Amino acid dipepetide frequency for Subdoligranulum sp. 4_3_54A2FAA

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.03AlaAla: 15.03 ± 0.197	1.815AlaCys: 1.815 ± 0.048	5.883AlaAsp: 5.883 ± 0.073	6.722AlaGlu: 6.722 ± 0.078	3.869AlaPhe: 3.869 ± 0.068	8.76AlaGly: 8.76 ± 0.098	1.76AlaHis: 1.76 ± 0.039	4.365AlaIle: 4.365 ± 0.07	4.412AlaLys: 4.412 ± 0.073	11.283AlaLeu: 11.283 ± 0.127	2.855AlaMet: 2.855 ± 0.051	2.634AlaAsn: 2.634 ± 0.055	4.388AlaPro: 4.388 ± 0.084	4.379AlaGln: 4.379 ± 0.07	6.107AlaArg: 6.107 ± 0.082	4.697AlaSer: 4.697 ± 0.067	3.61AlaThr: 3.61 ± 0.064	8.811AlaVal: 8.811 ± 0.104	1.059AlaTrp: 1.059 ± 0.031	3.246AlaTyr: 3.246 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.904CysAla: 1.904 ± 0.039	0.378CysCys: 0.378 ± 0.019	0.889CysAsp: 0.889 ± 0.03	0.989CysGlu: 0.989 ± 0.034	0.703CysPhe: 0.703 ± 0.024	1.926CysGly: 1.926 ± 0.046	0.325CysHis: 0.325 ± 0.018	0.943CysIle: 0.943 ± 0.032	0.685CysLys: 0.685 ± 0.022	1.344CysLeu: 1.344 ± 0.037	0.453CysMet: 0.453 ± 0.021	0.505CysAsn: 0.505 ± 0.023	0.85CysPro: 0.85 ± 0.029	0.359CysGln: 0.359 ± 0.019	1.132CysArg: 1.132 ± 0.03	0.903CysSer: 0.903 ± 0.031	1.004CysThr: 1.004 ± 0.03	1.315CysVal: 1.315 ± 0.036	0.184CysTrp: 0.184 ± 0.012	0.55CysTyr: 0.55 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	6.194AspAla: 6.194 ± 0.093	0.801AspCys: 0.801 ± 0.028	2.75AspAsp: 2.75 ± 0.059	4.127AspGlu: 4.127 ± 0.062	2.442AspPhe: 2.442 ± 0.048	5.175AspGly: 5.175 ± 0.081	0.768AspHis: 0.768 ± 0.026	3.579AspIle: 3.579 ± 0.053	2.541AspLys: 2.541 ± 0.058	4.079AspLeu: 4.079 ± 0.054	1.631AspMet: 1.631 ± 0.039	1.631AspAsn: 1.631 ± 0.041	2.213AspPro: 2.213 ± 0.044	0.917AspGln: 0.917 ± 0.028	2.441AspArg: 2.441 ± 0.051	2.659AspSer: 2.659 ± 0.047	3.129AspThr: 3.129 ± 0.054	3.951AspVal: 3.951 ± 0.055	0.689AspTrp: 0.689 ± 0.028	2.267AspTyr: 2.267 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	6.426GluAla: 6.426 ± 0.075	0.816GluCys: 0.816 ± 0.025	3.453GluAsp: 3.453 ± 0.063	4.83GluGlu: 4.83 ± 0.086	2.215GluPhe: 2.215 ± 0.046	4.074GluGly: 4.074 ± 0.057	1.401GluHis: 1.401 ± 0.034	3.597GluIle: 3.597 ± 0.057	4.699GluLys: 4.699 ± 0.067	6.354GluLeu: 6.354 ± 0.075	2.071GluMet: 2.071 ± 0.043	3.298GluAsn: 3.298 ± 0.052	2.295GluPro: 2.295 ± 0.052	3.09GluGln: 3.09 ± 0.064	4.008GluArg: 4.008 ± 0.066	2.857GluSer: 2.857 ± 0.047	3.628GluThr: 3.628 ± 0.059	3.831GluVal: 3.831 ± 0.057	0.78GluTrp: 0.78 ± 0.025	2.646GluTyr: 2.646 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	4.012PheAla: 4.012 ± 0.062	0.877PheCys: 0.877 ± 0.028	2.404PheAsp: 2.404 ± 0.041	2.469PheGlu: 2.469 ± 0.045	1.84PhePhe: 1.84 ± 0.048	3.198PheGly: 3.198 ± 0.053	0.752PheHis: 0.752 ± 0.027	2.107PheIle: 2.107 ± 0.044	1.473PheLys: 1.473 ± 0.032	3.813PheLeu: 3.813 ± 0.072	0.881PheMet: 0.881 ± 0.03	1.373PheAsn: 1.373 ± 0.04	1.505PhePro: 1.505 ± 0.039	0.975PheGln: 0.975 ± 0.029	1.938PheArg: 1.938 ± 0.04	2.91PheSer: 2.91 ± 0.055	2.538PheThr: 2.538 ± 0.057	2.816PheVal: 2.816 ± 0.052	0.5PheTrp: 0.5 ± 0.021	1.595PheTyr: 1.595 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.745GlyAla: 7.745 ± 0.107	1.517GlyCys: 1.517 ± 0.038	3.661GlyAsp: 3.661 ± 0.062	4.788GlyGlu: 4.788 ± 0.057	3.191GlyPhe: 3.191 ± 0.058	6.36GlyGly: 6.36 ± 0.095	1.402GlyHis: 1.402 ± 0.036	4.429GlyIle: 4.429 ± 0.061	4.245GlyLys: 4.245 ± 0.062	7.005GlyLeu: 7.005 ± 0.092	2.562GlyMet: 2.562 ± 0.048	2.547GlyAsn: 2.547 ± 0.061	2.068GlyPro: 2.068 ± 0.046	2.305GlyGln: 2.305 ± 0.044	4.653GlyArg: 4.653 ± 0.081	4.116GlySer: 4.116 ± 0.066	4.59GlyThr: 4.59 ± 0.068	6.314GlyVal: 6.314 ± 0.088	1.031GlyTrp: 1.031 ± 0.04	3.133GlyTyr: 3.133 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.71HisAla: 1.71 ± 0.041	0.372HisCys: 0.372 ± 0.019	0.927HisAsp: 0.927 ± 0.029	0.989HisGlu: 0.989 ± 0.031	0.867HisPhe: 0.867 ± 0.028	1.559HisGly: 1.559 ± 0.035	0.409HisHis: 0.409 ± 0.019	1.194HisIle: 1.194 ± 0.034	0.713HisLys: 0.713 ± 0.023	1.612HisLeu: 1.612 ± 0.038	0.473HisMet: 0.473 ± 0.018	0.621HisAsn: 0.621 ± 0.025	0.993HisPro: 0.993 ± 0.031	0.444HisGln: 0.444 ± 0.017	1.044HisArg: 1.044 ± 0.03	1.062HisSer: 1.062 ± 0.032	1.146HisThr: 1.146 ± 0.029	1.088HisVal: 1.088 ± 0.029	0.243HisTrp: 0.243 ± 0.015	0.734HisTyr: 0.734 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.214IleAla: 5.214 ± 0.077	0.952IleCys: 0.952 ± 0.027	3.164IleAsp: 3.164 ± 0.053	3.28IleGlu: 3.28 ± 0.058	2.06IlePhe: 2.06 ± 0.051	3.789IleGly: 3.789 ± 0.071	0.936IleHis: 0.936 ± 0.031	2.771IleIle: 2.771 ± 0.061	2.23IleLys: 2.23 ± 0.053	4.975IleLeu: 4.975 ± 0.075	1.252IleMet: 1.252 ± 0.034	1.79IleAsn: 1.79 ± 0.049	2.539IlePro: 2.539 ± 0.053	1.514IleGln: 1.514 ± 0.038	3.043IleArg: 3.043 ± 0.056	3.381IleSer: 3.381 ± 0.063	3.195IleThr: 3.195 ± 0.052	3.715IleVal: 3.715 ± 0.061	0.55IleTrp: 0.55 ± 0.022	1.813IleTyr: 1.813 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.61LysAla: 4.61 ± 0.064	0.596LysCys: 0.596 ± 0.025	2.411LysAsp: 2.411 ± 0.047	3.603LysGlu: 3.603 ± 0.064	1.344LysPhe: 1.344 ± 0.035	3.217LysGly: 3.217 ± 0.054	0.825LysHis: 0.825 ± 0.026	2.58LysIle: 2.58 ± 0.051	3.52LysLys: 3.52 ± 0.066	4.271LysLeu: 4.271 ± 0.066	1.422LysMet: 1.422 ± 0.037	2.244LysAsn: 2.244 ± 0.041	1.954LysPro: 1.954 ± 0.042	1.851LysGln: 1.851 ± 0.046	2.846LysArg: 2.846 ± 0.046	2.486LysSer: 2.486 ± 0.051	3.009LysThr: 3.009 ± 0.053	2.738LysVal: 2.738 ± 0.05	0.509LysTrp: 0.509 ± 0.021	1.931LysTyr: 1.931 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	10.5LeuAla: 10.5 ± 0.127	2.272LeuCys: 2.272 ± 0.054	5.306LeuAsp: 5.306 ± 0.078	6.118LeuGlu: 6.118 ± 0.079	3.971LeuPhe: 3.971 ± 0.073	6.608LeuGly: 6.608 ± 0.094	1.814LeuHis: 1.814 ± 0.046	4.257LeuIle: 4.257 ± 0.073	4.084LeuLys: 4.084 ± 0.063	9.942LeuLeu: 9.942 ± 0.141	2.555LeuMet: 2.555 ± 0.047	3.023LeuAsn: 3.023 ± 0.053	4.749LeuPro: 4.749 ± 0.064	2.982LeuGln: 2.982 ± 0.045	5.932LeuArg: 5.932 ± 0.076	6.314LeuSer: 6.314 ± 0.09	5.197LeuThr: 5.197 ± 0.065	6.021LeuVal: 6.021 ± 0.086	1.103LeuTrp: 1.103 ± 0.034	3.538LeuTyr: 3.538 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.723MetAla: 2.723 ± 0.052	0.371MetCys: 0.371 ± 0.019	1.571MetAsp: 1.571 ± 0.033	2.077MetGlu: 2.077 ± 0.041	0.939MetPhe: 0.939 ± 0.031	1.977MetGly: 1.977 ± 0.044	0.464MetHis: 0.464 ± 0.02	1.226MetIle: 1.226 ± 0.036	1.741MetLys: 1.741 ± 0.037	3.042MetLeu: 3.042 ± 0.054	0.806MetMet: 0.806 ± 0.028	1.106MetAsn: 1.106 ± 0.03	1.384MetPro: 1.384 ± 0.035	1.1MetGln: 1.1 ± 0.035	1.604MetArg: 1.604 ± 0.039	1.515MetSer: 1.515 ± 0.033	1.517MetThr: 1.517 ± 0.04	1.72MetVal: 1.72 ± 0.039	0.255MetTrp: 0.255 ± 0.016	0.767MetTyr: 0.767 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.408AsnAla: 3.408 ± 0.056	0.542AsnCys: 0.542 ± 0.022	1.626AsnAsp: 1.626 ± 0.037	2.024AsnGlu: 2.024 ± 0.043	1.329AsnPhe: 1.329 ± 0.035	3.282AsnGly: 3.282 ± 0.062	0.576AsnHis: 0.576 ± 0.022	2.215AsnIle: 2.215 ± 0.045	1.489AsnLys: 1.489 ± 0.037	2.977AsnLeu: 2.977 ± 0.045	0.903AsnMet: 0.903 ± 0.03	1.211AsnAsn: 1.211 ± 0.036	1.693AsnPro: 1.693 ± 0.044	0.931AsnGln: 0.931 ± 0.03	1.944AsnArg: 1.944 ± 0.044	1.748AsnSer: 1.748 ± 0.048	2.077AsnThr: 2.077 ± 0.048	2.409AsnVal: 2.409 ± 0.057	0.433AsnTrp: 0.433 ± 0.02	1.362AsnTyr: 1.362 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.847ProAla: 4.847 ± 0.086	0.66ProCys: 0.66 ± 0.021	2.877ProAsp: 2.877 ± 0.052	3.892ProGlu: 3.892 ± 0.069	1.729ProPhe: 1.729 ± 0.039	3.423ProGly: 3.423 ± 0.062	0.816ProHis: 0.816 ± 0.023	1.849ProIle: 1.849 ± 0.039	1.566ProLys: 1.566 ± 0.039	3.71ProLeu: 3.71 ± 0.07	1.05ProMet: 1.05 ± 0.03	1.175ProAsn: 1.175 ± 0.028	1.552ProPro: 1.552 ± 0.047	1.681ProGln: 1.681 ± 0.041	2.056ProArg: 2.056 ± 0.048	2.02ProSer: 2.02 ± 0.042	1.849ProThr: 1.849 ± 0.042	3.646ProVal: 3.646 ± 0.059	0.476ProTrp: 0.476 ± 0.021	1.619ProTyr: 1.619 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.43GlnAla: 3.43 ± 0.058	0.434GlnCys: 0.434 ± 0.022	1.616GlnAsp: 1.616 ± 0.041	2.282GlnGlu: 2.282 ± 0.05	1.224GlnPhe: 1.224 ± 0.034	2.158GlnGly: 2.158 ± 0.041	0.58GlnHis: 0.58 ± 0.02	1.829GlnIle: 1.829 ± 0.041	2.177GlnLys: 2.177 ± 0.045	3.169GlnLeu: 3.169 ± 0.057	1.091GlnMet: 1.091 ± 0.032	1.511GlnAsn: 1.511 ± 0.035	1.482GlnPro: 1.482 ± 0.041	1.535GlnGln: 1.535 ± 0.046	2.17GlnArg: 2.17 ± 0.048	1.767GlnSer: 1.767 ± 0.04	1.891GlnThr: 1.891 ± 0.048	1.851GlnVal: 1.851 ± 0.036	0.383GlnTrp: 0.383 ± 0.017	1.322GlnTyr: 1.322 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	5.912ArgAla: 5.912 ± 0.098	0.953ArgCys: 0.953 ± 0.032	2.917ArgAsp: 2.917 ± 0.052	4.293ArgGlu: 4.293 ± 0.066	2.388ArgPhe: 2.388 ± 0.046	3.755ArgGly: 3.755 ± 0.067	1.134ArgHis: 1.134 ± 0.032	3.249ArgIle: 3.249 ± 0.053	2.771ArgLys: 2.771 ± 0.054	5.703ArgLeu: 5.703 ± 0.09	1.789ArgMet: 1.789 ± 0.035	1.8ArgAsn: 1.8 ± 0.05	2.418ArgPro: 2.418 ± 0.052	2.207ArgGln: 2.207 ± 0.048	4.459ArgArg: 4.459 ± 0.083	2.716ArgSer: 2.716 ± 0.044	3.086ArgThr: 3.086 ± 0.052	3.781ArgVal: 3.781 ± 0.065	0.766ArgTrp: 0.766 ± 0.025	2.292ArgTyr: 2.292 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.624SerAla: 5.624 ± 0.082	0.798SerCys: 0.798 ± 0.026	2.728SerAsp: 2.728 ± 0.047	3.097SerGlu: 3.097 ± 0.053	2.443SerPhe: 2.443 ± 0.047	5.177SerGly: 5.177 ± 0.077	1.003SerHis: 1.003 ± 0.026	3.131SerIle: 3.131 ± 0.056	2.103SerLys: 2.103 ± 0.044	4.848SerLeu: 4.848 ± 0.074	1.535SerMet: 1.535 ± 0.036	1.564SerAsn: 1.564 ± 0.037	2.139SerPro: 2.139 ± 0.043	1.604SerGln: 1.604 ± 0.038	3.034SerArg: 3.034 ± 0.054	3.025SerSer: 3.025 ± 0.078	2.805SerThr: 2.805 ± 0.049	4.306SerVal: 4.306 ± 0.062	0.578SerTrp: 0.578 ± 0.022	2.003SerTyr: 2.003 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	5.98ThrAla: 5.98 ± 0.079	0.692ThrCys: 0.692 ± 0.026	2.942ThrAsp: 2.942 ± 0.053	3.26ThrGlu: 3.26 ± 0.06	2.089ThrPhe: 2.089 ± 0.042	4.908ThrGly: 4.908 ± 0.074	1.006ThrHis: 1.006 ± 0.03	2.692ThrIle: 2.692 ± 0.053	2.124ThrLys: 2.124 ± 0.043	5.61ThrLeu: 5.61 ± 0.077	1.393ThrMet: 1.393 ± 0.033	1.59ThrAsn: 1.59 ± 0.037	2.924ThrPro: 2.924 ± 0.054	1.877ThrGln: 1.877 ± 0.044	2.651ThrArg: 2.651 ± 0.047	2.468ThrSer: 2.468 ± 0.05	2.543ThrThr: 2.543 ± 0.054	5.004ThrVal: 5.004 ± 0.086	0.553ThrTrp: 0.553 ± 0.026	1.776ThrTyr: 1.776 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.931ValAla: 5.931 ± 0.074	1.631ValCys: 1.631 ± 0.041	3.871ValAsp: 3.871 ± 0.06	4.432ValGlu: 4.432 ± 0.069	3.164ValPhe: 3.164 ± 0.058	4.445ValGly: 4.445 ± 0.075	1.24ValHis: 1.24 ± 0.036	3.586ValIle: 3.586 ± 0.071	3.255ValLys: 3.255 ± 0.049	7.821ValLeu: 7.821 ± 0.098	1.958ValMet: 1.958 ± 0.039	2.502ValAsn: 2.502 ± 0.046	3.414ValPro: 3.414 ± 0.055	2.459ValGln: 2.459 ± 0.043	4.361ValArg: 4.361 ± 0.074	4.372ValSer: 4.372 ± 0.061	4.266ValThr: 4.266 ± 0.074	4.844ValVal: 4.844 ± 0.074	0.853ValTrp: 0.853 ± 0.029	2.676ValTyr: 2.676 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.955TrpAla: 0.955 ± 0.031	0.188TrpCys: 0.188 ± 0.013	0.667TrpAsp: 0.667 ± 0.023	0.743TrpGlu: 0.743 ± 0.024	0.515TrpPhe: 0.515 ± 0.02	0.885TrpGly: 0.885 ± 0.03	0.262TrpHis: 0.262 ± 0.016	0.48TrpIle: 0.48 ± 0.018	0.554TrpLys: 0.554 ± 0.023	1.223TrpLeu: 1.223 ± 0.037	0.361TrpMet: 0.361 ± 0.018	0.597TrpAsn: 0.597 ± 0.028	0.409TrpPro: 0.409 ± 0.02	0.569TrpGln: 0.569 ± 0.023	0.704TrpArg: 0.704 ± 0.024	0.539TrpSer: 0.539 ± 0.022	0.589TrpThr: 0.589 ± 0.023	0.664TrpVal: 0.664 ± 0.026	0.163TrpTrp: 0.163 ± 0.013	0.448TrpTyr: 0.448 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.531TyrAla: 3.531 ± 0.06	0.676TyrCys: 0.676 ± 0.025	2.321TyrAsp: 2.321 ± 0.072	2.355TyrGlu: 2.355 ± 0.047	1.655TyrPhe: 1.655 ± 0.041	2.991TyrGly: 2.991 ± 0.06	0.727TyrHis: 0.727 ± 0.027	2.084TyrIle: 2.084 ± 0.042	1.588TyrLys: 1.588 ± 0.043	3.506TyrLeu: 3.506 ± 0.06	0.862TyrMet: 0.862 ± 0.025	1.456TyrAsn: 1.456 ± 0.042	1.522TyrPro: 1.522 ± 0.037	1.121TyrGln: 1.121 ± 0.033	2.259TyrArg: 2.259 ± 0.045	1.99TyrSer: 1.99 ± 0.045	2.413TyrThr: 2.413 ± 0.062	2.254TyrVal: 2.254 ± 0.041	0.405TyrTrp: 0.405 ± 0.018	1.554TyrTyr: 1.554 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4088 proteins (1219814 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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