Amino acid dipepetide frequency for Arthrobacter sp. 785

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.081AlaAla: 22.081 ± 0.255
0.741AlaCys: 0.741 ± 0.032
7.614AlaAsp: 7.614 ± 0.087
8.516AlaGlu: 8.516 ± 0.096
3.711AlaPhe: 3.711 ± 0.072
14.102AlaGly: 14.102 ± 0.139
2.045AlaHis: 2.045 ± 0.049
4.151AlaIle: 4.151 ± 0.071
3.086AlaLys: 3.086 ± 0.064
13.016AlaLeu: 13.016 ± 0.135
2.779AlaMet: 2.779 ± 0.056
2.548AlaAsn: 2.548 ± 0.057
6.396AlaPro: 6.396 ± 0.105
3.697AlaGln: 3.697 ± 0.063
8.31AlaArg: 8.31 ± 0.11
6.899AlaSer: 6.899 ± 0.086
5.815AlaThr: 5.815 ± 0.073
12.379AlaVal: 12.379 ± 0.131
1.59AlaTrp: 1.59 ± 0.04
2.491AlaTyr: 2.491 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.715CysAla: 0.715 ± 0.029
0.063CysCys: 0.063 ± 0.008
0.3CysAsp: 0.3 ± 0.017
0.297CysGlu: 0.297 ± 0.017
0.2CysPhe: 0.2 ± 0.013
0.694CysGly: 0.694 ± 0.027
0.113CysHis: 0.113 ± 0.012
0.26CysIle: 0.26 ± 0.016
0.091CysLys: 0.091 ± 0.009
0.583CysLeu: 0.583 ± 0.024
0.099CysMet: 0.099 ± 0.011
0.127CysAsn: 0.127 ± 0.011
0.366CysPro: 0.366 ± 0.019
0.115CysGln: 0.115 ± 0.011
0.455CysArg: 0.455 ± 0.023
0.43CysSer: 0.43 ± 0.021
0.417CysThr: 0.417 ± 0.022
0.439CysVal: 0.439 ± 0.02
0.083CysTrp: 0.083 ± 0.009
0.133CysTyr: 0.133 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.618AspAla: 7.618 ± 0.098
0.281AspCys: 0.281 ± 0.017
2.957AspAsp: 2.957 ± 0.061
3.471AspGlu: 3.471 ± 0.064
1.838AspPhe: 1.838 ± 0.044
5.758AspGly: 5.758 ± 0.085
1.006AspHis: 1.006 ± 0.031
2.362AspIle: 2.362 ± 0.054
1.195AspLys: 1.195 ± 0.042
6.003AspLeu: 6.003 ± 0.084
0.964AspMet: 0.964 ± 0.03
1.173AspAsn: 1.173 ± 0.037
4.079AspPro: 4.079 ± 0.074
1.472AspGln: 1.472 ± 0.04
3.806AspArg: 3.806 ± 0.068
2.953AspSer: 2.953 ± 0.053
3.08AspThr: 3.08 ± 0.054
4.71AspVal: 4.71 ± 0.078
0.822AspTrp: 0.822 ± 0.031
1.314AspTyr: 1.314 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.392GluAla: 7.392 ± 0.092
0.287GluCys: 0.287 ± 0.017
3.529GluAsp: 3.529 ± 0.059
3.7GluGlu: 3.7 ± 0.07
1.672GluPhe: 1.672 ± 0.044
4.27GluGly: 4.27 ± 0.067
1.406GluHis: 1.406 ± 0.044
2.576GluIle: 2.576 ± 0.055
1.762GluLys: 1.762 ± 0.054
6.751GluLeu: 6.751 ± 0.096
1.088GluMet: 1.088 ± 0.036
1.537GluAsn: 1.537 ± 0.044
3.074GluPro: 3.074 ± 0.058
2.467GluGln: 2.467 ± 0.05
4.08GluArg: 4.08 ± 0.068
2.966GluSer: 2.966 ± 0.061
3.225GluThr: 3.225 ± 0.053
4.224GluVal: 4.224 ± 0.068
0.756GluTrp: 0.756 ± 0.024
1.222GluTyr: 1.222 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.919PheAla: 3.919 ± 0.064
0.25PheCys: 0.25 ± 0.018
2.109PheAsp: 2.109 ± 0.052
1.714PheGlu: 1.714 ± 0.044
1.159PhePhe: 1.159 ± 0.043
3.377PheGly: 3.377 ± 0.065
0.556PheHis: 0.556 ± 0.025
1.273PheIle: 1.273 ± 0.036
0.638PheLys: 0.638 ± 0.027
3.126PheLeu: 3.126 ± 0.063
0.563PheMet: 0.563 ± 0.026
0.839PheAsn: 0.839 ± 0.027
1.55PhePro: 1.55 ± 0.041
0.742PheGln: 0.742 ± 0.027
1.912PheArg: 1.912 ± 0.043
2.121PheSer: 2.121 ± 0.044
2.19PheThr: 2.19 ± 0.05
2.4PheVal: 2.4 ± 0.051
0.468PheTrp: 0.468 ± 0.023
0.734PheTyr: 0.734 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
10.656GlyAla: 10.656 ± 0.111
0.657GlyCys: 0.657 ± 0.028
4.259GlyAsp: 4.259 ± 0.065
4.835GlyGlu: 4.835 ± 0.071
3.382GlyPhe: 3.382 ± 0.058
7.888GlyGly: 7.888 ± 0.115
1.795GlyHis: 1.795 ± 0.048
4.788GlyIle: 4.788 ± 0.074
2.733GlyLys: 2.733 ± 0.054
9.208GlyLeu: 9.208 ± 0.103
2.245GlyMet: 2.245 ± 0.046
2.4GlyAsn: 2.4 ± 0.054
4.325GlyPro: 4.325 ± 0.076
2.876GlyGln: 2.876 ± 0.053
6.47GlyArg: 6.47 ± 0.099
6.403GlySer: 6.403 ± 0.224
6.676GlyThr: 6.676 ± 0.076
7.16GlyVal: 7.16 ± 0.089
1.549GlyTrp: 1.549 ± 0.04
2.472GlyTyr: 2.472 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.09HisAla: 2.09 ± 0.046
0.127HisCys: 0.127 ± 0.013
0.96HisAsp: 0.96 ± 0.033
0.964HisGlu: 0.964 ± 0.027
0.601HisPhe: 0.601 ± 0.024
1.913HisGly: 1.913 ± 0.043
0.544HisHis: 0.544 ± 0.025
0.735HisIle: 0.735 ± 0.027
0.329HisLys: 0.329 ± 0.016
2.009HisLeu: 2.009 ± 0.046
0.335HisMet: 0.335 ± 0.016
0.419HisAsn: 0.419 ± 0.02
1.408HisPro: 1.408 ± 0.034
0.53HisGln: 0.53 ± 0.024
1.594HisArg: 1.594 ± 0.038
1.047HisSer: 1.047 ± 0.03
1.072HisThr: 1.072 ± 0.032
1.395HisVal: 1.395 ± 0.038
0.272HisTrp: 0.272 ± 0.015
0.429HisTyr: 0.429 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.275IleAla: 5.275 ± 0.077
0.348IleCys: 0.348 ± 0.019
2.581IleAsp: 2.581 ± 0.053
2.319IleGlu: 2.319 ± 0.058
1.32IlePhe: 1.32 ± 0.041
4.007IleGly: 4.007 ± 0.079
0.731IleHis: 0.731 ± 0.025
1.834IleIle: 1.834 ± 0.047
0.952IleLys: 0.952 ± 0.034
4.087IleLeu: 4.087 ± 0.074
0.726IleMet: 0.726 ± 0.029
1.202IleAsn: 1.202 ± 0.03
2.398IlePro: 2.398 ± 0.05
0.947IleGln: 0.947 ± 0.032
2.789IleArg: 2.789 ± 0.052
2.719IleSer: 2.719 ± 0.047
2.696IleThr: 2.696 ± 0.059
3.253IleVal: 3.253 ± 0.065
0.475IleTrp: 0.475 ± 0.021
0.832IleTyr: 0.832 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.015LysAla: 3.015 ± 0.061
0.092LysCys: 0.092 ± 0.01
1.516LysAsp: 1.516 ± 0.044
1.325LysGlu: 1.325 ± 0.037
0.649LysPhe: 0.649 ± 0.027
1.841LysGly: 1.841 ± 0.052
0.477LysHis: 0.477 ± 0.021
1.125LysIle: 1.125 ± 0.034
0.865LysLys: 0.865 ± 0.037
2.257LysLeu: 2.257 ± 0.056
0.606LysMet: 0.606 ± 0.026
0.655LysAsn: 0.655 ± 0.024
1.389LysPro: 1.389 ± 0.046
0.798LysGln: 0.798 ± 0.027
1.577LysArg: 1.577 ± 0.04
1.395LysSer: 1.395 ± 0.04
1.561LysThr: 1.561 ± 0.042
2.045LysVal: 2.045 ± 0.045
0.296LysTrp: 0.296 ± 0.017
0.576LysTyr: 0.576 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
14.644LeuAla: 14.644 ± 0.152
0.617LeuCys: 0.617 ± 0.025
6.101LeuAsp: 6.101 ± 0.083
5.527LeuGlu: 5.527 ± 0.083
3.006LeuPhe: 3.006 ± 0.063
9.222LeuGly: 9.222 ± 0.105
2.006LeuHis: 2.006 ± 0.041
4.304LeuIle: 4.304 ± 0.074
2.347LeuLys: 2.347 ± 0.056
10.993LeuLeu: 10.993 ± 0.145
2.043LeuMet: 2.043 ± 0.047
2.417LeuAsn: 2.417 ± 0.046
6.16LeuPro: 6.16 ± 0.084
3.099LeuGln: 3.099 ± 0.056
7.245LeuArg: 7.245 ± 0.099
6.179LeuSer: 6.179 ± 0.089
6.327LeuThr: 6.327 ± 0.086
8.471LeuVal: 8.471 ± 0.092
1.242LeuTrp: 1.242 ± 0.042
1.806LeuTyr: 1.806 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
2.544MetAla: 2.544 ± 0.054
0.107MetCys: 0.107 ± 0.011
1.144MetAsp: 1.144 ± 0.038
1.045MetGlu: 1.045 ± 0.034
0.581MetPhe: 0.581 ± 0.023
1.678MetGly: 1.678 ± 0.037
0.392MetHis: 0.392 ± 0.022
0.861MetIle: 0.861 ± 0.028
0.566MetLys: 0.566 ± 0.023
2.018MetLeu: 2.018 ± 0.054
0.401MetMet: 0.401 ± 0.02
0.59MetAsn: 0.59 ± 0.026
1.194MetPro: 1.194 ± 0.036
0.598MetGln: 0.598 ± 0.025
1.24MetArg: 1.24 ± 0.036
1.554MetSer: 1.554 ± 0.039
1.551MetThr: 1.551 ± 0.037
1.628MetVal: 1.628 ± 0.04
0.193MetTrp: 0.193 ± 0.011
0.344MetTyr: 0.344 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.925AsnAla: 2.925 ± 0.055
0.143AsnCys: 0.143 ± 0.012
1.208AsnAsp: 1.208 ± 0.035
1.169AsnGlu: 1.169 ± 0.036
0.788AsnPhe: 0.788 ± 0.031
2.358AsnGly: 2.358 ± 0.054
0.408AsnHis: 0.408 ± 0.021
1.042AsnIle: 1.042 ± 0.032
0.591AsnLys: 0.591 ± 0.028
2.415AsnLeu: 2.415 ± 0.047
0.459AsnMet: 0.459 ± 0.021
0.695AsnAsn: 0.695 ± 0.033
1.847AsnPro: 1.847 ± 0.042
0.688AsnGln: 0.688 ± 0.027
1.612AsnArg: 1.612 ± 0.045
1.304AsnSer: 1.304 ± 0.035
1.432AsnThr: 1.432 ± 0.045
1.838AsnVal: 1.838 ± 0.043
0.392AsnTrp: 0.392 ± 0.019
0.596AsnTyr: 0.596 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
8.245ProAla: 8.245 ± 0.125
0.224ProCys: 0.224 ± 0.014
3.863ProAsp: 3.863 ± 0.066
4.451ProGlu: 4.451 ± 0.066
1.659ProPhe: 1.659 ± 0.045
6.001ProGly: 6.001 ± 0.09
1.013ProHis: 1.013 ± 0.033
1.492ProIle: 1.492 ± 0.04
1.232ProLys: 1.232 ± 0.036
5.168ProLeu: 5.168 ± 0.068
1.005ProMet: 1.005 ± 0.032
1.095ProAsn: 1.095 ± 0.036
2.375ProPro: 2.375 ± 0.066
1.673ProGln: 1.673 ± 0.037
3.169ProArg: 3.169 ± 0.064
3.219ProSer: 3.219 ± 0.065
2.7ProThr: 2.7 ± 0.048
5.253ProVal: 5.253 ± 0.084
0.76ProTrp: 0.76 ± 0.03
1.102ProTyr: 1.102 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.863GlnAla: 3.863 ± 0.069
0.159GlnCys: 0.159 ± 0.013
1.622GlnAsp: 1.622 ± 0.043
1.697GlnGlu: 1.697 ± 0.041
0.8GlnPhe: 0.8 ± 0.025
2.311GlnGly: 2.311 ± 0.045
0.649GlnHis: 0.649 ± 0.024
1.324GlnIle: 1.324 ± 0.036
0.767GlnLys: 0.767 ± 0.028
3.424GlnLeu: 3.424 ± 0.061
0.645GlnMet: 0.645 ± 0.028
0.669GlnAsn: 0.669 ± 0.028
1.618GlnPro: 1.618 ± 0.039
1.326GlnGln: 1.326 ± 0.04
2.223GlnArg: 2.223 ± 0.047
1.485GlnSer: 1.485 ± 0.04
1.491GlnThr: 1.491 ± 0.039
2.5GlnVal: 2.5 ± 0.05
0.495GlnTrp: 0.495 ± 0.021
0.666GlnTyr: 0.666 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
7.343ArgAla: 7.343 ± 0.103
0.369ArgCys: 0.369 ± 0.018
3.666ArgAsp: 3.666 ± 0.069
4.102ArgGlu: 4.102 ± 0.07
2.403ArgPhe: 2.403 ± 0.049
4.964ArgGly: 4.964 ± 0.067
1.452ArgHis: 1.452 ± 0.037
3.453ArgIle: 3.453 ± 0.057
1.764ArgLys: 1.764 ± 0.047
7.151ArgLeu: 7.151 ± 0.097
1.601ArgMet: 1.601 ± 0.039
1.839ArgAsn: 1.839 ± 0.042
3.609ArgPro: 3.609 ± 0.06
2.271ArgGln: 2.271 ± 0.05
6.28ArgArg: 6.28 ± 0.103
4.315ArgSer: 4.315 ± 0.061
4.333ArgThr: 4.333 ± 0.069
4.876ArgVal: 4.876 ± 0.067
1.104ArgTrp: 1.104 ± 0.035
1.58ArgTyr: 1.58 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
7.856SerAla: 7.856 ± 0.085
0.369SerCys: 0.369 ± 0.02
2.916SerAsp: 2.916 ± 0.054
3.003SerGlu: 3.003 ± 0.061
1.935SerPhe: 1.935 ± 0.045
6.515SerGly: 6.515 ± 0.096
1.0SerHis: 1.0 ± 0.031
2.428SerIle: 2.428 ± 0.051
1.296SerLys: 1.296 ± 0.037
5.924SerLeu: 5.924 ± 0.079
1.343SerMet: 1.343 ± 0.04
1.342SerAsn: 1.342 ± 0.041
3.3SerPro: 3.3 ± 0.056
1.434SerGln: 1.434 ± 0.042
3.981SerArg: 3.981 ± 0.069
3.762SerSer: 3.762 ± 0.075
3.67SerThr: 3.67 ± 0.08
5.025SerVal: 5.025 ± 0.156
0.909SerTrp: 0.909 ± 0.028
1.395SerTyr: 1.395 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
8.121ThrAla: 8.121 ± 0.09
0.315ThrCys: 0.315 ± 0.019
3.423ThrAsp: 3.423 ± 0.067
3.278ThrGlu: 3.278 ± 0.067
1.809ThrPhe: 1.809 ± 0.041
6.414ThrGly: 6.414 ± 0.083
1.02ThrHis: 1.02 ± 0.032
2.245ThrIle: 2.245 ± 0.049
1.252ThrLys: 1.252 ± 0.033
5.641ThrLeu: 5.641 ± 0.071
1.034ThrMet: 1.034 ± 0.03
1.292ThrAsn: 1.292 ± 0.034
3.707ThrPro: 3.707 ± 0.059
1.402ThrGln: 1.402 ± 0.037
3.366ThrArg: 3.366 ± 0.059
3.357ThrSer: 3.357 ± 0.055
3.22ThrThr: 3.22 ± 0.061
5.705ThrVal: 5.705 ± 0.07
0.734ThrTrp: 0.734 ± 0.028
1.315ThrTyr: 1.315 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
9.656ValAla: 9.656 ± 0.125
0.57ValCys: 0.57 ± 0.022
5.02ValAsp: 5.02 ± 0.064
4.713ValGlu: 4.713 ± 0.068
2.875ValPhe: 2.875 ± 0.056
6.435ValGly: 6.435 ± 0.166
1.565ValHis: 1.565 ± 0.043
3.821ValIle: 3.821 ± 0.067
1.755ValLys: 1.755 ± 0.041
9.887ValLeu: 9.887 ± 0.111
1.643ValMet: 1.643 ± 0.044
2.096ValAsn: 2.096 ± 0.046
5.054ValPro: 5.054 ± 0.076
2.398ValGln: 2.398 ± 0.049
5.68ValArg: 5.68 ± 0.068
5.152ValSer: 5.152 ± 0.074
5.129ValThr: 5.129 ± 0.081
7.508ValVal: 7.508 ± 0.093
0.97ValTrp: 0.97 ± 0.032
1.551ValTyr: 1.551 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.452TrpAla: 1.452 ± 0.039
0.1TrpCys: 0.1 ± 0.008
0.793TrpAsp: 0.793 ± 0.03
0.668TrpGlu: 0.668 ± 0.024
0.495TrpPhe: 0.495 ± 0.024
0.931TrpGly: 0.931 ± 0.027
0.296TrpHis: 0.296 ± 0.019
0.703TrpIle: 0.703 ± 0.027
0.404TrpLys: 0.404 ± 0.021
1.697TrpLeu: 1.697 ± 0.043
0.324TrpMet: 0.324 ± 0.02
0.482TrpAsn: 0.482 ± 0.022
0.638TrpPro: 0.638 ± 0.024
0.558TrpGln: 0.558 ± 0.022
0.981TrpArg: 0.981 ± 0.034
0.81TrpSer: 0.81 ± 0.028
0.85TrpThr: 0.85 ± 0.027
1.001TrpVal: 1.001 ± 0.032
0.301TrpTrp: 0.301 ± 0.018
0.294TrpTyr: 0.294 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.554TyrAla: 2.554 ± 0.047
0.159TyrCys: 0.159 ± 0.013
1.279TyrAsp: 1.279 ± 0.049
1.19TyrGlu: 1.19 ± 0.034
0.757TyrPhe: 0.757 ± 0.025
2.1TyrGly: 2.1 ± 0.048
0.299TyrHis: 0.299 ± 0.019
0.714TyrIle: 0.714 ± 0.027
0.437TyrLys: 0.437 ± 0.021
2.401TyrLeu: 2.401 ± 0.047
0.325TyrMet: 0.325 ± 0.014
0.491TyrAsn: 0.491 ± 0.025
1.214TyrPro: 1.214 ± 0.029
0.644TyrGln: 0.644 ± 0.032
1.705TyrArg: 1.705 ± 0.047
1.335TyrSer: 1.335 ± 0.035
1.217TyrThr: 1.217 ± 0.034
1.667TyrVal: 1.667 ± 0.043
0.365TyrTrp: 0.365 ± 0.02
0.507TyrTyr: 0.507 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3176 proteins (1047178 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski