Amino acid dipepetide frequency for Uncinula necator (Grape powdery mildew)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.132AlaAla: 5.132 ± 0.058	0.877AlaCys: 0.877 ± 0.018	2.834AlaAsp: 2.834 ± 0.033	3.857AlaGlu: 3.857 ± 0.038	2.444AlaPhe: 2.444 ± 0.031	3.607AlaGly: 3.607 ± 0.043	1.317AlaHis: 1.317 ± 0.021	4.46AlaIle: 4.46 ± 0.042	4.04AlaLys: 4.04 ± 0.045	6.215AlaLeu: 6.215 ± 0.048	1.348AlaMet: 1.348 ± 0.023	2.829AlaAsn: 2.829 ± 0.034	3.108AlaPro: 3.108 ± 0.037	2.611AlaGln: 2.611 ± 0.034	3.776AlaArg: 3.776 ± 0.041	5.585AlaSer: 5.585 ± 0.043	3.959AlaThr: 3.959 ± 0.039	3.551AlaVal: 3.551 ± 0.045	0.816AlaTrp: 0.816 ± 0.019	1.736AlaTyr: 1.736 ± 0.028	0.001AlaXaa: 0.001 ± 0.001
Cys	0.756CysAla: 0.756 ± 0.017	0.222CysCys: 0.222 ± 0.009	0.691CysAsp: 0.691 ± 0.017	0.751CysGlu: 0.751 ± 0.018	0.554CysPhe: 0.554 ± 0.016	1.003CysGly: 1.003 ± 0.023	0.357CysHis: 0.357 ± 0.012	0.864CysIle: 0.864 ± 0.019	0.821CysLys: 0.821 ± 0.016	1.413CysLeu: 1.413 ± 0.025	0.31CysMet: 0.31 ± 0.011	0.655CysAsn: 0.655 ± 0.016	0.592CysPro: 0.592 ± 0.015	0.546CysGln: 0.546 ± 0.013	0.788CysArg: 0.788 ± 0.017	1.235CysSer: 1.235 ± 0.022	0.7CysThr: 0.7 ± 0.016	0.698CysVal: 0.698 ± 0.015	0.189CysTrp: 0.189 ± 0.009	0.385CysTyr: 0.385 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.036AspAla: 3.036 ± 0.037	0.681AspCys: 0.681 ± 0.015	3.475AspAsp: 3.475 ± 0.047	4.403AspGlu: 4.403 ± 0.051	2.385AspPhe: 2.385 ± 0.027	2.886AspGly: 2.886 ± 0.036	1.131AspHis: 1.131 ± 0.02	3.791AspIle: 3.791 ± 0.037	3.001AspLys: 3.001 ± 0.033	5.137AspLeu: 5.137 ± 0.039	1.053AspMet: 1.053 ± 0.022	2.543AspAsn: 2.543 ± 0.033	2.529AspPro: 2.529 ± 0.028	2.049AspGln: 2.049 ± 0.024	2.569AspArg: 2.569 ± 0.034	4.647AspSer: 4.647 ± 0.041	2.74AspThr: 2.74 ± 0.032	2.928AspVal: 2.928 ± 0.031	0.694AspTrp: 0.694 ± 0.017	1.556AspTyr: 1.556 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	4.392GluAla: 4.392 ± 0.051	0.695GluCys: 0.695 ± 0.015	3.889GluAsp: 3.889 ± 0.041	5.409GluGlu: 5.409 ± 0.066	2.355GluPhe: 2.355 ± 0.031	2.848GluGly: 2.848 ± 0.032	1.146GluHis: 1.146 ± 0.02	5.063GluIle: 5.063 ± 0.045	5.299GluLys: 5.299 ± 0.061	5.56GluLeu: 5.56 ± 0.05	1.385GluMet: 1.385 ± 0.023	4.129GluAsn: 4.129 ± 0.045	2.156GluPro: 2.156 ± 0.029	2.388GluGln: 2.388 ± 0.032	3.723GluArg: 3.723 ± 0.044	5.244GluSer: 5.244 ± 0.054	3.487GluThr: 3.487 ± 0.034	3.464GluVal: 3.464 ± 0.038	0.834GluTrp: 0.834 ± 0.016	1.799GluTyr: 1.799 ± 0.028	0.001GluXaa: 0.001 ± 0.0
Phe	2.454PheAla: 2.454 ± 0.035	0.651PheCys: 0.651 ± 0.016	2.336PheAsp: 2.336 ± 0.031	2.449PheGlu: 2.449 ± 0.026	1.601PhePhe: 1.601 ± 0.028	2.449PheGly: 2.449 ± 0.038	0.93PheHis: 0.93 ± 0.021	2.31PheIle: 2.31 ± 0.03	2.226PheLys: 2.226 ± 0.025	3.745PheLeu: 3.745 ± 0.039	0.75PheMet: 0.75 ± 0.015	1.884PheAsn: 1.884 ± 0.022	1.907PhePro: 1.907 ± 0.029	1.605PheGln: 1.605 ± 0.025	2.009PheArg: 2.009 ± 0.03	3.692PheSer: 3.692 ± 0.033	2.198PheThr: 2.198 ± 0.028	2.073PheVal: 2.073 ± 0.027	0.508PheTrp: 0.508 ± 0.014	1.135PheTyr: 1.135 ± 0.019	0.001PheXaa: 0.001 ± 0.0
Gly	3.335GlyAla: 3.335 ± 0.046	0.726GlyCys: 0.726 ± 0.019	2.59GlyAsp: 2.59 ± 0.031	2.932GlyGlu: 2.932 ± 0.031	2.386GlyPhe: 2.386 ± 0.03	3.673GlyGly: 3.673 ± 0.055	1.328GlyHis: 1.328 ± 0.029	3.917GlyIle: 3.917 ± 0.041	3.563GlyLys: 3.563 ± 0.035	4.977GlyLeu: 4.977 ± 0.048	1.106GlyMet: 1.106 ± 0.019	2.831GlyAsn: 2.831 ± 0.033	2.287GlyPro: 2.287 ± 0.033	1.971GlyGln: 1.971 ± 0.027	3.036GlyArg: 3.036 ± 0.034	4.618GlySer: 4.618 ± 0.038	3.044GlyThr: 3.044 ± 0.036	3.102GlyVal: 3.102 ± 0.038	0.788GlyTrp: 0.788 ± 0.016	1.722GlyTyr: 1.722 ± 0.028	0.001GlyXaa: 0.001 ± 0.0
His	1.239HisAla: 1.239 ± 0.017	0.313HisCys: 0.313 ± 0.011	1.153HisAsp: 1.153 ± 0.022	1.396HisGlu: 1.396 ± 0.021	0.892HisPhe: 0.892 ± 0.016	1.249HisGly: 1.249 ± 0.025	0.696HisHis: 0.696 ± 0.016	1.443HisIle: 1.443 ± 0.022	1.227HisLys: 1.227 ± 0.019	2.11HisLeu: 2.11 ± 0.024	0.39HisMet: 0.39 ± 0.011	1.125HisAsn: 1.125 ± 0.023	1.298HisPro: 1.298 ± 0.023	1.027HisGln: 1.027 ± 0.021	1.386HisArg: 1.386 ± 0.025	1.951HisSer: 1.951 ± 0.028	1.158HisThr: 1.158 ± 0.021	1.135HisVal: 1.135 ± 0.02	0.257HisTrp: 0.257 ± 0.011	0.661HisTyr: 0.661 ± 0.016	0.001HisXaa: 0.001 ± 0.0
Ile	4.256IleAla: 4.256 ± 0.039	1.079IleCys: 1.079 ± 0.021	3.935IleAsp: 3.935 ± 0.041	4.414IleGlu: 4.414 ± 0.046	2.829IlePhe: 2.829 ± 0.034	3.503IleGly: 3.503 ± 0.039	1.453IleHis: 1.453 ± 0.023	4.126IleIle: 4.126 ± 0.041	4.132IleLys: 4.132 ± 0.038	6.355IleLeu: 6.355 ± 0.05	1.236IleMet: 1.236 ± 0.019	3.386IleAsn: 3.386 ± 0.035	3.685IlePro: 3.685 ± 0.038	2.63IleGln: 2.63 ± 0.032	3.582IleArg: 3.582 ± 0.036	6.692IleSer: 6.692 ± 0.055	3.703IleThr: 3.703 ± 0.038	3.455IleVal: 3.455 ± 0.036	0.786IleTrp: 0.786 ± 0.019	1.826IleTyr: 1.826 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.302LysAla: 4.302 ± 0.046	0.845LysCys: 0.845 ± 0.018	3.47LysAsp: 3.47 ± 0.037	4.554LysGlu: 4.554 ± 0.052	2.389LysPhe: 2.389 ± 0.033	2.961LysGly: 2.961 ± 0.033	1.212LysHis: 1.212 ± 0.021	4.848LysIle: 4.848 ± 0.044	5.486LysLys: 5.486 ± 0.065	5.864LysLeu: 5.864 ± 0.049	1.284LysMet: 1.284 ± 0.022	4.026LysAsn: 4.026 ± 0.037	2.945LysPro: 2.945 ± 0.033	2.245LysGln: 2.245 ± 0.03	3.913LysArg: 3.913 ± 0.04	5.969LysSer: 5.969 ± 0.053	3.693LysThr: 3.693 ± 0.034	3.371LysVal: 3.371 ± 0.036	0.728LysTrp: 0.728 ± 0.015	1.96LysTyr: 1.96 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	6.365LeuAla: 6.365 ± 0.049	1.275LeuCys: 1.275 ± 0.02	5.081LeuAsp: 5.081 ± 0.04	6.214LeuGlu: 6.214 ± 0.058	3.352LeuPhe: 3.352 ± 0.04	4.857LeuGly: 4.857 ± 0.042	2.104LeuHis: 2.104 ± 0.025	5.5LeuIle: 5.5 ± 0.052	6.114LeuLys: 6.114 ± 0.05	8.203LeuLeu: 8.203 ± 0.075	1.775LeuMet: 1.775 ± 0.023	4.641LeuAsn: 4.641 ± 0.045	5.023LeuPro: 5.023 ± 0.047	4.073LeuGln: 4.073 ± 0.043	5.511LeuArg: 5.511 ± 0.046	8.618LeuSer: 8.618 ± 0.06	4.939LeuThr: 4.939 ± 0.041	4.712LeuVal: 4.712 ± 0.042	1.006LeuTrp: 1.006 ± 0.021	2.422LeuTyr: 2.422 ± 0.03	0.001LeuXaa: 0.001 ± 0.001
Met	1.711MetAla: 1.711 ± 0.023	0.217MetCys: 0.217 ± 0.008	1.016MetAsp: 1.016 ± 0.019	1.259MetGlu: 1.259 ± 0.022	0.603MetPhe: 0.603 ± 0.014	1.133MetGly: 1.133 ± 0.021	0.375MetHis: 0.375 ± 0.012	1.342MetIle: 1.342 ± 0.02	1.34MetLys: 1.34 ± 0.022	1.67MetLeu: 1.67 ± 0.024	0.494MetMet: 0.494 ± 0.014	1.049MetAsn: 1.049 ± 0.02	0.955MetPro: 0.955 ± 0.018	0.747MetGln: 0.747 ± 0.017	1.133MetArg: 1.133 ± 0.021	1.739MetSer: 1.739 ± 0.021	1.225MetThr: 1.225 ± 0.02	1.052MetVal: 1.052 ± 0.02	0.194MetTrp: 0.194 ± 0.008	0.449MetTyr: 0.449 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.799AsnAla: 2.799 ± 0.027	0.862AsnCys: 0.862 ± 0.017	2.768AsnAsp: 2.768 ± 0.033	3.335AsnGlu: 3.335 ± 0.038	2.439AsnPhe: 2.439 ± 0.033	2.986AsnGly: 2.986 ± 0.029	1.259AsnHis: 1.259 ± 0.021	3.771AsnIle: 3.771 ± 0.036	3.079AsnLys: 3.079 ± 0.029	5.231AsnLeu: 5.231 ± 0.049	1.037AsnMet: 1.037 ± 0.016	2.98AsnAsn: 2.98 ± 0.049	2.663AsnPro: 2.663 ± 0.034	2.236AsnGln: 2.236 ± 0.032	2.51AsnArg: 2.51 ± 0.028	5.414AsnSer: 5.414 ± 0.054	2.958AsnThr: 2.958 ± 0.03	2.609AsnVal: 2.609 ± 0.03	0.635AsnTrp: 0.635 ± 0.014	1.621AsnTyr: 1.621 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	2.986ProAla: 2.986 ± 0.033	0.552ProCys: 0.552 ± 0.014	2.393ProAsp: 2.393 ± 0.033	3.192ProGlu: 3.192 ± 0.035	1.848ProPhe: 1.848 ± 0.026	2.526ProGly: 2.526 ± 0.034	1.192ProHis: 1.192 ± 0.02	3.367ProIle: 3.367 ± 0.037	3.168ProLys: 3.168 ± 0.032	4.307ProLeu: 4.307 ± 0.038	0.828ProMet: 0.828 ± 0.02	2.565ProAsn: 2.565 ± 0.031	3.511ProPro: 3.511 ± 0.055	2.132ProGln: 2.132 ± 0.036	2.63ProArg: 2.63 ± 0.033	5.357ProSer: 5.357 ± 0.059	3.469ProThr: 3.469 ± 0.039	2.652ProVal: 2.652 ± 0.03	0.497ProTrp: 0.497 ± 0.014	1.365ProTyr: 1.365 ± 0.024	0.001ProXaa: 0.001 ± 0.001
Gln	2.833GlnAla: 2.833 ± 0.033	0.464GlnCys: 0.464 ± 0.014	2.017GlnAsp: 2.017 ± 0.024	2.65GlnGlu: 2.65 ± 0.031	1.403GlnPhe: 1.403 ± 0.022	1.908GlnGly: 1.908 ± 0.026	0.859GlnHis: 0.859 ± 0.022	2.895GlnIle: 2.895 ± 0.034	3.034GlnLys: 3.034 ± 0.038	3.545GlnLeu: 3.545 ± 0.035	0.85GlnMet: 0.85 ± 0.017	2.642GlnAsn: 2.642 ± 0.029	1.881GlnPro: 1.881 ± 0.029	2.144GlnGln: 2.144 ± 0.053	2.426GlnArg: 2.426 ± 0.032	3.551GlnSer: 3.551 ± 0.04	2.249GlnThr: 2.249 ± 0.025	2.123GlnVal: 2.123 ± 0.028	0.431GlnTrp: 0.431 ± 0.011	1.183GlnTyr: 1.183 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.627ArgAla: 3.627 ± 0.036	0.806ArgCys: 0.806 ± 0.018	2.841ArgAsp: 2.841 ± 0.036	3.774ArgGlu: 3.774 ± 0.042	2.013ArgPhe: 2.013 ± 0.028	2.877ArgGly: 2.877 ± 0.042	1.239ArgHis: 1.239 ± 0.024	3.508ArgIle: 3.508 ± 0.034	4.263ArgLys: 4.263 ± 0.042	5.196ArgLeu: 5.196 ± 0.045	1.101ArgMet: 1.101 ± 0.02	3.047ArgAsn: 3.047 ± 0.033	2.728ArgPro: 2.728 ± 0.034	2.489ArgGln: 2.489 ± 0.03	3.994ArgArg: 3.994 ± 0.043	4.744ArgSer: 4.744 ± 0.046	2.848ArgThr: 2.848 ± 0.033	2.956ArgVal: 2.956 ± 0.032	0.655ArgTrp: 0.655 ± 0.015	1.562ArgTyr: 1.562 ± 0.025	0.002ArgXaa: 0.002 ± 0.001
Ser	4.929SerAla: 4.929 ± 0.044	1.162SerCys: 1.162 ± 0.022	4.691SerAsp: 4.691 ± 0.044	5.228SerGlu: 5.228 ± 0.049	3.521SerPhe: 3.521 ± 0.032	5.013SerGly: 5.013 ± 0.046	2.175SerHis: 2.175 ± 0.031	6.122SerIle: 6.122 ± 0.046	6.043SerLys: 6.043 ± 0.046	8.476SerLeu: 8.476 ± 0.066	1.775SerMet: 1.775 ± 0.027	5.337SerAsn: 5.337 ± 0.053	5.253SerPro: 5.253 ± 0.065	4.149SerGln: 4.149 ± 0.041	5.168SerArg: 5.168 ± 0.049	10.515SerSer: 10.515 ± 0.101	5.857SerThr: 5.857 ± 0.051	4.381SerVal: 4.381 ± 0.043	1.022SerTrp: 1.022 ± 0.018	2.417SerTyr: 2.417 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	3.671ThrAla: 3.671 ± 0.038	0.765ThrCys: 0.765 ± 0.018	2.649ThrAsp: 2.649 ± 0.03	3.323ThrGlu: 3.323 ± 0.04	2.109ThrPhe: 2.109 ± 0.027	3.218ThrGly: 3.218 ± 0.04	1.226ThrHis: 1.226 ± 0.018	3.69ThrIle: 3.69 ± 0.039	3.573ThrLys: 3.573 ± 0.036	5.177ThrLeu: 5.177 ± 0.041	1.06ThrMet: 1.06 ± 0.019	2.978ThrAsn: 2.978 ± 0.036	3.496ThrPro: 3.496 ± 0.038	2.335ThrGln: 2.335 ± 0.028	2.999ThrArg: 2.999 ± 0.036	5.921ThrSer: 5.921 ± 0.053	3.702ThrThr: 3.702 ± 0.042	3.107ThrVal: 3.107 ± 0.036	0.702ThrTrp: 0.702 ± 0.016	1.537ThrTyr: 1.537 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	3.775ValAla: 3.775 ± 0.041	0.732ValCys: 0.732 ± 0.016	3.077ValAsp: 3.077 ± 0.037	3.675ValGlu: 3.675 ± 0.039	2.103ValPhe: 2.103 ± 0.024	2.885ValGly: 2.885 ± 0.036	1.057ValHis: 1.057 ± 0.018	3.456ValIle: 3.456 ± 0.035	3.369ValLys: 3.369 ± 0.032	4.618ValLeu: 4.618 ± 0.041	1.08ValMet: 1.08 ± 0.019	2.541ValAsn: 2.541 ± 0.032	2.717ValPro: 2.717 ± 0.032	1.967ValGln: 1.967 ± 0.023	2.772ValArg: 2.772 ± 0.031	4.464ValSer: 4.464 ± 0.04	3.111ValThr: 3.111 ± 0.036	3.13ValVal: 3.13 ± 0.043	0.645ValTrp: 0.645 ± 0.017	1.392ValTyr: 1.392 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	0.871TrpAla: 0.871 ± 0.018	0.17TrpCys: 0.17 ± 0.006	0.717TrpAsp: 0.717 ± 0.017	0.7TrpGlu: 0.7 ± 0.015	0.407TrpPhe: 0.407 ± 0.012	0.627TrpGly: 0.627 ± 0.017	0.309TrpHis: 0.309 ± 0.011	0.821TrpIle: 0.821 ± 0.02	0.812TrpLys: 0.812 ± 0.016	1.104TrpLeu: 1.104 ± 0.021	0.3TrpMet: 0.3 ± 0.009	0.63TrpAsn: 0.63 ± 0.014	0.488TrpPro: 0.488 ± 0.013	0.454TrpGln: 0.454 ± 0.013	0.75TrpArg: 0.75 ± 0.018	0.887TrpSer: 0.887 ± 0.018	0.7TrpThr: 0.7 ± 0.017	0.665TrpVal: 0.665 ± 0.014	0.216TrpTrp: 0.216 ± 0.009	0.314TrpTyr: 0.314 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.632TyrAla: 1.632 ± 0.023	0.436TyrCys: 0.436 ± 0.012	1.61TyrAsp: 1.61 ± 0.023	1.753TyrGlu: 1.753 ± 0.028	1.281TyrPhe: 1.281 ± 0.021	1.723TyrGly: 1.723 ± 0.023	0.742TyrHis: 0.742 ± 0.017	1.765TyrIle: 1.765 ± 0.027	1.473TyrLys: 1.473 ± 0.025	2.883TyrLeu: 2.883 ± 0.036	0.539TyrMet: 0.539 ± 0.012	1.373TyrAsn: 1.373 ± 0.02	1.316TyrPro: 1.316 ± 0.026	1.291TyrGln: 1.291 ± 0.024	1.595TyrArg: 1.595 ± 0.027	2.391TyrSer: 2.391 ± 0.031	1.498TyrThr: 1.498 ± 0.024	1.4TyrVal: 1.4 ± 0.02	0.34TyrTrp: 0.34 ± 0.01	0.913TyrTyr: 0.913 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.252XaaXaa: 0.252 ± 0.063

Statistics based on 6482 proteins (3060911 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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