Amino acid dipepetide frequency for Vibrio phage phiV039C

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.586AlaAla: 5.586 ± 1.139
1.117AlaCys: 1.117 ± 0.356
5.251AlaAsp: 5.251 ± 0.903
6.368AlaGlu: 6.368 ± 1.236
2.793AlaPhe: 2.793 ± 0.722
4.469AlaGly: 4.469 ± 0.726
0.782AlaHis: 0.782 ± 0.268
5.251AlaIle: 5.251 ± 0.89
5.921AlaLys: 5.921 ± 0.826
6.033AlaLeu: 6.033 ± 1.005
2.793AlaMet: 2.793 ± 0.495
3.24AlaAsn: 3.24 ± 0.615
1.676AlaPro: 1.676 ± 0.359
1.899AlaGln: 1.899 ± 0.347
4.245AlaArg: 4.245 ± 0.796
5.809AlaSer: 5.809 ± 0.74
5.698AlaThr: 5.698 ± 1.087
5.139AlaVal: 5.139 ± 0.631
1.117AlaTrp: 1.117 ± 0.358
2.458AlaTyr: 2.458 ± 0.642
0.0AlaXaa: 0.0 ± 0.0
Cys
0.447CysAla: 0.447 ± 0.178
0.112CysCys: 0.112 ± 0.095
0.67CysAsp: 0.67 ± 0.26
1.229CysGlu: 1.229 ± 0.396
0.67CysPhe: 0.67 ± 0.278
0.67CysGly: 0.67 ± 0.276
0.559CysHis: 0.559 ± 0.312
1.229CysIle: 1.229 ± 0.398
0.335CysLys: 0.335 ± 0.173
0.67CysLeu: 0.67 ± 0.333
0.223CysMet: 0.223 ± 0.138
0.335CysAsn: 0.335 ± 0.182
0.447CysPro: 0.447 ± 0.192
0.112CysGln: 0.112 ± 0.113
0.447CysArg: 0.447 ± 0.243
1.229CysSer: 1.229 ± 0.36
0.335CysThr: 0.335 ± 0.192
0.894CysVal: 0.894 ± 0.352
0.223CysTrp: 0.223 ± 0.158
0.335CysTyr: 0.335 ± 0.208
0.0CysXaa: 0.0 ± 0.0
Asp
6.256AspAla: 6.256 ± 0.937
0.894AspCys: 0.894 ± 0.311
3.798AspAsp: 3.798 ± 0.765
4.469AspGlu: 4.469 ± 0.609
2.681AspPhe: 2.681 ± 0.653
5.139AspGly: 5.139 ± 0.742
1.117AspHis: 1.117 ± 0.322
3.91AspIle: 3.91 ± 0.658
2.905AspLys: 2.905 ± 0.656
4.692AspLeu: 4.692 ± 0.658
2.123AspMet: 2.123 ± 0.571
3.24AspAsn: 3.24 ± 0.496
2.011AspPro: 2.011 ± 0.568
2.905AspGln: 2.905 ± 0.568
2.123AspArg: 2.123 ± 0.547
5.698AspSer: 5.698 ± 0.686
3.352AspThr: 3.352 ± 0.599
3.798AspVal: 3.798 ± 0.619
1.341AspTrp: 1.341 ± 0.411
2.458AspTyr: 2.458 ± 0.601
0.0AspXaa: 0.0 ± 0.0
Glu
4.134GluAla: 4.134 ± 0.981
0.67GluCys: 0.67 ± 0.274
3.128GluAsp: 3.128 ± 0.595
6.256GluGlu: 6.256 ± 2.225
3.016GluPhe: 3.016 ± 0.542
3.24GluGly: 3.24 ± 0.469
1.452GluHis: 1.452 ± 0.335
5.809GluIle: 5.809 ± 0.644
5.586GluLys: 5.586 ± 1.123
7.038GluLeu: 7.038 ± 1.073
2.123GluMet: 2.123 ± 0.494
2.793GluAsn: 2.793 ± 0.554
1.899GluPro: 1.899 ± 0.426
3.575GluGln: 3.575 ± 0.711
4.245GluArg: 4.245 ± 1.092
5.027GluSer: 5.027 ± 0.623
3.016GluThr: 3.016 ± 0.468
5.027GluVal: 5.027 ± 1.043
1.341GluTrp: 1.341 ± 0.358
2.57GluTyr: 2.57 ± 0.557
0.0GluXaa: 0.0 ± 0.0
Phe
2.905PheAla: 2.905 ± 0.626
0.112PheCys: 0.112 ± 0.113
3.798PheAsp: 3.798 ± 0.564
3.575PheGlu: 3.575 ± 0.656
1.341PhePhe: 1.341 ± 0.303
3.687PheGly: 3.687 ± 0.763
0.335PheHis: 0.335 ± 0.187
2.123PheIle: 2.123 ± 0.49
1.452PheLys: 1.452 ± 0.349
2.234PheLeu: 2.234 ± 0.499
0.782PheMet: 0.782 ± 0.288
3.463PheAsn: 3.463 ± 0.644
1.676PhePro: 1.676 ± 0.428
0.67PheGln: 0.67 ± 0.282
1.229PheArg: 1.229 ± 0.368
3.128PheSer: 3.128 ± 0.708
3.128PheThr: 3.128 ± 0.402
1.788PheVal: 1.788 ± 0.294
0.335PheTrp: 0.335 ± 0.17
1.676PheTyr: 1.676 ± 0.381
0.0PheXaa: 0.0 ± 0.0
Gly
4.692GlyAla: 4.692 ± 0.855
1.229GlyCys: 1.229 ± 0.351
4.692GlyAsp: 4.692 ± 0.688
4.469GlyGlu: 4.469 ± 0.729
3.463GlyPhe: 3.463 ± 0.487
6.368GlyGly: 6.368 ± 0.972
1.117GlyHis: 1.117 ± 0.335
3.91GlyIle: 3.91 ± 0.645
4.804GlyLys: 4.804 ± 0.637
4.692GlyLeu: 4.692 ± 0.622
2.234GlyMet: 2.234 ± 0.494
4.022GlyAsn: 4.022 ± 0.731
1.229GlyPro: 1.229 ± 0.451
3.016GlyGln: 3.016 ± 0.606
2.905GlyArg: 2.905 ± 0.644
4.357GlySer: 4.357 ± 0.771
4.469GlyThr: 4.469 ± 0.782
5.363GlyVal: 5.363 ± 1.163
1.005GlyTrp: 1.005 ± 0.265
3.463GlyTyr: 3.463 ± 0.603
0.0GlyXaa: 0.0 ± 0.0
His
0.559HisAla: 0.559 ± 0.249
0.447HisCys: 0.447 ± 0.221
1.564HisAsp: 1.564 ± 0.441
1.229HisGlu: 1.229 ± 0.365
0.559HisPhe: 0.559 ± 0.269
1.229HisGly: 1.229 ± 0.337
0.0HisHis: 0.0 ± 0.0
0.894HisIle: 0.894 ± 0.261
1.341HisLys: 1.341 ± 0.382
1.676HisLeu: 1.676 ± 0.32
0.223HisMet: 0.223 ± 0.143
0.782HisAsn: 0.782 ± 0.259
0.67HisPro: 0.67 ± 0.256
0.782HisGln: 0.782 ± 0.219
0.894HisArg: 0.894 ± 0.284
1.005HisSer: 1.005 ± 0.328
0.559HisThr: 0.559 ± 0.276
0.894HisVal: 0.894 ± 0.271
0.223HisTrp: 0.223 ± 0.138
0.447HisTyr: 0.447 ± 0.216
0.0HisXaa: 0.0 ± 0.0
Ile
5.586IleAla: 5.586 ± 0.833
0.67IleCys: 0.67 ± 0.287
5.027IleAsp: 5.027 ± 0.771
6.145IleGlu: 6.145 ± 0.816
1.117IlePhe: 1.117 ± 0.304
4.692IleGly: 4.692 ± 0.501
0.335IleHis: 0.335 ± 0.18
2.793IleIle: 2.793 ± 0.517
5.474IleLys: 5.474 ± 0.805
3.463IleLeu: 3.463 ± 0.669
1.899IleMet: 1.899 ± 0.453
4.357IleAsn: 4.357 ± 0.658
2.234IlePro: 2.234 ± 0.624
2.681IleGln: 2.681 ± 0.637
2.57IleArg: 2.57 ± 0.426
3.575IleSer: 3.575 ± 0.617
3.352IleThr: 3.352 ± 0.663
2.458IleVal: 2.458 ± 0.615
0.335IleTrp: 0.335 ± 0.18
2.458IleTyr: 2.458 ± 0.581
0.0IleXaa: 0.0 ± 0.0
Lys
5.698LysAla: 5.698 ± 1.1
0.782LysCys: 0.782 ± 0.271
3.687LysAsp: 3.687 ± 0.611
5.809LysGlu: 5.809 ± 1.059
3.128LysPhe: 3.128 ± 0.564
4.469LysGly: 4.469 ± 0.644
1.005LysHis: 1.005 ± 0.335
4.58LysIle: 4.58 ± 0.963
4.022LysLys: 4.022 ± 0.732
5.139LysLeu: 5.139 ± 0.782
1.452LysMet: 1.452 ± 0.383
2.681LysAsn: 2.681 ± 0.425
2.234LysPro: 2.234 ± 0.566
2.234LysGln: 2.234 ± 0.469
3.352LysArg: 3.352 ± 0.757
4.245LysSer: 4.245 ± 0.574
4.022LysThr: 4.022 ± 0.626
4.692LysVal: 4.692 ± 0.686
0.782LysTrp: 0.782 ± 0.313
1.899LysTyr: 1.899 ± 0.383
0.0LysXaa: 0.0 ± 0.0
Leu
6.927LeuAla: 6.927 ± 1.002
1.229LeuCys: 1.229 ± 0.386
5.698LeuAsp: 5.698 ± 0.836
3.91LeuGlu: 3.91 ± 0.775
3.128LeuPhe: 3.128 ± 0.569
3.91LeuGly: 3.91 ± 0.685
1.676LeuHis: 1.676 ± 0.427
4.804LeuIle: 4.804 ± 0.61
5.474LeuLys: 5.474 ± 0.849
4.245LeuLeu: 4.245 ± 0.875
1.452LeuMet: 1.452 ± 0.428
4.022LeuAsn: 4.022 ± 0.806
3.352LeuPro: 3.352 ± 0.491
2.57LeuGln: 2.57 ± 0.579
3.463LeuArg: 3.463 ± 0.653
6.703LeuSer: 6.703 ± 0.987
5.027LeuThr: 5.027 ± 0.779
3.798LeuVal: 3.798 ± 0.521
0.67LeuTrp: 0.67 ± 0.299
1.676LeuTyr: 1.676 ± 0.523
0.0LeuXaa: 0.0 ± 0.0
Met
2.681MetAla: 2.681 ± 0.415
0.223MetCys: 0.223 ± 0.137
2.681MetAsp: 2.681 ± 0.506
0.782MetGlu: 0.782 ± 0.282
1.005MetPhe: 1.005 ± 0.283
2.234MetGly: 2.234 ± 0.54
0.112MetHis: 0.112 ± 0.114
1.564MetIle: 1.564 ± 0.382
1.229MetLys: 1.229 ± 0.337
1.676MetLeu: 1.676 ± 0.396
1.005MetMet: 1.005 ± 0.266
1.341MetAsn: 1.341 ± 0.398
0.559MetPro: 0.559 ± 0.246
0.782MetGln: 0.782 ± 0.311
1.676MetArg: 1.676 ± 0.426
3.016MetSer: 3.016 ± 0.413
2.011MetThr: 2.011 ± 0.518
1.452MetVal: 1.452 ± 0.384
0.223MetTrp: 0.223 ± 0.135
0.335MetTyr: 0.335 ± 0.171
0.0MetXaa: 0.0 ± 0.0
Asn
3.687AsnAla: 3.687 ± 0.81
0.559AsnCys: 0.559 ± 0.261
3.016AsnAsp: 3.016 ± 0.531
4.134AsnGlu: 4.134 ± 0.648
2.57AsnPhe: 2.57 ± 0.7
5.698AsnGly: 5.698 ± 0.71
0.894AsnHis: 0.894 ± 0.263
3.463AsnIle: 3.463 ± 0.453
3.128AsnLys: 3.128 ± 0.585
5.363AsnLeu: 5.363 ± 0.724
1.341AsnMet: 1.341 ± 0.355
2.011AsnAsn: 2.011 ± 0.516
3.24AsnPro: 3.24 ± 0.609
2.458AsnGln: 2.458 ± 0.59
2.346AsnArg: 2.346 ± 0.533
3.24AsnSer: 3.24 ± 0.82
2.234AsnThr: 2.234 ± 0.559
2.905AsnVal: 2.905 ± 0.719
0.447AsnTrp: 0.447 ± 0.192
2.234AsnTyr: 2.234 ± 0.391
0.0AsnXaa: 0.0 ± 0.0
Pro
2.458ProAla: 2.458 ± 0.58
0.559ProCys: 0.559 ± 0.249
3.016ProAsp: 3.016 ± 0.627
2.793ProGlu: 2.793 ± 0.549
1.452ProPhe: 1.452 ± 0.354
1.788ProGly: 1.788 ± 0.55
0.335ProHis: 0.335 ± 0.227
2.011ProIle: 2.011 ± 0.416
2.011ProLys: 2.011 ± 0.492
2.793ProLeu: 2.793 ± 0.51
0.559ProMet: 0.559 ± 0.229
3.016ProAsn: 3.016 ± 0.489
1.564ProPro: 1.564 ± 0.348
1.452ProGln: 1.452 ± 0.587
1.452ProArg: 1.452 ± 0.357
2.905ProSer: 2.905 ± 0.602
1.788ProThr: 1.788 ± 0.509
3.128ProVal: 3.128 ± 0.65
0.782ProTrp: 0.782 ± 0.264
0.782ProTyr: 0.782 ± 0.235
0.0ProXaa: 0.0 ± 0.0
Gln
2.793GlnAla: 2.793 ± 0.51
0.335GlnCys: 0.335 ± 0.17
1.341GlnAsp: 1.341 ± 0.27
2.905GlnGlu: 2.905 ± 0.599
1.117GlnPhe: 1.117 ± 0.342
2.793GlnGly: 2.793 ± 0.683
0.67GlnHis: 0.67 ± 0.222
2.57GlnIle: 2.57 ± 0.446
2.57GlnLys: 2.57 ± 0.562
3.798GlnLeu: 3.798 ± 0.718
1.005GlnMet: 1.005 ± 0.327
1.564GlnAsn: 1.564 ± 0.349
2.011GlnPro: 2.011 ± 0.573
2.793GlnGln: 2.793 ± 0.868
1.899GlnArg: 1.899 ± 0.746
2.681GlnSer: 2.681 ± 0.532
2.123GlnThr: 2.123 ± 0.44
3.687GlnVal: 3.687 ± 0.699
1.341GlnTrp: 1.341 ± 0.304
1.452GlnTyr: 1.452 ± 0.436
0.0GlnXaa: 0.0 ± 0.0
Arg
2.458ArgAla: 2.458 ± 0.578
0.335ArgCys: 0.335 ± 0.201
3.575ArgAsp: 3.575 ± 0.756
2.57ArgGlu: 2.57 ± 0.754
1.452ArgPhe: 1.452 ± 0.503
2.57ArgGly: 2.57 ± 0.493
1.005ArgHis: 1.005 ± 0.294
2.123ArgIle: 2.123 ± 0.5
4.58ArgLys: 4.58 ± 1.133
3.128ArgLeu: 3.128 ± 0.464
1.117ArgMet: 1.117 ± 0.325
2.681ArgAsn: 2.681 ± 0.672
2.011ArgPro: 2.011 ± 0.413
2.905ArgGln: 2.905 ± 0.833
2.458ArgArg: 2.458 ± 0.582
2.458ArgSer: 2.458 ± 0.446
2.681ArgThr: 2.681 ± 0.502
2.458ArgVal: 2.458 ± 0.566
0.67ArgTrp: 0.67 ± 0.21
1.341ArgTyr: 1.341 ± 0.319
0.0ArgXaa: 0.0 ± 0.0
Ser
5.474SerAla: 5.474 ± 0.883
0.782SerCys: 0.782 ± 0.234
4.357SerAsp: 4.357 ± 0.618
4.469SerGlu: 4.469 ± 0.773
3.24SerPhe: 3.24 ± 0.522
6.591SerGly: 6.591 ± 1.017
1.452SerHis: 1.452 ± 0.498
4.469SerIle: 4.469 ± 0.655
5.139SerLys: 5.139 ± 0.718
4.469SerLeu: 4.469 ± 0.966
1.899SerMet: 1.899 ± 0.473
5.586SerAsn: 5.586 ± 0.758
1.899SerPro: 1.899 ± 0.394
2.793SerGln: 2.793 ± 0.495
2.57SerArg: 2.57 ± 0.724
5.027SerSer: 5.027 ± 0.784
4.357SerThr: 4.357 ± 0.727
6.145SerVal: 6.145 ± 0.69
0.447SerTrp: 0.447 ± 0.213
1.676SerTyr: 1.676 ± 0.438
0.0SerXaa: 0.0 ± 0.0
Thr
4.804ThrAla: 4.804 ± 1.128
0.223ThrCys: 0.223 ± 0.162
2.57ThrAsp: 2.57 ± 0.608
3.687ThrGlu: 3.687 ± 0.556
1.788ThrPhe: 1.788 ± 0.357
4.58ThrGly: 4.58 ± 0.801
0.67ThrHis: 0.67 ± 0.253
3.352ThrIle: 3.352 ± 0.651
3.352ThrLys: 3.352 ± 0.52
4.916ThrLeu: 4.916 ± 0.99
1.229ThrMet: 1.229 ± 0.335
3.687ThrAsn: 3.687 ± 0.647
4.134ThrPro: 4.134 ± 0.604
2.905ThrGln: 2.905 ± 0.486
2.234ThrArg: 2.234 ± 0.501
3.687ThrSer: 3.687 ± 0.747
3.687ThrThr: 3.687 ± 0.786
3.91ThrVal: 3.91 ± 0.852
0.894ThrTrp: 0.894 ± 0.309
2.011ThrTyr: 2.011 ± 0.512
0.0ThrXaa: 0.0 ± 0.0
Val
7.038ValAla: 7.038 ± 0.827
0.447ValCys: 0.447 ± 0.218
4.692ValAsp: 4.692 ± 0.704
3.463ValGlu: 3.463 ± 0.63
2.57ValPhe: 2.57 ± 0.346
4.357ValGly: 4.357 ± 0.653
1.005ValHis: 1.005 ± 0.341
3.798ValIle: 3.798 ± 0.98
4.134ValLys: 4.134 ± 0.853
3.352ValLeu: 3.352 ± 0.618
1.005ValMet: 1.005 ± 0.363
3.128ValAsn: 3.128 ± 0.508
2.234ValPro: 2.234 ± 0.624
3.016ValGln: 3.016 ± 0.769
2.346ValArg: 2.346 ± 0.586
6.033ValSer: 6.033 ± 1.131
4.134ValThr: 4.134 ± 0.896
2.793ValVal: 2.793 ± 0.666
0.894ValTrp: 0.894 ± 0.275
2.681ValTyr: 2.681 ± 0.419
0.0ValXaa: 0.0 ± 0.0
Trp
0.782TrpAla: 0.782 ± 0.272
0.112TrpCys: 0.112 ± 0.095
0.335TrpAsp: 0.335 ± 0.178
1.005TrpGlu: 1.005 ± 0.456
1.005TrpPhe: 1.005 ± 0.315
0.335TrpGly: 0.335 ± 0.173
0.447TrpHis: 0.447 ± 0.232
1.005TrpIle: 1.005 ± 0.261
1.229TrpLys: 1.229 ± 0.36
1.676TrpLeu: 1.676 ± 0.345
0.447TrpMet: 0.447 ± 0.21
0.894TrpAsn: 0.894 ± 0.222
0.223TrpPro: 0.223 ± 0.141
0.67TrpGln: 0.67 ± 0.243
0.335TrpArg: 0.335 ± 0.19
1.005TrpSer: 1.005 ± 0.269
0.335TrpThr: 0.335 ± 0.17
0.67TrpVal: 0.67 ± 0.248
0.447TrpTrp: 0.447 ± 0.177
1.117TrpTyr: 1.117 ± 0.318
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.681TyrAla: 2.681 ± 0.537
0.335TyrCys: 0.335 ± 0.181
2.011TyrAsp: 2.011 ± 0.417
2.681TyrGlu: 2.681 ± 0.451
1.341TyrPhe: 1.341 ± 0.29
2.681TyrGly: 2.681 ± 0.429
1.005TyrHis: 1.005 ± 0.27
1.676TyrIle: 1.676 ± 0.38
1.229TyrLys: 1.229 ± 0.311
2.681TyrLeu: 2.681 ± 0.512
1.564TyrMet: 1.564 ± 0.469
2.123TyrAsn: 2.123 ± 0.465
1.341TyrPro: 1.341 ± 0.304
1.229TyrGln: 1.229 ± 0.309
1.788TyrArg: 1.788 ± 0.471
2.011TyrSer: 2.011 ± 0.552
2.011TyrThr: 2.011 ± 0.464
2.123TyrVal: 2.123 ± 0.412
0.559TyrTrp: 0.559 ± 0.258
0.894TyrTyr: 0.894 ± 0.307
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 36 proteins (8952 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski