Amino acid dipepetide frequency for Planctomycetes bacterium HG15A2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.256AlaAla: 11.256 ± 0.114	1.123AlaCys: 1.123 ± 0.027	5.846AlaAsp: 5.846 ± 0.07	6.814AlaGlu: 6.814 ± 0.073	3.339AlaPhe: 3.339 ± 0.045	8.181AlaGly: 8.181 ± 0.083	1.64AlaHis: 1.64 ± 0.032	5.404AlaIle: 5.404 ± 0.065	4.105AlaLys: 4.105 ± 0.064	8.987AlaLeu: 8.987 ± 0.093	2.421AlaMet: 2.421 ± 0.039	3.329AlaAsn: 3.329 ± 0.054	3.817AlaPro: 3.817 ± 0.052	3.527AlaGln: 3.527 ± 0.051	5.132AlaArg: 5.132 ± 0.06	6.471AlaSer: 6.471 ± 0.073	6.136AlaThr: 6.136 ± 0.059	6.98AlaVal: 6.98 ± 0.077	1.368AlaTrp: 1.368 ± 0.03	2.193AlaTyr: 2.193 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.792CysAla: 0.792 ± 0.024	0.271CysCys: 0.271 ± 0.027	0.657CysAsp: 0.657 ± 0.021	0.711CysGlu: 0.711 ± 0.027	0.421CysPhe: 0.421 ± 0.016	1.106CysGly: 1.106 ± 0.036	0.365CysHis: 0.365 ± 0.019	0.437CysIle: 0.437 ± 0.014	0.363CysLys: 0.363 ± 0.018	1.179CysLeu: 1.179 ± 0.027	0.208CysMet: 0.208 ± 0.011	0.315CysAsn: 0.315 ± 0.014	0.576CysPro: 0.576 ± 0.02	0.467CysGln: 0.467 ± 0.015	0.738CysArg: 0.738 ± 0.024	0.69CysSer: 0.69 ± 0.023	0.538CysThr: 0.538 ± 0.017	0.737CysVal: 0.737 ± 0.023	0.176CysTrp: 0.176 ± 0.01	0.311CysTyr: 0.311 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.587AspAla: 5.587 ± 0.063	0.604AspCys: 0.604 ± 0.022	3.637AspAsp: 3.637 ± 0.064	3.968AspGlu: 3.968 ± 0.059	2.761AspPhe: 2.761 ± 0.043	5.563AspGly: 5.563 ± 0.095	1.297AspHis: 1.297 ± 0.029	2.614AspIle: 2.614 ± 0.04	1.841AspLys: 1.841 ± 0.032	5.853AspLeu: 5.853 ± 0.071	1.047AspMet: 1.047 ± 0.024	1.843AspAsn: 1.843 ± 0.044	3.183AspPro: 3.183 ± 0.048	2.274AspGln: 2.274 ± 0.037	3.526AspArg: 3.526 ± 0.048	3.768AspSer: 3.768 ± 0.051	2.788AspThr: 2.788 ± 0.039	4.023AspVal: 4.023 ± 0.049	1.026AspTrp: 1.026 ± 0.026	1.755AspTyr: 1.755 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.246GluAla: 6.246 ± 0.077	0.536GluCys: 0.536 ± 0.021	3.163GluAsp: 3.163 ± 0.054	4.44GluGlu: 4.44 ± 0.079	2.432GluPhe: 2.432 ± 0.04	4.322GluGly: 4.322 ± 0.058	1.452GluHis: 1.452 ± 0.032	3.526GluIle: 3.526 ± 0.049	2.926GluLys: 2.926 ± 0.05	7.203GluLeu: 7.203 ± 0.067	1.513GluMet: 1.513 ± 0.035	2.158GluAsn: 2.158 ± 0.041	3.14GluPro: 3.14 ± 0.054	3.484GluGln: 3.484 ± 0.055	4.003GluArg: 4.003 ± 0.056	4.171GluSer: 4.171 ± 0.052	3.559GluThr: 3.559 ± 0.046	4.625GluVal: 4.625 ± 0.053	0.783GluTrp: 0.783 ± 0.02	1.53GluTyr: 1.53 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.721PheAla: 3.721 ± 0.046	0.459PheCys: 0.459 ± 0.016	2.823PheAsp: 2.823 ± 0.041	2.362PheGlu: 2.362 ± 0.04	1.43PhePhe: 1.43 ± 0.031	3.275PheGly: 3.275 ± 0.047	0.736PheHis: 0.736 ± 0.024	1.482PheIle: 1.482 ± 0.031	1.045PheLys: 1.045 ± 0.027	3.592PheLeu: 3.592 ± 0.051	0.646PheMet: 0.646 ± 0.02	1.348PheAsn: 1.348 ± 0.033	1.575PhePro: 1.575 ± 0.032	1.32PheGln: 1.32 ± 0.024	2.052PheArg: 2.052 ± 0.033	2.581PheSer: 2.581 ± 0.041	2.25PheThr: 2.25 ± 0.04	2.61PheVal: 2.61 ± 0.04	0.533PheTrp: 0.533 ± 0.019	0.971PheTyr: 0.971 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	6.537GlyAla: 6.537 ± 0.082	0.989GlyCys: 0.989 ± 0.036	5.171GlyAsp: 5.171 ± 0.088	5.138GlyGlu: 5.138 ± 0.084	3.047GlyPhe: 3.047 ± 0.047	7.084GlyGly: 7.084 ± 0.117	1.66GlyHis: 1.66 ± 0.033	4.109GlyIle: 4.109 ± 0.055	3.718GlyLys: 3.718 ± 0.061	7.257GlyLeu: 7.257 ± 0.073	1.931GlyMet: 1.931 ± 0.036	3.138GlyAsn: 3.138 ± 0.061	3.175GlyPro: 3.175 ± 0.055	3.15GlyGln: 3.15 ± 0.044	4.5GlyArg: 4.5 ± 0.057	5.698GlySer: 5.698 ± 0.097	5.081GlyThr: 5.081 ± 0.091	5.789GlyVal: 5.789 ± 0.067	1.32GlyTrp: 1.32 ± 0.03	2.233GlyTyr: 2.233 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.893HisAla: 1.893 ± 0.034	0.325HisCys: 0.325 ± 0.014	1.24HisAsp: 1.24 ± 0.029	1.32HisGlu: 1.32 ± 0.035	0.91HisPhe: 0.91 ± 0.027	1.705HisGly: 1.705 ± 0.034	0.593HisHis: 0.593 ± 0.02	0.891HisIle: 0.891 ± 0.023	0.627HisLys: 0.627 ± 0.019	2.149HisLeu: 2.149 ± 0.045	0.374HisMet: 0.374 ± 0.016	0.688HisAsn: 0.688 ± 0.021	1.237HisPro: 1.237 ± 0.03	0.82HisGln: 0.82 ± 0.023	1.365HisArg: 1.365 ± 0.031	1.351HisSer: 1.351 ± 0.031	1.043HisThr: 1.043 ± 0.029	1.431HisVal: 1.431 ± 0.029	0.435HisTrp: 0.435 ± 0.017	0.642HisTyr: 0.642 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.754IleAla: 5.754 ± 0.061	0.618IleCys: 0.618 ± 0.019	3.845IleAsp: 3.845 ± 0.048	3.675IleGlu: 3.675 ± 0.054	1.418IlePhe: 1.418 ± 0.029	4.09IleGly: 4.09 ± 0.055	1.004IleHis: 1.004 ± 0.025	1.861IleIle: 1.861 ± 0.037	1.446IleLys: 1.446 ± 0.031	3.962IleLeu: 3.962 ± 0.057	0.743IleMet: 0.743 ± 0.02	1.665IleAsn: 1.665 ± 0.039	2.323IlePro: 2.323 ± 0.039	1.546IleGln: 1.546 ± 0.033	2.765IleArg: 2.765 ± 0.039	3.154IleSer: 3.154 ± 0.043	2.762IleThr: 2.762 ± 0.047	3.794IleVal: 3.794 ± 0.048	0.57IleTrp: 0.57 ± 0.02	1.188IleTyr: 1.188 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.206LysAla: 3.206 ± 0.05	0.344LysCys: 0.344 ± 0.016	1.641LysAsp: 1.641 ± 0.036	2.309LysGlu: 2.309 ± 0.051	1.285LysPhe: 1.285 ± 0.029	2.193LysGly: 2.193 ± 0.04	0.95LysHis: 0.95 ± 0.029	1.891LysIle: 1.891 ± 0.038	2.012LysLys: 2.012 ± 0.057	4.244LysLeu: 4.244 ± 0.056	0.842LysMet: 0.842 ± 0.021	1.305LysAsn: 1.305 ± 0.03	2.269LysPro: 2.269 ± 0.035	2.01LysGln: 2.01 ± 0.04	2.5LysArg: 2.5 ± 0.04	2.497LysSer: 2.497 ± 0.048	2.183LysThr: 2.183 ± 0.044	2.508LysVal: 2.508 ± 0.048	0.512LysTrp: 0.512 ± 0.019	0.993LysTyr: 0.993 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	11.804LeuAla: 11.804 ± 0.105	1.1LeuCys: 1.1 ± 0.027	5.801LeuAsp: 5.801 ± 0.059	6.219LeuGlu: 6.219 ± 0.068	3.438LeuPhe: 3.438 ± 0.052	7.844LeuGly: 7.844 ± 0.078	1.985LeuHis: 1.985 ± 0.038	4.438LeuIle: 4.438 ± 0.057	3.658LeuLys: 3.658 ± 0.055	10.7LeuLeu: 10.7 ± 0.11	1.932LeuMet: 1.932 ± 0.042	3.089LeuAsn: 3.089 ± 0.046	5.446LeuPro: 5.446 ± 0.068	3.719LeuGln: 3.719 ± 0.046	6.1LeuArg: 6.1 ± 0.078	6.803LeuSer: 6.803 ± 0.067	5.892LeuThr: 5.892 ± 0.072	7.41LeuVal: 7.41 ± 0.075	1.302LeuTrp: 1.302 ± 0.032	2.148LeuTyr: 2.148 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.067MetAla: 2.067 ± 0.041	0.2MetCys: 0.2 ± 0.012	0.82MetAsp: 0.82 ± 0.02	0.978MetGlu: 0.978 ± 0.024	0.669MetPhe: 0.669 ± 0.022	1.44MetGly: 1.44 ± 0.032	0.462MetHis: 0.462 ± 0.016	1.096MetIle: 1.096 ± 0.028	1.023MetLys: 1.023 ± 0.026	2.36MetLeu: 2.36 ± 0.043	0.463MetMet: 0.463 ± 0.017	0.825MetAsn: 0.825 ± 0.024	1.353MetPro: 1.353 ± 0.027	0.946MetGln: 0.946 ± 0.021	1.315MetArg: 1.315 ± 0.029	1.519MetSer: 1.519 ± 0.028	1.278MetThr: 1.278 ± 0.027	1.354MetVal: 1.354 ± 0.031	0.212MetTrp: 0.212 ± 0.01	0.372MetTyr: 0.372 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.082AsnAla: 3.082 ± 0.045	0.397AsnCys: 0.397 ± 0.018	2.079AsnAsp: 2.079 ± 0.044	1.986AsnGlu: 1.986 ± 0.035	1.357AsnPhe: 1.357 ± 0.03	3.084AsnGly: 3.084 ± 0.06	0.727AsnHis: 0.727 ± 0.018	1.463AsnIle: 1.463 ± 0.033	1.006AsnLys: 1.006 ± 0.023	3.276AsnLeu: 3.276 ± 0.049	0.626AsnMet: 0.626 ± 0.018	1.376AsnAsn: 1.376 ± 0.039	2.082AsnPro: 2.082 ± 0.039	1.438AsnGln: 1.438 ± 0.028	2.114AsnArg: 2.114 ± 0.038	2.462AsnSer: 2.462 ± 0.042	1.859AsnThr: 1.859 ± 0.036	2.361AsnVal: 2.361 ± 0.044	0.608AsnTrp: 0.608 ± 0.018	1.076AsnTyr: 1.076 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.902ProAla: 4.902 ± 0.06	0.379ProCys: 0.379 ± 0.016	2.857ProAsp: 2.857 ± 0.044	4.049ProGlu: 4.049 ± 0.056	1.713ProPhe: 1.713 ± 0.03	4.031ProGly: 4.031 ± 0.053	1.008ProHis: 1.008 ± 0.025	2.267ProIle: 2.267 ± 0.04	1.912ProLys: 1.912 ± 0.038	4.622ProLeu: 4.622 ± 0.062	0.935ProMet: 0.935 ± 0.02	1.879ProAsn: 1.879 ± 0.038	2.434ProPro: 2.434 ± 0.046	1.983ProGln: 1.983 ± 0.045	2.506ProArg: 2.506 ± 0.05	3.443ProSer: 3.443 ± 0.045	3.18ProThr: 3.18 ± 0.046	3.499ProVal: 3.499 ± 0.052	0.758ProTrp: 0.758 ± 0.022	1.136ProTyr: 1.136 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.346GlnAla: 4.346 ± 0.056	0.386GlnCys: 0.386 ± 0.015	1.697GlnAsp: 1.697 ± 0.029	2.378GlnGlu: 2.378 ± 0.045	1.563GlnPhe: 1.563 ± 0.034	2.737GlnGly: 2.737 ± 0.045	0.926GlnHis: 0.926 ± 0.024	2.102GlnIle: 2.102 ± 0.034	1.337GlnLys: 1.337 ± 0.028	4.884GlnLeu: 4.884 ± 0.064	0.863GlnMet: 0.863 ± 0.025	1.193GlnAsn: 1.193 ± 0.029	2.132GlnPro: 2.132 ± 0.04	2.386GlnGln: 2.386 ± 0.05	2.963GlnArg: 2.963 ± 0.049	2.579GlnSer: 2.579 ± 0.04	2.127GlnThr: 2.127 ± 0.038	2.875GlnVal: 2.875 ± 0.043	0.669GlnTrp: 0.669 ± 0.021	0.942GlnTyr: 0.942 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	4.597ArgAla: 4.597 ± 0.051	0.609ArgCys: 0.609 ± 0.019	3.37ArgAsp: 3.37 ± 0.05	4.138ArgGlu: 4.138 ± 0.056	2.416ArgPhe: 2.416 ± 0.04	4.094ArgGly: 4.094 ± 0.052	1.323ArgHis: 1.323 ± 0.031	3.228ArgIle: 3.228 ± 0.041	2.495ArgLys: 2.495 ± 0.035	6.318ArgLeu: 6.318 ± 0.083	1.488ArgMet: 1.488 ± 0.029	1.97ArgAsn: 1.97 ± 0.032	2.664ArgPro: 2.664 ± 0.038	2.673ArgGln: 2.673 ± 0.044	4.647ArgArg: 4.647 ± 0.063	3.741ArgSer: 3.741 ± 0.051	3.171ArgThr: 3.171 ± 0.045	4.203ArgVal: 4.203 ± 0.05	1.059ArgTrp: 1.059 ± 0.028	1.696ArgTyr: 1.696 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.96SerAla: 5.96 ± 0.063	0.716SerCys: 0.716 ± 0.023	3.946SerAsp: 3.946 ± 0.05	4.106SerGlu: 4.106 ± 0.052	2.363SerPhe: 2.363 ± 0.046	6.109SerGly: 6.109 ± 0.101	1.341SerHis: 1.341 ± 0.028	3.17SerIle: 3.17 ± 0.048	2.376SerLys: 2.376 ± 0.04	6.864SerLeu: 6.864 ± 0.07	1.368SerMet: 1.368 ± 0.03	2.402SerAsn: 2.402 ± 0.048	3.574SerPro: 3.574 ± 0.051	2.687SerGln: 2.687 ± 0.043	3.738SerArg: 3.738 ± 0.043	4.888SerSer: 4.888 ± 0.062	4.108SerThr: 4.108 ± 0.057	4.482SerVal: 4.482 ± 0.053	0.938SerTrp: 0.938 ± 0.021	1.663SerTyr: 1.663 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.611ThrAla: 5.611 ± 0.071	0.589ThrCys: 0.589 ± 0.02	3.269ThrAsp: 3.269 ± 0.044	3.156ThrGlu: 3.156 ± 0.05	2.09ThrPhe: 2.09 ± 0.037	5.131ThrGly: 5.131 ± 0.073	1.156ThrHis: 1.156 ± 0.022	3.215ThrIle: 3.215 ± 0.057	1.998ThrLys: 1.998 ± 0.037	6.188ThrLeu: 6.188 ± 0.07	1.097ThrMet: 1.097 ± 0.024	2.073ThrAsn: 2.073 ± 0.042	3.328ThrPro: 3.328 ± 0.043	2.053ThrGln: 2.053 ± 0.031	2.879ThrArg: 2.879 ± 0.04	3.856ThrSer: 3.856 ± 0.055	3.663ThrThr: 3.663 ± 0.058	4.278ThrVal: 4.278 ± 0.06	0.818ThrTrp: 0.818 ± 0.026	1.397ThrTyr: 1.397 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.371ValAla: 7.371 ± 0.079	0.876ValCys: 0.876 ± 0.029	4.641ValAsp: 4.641 ± 0.057	4.951ValGlu: 4.951 ± 0.068	2.522ValPhe: 2.522 ± 0.042	5.548ValGly: 5.548 ± 0.061	1.362ValHis: 1.362 ± 0.031	3.466ValIle: 3.466 ± 0.048	2.425ValLys: 2.425 ± 0.041	6.898ValLeu: 6.898 ± 0.079	1.487ValMet: 1.487 ± 0.032	2.392ValAsn: 2.392 ± 0.046	3.457ValPro: 3.457 ± 0.056	2.446ValGln: 2.446 ± 0.036	4.197ValArg: 4.197 ± 0.053	4.547ValSer: 4.547 ± 0.058	4.237ValThr: 4.237 ± 0.055	5.783ValVal: 5.783 ± 0.06	0.986ValTrp: 0.986 ± 0.024	1.634ValTyr: 1.634 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.139TrpAla: 1.139 ± 0.026	0.189TrpCys: 0.189 ± 0.011	0.761TrpAsp: 0.761 ± 0.023	0.792TrpGlu: 0.792 ± 0.024	0.552TrpPhe: 0.552 ± 0.022	0.974TrpGly: 0.974 ± 0.027	0.442TrpHis: 0.442 ± 0.017	0.723TrpIle: 0.723 ± 0.022	0.66TrpLys: 0.66 ± 0.021	1.695TrpLeu: 1.695 ± 0.037	0.353TrpMet: 0.353 ± 0.016	0.593TrpAsn: 0.593 ± 0.019	0.664TrpPro: 0.664 ± 0.02	0.992TrpGln: 0.992 ± 0.024	0.988TrpArg: 0.988 ± 0.026	0.983TrpSer: 0.983 ± 0.027	0.78TrpThr: 0.78 ± 0.024	0.839TrpVal: 0.839 ± 0.022	0.277TrpTrp: 0.277 ± 0.014	0.369TrpTyr: 0.369 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.197TyrAla: 2.197 ± 0.042	0.347TyrCys: 0.347 ± 0.013	1.691TyrAsp: 1.691 ± 0.035	1.723TyrGlu: 1.723 ± 0.036	1.083TyrPhe: 1.083 ± 0.025	2.215TyrGly: 2.215 ± 0.036	0.609TyrHis: 0.609 ± 0.021	0.8TyrIle: 0.8 ± 0.023	0.721TyrLys: 0.721 ± 0.023	2.597TyrLeu: 2.597 ± 0.043	0.416TyrMet: 0.416 ± 0.017	0.876TyrAsn: 0.876 ± 0.026	1.065TyrPro: 1.065 ± 0.027	1.165TyrGln: 1.165 ± 0.027	1.869TyrArg: 1.869 ± 0.035	1.6TyrSer: 1.6 ± 0.033	1.211TyrThr: 1.211 ± 0.031	1.646TyrVal: 1.646 ± 0.036	0.417TyrTrp: 0.417 ± 0.019	0.848TyrTyr: 0.848 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4864 proteins (1702111 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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