Amino acid dipepetide frequency for Microviridae sp. ctzVR26

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.027AlaAla: 10.027 ± 4.706
0.668AlaCys: 0.668 ± 0.608
6.016AlaAsp: 6.016 ± 2.161
2.674AlaGlu: 2.674 ± 1.878
2.674AlaPhe: 2.674 ± 0.755
7.353AlaGly: 7.353 ± 2.414
2.005AlaHis: 2.005 ± 1.029
2.674AlaIle: 2.674 ± 1.837
6.016AlaLys: 6.016 ± 2.226
8.021AlaLeu: 8.021 ± 1.531
4.011AlaMet: 4.011 ± 1.572
3.342AlaAsn: 3.342 ± 1.544
8.021AlaPro: 8.021 ± 4.19
2.005AlaGln: 2.005 ± 1.225
7.353AlaArg: 7.353 ± 2.336
2.005AlaSer: 2.005 ± 1.471
3.342AlaThr: 3.342 ± 0.655
7.353AlaVal: 7.353 ± 1.449
0.668AlaTrp: 0.668 ± 0.644
2.674AlaTyr: 2.674 ± 0.753
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.337CysAsp: 1.337 ± 0.98
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
2.005CysGly: 2.005 ± 1.824
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.668CysLys: 0.668 ± 0.49
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.814
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.668CysGln: 0.668 ± 0.888
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
5.348AspAla: 5.348 ± 2.014
0.0AspCys: 0.0 ± 0.0
2.005AspAsp: 2.005 ± 0.838
2.005AspGlu: 2.005 ± 1.824
7.353AspPhe: 7.353 ± 1.904
4.011AspGly: 4.011 ± 1.207
0.668AspHis: 0.668 ± 0.49
2.005AspIle: 2.005 ± 0.58
3.342AspLys: 3.342 ± 1.296
5.348AspLeu: 5.348 ± 1.459
0.668AspMet: 0.668 ± 0.49
1.337AspAsn: 1.337 ± 1.157
1.337AspPro: 1.337 ± 0.675
1.337AspGln: 1.337 ± 0.98
4.011AspArg: 4.011 ± 1.028
3.342AspSer: 3.342 ± 1.071
4.011AspThr: 4.011 ± 1.977
3.342AspVal: 3.342 ± 2.075
1.337AspTrp: 1.337 ± 0.882
2.674AspTyr: 2.674 ± 1.428
0.0AspXaa: 0.0 ± 0.0
Glu
3.342GluAla: 3.342 ± 1.522
0.668GluCys: 0.668 ± 0.49
2.674GluAsp: 2.674 ± 1.088
2.005GluGlu: 2.005 ± 1.515
3.342GluPhe: 3.342 ± 1.281
2.005GluGly: 2.005 ± 1.133
1.337GluHis: 1.337 ± 0.565
0.668GluIle: 0.668 ± 0.734
4.011GluLys: 4.011 ± 1.912
8.69GluLeu: 8.69 ± 2.269
0.668GluMet: 0.668 ± 0.615
2.005GluAsn: 2.005 ± 1.278
0.668GluPro: 0.668 ± 0.644
2.005GluGln: 2.005 ± 0.838
4.011GluArg: 4.011 ± 1.605
4.679GluSer: 4.679 ± 2.029
2.674GluThr: 2.674 ± 1.607
6.016GluVal: 6.016 ± 1.739
0.668GluTrp: 0.668 ± 0.644
3.342GluTyr: 3.342 ± 1.363
0.0GluXaa: 0.0 ± 0.0
Phe
4.679PheAla: 4.679 ± 0.935
0.0PheCys: 0.0 ± 0.0
2.005PheAsp: 2.005 ± 1.558
1.337PheGlu: 1.337 ± 0.747
2.674PhePhe: 2.674 ± 1.288
2.674PheGly: 2.674 ± 0.978
0.0PheHis: 0.0 ± 0.0
1.337PheIle: 1.337 ± 0.98
2.674PheLys: 2.674 ± 1.088
3.342PheLeu: 3.342 ± 1.352
1.337PheMet: 1.337 ± 0.935
2.674PheAsn: 2.674 ± 1.235
1.337PhePro: 1.337 ± 0.565
0.0PheGln: 0.0 ± 0.0
2.674PheArg: 2.674 ± 1.174
2.674PheSer: 2.674 ± 1.343
0.668PheThr: 0.668 ± 0.49
2.005PheVal: 2.005 ± 0.866
0.668PheTrp: 0.668 ± 0.818
1.337PheTyr: 1.337 ± 0.98
0.0PheXaa: 0.0 ± 0.0
Gly
4.679GlyAla: 4.679 ± 1.161
0.0GlyCys: 0.0 ± 0.0
3.342GlyAsp: 3.342 ± 0.947
5.348GlyGlu: 5.348 ± 1.354
2.005GlyPhe: 2.005 ± 0.97
5.348GlyGly: 5.348 ± 2.777
0.668GlyHis: 0.668 ± 0.49
4.011GlyIle: 4.011 ± 1.314
4.011GlyLys: 4.011 ± 1.644
4.679GlyLeu: 4.679 ± 1.016
1.337GlyMet: 1.337 ± 1.137
1.337GlyAsn: 1.337 ± 0.882
2.674GlyPro: 2.674 ± 1.455
2.005GlyGln: 2.005 ± 1.225
4.679GlyArg: 4.679 ± 1.722
6.684GlySer: 6.684 ± 1.693
7.353GlyThr: 7.353 ± 5.393
5.348GlyVal: 5.348 ± 2.751
0.668GlyTrp: 0.668 ± 0.818
6.016GlyTyr: 6.016 ± 1.255
0.0GlyXaa: 0.0 ± 0.0
His
2.005HisAla: 2.005 ± 1.337
0.0HisCys: 0.0 ± 0.0
0.668HisAsp: 0.668 ± 0.49
0.668HisGlu: 0.668 ± 0.608
0.0HisPhe: 0.0 ± 0.0
4.011HisGly: 4.011 ± 1.746
0.0HisHis: 0.0 ± 0.0
1.337HisIle: 1.337 ± 1.467
0.0HisLys: 0.0 ± 0.0
2.005HisLeu: 2.005 ± 0.96
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
0.668HisGln: 0.668 ± 0.791
0.668HisArg: 0.668 ± 0.608
2.674HisSer: 2.674 ± 1.638
0.668HisThr: 0.668 ± 0.888
1.337HisVal: 1.337 ± 0.565
0.668HisTrp: 0.668 ± 0.49
3.342HisTyr: 3.342 ± 1.444
0.0HisXaa: 0.0 ± 0.0
Ile
6.016IleAla: 6.016 ± 1.793
0.0IleCys: 0.0 ± 0.0
2.005IleAsp: 2.005 ± 0.838
3.342IleGlu: 3.342 ± 1.465
1.337IlePhe: 1.337 ± 0.565
4.011IleGly: 4.011 ± 0.932
0.668IleHis: 0.668 ± 1.031
2.674IleIle: 2.674 ± 2.127
2.674IleLys: 2.674 ± 1.846
0.668IleLeu: 0.668 ± 0.49
0.668IleMet: 0.668 ± 1.031
2.674IleAsn: 2.674 ± 1.13
3.342IlePro: 3.342 ± 1.71
3.342IleGln: 3.342 ± 1.522
3.342IleArg: 3.342 ± 1.161
0.668IleSer: 0.668 ± 0.734
2.005IleThr: 2.005 ± 0.96
1.337IleVal: 1.337 ± 0.98
0.668IleTrp: 0.668 ± 0.49
0.668IleTyr: 0.668 ± 0.608
0.0IleXaa: 0.0 ± 0.0
Lys
2.005LysAla: 2.005 ± 1.133
0.668LysCys: 0.668 ± 0.888
2.005LysAsp: 2.005 ± 0.988
8.021LysGlu: 8.021 ± 2.333
2.674LysPhe: 2.674 ± 1.002
3.342LysGly: 3.342 ± 1.304
0.668LysHis: 0.668 ± 0.49
1.337LysIle: 1.337 ± 0.891
6.016LysLys: 6.016 ± 2.747
4.679LysLeu: 4.679 ± 0.847
4.011LysMet: 4.011 ± 2.72
3.342LysAsn: 3.342 ± 1.944
4.011LysPro: 4.011 ± 2.522
0.668LysGln: 0.668 ± 0.644
9.358LysArg: 9.358 ± 3.237
4.679LysSer: 4.679 ± 1.916
4.011LysThr: 4.011 ± 2.143
2.674LysVal: 2.674 ± 1.983
0.0LysTrp: 0.0 ± 0.0
1.337LysTyr: 1.337 ± 0.882
0.0LysXaa: 0.0 ± 0.0
Leu
9.358LeuAla: 9.358 ± 1.966
0.668LeuCys: 0.668 ± 0.608
7.353LeuAsp: 7.353 ± 1.875
6.016LeuGlu: 6.016 ± 2.315
0.668LeuPhe: 0.668 ± 0.49
6.016LeuGly: 6.016 ± 2.488
4.011LeuHis: 4.011 ± 3.165
2.674LeuIle: 2.674 ± 1.428
6.684LeuLys: 6.684 ± 3.901
6.684LeuLeu: 6.684 ± 2.034
2.005LeuMet: 2.005 ± 0.896
4.011LeuAsn: 4.011 ± 1.536
6.016LeuPro: 6.016 ± 1.997
4.011LeuGln: 4.011 ± 0.699
4.011LeuArg: 4.011 ± 2.101
4.011LeuSer: 4.011 ± 1.505
8.021LeuThr: 8.021 ± 3.012
5.348LeuVal: 5.348 ± 2.78
0.668LeuTrp: 0.668 ± 0.49
2.005LeuTyr: 2.005 ± 1.514
0.0LeuXaa: 0.0 ± 0.0
Met
3.342MetAla: 3.342 ± 2.317
0.0MetCys: 0.0 ± 0.0
1.337MetAsp: 1.337 ± 0.747
2.005MetGlu: 2.005 ± 0.724
2.005MetPhe: 2.005 ± 1.471
1.337MetGly: 1.337 ± 0.675
0.0MetHis: 0.0 ± 0.0
1.337MetIle: 1.337 ± 1.023
1.337MetLys: 1.337 ± 1.271
2.674MetLeu: 2.674 ± 0.799
0.668MetMet: 0.668 ± 0.644
0.668MetAsn: 0.668 ± 0.49
4.011MetPro: 4.011 ± 2.024
2.674MetGln: 2.674 ± 1.288
2.005MetArg: 2.005 ± 0.988
0.668MetSer: 0.668 ± 0.608
1.337MetThr: 1.337 ± 1.467
0.668MetVal: 0.668 ± 0.791
3.342MetTrp: 3.342 ± 1.139
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.679AsnAla: 4.679 ± 2.381
0.0AsnCys: 0.0 ± 0.0
6.016AsnAsp: 6.016 ± 1.429
2.005AsnGlu: 2.005 ± 0.724
1.337AsnPhe: 1.337 ± 0.766
2.674AsnGly: 2.674 ± 1.088
2.005AsnHis: 2.005 ± 1.187
0.668AsnIle: 0.668 ± 1.031
4.679AsnLys: 4.679 ± 1.037
5.348AsnLeu: 5.348 ± 1.02
0.668AsnMet: 0.668 ± 0.644
1.337AsnAsn: 1.337 ± 1.082
1.337AsnPro: 1.337 ± 1.004
0.668AsnGln: 0.668 ± 0.791
1.337AsnArg: 1.337 ± 0.766
2.674AsnSer: 2.674 ± 0.755
2.005AsnThr: 2.005 ± 1.471
2.674AsnVal: 2.674 ± 1.203
1.337AsnTrp: 1.337 ± 0.98
0.668AsnTyr: 0.668 ± 0.888
0.0AsnXaa: 0.0 ± 0.0
Pro
5.348ProAla: 5.348 ± 3.144
0.0ProCys: 0.0 ± 0.0
2.674ProAsp: 2.674 ± 1.549
3.342ProGlu: 3.342 ± 1.481
4.011ProPhe: 4.011 ± 1.535
4.011ProGly: 4.011 ± 1.002
0.668ProHis: 0.668 ± 0.608
3.342ProIle: 3.342 ± 1.102
2.005ProLys: 2.005 ± 1.146
4.011ProLeu: 4.011 ± 1.485
2.005ProMet: 2.005 ± 1.225
1.337ProAsn: 1.337 ± 0.766
4.011ProPro: 4.011 ± 3.1
3.342ProGln: 3.342 ± 1.543
2.005ProArg: 2.005 ± 1.884
4.011ProSer: 4.011 ± 1.684
2.674ProThr: 2.674 ± 1.407
3.342ProVal: 3.342 ± 1.312
0.0ProTrp: 0.0 ± 0.0
0.668ProTyr: 0.668 ± 0.644
0.0ProXaa: 0.0 ± 0.0
Gln
4.679GlnAla: 4.679 ± 2.071
0.0GlnCys: 0.0 ± 0.0
2.005GlnAsp: 2.005 ± 1.278
0.0GlnGlu: 0.0 ± 0.0
0.0GlnPhe: 0.0 ± 0.0
0.668GlnGly: 0.668 ± 0.888
0.668GlnHis: 0.668 ± 0.644
2.674GlnIle: 2.674 ± 1.455
4.011GlnLys: 4.011 ± 1.12
2.005GlnLeu: 2.005 ± 0.58
2.005GlnMet: 2.005 ± 0.593
0.668GlnAsn: 0.668 ± 0.888
1.337GlnPro: 1.337 ± 1.004
2.005GlnGln: 2.005 ± 1.278
2.674GlnArg: 2.674 ± 0.753
4.011GlnSer: 4.011 ± 1.367
4.679GlnThr: 4.679 ± 1.286
2.674GlnVal: 2.674 ± 0.834
0.668GlnTrp: 0.668 ± 0.644
1.337GlnTyr: 1.337 ± 1.031
0.0GlnXaa: 0.0 ± 0.0
Arg
5.348ArgAla: 5.348 ± 1.722
0.0ArgCys: 0.0 ± 0.0
5.348ArgAsp: 5.348 ± 2.418
3.342ArgGlu: 3.342 ± 1.296
1.337ArgPhe: 1.337 ± 0.98
3.342ArgGly: 3.342 ± 0.693
2.005ArgHis: 2.005 ± 1.884
3.342ArgIle: 3.342 ± 1.363
3.342ArgLys: 3.342 ± 2.941
5.348ArgLeu: 5.348 ± 1.968
2.674ArgMet: 2.674 ± 1.045
4.679ArgAsn: 4.679 ± 2.338
4.679ArgPro: 4.679 ± 2.335
4.011ArgGln: 4.011 ± 1.147
3.342ArgArg: 3.342 ± 0.999
4.679ArgSer: 4.679 ± 2.387
5.348ArgThr: 5.348 ± 1.733
0.668ArgVal: 0.668 ± 0.49
0.0ArgTrp: 0.0 ± 0.0
2.674ArgTyr: 2.674 ± 0.978
0.0ArgXaa: 0.0 ± 0.0
Ser
6.684SerAla: 6.684 ± 2.436
0.0SerCys: 0.0 ± 0.0
2.005SerAsp: 2.005 ± 1.224
4.679SerGlu: 4.679 ± 0.947
2.005SerPhe: 2.005 ± 0.988
7.353SerGly: 7.353 ± 2.031
1.337SerHis: 1.337 ± 0.565
3.342SerIle: 3.342 ± 1.377
1.337SerLys: 1.337 ± 0.811
7.353SerLeu: 7.353 ± 1.92
2.005SerMet: 2.005 ± 0.838
2.674SerAsn: 2.674 ± 1.002
1.337SerPro: 1.337 ± 0.675
4.011SerGln: 4.011 ± 2.487
6.016SerArg: 6.016 ± 1.326
2.674SerSer: 2.674 ± 0.686
2.005SerThr: 2.005 ± 0.866
2.674SerVal: 2.674 ± 1.108
1.337SerTrp: 1.337 ± 1.32
3.342SerTyr: 3.342 ± 2.172
0.0SerXaa: 0.0 ± 0.0
Thr
6.016ThrAla: 6.016 ± 2.999
1.337ThrCys: 1.337 ± 0.811
2.005ThrAsp: 2.005 ± 0.838
2.005ThrGlu: 2.005 ± 1.066
1.337ThrPhe: 1.337 ± 0.675
5.348ThrGly: 5.348 ± 1.574
0.668ThrHis: 0.668 ± 0.49
3.342ThrIle: 3.342 ± 1.469
3.342ThrLys: 3.342 ± 0.968
4.679ThrLeu: 4.679 ± 2.009
2.005ThrMet: 2.005 ± 0.58
3.342ThrAsn: 3.342 ± 1.022
0.668ThrPro: 0.668 ± 0.791
2.674ThrGln: 2.674 ± 1.146
3.342ThrArg: 3.342 ± 1.097
6.016ThrSer: 6.016 ± 1.458
4.679ThrThr: 4.679 ± 2.76
4.679ThrVal: 4.679 ± 2.032
1.337ThrTrp: 1.337 ± 0.766
1.337ThrTyr: 1.337 ± 1.031
0.0ThrXaa: 0.0 ± 0.0
Val
2.005ValAla: 2.005 ± 1.031
0.668ValCys: 0.668 ± 0.608
0.668ValAsp: 0.668 ± 0.791
3.342ValGlu: 3.342 ± 1.233
0.668ValPhe: 0.668 ± 0.734
4.011ValGly: 4.011 ± 1.147
0.668ValHis: 0.668 ± 0.608
4.679ValIle: 4.679 ± 2.213
6.684ValLys: 6.684 ± 2.66
8.69ValLeu: 8.69 ± 2.828
2.005ValMet: 2.005 ± 0.866
4.011ValAsn: 4.011 ± 1.602
5.348ValPro: 5.348 ± 0.949
1.337ValGln: 1.337 ± 1.157
2.674ValArg: 2.674 ± 1.344
4.679ValSer: 4.679 ± 1.489
2.674ValThr: 2.674 ± 0.978
4.679ValVal: 4.679 ± 2.883
0.0ValTrp: 0.0 ± 0.0
1.337ValTyr: 1.337 ± 0.791
0.0ValXaa: 0.0 ± 0.0
Trp
1.337TrpAla: 1.337 ± 1.023
0.0TrpCys: 0.0 ± 0.0
0.668TrpAsp: 0.668 ± 0.644
1.337TrpGlu: 1.337 ± 0.675
0.0TrpPhe: 0.0 ± 0.0
0.668TrpGly: 0.668 ± 0.644
1.337TrpHis: 1.337 ± 1.113
0.0TrpIle: 0.0 ± 0.0
1.337TrpLys: 1.337 ± 1.004
0.668TrpLeu: 0.668 ± 0.818
0.0TrpMet: 0.0 ± 0.0
1.337TrpAsn: 1.337 ± 0.98
2.005TrpPro: 2.005 ± 1.496
0.0TrpGln: 0.0 ± 0.0
0.668TrpArg: 0.668 ± 0.49
2.005TrpSer: 2.005 ± 0.988
0.668TrpThr: 0.668 ± 0.818
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.005TyrAla: 2.005 ± 0.724
0.668TyrCys: 0.668 ± 0.49
3.342TyrAsp: 3.342 ± 2.033
2.005TyrGlu: 2.005 ± 1.029
0.668TyrPhe: 0.668 ± 0.608
2.005TyrGly: 2.005 ± 0.96
1.337TyrHis: 1.337 ± 1.031
0.668TyrIle: 0.668 ± 0.49
1.337TyrLys: 1.337 ± 0.565
5.348TyrLeu: 5.348 ± 2.117
2.005TyrMet: 2.005 ± 1.029
3.342TyrAsn: 3.342 ± 0.947
0.668TyrPro: 0.668 ± 0.608
1.337TyrGln: 1.337 ± 0.766
1.337TyrArg: 1.337 ± 1.157
1.337TyrSer: 1.337 ± 0.675
1.337TyrThr: 1.337 ± 1.023
4.011TyrVal: 4.011 ± 0.835
0.0TyrTrp: 0.0 ± 0.0
2.005TyrTyr: 2.005 ± 1.471
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (1497 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski