Amino acid dipepetide frequency for Streptococcus satellite phage Javan167

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.0AlaCys: 0.0 ± 0.0
2.66AlaAsp: 2.66 ± 1.485
3.546AlaGlu: 3.546 ± 1.154
2.216AlaPhe: 2.216 ± 0.755
3.103AlaGly: 3.103 ± 1.266
0.0AlaHis: 0.0 ± 0.0
1.773AlaIle: 1.773 ± 0.954
6.206AlaLys: 6.206 ± 1.639
6.649AlaLeu: 6.649 ± 1.868
0.887AlaMet: 0.887 ± 0.516
0.443AlaAsn: 0.443 ± 0.42
1.773AlaPro: 1.773 ± 0.809
1.773AlaGln: 1.773 ± 1.074
1.773AlaArg: 1.773 ± 0.873
3.546AlaSer: 3.546 ± 2.066
5.319AlaThr: 5.319 ± 1.442
2.216AlaVal: 2.216 ± 0.846
0.443AlaTrp: 0.443 ± 0.324
4.876AlaTyr: 4.876 ± 1.135
0.0AlaXaa: 0.0 ± 0.0
Cys
0.443CysAla: 0.443 ± 0.386
0.0CysCys: 0.0 ± 0.0
0.443CysAsp: 0.443 ± 0.574
0.443CysGlu: 0.443 ± 0.386
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.443CysLeu: 0.443 ± 0.42
0.887CysMet: 0.887 ± 0.658
0.0CysAsn: 0.0 ± 0.0
0.887CysPro: 0.887 ± 0.494
0.0CysGln: 0.0 ± 0.0
0.443CysArg: 0.443 ± 0.324
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.443CysTrp: 0.443 ± 0.459
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.443AspAla: 0.443 ± 0.42
0.0AspCys: 0.0 ± 0.0
2.216AspAsp: 2.216 ± 0.709
4.876AspGlu: 4.876 ± 1.649
3.989AspPhe: 3.989 ± 1.303
0.443AspGly: 0.443 ± 0.324
0.887AspHis: 0.887 ± 0.912
3.989AspIle: 3.989 ± 1.266
7.979AspLys: 7.979 ± 1.481
5.319AspLeu: 5.319 ± 1.445
0.0AspMet: 0.0 ± 0.0
3.546AspAsn: 3.546 ± 0.816
0.887AspPro: 0.887 ± 0.481
1.33AspGln: 1.33 ± 0.687
0.887AspArg: 0.887 ± 0.84
5.762AspSer: 5.762 ± 1.469
2.66AspThr: 2.66 ± 0.851
3.103AspVal: 3.103 ± 1.142
2.216AspTrp: 2.216 ± 0.815
3.989AspTyr: 3.989 ± 0.882
0.0AspXaa: 0.0 ± 0.0
Glu
2.66GluAla: 2.66 ± 0.81
0.443GluCys: 0.443 ± 0.386
5.762GluAsp: 5.762 ± 2.165
7.979GluGlu: 7.979 ± 1.199
5.762GluPhe: 5.762 ± 0.922
3.546GluGly: 3.546 ± 1.367
0.0GluHis: 0.0 ± 0.0
9.309GluIle: 9.309 ± 1.485
8.422GluLys: 8.422 ± 1.833
7.979GluLeu: 7.979 ± 1.654
2.216GluMet: 2.216 ± 1.096
6.206GluAsn: 6.206 ± 1.768
0.887GluPro: 0.887 ± 0.839
5.762GluGln: 5.762 ± 1.675
3.546GluArg: 3.546 ± 1.051
3.989GluSer: 3.989 ± 1.059
3.546GluThr: 3.546 ± 1.176
3.989GluVal: 3.989 ± 0.802
0.443GluTrp: 0.443 ± 0.417
3.546GluTyr: 3.546 ± 1.452
0.0GluXaa: 0.0 ± 0.0
Phe
1.773PheAla: 1.773 ± 0.989
0.443PheCys: 0.443 ± 0.386
3.103PheAsp: 3.103 ± 0.762
3.989PheGlu: 3.989 ± 1.185
2.66PhePhe: 2.66 ± 1.124
2.216PheGly: 2.216 ± 0.859
0.443PheHis: 0.443 ± 0.324
2.66PheIle: 2.66 ± 0.976
4.433PheLys: 4.433 ± 1.406
5.762PheLeu: 5.762 ± 0.633
0.443PheMet: 0.443 ± 0.372
2.216PheAsn: 2.216 ± 0.967
1.33PhePro: 1.33 ± 0.78
2.216PheGln: 2.216 ± 0.707
1.33PheArg: 1.33 ± 0.536
2.66PheSer: 2.66 ± 0.783
0.887PheThr: 0.887 ± 0.535
2.216PheVal: 2.216 ± 1.28
0.0PheTrp: 0.0 ± 0.0
2.66PheTyr: 2.66 ± 0.579
0.0PheXaa: 0.0 ± 0.0
Gly
3.103GlyAla: 3.103 ± 1.037
0.443GlyCys: 0.443 ± 0.324
1.773GlyAsp: 1.773 ± 0.97
1.773GlyGlu: 1.773 ± 0.902
2.66GlyPhe: 2.66 ± 0.877
1.33GlyGly: 1.33 ± 0.811
1.33GlyHis: 1.33 ± 0.633
3.546GlyIle: 3.546 ± 0.871
3.103GlyLys: 3.103 ± 0.836
5.762GlyLeu: 5.762 ± 1.394
0.887GlyMet: 0.887 ± 0.494
1.773GlyAsn: 1.773 ± 0.985
0.443GlyPro: 0.443 ± 0.417
2.216GlyGln: 2.216 ± 0.916
3.546GlyArg: 3.546 ± 0.896
3.989GlySer: 3.989 ± 0.939
1.33GlyThr: 1.33 ± 0.609
3.103GlyVal: 3.103 ± 0.98
0.887GlyTrp: 0.887 ± 0.473
2.216GlyTyr: 2.216 ± 1.09
0.0GlyXaa: 0.0 ± 0.0
His
0.887HisAla: 0.887 ± 0.542
0.0HisCys: 0.0 ± 0.0
0.887HisAsp: 0.887 ± 0.468
0.0HisGlu: 0.0 ± 0.0
0.887HisPhe: 0.887 ± 0.648
1.33HisGly: 1.33 ± 0.745
0.0HisHis: 0.0 ± 0.0
1.773HisIle: 1.773 ± 0.632
0.887HisLys: 0.887 ± 0.55
1.773HisLeu: 1.773 ± 0.653
0.0HisMet: 0.0 ± 0.0
1.33HisAsn: 1.33 ± 0.934
0.887HisPro: 0.887 ± 0.69
0.443HisGln: 0.443 ± 0.386
0.887HisArg: 0.887 ± 0.648
1.33HisSer: 1.33 ± 0.647
2.216HisThr: 2.216 ± 0.836
0.887HisVal: 0.887 ± 0.485
0.0HisTrp: 0.0 ± 0.0
1.33HisTyr: 1.33 ± 0.57
0.0HisXaa: 0.0 ± 0.0
Ile
2.66IleAla: 2.66 ± 1.23
0.0IleCys: 0.0 ± 0.0
7.092IleAsp: 7.092 ± 1.683
3.989IleGlu: 3.989 ± 1.449
1.33IlePhe: 1.33 ± 0.625
3.546IleGly: 3.546 ± 0.96
2.66IleHis: 2.66 ± 1.327
5.319IleIle: 5.319 ± 1.943
8.865IleLys: 8.865 ± 1.978
3.989IleLeu: 3.989 ± 0.663
2.216IleMet: 2.216 ± 0.804
5.762IleAsn: 5.762 ± 1.27
2.66IlePro: 2.66 ± 0.801
2.216IleGln: 2.216 ± 0.992
2.216IleArg: 2.216 ± 1.052
5.319IleSer: 5.319 ± 1.591
5.319IleThr: 5.319 ± 1.436
3.989IleVal: 3.989 ± 1.179
0.0IleTrp: 0.0 ± 0.0
1.773IleTyr: 1.773 ± 0.512
0.0IleXaa: 0.0 ± 0.0
Lys
6.649LysAla: 6.649 ± 1.771
0.443LysCys: 0.443 ± 0.459
5.319LysAsp: 5.319 ± 1.421
13.298LysGlu: 13.298 ± 1.647
2.216LysPhe: 2.216 ± 0.682
5.319LysGly: 5.319 ± 1.288
3.546LysHis: 3.546 ± 0.905
6.649LysIle: 6.649 ± 1.532
10.638LysLys: 10.638 ± 1.951
6.649LysLeu: 6.649 ± 1.493
2.66LysMet: 2.66 ± 1.556
7.535LysAsn: 7.535 ± 1.337
4.876LysPro: 4.876 ± 1.842
5.762LysGln: 5.762 ± 1.286
4.433LysArg: 4.433 ± 1.025
4.876LysSer: 4.876 ± 1.111
7.535LysThr: 7.535 ± 1.433
3.546LysVal: 3.546 ± 1.345
0.0LysTrp: 0.0 ± 0.0
5.319LysTyr: 5.319 ± 1.685
0.0LysXaa: 0.0 ± 0.0
Leu
8.865LeuAla: 8.865 ± 1.211
0.443LeuCys: 0.443 ± 0.536
5.319LeuAsp: 5.319 ± 1.305
7.979LeuGlu: 7.979 ± 1.639
3.103LeuPhe: 3.103 ± 0.829
5.762LeuGly: 5.762 ± 1.642
0.887LeuHis: 0.887 ± 0.501
7.092LeuIle: 7.092 ± 1.638
9.309LeuLys: 9.309 ± 1.53
7.979LeuLeu: 7.979 ± 1.595
2.216LeuMet: 2.216 ± 0.727
6.649LeuAsn: 6.649 ± 1.712
1.773LeuPro: 1.773 ± 0.838
4.433LeuGln: 4.433 ± 1.153
6.206LeuArg: 6.206 ± 1.389
6.206LeuSer: 6.206 ± 1.332
7.535LeuThr: 7.535 ± 1.929
5.319LeuVal: 5.319 ± 1.502
0.443LeuTrp: 0.443 ± 0.324
1.33LeuTyr: 1.33 ± 0.768
0.0LeuXaa: 0.0 ± 0.0
Met
2.216MetAla: 2.216 ± 1.142
0.0MetCys: 0.0 ± 0.0
1.33MetAsp: 1.33 ± 0.609
1.773MetGlu: 1.773 ± 0.799
0.443MetPhe: 0.443 ± 0.324
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.773MetIle: 1.773 ± 0.61
2.66MetLys: 2.66 ± 1.024
1.773MetLeu: 1.773 ± 0.556
0.443MetMet: 0.443 ± 0.417
1.773MetAsn: 1.773 ± 0.812
0.0MetPro: 0.0 ± 0.0
1.33MetGln: 1.33 ± 0.829
1.773MetArg: 1.773 ± 0.829
0.443MetSer: 0.443 ± 0.417
1.773MetThr: 1.773 ± 0.737
0.887MetVal: 0.887 ± 0.485
0.0MetTrp: 0.0 ± 0.0
0.887MetTyr: 0.887 ± 0.589
0.0MetXaa: 0.0 ± 0.0
Asn
4.433AsnAla: 4.433 ± 1.342
0.0AsnCys: 0.0 ± 0.0
1.773AsnAsp: 1.773 ± 1.178
4.876AsnGlu: 4.876 ± 1.431
3.103AsnPhe: 3.103 ± 1.027
3.103AsnGly: 3.103 ± 0.949
1.33AsnHis: 1.33 ± 0.459
2.216AsnIle: 2.216 ± 0.809
6.206AsnLys: 6.206 ± 1.689
4.876AsnLeu: 4.876 ± 1.759
1.773AsnMet: 1.773 ± 1.04
5.319AsnAsn: 5.319 ± 1.804
1.773AsnPro: 1.773 ± 0.528
1.33AsnGln: 1.33 ± 0.652
2.66AsnArg: 2.66 ± 0.951
5.319AsnSer: 5.319 ± 1.272
4.876AsnThr: 4.876 ± 1.151
2.216AsnVal: 2.216 ± 1.28
0.0AsnTrp: 0.0 ± 0.0
4.876AsnTyr: 4.876 ± 1.347
0.0AsnXaa: 0.0 ± 0.0
Pro
0.887ProAla: 0.887 ± 0.468
0.0ProCys: 0.0 ± 0.0
2.216ProAsp: 2.216 ± 1.273
2.66ProGlu: 2.66 ± 1.592
0.887ProPhe: 0.887 ± 0.485
0.443ProGly: 0.443 ± 0.417
0.0ProHis: 0.0 ± 0.0
2.66ProIle: 2.66 ± 0.865
4.433ProLys: 4.433 ± 1.622
3.546ProLeu: 3.546 ± 0.886
1.33ProMet: 1.33 ± 0.807
1.33ProAsn: 1.33 ± 0.829
0.0ProPro: 0.0 ± 0.0
0.887ProGln: 0.887 ± 0.643
0.887ProArg: 0.887 ± 0.542
1.33ProSer: 1.33 ± 0.514
0.443ProThr: 0.443 ± 0.42
0.0ProVal: 0.0 ± 0.0
0.0ProTrp: 0.0 ± 0.0
1.33ProTyr: 1.33 ± 0.687
0.0ProXaa: 0.0 ± 0.0
Gln
3.546GlnAla: 3.546 ± 1.146
0.0GlnCys: 0.0 ± 0.0
2.66GlnAsp: 2.66 ± 0.614
3.103GlnGlu: 3.103 ± 1.376
0.0GlnPhe: 0.0 ± 0.0
1.33GlnGly: 1.33 ± 0.84
0.887GlnHis: 0.887 ± 0.542
3.546GlnIle: 3.546 ± 1.127
6.206GlnLys: 6.206 ± 0.996
3.103GlnLeu: 3.103 ± 0.908
0.887GlnMet: 0.887 ± 0.501
1.773GlnAsn: 1.773 ± 0.795
0.443GlnPro: 0.443 ± 0.42
2.216GlnGln: 2.216 ± 0.857
1.773GlnArg: 1.773 ± 0.948
1.33GlnSer: 1.33 ± 0.719
3.989GlnThr: 3.989 ± 1.582
4.876GlnVal: 4.876 ± 1.391
0.0GlnTrp: 0.0 ± 0.0
1.33GlnTyr: 1.33 ± 0.609
0.0GlnXaa: 0.0 ± 0.0
Arg
1.33ArgAla: 1.33 ± 0.652
0.0ArgCys: 0.0 ± 0.0
2.66ArgAsp: 2.66 ± 1.146
4.876ArgGlu: 4.876 ± 1.321
1.33ArgPhe: 1.33 ± 0.673
1.773ArgGly: 1.773 ± 0.907
1.33ArgHis: 1.33 ± 0.609
1.773ArgIle: 1.773 ± 0.732
3.989ArgLys: 3.989 ± 0.563
4.433ArgLeu: 4.433 ± 1.042
0.0ArgMet: 0.0 ± 0.424
2.66ArgAsn: 2.66 ± 0.841
0.443ArgPro: 0.443 ± 0.401
1.773ArgGln: 1.773 ± 0.674
2.216ArgArg: 2.216 ± 1.063
2.66ArgSer: 2.66 ± 0.995
3.989ArgThr: 3.989 ± 1.064
1.33ArgVal: 1.33 ± 0.81
0.443ArgTrp: 0.443 ± 0.45
2.216ArgTyr: 2.216 ± 0.758
0.0ArgXaa: 0.0 ± 0.0
Ser
3.546SerAla: 3.546 ± 1.759
0.0SerCys: 0.0 ± 0.0
3.103SerAsp: 3.103 ± 0.794
3.989SerGlu: 3.989 ± 1.277
2.66SerPhe: 2.66 ± 1.068
2.216SerGly: 2.216 ± 0.842
1.33SerHis: 1.33 ± 0.713
5.762SerIle: 5.762 ± 1.942
8.865SerLys: 8.865 ± 1.528
6.206SerLeu: 6.206 ± 1.646
2.216SerMet: 2.216 ± 0.692
3.546SerAsn: 3.546 ± 1.13
1.773SerPro: 1.773 ± 0.847
2.66SerGln: 2.66 ± 1.235
1.33SerArg: 1.33 ± 0.79
1.773SerSer: 1.773 ± 0.816
4.433SerThr: 4.433 ± 1.459
3.103SerVal: 3.103 ± 0.878
1.33SerTrp: 1.33 ± 0.729
1.773SerTyr: 1.773 ± 0.558
0.0SerXaa: 0.0 ± 0.0
Thr
2.216ThrAla: 2.216 ± 1.037
0.0ThrCys: 0.0 ± 0.0
1.33ThrAsp: 1.33 ± 0.799
5.319ThrGlu: 5.319 ± 1.24
2.216ThrPhe: 2.216 ± 0.965
5.762ThrGly: 5.762 ± 1.755
1.33ThrHis: 1.33 ± 0.713
5.762ThrIle: 5.762 ± 1.229
5.319ThrLys: 5.319 ± 2.538
10.195ThrLeu: 10.195 ± 1.315
0.887ThrMet: 0.887 ± 0.648
4.433ThrAsn: 4.433 ± 1.016
2.216ThrPro: 2.216 ± 0.96
2.216ThrGln: 2.216 ± 0.601
2.66ThrArg: 2.66 ± 1.375
2.66ThrSer: 2.66 ± 0.934
3.989ThrThr: 3.989 ± 1.376
4.876ThrVal: 4.876 ± 1.484
0.443ThrTrp: 0.443 ± 0.417
1.773ThrTyr: 1.773 ± 0.875
0.0ThrXaa: 0.0 ± 0.0
Val
3.103ValAla: 3.103 ± 1.284
0.887ValCys: 0.887 ± 0.671
3.103ValAsp: 3.103 ± 1.277
4.433ValGlu: 4.433 ± 1.115
4.433ValPhe: 4.433 ± 1.155
3.103ValGly: 3.103 ± 0.892
0.443ValHis: 0.443 ± 0.324
3.103ValIle: 3.103 ± 0.866
4.433ValLys: 4.433 ± 1.151
2.216ValLeu: 2.216 ± 0.915
0.887ValMet: 0.887 ± 0.582
3.546ValAsn: 3.546 ± 1.08
0.887ValPro: 0.887 ± 0.468
1.33ValGln: 1.33 ± 0.963
0.443ValArg: 0.443 ± 0.401
3.989ValSer: 3.989 ± 1.481
3.546ValThr: 3.546 ± 0.968
2.216ValVal: 2.216 ± 1.112
0.0ValTrp: 0.0 ± 0.0
2.216ValTyr: 2.216 ± 0.838
0.0ValXaa: 0.0 ± 0.0
Trp
0.443TrpAla: 0.443 ± 0.417
0.0TrpCys: 0.0 ± 0.0
0.443TrpAsp: 0.443 ± 0.324
1.773TrpGlu: 1.773 ± 0.79
0.443TrpPhe: 0.443 ± 0.417
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.443TrpIle: 0.443 ± 0.536
0.887TrpLys: 0.887 ± 0.449
0.887TrpLeu: 0.887 ± 0.449
0.0TrpMet: 0.0 ± 0.0
0.887TrpAsn: 0.887 ± 0.524
0.0TrpPro: 0.0 ± 0.0
0.443TrpGln: 0.443 ± 0.386
0.0TrpArg: 0.0 ± 0.0
0.887TrpSer: 0.887 ± 0.468
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.443TrpTrp: 0.443 ± 0.324
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
1.33TyrCys: 1.33 ± 0.93
1.33TyrAsp: 1.33 ± 0.514
5.319TyrGlu: 5.319 ± 1.492
3.103TyrPhe: 3.103 ± 1.63
0.887TyrGly: 0.887 ± 0.473
1.33TyrHis: 1.33 ± 0.934
1.773TyrIle: 1.773 ± 0.769
4.433TyrLys: 4.433 ± 1.226
9.309TyrLeu: 9.309 ± 2.408
0.0TyrMet: 0.0 ± 0.0
1.33TyrAsn: 1.33 ± 0.548
1.33TyrPro: 1.33 ± 0.683
2.66TyrGln: 2.66 ± 0.809
2.66TyrArg: 2.66 ± 1.164
3.546TyrSer: 3.546 ± 1.484
2.216TyrThr: 2.216 ± 0.775
0.443TyrVal: 0.443 ± 0.401
0.443TyrTrp: 0.443 ± 0.386
2.66TyrTyr: 2.66 ± 1.347
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (2257 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski