArg: 5.557 ± 0.097
5.782GlySer: 5.782 ± 0.084
4.673GlyThr: 4.673 ± 0.087
6.315GlyVal: 6.315 ± 0.112
0.995GlyTrp: 0.995 ± 0.042
2.572GlyTyr: 2.572 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
2.214HisAla: 2.214 ± 0.064
0.295HisCys: 0.295 ± 0.021
1.323HisAsp: 1.323 ± 0.051
1.331HisGlu: 1.331 ± 0.047
0.671HisPhe: 0.671 ± 0.038
1.821HisGly: 1.821 ± 0.056
0.437HisHis: 0.437 ± 0.024
1.064HisIle: 1.064 ± 0.041
0.43HisLys: 0.43 ± 0.025
1.935HisLeu: 1.935 ± 0.063
0.513HisMet: 0.513 ± 0.027
0.422HisAsn: 0.422 ± 0.026
1.171HisPro: 1.171 ± 0.046
0.469HisGln: 0.469 ± 0.025
1.548HisArg: 1.548 ± 0.045
0.955HisSer: 0.955 ± 0.036
0.868HisThr: 0.868 ± 0.037
1.743HisVal: 1.743 ± 0.056
0.169HisTrp: 0.169 ± 0.017
0.476HisTyr: 0.476 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
7.921IleAla: 7.921 ± 0.127
1.111IleCys: 1.111 ± 0.043
4.681IleAsp: 4.681 ± 0.086
4.534IleGlu: 4.534 ± 0.092
1.945IlePhe: 1.945 ± 0.061
5.314IleGly: 5.314 ± 0.109
0.937IleHis: 0.937 ± 0.04
3.293IleIle: 3.293 ± 0.087
1.83IleLys: 1.83 ± 0.061
4.497IleLeu: 4.497 ± 0.087
1.659IleMet: 1.659 ± 0.053
1.558IleAsn: 1.558 ± 0.051
2.656IlePro: 2.656 ± 0.073
1.401IleGln: 1.401 ± 0.048
3.449IleArg: 3.449 ± 0.087
4.308IleSer: 4.308 ± 0.076
3.104IleThr: 3.104 ± 0.081
4.922IleVal: 4.922 ± 0.098
0.626IleTrp: 0.626 ± 0.037
1.408IleTyr: 1.408 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
2.898LysAla: 2.898 ± 0.08
0.3LysCys: 0.3 ± 0.02
1.668LysAsp: 1.668 ± 0.064
1.659LysGlu: 1.659 ± 0.059
0.792LysPhe: 0.792 ± 0.04
2.3LysGly: 2.3 ± 0.06
0.572LysHis: 0.572 ± 0.03
2.067LysIle: 2.067 ± 0.061
1.802LysLys: 1.802 ± 0.084
2.898LysLeu: 2.898 ± 0.072
0.956LysMet: 0.956 ± 0.043
1.095LysAsn: 1.095 ± 0.043
1.409LysPro: 1.409 ± 0.054
1.031LysGln: 1.031 ± 0.041
2.879LysArg: 2.879 ± 0.063
2.103LysSer: 2.103 ± 0.064
2.152LysThr: 2.152 ± 0.061
2.092LysVal: 2.092 ± 0.066
0.202LysTrp: 0.202 ± 0.02
0.684LysTyr: 0.684 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
11.266LeuAla: 11.266 ± 0.159
1.419LeuCys: 1.419 ± 0.049
6.378LeuAsp: 6.378 ± 0.117
5.567LeuGlu: 5.567 ± 0.112
3.429LeuPhe: 3.429 ± 0.076
7.815LeuGly: 7.815 ± 0.135
1.616LeuHis: 1.616 ± 0.048
5.736LeuIle: 5.736 ± 0.107
2.962LeuLys: 2.962 ± 0.078
8.737LeuLeu: 8.737 ± 0.157
2.532LeuMet: 2.532 ± 0.067
2.362LeuAsn: 2.362 ± 0.065
4.086LeuPro: 4.086 ± 0.075
2.085LeuGln: 2.085 ± 0.067
6.114LeuArg: 6.114 ± 0.118
7.123LeuSer: 7.123 ± 0.129
4.84LeuThr: 4.84 ± 0.083
7.147LeuVal: 7.147 ± 0.126
0.79LeuTrp: 0.79 ± 0.038
2.134LeuTyr: 2.134 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.758MetAla: 2.758 ± 0.072
0.381MetCys: 0.381 ± 0.027
1.442MetAsp: 1.442 ± 0.054
1.248MetGlu: 1.248 ± 0.046
0.883MetPhe: 0.883 ± 0.045
2.191MetGly: 2.191 ± 0.059
0.552MetHis: 0.552 ± 0.028
1.704MetIle: 1.704 ± 0.053
0.982MetLys: 0.982 ± 0.04
2.605MetLeu: 2.605 ± 0.073
0.653MetMet: 0.653 ± 0.03
0.911MetAsn: 0.911 ± 0.04
1.292MetPro: 1.292 ± 0.045
0.753MetGln: 0.753 ± 0.035
2.318MetArg: 2.318 ± 0.061
2.023MetSer: 2.023 ± 0.061
1.383MetThr: 1.383 ± 0.049
1.789MetVal: 1.789 ± 0.06
0.241MetTrp: 0.241 ± 0.02
0.529MetTyr: 0.529 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.4AsnAla: 2.4 ± 0.066
0.314AsnCys: 0.314 ± 0.024
1.461AsnAsp: 1.461 ± 0.043
1.605AsnGlu: 1.605 ± 0.047
0.847AsnPhe: 0.847 ± 0.037
2.017AsnGly: 2.017 ± 0.059
0.472AsnHis: 0.472 ± 0.034
1.676AsnIle: 1.676 ± 0.062
0.865AsnLys: 0.865 ± 0.04
2.584AsnLeu: 2.584 ± 0.063
0.727AsnMet: 0.727 ± 0.035
0.668AsnAsn: 0.668 ± 0.035
1.621AsnPro: 1.621 ± 0.057
0.725AsnGln: 0.725 ± 0.037
1.725AsnArg: 1.725 ± 0.047
1.517AsnSer: 1.517 ± 0.051
1.338AsnThr: 1.338 ± 0.052
2.051AsnVal: 2.051 ± 0.06
0.29AsnTrp: 0.29 ± 0.025
0.684AsnTyr: 0.684 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
4.71ProAla: 4.71 ± 0.096
0.617ProCys: 0.617 ± 0.038
3.034ProAsp: 3.034 ± 0.077
2.848ProGlu: 2.848 ± 0.069
1.662ProPhe: 1.662 ± 0.051
3.337ProGly: 3.337 ± 0.076
0.938ProHis: 0.938 ± 0.045
2.388ProIle: 2.388 ± 0.072
1.355ProLys: 1.355 ± 0.053
3.817ProLeu: 3.817 ± 0.086
0.907ProMet: 0.907 ± 0.037
1.096ProAsn: 1.096 ± 0.051
1.215ProPro: 1.215 ± 0.048
1.285ProGln: 1.285 ± 0.047
2.555ProArg: 2.555 ± 0.078
2.858ProSer: 2.858 ± 0.069
2.157ProThr: 2.157 ± 0.063
3.548ProVal: 3.548 ± 0.08
0.569ProTrp: 0.569 ± 0.027
1.197ProTyr: 1.197 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
3.035GlnAla: 3.035 ± 0.07
0.241GlnCys: 0.241 ± 0.02
1.491GlnAsp: 1.491 ± 0.052
1.372GlnGlu: 1.372 ± 0.046
0.891GlnPhe: 0.891 ± 0.042
2.167GlnGly: 2.167 ± 0.064
0.526GlnHis: 0.526 ± 0.033
1.976GlnIle: 1.976 ± 0.059
0.906GlnLys: 0.906 ± 0.042
2.688GlnLeu: 2.688 ± 0.077
0.89GlnMet: 0.89 ± 0.04
0.775GlnAsn: 0.775 ± 0.036
1.116GlnPro: 1.116 ± 0.045
1.114GlnGln: 1.114 ± 0.045
2.268GlnArg: 2.268 ± 0.056
1.593GlnSer: 1.593 ± 0.052
1.712GlnThr: 1.712 ± 0.059
2.02GlnVal: 2.02 ± 0.063
0.254GlnTrp: 0.254 ± 0.021
0.564GlnTyr: 0.564 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
8.438ArgAla: 8.438 ± 0.16
1.178ArgCys: 1.178 ± 0.045
4.788ArgAsp: 4.788 ± 0.103
4.637ArgGlu: 4.637 ± 0.106
2.859ArgPhe: 2.859 ± 0.07
5.021ArgGly: 5.021 ± 0.117
1.486ArgHis: 1.486 ± 0.048
4.588ArgIle: 4.588 ± 0.097
2.041ArgLys: 2.041 ± 0.058
6.67ArgLeu: 6.67 ± 0.127
2.03ArgMet: 2.03 ± 0.059
1.621ArgAsn: 1.621 ± 0.053
2.849ArgPro: 2.849 ± 0.078
1.9ArgGln: 1.9 ± 0.059
6.326ArgArg: 6.326 ± 0.144
5.104ArgSer: 5.104 ± 0.106
3.469ArgThr: 3.469 ± 0.076
5.109ArgVal: 5.109 ± 0.105
0.782ArgTrp: 0.782 ± 0.038
2.235ArgTyr: 2.235 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
7.537SerAla: 7.537 ± 0.119
1.153SerCys: 1.153 ± 0.044
4.174SerAsp: 4.174 ± 0.084
3.817SerGlu: 3.817 ± 0.09
2.801SerPhe: 2.801 ± 0.075
5.964SerGly: 5.964 ± 0.123
1.281SerHis: 1.281 ± 0.046
4.071SerIle: 4.071 ± 0.082
2.137SerLys: 2.137 ± 0.067
5.951SerLeu: 5.951 ± 0.115
1.932SerMet: 1.932 ± 0.059
1.634SerAsn: 1.634 ± 0.052
2.423SerPro: 2.423 ± 0.066
1.8SerGln: 1.8 ± 0.056
4.451SerArg: 4.451 ± 0.101
4.767SerSer: 4.767 ± 0.111
3.307SerThr: 3.307 ± 0.067
4.933SerVal: 4.933 ± 0.097
0.862SerTrp: 0.862 ± 0.038
2.004SerTyr: 2.004 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
5.181ThrAla: 5.181 ± 0.105
0.821ThrCys: 0.821 ± 0.045
3.169ThrAsp: 3.169 ± 0.075
2.801ThrGlu: 2.801 ± 0.067
1.999ThrPhe: 1.999 ± 0.061
4.876ThrGly: 4.876 ± 0.108
1.052ThrHis: 1.052 ± 0.038
3.157ThrIle: 3.157 ± 0.081
1.574ThrLys: 1.574 ± 0.052
4.723ThrLeu: 4.723 ± 0.078
1.303ThrMet: 1.303 ± 0.042
1.232ThrAsn: 1.232 ± 0.051
2.548ThrPro: 2.548 ± 0.069
1.416ThrGln: 1.416 ± 0.045
3.301ThrArg: 3.301 ± 0.07
3.381ThrSer: 3.381 ± 0.09
2.607ThrThr: 2.607 ± 0.08
4.171ThrVal: 4.171 ± 0.091
0.598ThrTrp: 0.598 ± 0.031
1.499ThrTyr: 1.499 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
8.056ValAla: 8.056 ± 0.138
1.447ValCys: 1.447 ± 0.043
4.453ValAsp: 4.453 ± 0.085
4.506ValGlu: 4.506 ± 0.096
2.98ValPhe: 2.98 ± 0.077
5.445ValGly: 5.445 ± 0.113
1.393ValHis: 1.393 ± 0.048
4.638ValIle: 4.638 ± 0.099
2.217ValLys: 2.217 ± 0.063
7.343ValLeu: 7.343 ± 0.123
1.918ValMet: 1.918 ± 0.062
2.059ValAsn: 2.059 ± 0.06
3.488ValPro: 3.488 ± 0.073
1.649ValGln: 1.649 ± 0.054
5.35ValArg: 5.35 ± 0.114
5.595ValSer: 5.595 ± 0.095
3.77ValThr: 3.77 ± 0.092
5.653ValVal: 5.653 ± 0.12
0.686ValTrp: 0.686 ± 0.034
1.696ValTyr: 1.696 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.929TrpAla: 0.929 ± 0.039
0.199TrpCys: 0.199 ± 0.017
0.583TrpAsp: 0.583 ± 0.03
0.541TrpGlu: 0.541 ± 0.031
0.419TrpPhe: 0.419 ± 0.025
0.805TrpGly: 0.805 ± 0.041
0.228TrpHis: 0.228 ± 0.018
0.613TrpIle: 0.613 ± 0.032
0.318TrpLys: 0.318 ± 0.026
1.105TrpLeu: 1.105 ± 0.045
0.303TrpMet: 0.303 ± 0.021
0.345TrpAsn: 0.345 ± 0.024
0.373TrpPro: 0.373 ± 0.025
0.367TrpGln: 0.367 ± 0.028
0.81TrpArg: 0.81 ± 0.042
0.72TrpSer: 0.72 ± 0.039
0.56TrpThr: 0.56 ± 0.032
0.619TrpVal: 0.619 ± 0.031
0.15TrpTrp: 0.15 ± 0.018
0.314TrpTyr: 0.314 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.623TyrAla: 2.623 ± 0.068
0.352TyrCys: 0.352 ± 0.024
1.624TyrAsp: 1.624 ± 0.057
1.584TyrGlu: 1.584 ± 0.055
1.023TyrPhe: 1.023 ± 0.047
2.128TyrGly: 2.128 ± 0.062
0.645TyrHis: 0.645 ± 0.032
1.38TyrIle: 1.38 ± 0.049
0.601TyrLys: 0.601 ± 0.035
2.841TyrLeu: 2.841 ± 0.073
0.595TyrMet: 0.595 ± 0.034
0.71TyrAsn: 0.71 ± 0.041
1.197TyrPro: 1.197 ± 0.05
0.833TyrGln: 0.833 ± 0.037
2.043TyrArg: 2.043 ± 0.06
1.414TyrSer: 1.414 ± 0.049
1.349TyrThr: 1.349 ± 0.051
1.784TyrVal: 1.784 ± 0.058
0.249TyrTrp: 0.249 ± 0.023
0.718TyrTyr: 0.718 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1768 proteins (613803 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski