Amino acid dipepetide frequency for Sphingomonas sanxanigenens DSM 19645 = NX02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.654AlaAla: 21.654 ± 0.182	1.015AlaCys: 1.015 ± 0.026	8.277AlaAsp: 8.277 ± 0.071	7.71AlaGlu: 7.71 ± 0.089	4.572AlaPhe: 4.572 ± 0.05	12.736AlaGly: 12.736 ± 0.137	2.442AlaHis: 2.442 ± 0.04	7.08AlaIle: 7.08 ± 0.072	3.439AlaLys: 3.439 ± 0.049	14.762AlaLeu: 14.762 ± 0.13	3.899AlaMet: 3.899 ± 0.058	2.947AlaAsn: 2.947 ± 0.043	6.939AlaPro: 6.939 ± 0.076	4.293AlaGln: 4.293 ± 0.051	10.499AlaArg: 10.499 ± 0.098	6.246AlaSer: 6.246 ± 0.06	7.033AlaThr: 7.033 ± 0.067	9.128AlaVal: 9.128 ± 0.072	1.851AlaTrp: 1.851 ± 0.035	2.693AlaTyr: 2.693 ± 0.045	0.001AlaXaa: 0.001 ± 0.001
Cys	0.982CysAla: 0.982 ± 0.028	0.095CysCys: 0.095 ± 0.007	0.462CysAsp: 0.462 ± 0.017	0.354CysGlu: 0.354 ± 0.015	0.307CysPhe: 0.307 ± 0.014	0.856CysGly: 0.856 ± 0.022	0.226CysHis: 0.226 ± 0.015	0.315CysIle: 0.315 ± 0.013	0.146CysLys: 0.146 ± 0.009	0.663CysLeu: 0.663 ± 0.018	0.135CysMet: 0.135 ± 0.008	0.172CysAsn: 0.172 ± 0.009	0.426CysPro: 0.426 ± 0.015	0.174CysGln: 0.174 ± 0.008	0.593CysArg: 0.593 ± 0.02	0.404CysSer: 0.404 ± 0.013	0.371CysThr: 0.371 ± 0.014	0.515CysVal: 0.515 ± 0.019	0.121CysTrp: 0.121 ± 0.008	0.163CysTyr: 0.163 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.547AspAla: 8.547 ± 0.077	0.432AspCys: 0.432 ± 0.015	3.536AspAsp: 3.536 ± 0.056	3.319AspGlu: 3.319 ± 0.046	2.19AspPhe: 2.19 ± 0.033	6.253AspGly: 6.253 ± 0.068	1.382AspHis: 1.382 ± 0.029	3.005AspIle: 3.005 ± 0.052	1.353AspLys: 1.353 ± 0.03	5.825AspLeu: 5.825 ± 0.061	1.335AspMet: 1.335 ± 0.025	1.237AspAsn: 1.237 ± 0.029	3.953AspPro: 3.953 ± 0.051	1.711AspGln: 1.711 ± 0.029	5.396AspArg: 5.396 ± 0.062	2.244AspSer: 2.244 ± 0.04	2.702AspThr: 2.702 ± 0.079	4.283AspVal: 4.283 ± 0.053	1.154AspTrp: 1.154 ± 0.028	1.678AspTyr: 1.678 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.712GluAla: 7.712 ± 0.079	0.291GluCys: 0.291 ± 0.014	2.746GluAsp: 2.746 ± 0.048	2.61GluGlu: 2.61 ± 0.046	1.343GluPhe: 1.343 ± 0.027	4.425GluGly: 4.425 ± 0.059	1.099GluHis: 1.099 ± 0.026	2.876GluIle: 2.876 ± 0.04	1.662GluLys: 1.662 ± 0.031	4.612GluLeu: 4.612 ± 0.062	1.286GluMet: 1.286 ± 0.026	1.26GluAsn: 1.26 ± 0.027	2.631GluPro: 2.631 ± 0.048	1.899GluGln: 1.899 ± 0.036	5.092GluArg: 5.092 ± 0.07	2.024GluSer: 2.024 ± 0.035	3.193GluThr: 3.193 ± 0.04	3.263GluVal: 3.263 ± 0.048	0.735GluTrp: 0.735 ± 0.022	0.849GluTyr: 0.849 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	4.957PheAla: 4.957 ± 0.061	0.285PheCys: 0.285 ± 0.013	2.884PheAsp: 2.884 ± 0.048	1.999PheGlu: 1.999 ± 0.035	1.23PhePhe: 1.23 ± 0.03	3.785PheGly: 3.785 ± 0.057	0.738PheHis: 0.738 ± 0.02	1.356PheIle: 1.356 ± 0.026	0.724PheLys: 0.724 ± 0.019	2.939PheLeu: 2.939 ± 0.047	0.722PheMet: 0.722 ± 0.019	1.007PheAsn: 1.007 ± 0.024	1.455PhePro: 1.455 ± 0.035	0.871PheGln: 0.871 ± 0.022	2.303PheArg: 2.303 ± 0.037	1.916PheSer: 1.916 ± 0.033	1.972PheThr: 1.972 ± 0.03	2.668PheVal: 2.668 ± 0.042	0.505PheTrp: 0.505 ± 0.019	0.904PheTyr: 0.904 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	11.049GlyAla: 11.049 ± 0.107	0.813GlyCys: 0.813 ± 0.023	5.298GlyAsp: 5.298 ± 0.098	4.734GlyGlu: 4.734 ± 0.056	3.748GlyPhe: 3.748 ± 0.048	8.877GlyGly: 8.877 ± 0.191	1.871GlyHis: 1.871 ± 0.038	4.641GlyIle: 4.641 ± 0.054	2.851GlyLys: 2.851 ± 0.043	8.641GlyLeu: 8.641 ± 0.069	2.286GlyMet: 2.286 ± 0.04	2.352GlyAsn: 2.352 ± 0.073	3.659GlyPro: 3.659 ± 0.04	2.814GlyGln: 2.814 ± 0.04	7.12GlyArg: 7.12 ± 0.065	4.968GlySer: 4.968 ± 0.086	5.124GlyThr: 5.124 ± 0.091	6.398GlyVal: 6.398 ± 0.068	1.785GlyTrp: 1.785 ± 0.035	2.455GlyTyr: 2.455 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.516HisAla: 2.516 ± 0.038	0.204HisCys: 0.204 ± 0.012	1.274HisAsp: 1.274 ± 0.029	0.963HisGlu: 0.963 ± 0.024	0.789HisPhe: 0.789 ± 0.021	2.032HisGly: 2.032 ± 0.035	0.577HisHis: 0.577 ± 0.019	0.928HisIle: 0.928 ± 0.024	0.39HisLys: 0.39 ± 0.016	1.892HisLeu: 1.892 ± 0.033	0.463HisMet: 0.463 ± 0.017	0.426HisAsn: 0.426 ± 0.015	1.336HisPro: 1.336 ± 0.032	0.531HisGln: 0.531 ± 0.016	1.608HisArg: 1.608 ± 0.033	0.852HisSer: 0.852 ± 0.02	0.611HisThr: 0.611 ± 0.018	1.522HisVal: 1.522 ± 0.031	0.346HisTrp: 0.346 ± 0.014	0.569HisTyr: 0.569 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	8.244IleAla: 8.244 ± 0.072	0.391IleCys: 0.391 ± 0.014	4.228IleAsp: 4.228 ± 0.062	3.479IleGlu: 3.479 ± 0.052	1.534IlePhe: 1.534 ± 0.032	5.318IleGly: 5.318 ± 0.057	0.891IleHis: 0.891 ± 0.022	1.933IleIle: 1.933 ± 0.037	1.03IleLys: 1.03 ± 0.025	3.908IleLeu: 3.908 ± 0.052	0.803IleMet: 0.803 ± 0.023	1.217IleAsn: 1.217 ± 0.033	2.119IlePro: 2.119 ± 0.031	1.104IleGln: 1.104 ± 0.025	3.392IleArg: 3.392 ± 0.047	2.424IleSer: 2.424 ± 0.04	2.426IleThr: 2.426 ± 0.045	4.302IleVal: 4.302 ± 0.045	0.582IleTrp: 0.582 ± 0.019	1.003IleTyr: 1.003 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.602LysAla: 3.602 ± 0.057	0.109LysCys: 0.109 ± 0.008	1.313LysAsp: 1.313 ± 0.03	1.001LysGlu: 1.001 ± 0.025	0.669LysPhe: 0.669 ± 0.019	2.222LysGly: 2.222 ± 0.038	0.478LysHis: 0.478 ± 0.016	1.189LysIle: 1.189 ± 0.03	0.781LysLys: 0.781 ± 0.024	2.758LysLeu: 2.758 ± 0.05	0.604LysMet: 0.604 ± 0.02	0.529LysAsn: 0.529 ± 0.018	1.84LysPro: 1.84 ± 0.035	0.768LysGln: 0.768 ± 0.023	2.093LysArg: 2.093 ± 0.038	1.303LysSer: 1.303 ± 0.029	1.477LysThr: 1.477 ± 0.029	1.858LysVal: 1.858 ± 0.038	0.313LysTrp: 0.313 ± 0.011	0.462LysTyr: 0.462 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.302LeuAla: 14.302 ± 0.12	0.824LeuCys: 0.824 ± 0.022	6.409LeuAsp: 6.409 ± 0.071	4.451LeuGlu: 4.451 ± 0.053	3.683LeuPhe: 3.683 ± 0.048	8.315LeuGly: 8.315 ± 0.078	1.824LeuHis: 1.824 ± 0.037	4.938LeuIle: 4.938 ± 0.06	2.687LeuLys: 2.687 ± 0.04	9.548LeuLeu: 9.548 ± 0.115	2.076LeuMet: 2.076 ± 0.04	2.266LeuAsn: 2.266 ± 0.036	5.764LeuPro: 5.764 ± 0.068	2.489LeuGln: 2.489 ± 0.038	6.987LeuArg: 6.987 ± 0.072	5.695LeuSer: 5.695 ± 0.063	5.556LeuThr: 5.556 ± 0.069	7.255LeuVal: 7.255 ± 0.073	1.242LeuTrp: 1.242 ± 0.028	1.958LeuTyr: 1.958 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	3.191MetAla: 3.191 ± 0.047	0.143MetCys: 0.143 ± 0.008	1.048MetAsp: 1.048 ± 0.027	0.939MetGlu: 0.939 ± 0.022	0.69MetPhe: 0.69 ± 0.022	1.723MetGly: 1.723 ± 0.031	0.403MetHis: 0.403 ± 0.016	1.331MetIle: 1.331 ± 0.026	0.816MetLys: 0.816 ± 0.021	2.696MetLeu: 2.696 ± 0.044	0.671MetMet: 0.671 ± 0.019	0.608MetAsn: 0.608 ± 0.019	1.507MetPro: 1.507 ± 0.026	0.653MetGln: 0.653 ± 0.018	1.887MetArg: 1.887 ± 0.033	1.317MetSer: 1.317 ± 0.028	1.696MetThr: 1.696 ± 0.03	1.564MetVal: 1.564 ± 0.027	0.212MetTrp: 0.212 ± 0.011	0.246MetTyr: 0.246 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.147AsnAla: 3.147 ± 0.044	0.206AsnCys: 0.206 ± 0.011	1.515AsnAsp: 1.515 ± 0.054	1.006AsnGlu: 1.006 ± 0.023	0.814AsnPhe: 0.814 ± 0.024	2.386AsnGly: 2.386 ± 0.05	0.441AsnHis: 0.441 ± 0.016	1.262AsnIle: 1.262 ± 0.027	0.49AsnLys: 0.49 ± 0.018	2.313AsnLeu: 2.313 ± 0.043	0.498AsnMet: 0.498 ± 0.016	0.637AsnAsn: 0.637 ± 0.021	1.699AsnPro: 1.699 ± 0.03	0.719AsnGln: 0.719 ± 0.021	1.804AsnArg: 1.804 ± 0.033	1.105AsnSer: 1.105 ± 0.028	1.063AsnThr: 1.063 ± 0.032	1.726AsnVal: 1.726 ± 0.037	0.417AsnTrp: 0.417 ± 0.015	0.677AsnTyr: 0.677 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.953ProAla: 7.953 ± 0.083	0.326ProCys: 0.326 ± 0.013	3.815ProAsp: 3.815 ± 0.051	3.446ProGlu: 3.446 ± 0.048	1.966ProPhe: 1.966 ± 0.035	5.079ProGly: 5.079 ± 0.048	1.019ProHis: 1.019 ± 0.026	2.529ProIle: 2.529 ± 0.04	1.329ProLys: 1.329 ± 0.03	4.986ProLeu: 4.986 ± 0.061	1.204ProMet: 1.204 ± 0.026	1.221ProAsn: 1.221 ± 0.028	3.039ProPro: 3.039 ± 0.064	1.609ProGln: 1.609 ± 0.03	3.432ProArg: 3.432 ± 0.05	2.591ProSer: 2.591 ± 0.038	2.653ProThr: 2.653 ± 0.042	4.236ProVal: 4.236 ± 0.053	0.725ProTrp: 0.725 ± 0.02	1.071ProTyr: 1.071 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.069GlnAla: 4.069 ± 0.048	0.2GlnCys: 0.2 ± 0.01	1.379GlnAsp: 1.379 ± 0.027	1.136GlnGlu: 1.136 ± 0.028	1.042GlnPhe: 1.042 ± 0.022	2.385GlnGly: 2.385 ± 0.033	0.573GlnHis: 0.573 ± 0.018	1.646GlnIle: 1.646 ± 0.031	0.715GlnLys: 0.715 ± 0.018	2.854GlnLeu: 2.854 ± 0.041	0.732GlnMet: 0.732 ± 0.02	0.724GlnAsn: 0.724 ± 0.024	1.915GlnPro: 1.915 ± 0.03	1.097GlnGln: 1.097 ± 0.033	2.647GlnArg: 2.647 ± 0.04	1.556GlnSer: 1.556 ± 0.031	1.549GlnThr: 1.549 ± 0.033	2.061GlnVal: 2.061 ± 0.031	0.417GlnTrp: 0.417 ± 0.015	0.567GlnTyr: 0.567 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.729ArgAla: 9.729 ± 0.096	0.565ArgCys: 0.565 ± 0.02	4.563ArgAsp: 4.563 ± 0.05	3.797ArgGlu: 3.797 ± 0.056	3.412ArgPhe: 3.412 ± 0.049	5.577ArgGly: 5.577 ± 0.062	1.806ArgHis: 1.806 ± 0.032	4.503ArgIle: 4.503 ± 0.049	1.956ArgLys: 1.956 ± 0.039	8.655ArgLeu: 8.655 ± 0.091	2.017ArgMet: 2.017 ± 0.032	1.89ArgAsn: 1.89 ± 0.032	3.974ArgPro: 3.974 ± 0.059	2.55ArgGln: 2.55 ± 0.038	6.777ArgArg: 6.777 ± 0.079	3.859ArgSer: 3.859 ± 0.05	3.902ArgThr: 3.902 ± 0.046	5.018ArgVal: 5.018 ± 0.055	1.377ArgTrp: 1.377 ± 0.029	2.022ArgTyr: 2.022 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.338SerAla: 6.338 ± 0.067	0.397SerCys: 0.397 ± 0.016	2.881SerAsp: 2.881 ± 0.04	2.261SerGlu: 2.261 ± 0.037	2.162SerPhe: 2.162 ± 0.035	5.303SerGly: 5.303 ± 0.067	0.942SerHis: 0.942 ± 0.024	2.667SerIle: 2.667 ± 0.051	1.168SerLys: 1.168 ± 0.024	4.859SerLeu: 4.859 ± 0.057	1.093SerMet: 1.093 ± 0.023	1.263SerAsn: 1.263 ± 0.033	2.703SerPro: 2.703 ± 0.039	1.345SerGln: 1.345 ± 0.03	3.639SerArg: 3.639 ± 0.052	2.477SerSer: 2.477 ± 0.048	2.528SerThr: 2.528 ± 0.045	3.593SerVal: 3.593 ± 0.052	0.717SerTrp: 0.717 ± 0.019	1.383SerTyr: 1.383 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.807ThrAla: 6.807 ± 0.077	0.349ThrCys: 0.349 ± 0.014	3.029ThrAsp: 3.029 ± 0.047	2.343ThrGlu: 2.343 ± 0.038	1.658ThrPhe: 1.658 ± 0.035	5.469ThrGly: 5.469 ± 0.096	0.929ThrHis: 0.929 ± 0.02	3.098ThrIle: 3.098 ± 0.049	1.117ThrLys: 1.117 ± 0.028	5.953ThrLeu: 5.953 ± 0.081	1.234ThrMet: 1.234 ± 0.027	1.214ThrAsn: 1.214 ± 0.03	3.476ThrPro: 3.476 ± 0.051	1.352ThrGln: 1.352 ± 0.026	3.642ThrArg: 3.642 ± 0.051	2.572ThrSer: 2.572 ± 0.048	2.813ThrThr: 2.813 ± 0.069	4.225ThrVal: 4.225 ± 0.054	0.662ThrTrp: 0.662 ± 0.018	1.21ThrTyr: 1.21 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	10.082ValAla: 10.082 ± 0.089	0.509ValCys: 0.509 ± 0.016	4.52ValAsp: 4.52 ± 0.052	4.316ValGlu: 4.316 ± 0.058	2.027ValPhe: 2.027 ± 0.04	5.709ValGly: 5.709 ± 0.069	1.335ValHis: 1.335 ± 0.024	3.499ValIle: 3.499 ± 0.044	1.826ValLys: 1.826 ± 0.038	6.539ValLeu: 6.539 ± 0.068	1.537ValMet: 1.537 ± 0.031	1.932ValAsn: 1.932 ± 0.036	4.014ValPro: 4.014 ± 0.045	2.001ValGln: 2.001 ± 0.032	5.393ValArg: 5.393 ± 0.062	4.075ValSer: 4.075 ± 0.051	4.562ValThr: 4.562 ± 0.074	5.246ValVal: 5.246 ± 0.065	0.816ValTrp: 0.816 ± 0.022	1.354ValTyr: 1.354 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.483TrpAla: 1.483 ± 0.029	0.112TrpCys: 0.112 ± 0.008	0.737TrpAsp: 0.737 ± 0.021	0.625TrpGlu: 0.625 ± 0.019	0.557TrpPhe: 0.557 ± 0.02	0.97TrpGly: 0.97 ± 0.022	0.387TrpHis: 0.387 ± 0.014	0.722TrpIle: 0.722 ± 0.02	0.399TrpLys: 0.399 ± 0.016	1.794TrpLeu: 1.794 ± 0.033	0.331TrpMet: 0.331 ± 0.013	0.428TrpAsn: 0.428 ± 0.016	0.743TrpPro: 0.743 ± 0.022	0.6TrpGln: 0.6 ± 0.017	1.492TrpArg: 1.492 ± 0.029	0.925TrpSer: 0.925 ± 0.02	0.893TrpThr: 0.893 ± 0.02	0.807TrpVal: 0.807 ± 0.021	0.268TrpTrp: 0.268 ± 0.012	0.315TrpTyr: 0.315 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.852TyrAla: 2.852 ± 0.041	0.215TyrCys: 0.215 ± 0.012	1.622TyrAsp: 1.622 ± 0.053	1.121TyrGlu: 1.121 ± 0.023	0.829TyrPhe: 0.829 ± 0.022	2.063TyrGly: 2.063 ± 0.041	0.467TyrHis: 0.467 ± 0.014	0.813TyrIle: 0.813 ± 0.023	0.489TyrLys: 0.489 ± 0.016	2.073TyrLeu: 2.073 ± 0.036	0.413TyrMet: 0.413 ± 0.016	0.594TyrAsn: 0.594 ± 0.021	1.037TyrPro: 1.037 ± 0.027	0.681TyrGln: 0.681 ± 0.021	2.153TyrArg: 2.153 ± 0.036	1.167TyrSer: 1.167 ± 0.027	1.028TyrThr: 1.028 ± 0.032	1.622TyrVal: 1.622 ± 0.038	0.343TyrTrp: 0.343 ± 0.013	0.621TyrTyr: 0.621 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6101 proteins (1922014 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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