Amino acid dipepetide frequency for Methanimicrococcus blatticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.304AlaAla: 8.304 ± 0.223	0.867AlaCys: 0.867 ± 0.046	5.514AlaAsp: 5.514 ± 0.113	6.127AlaGlu: 6.127 ± 0.141	3.13AlaPhe: 3.13 ± 0.08	6.494AlaGly: 6.494 ± 0.148	1.175AlaHis: 1.175 ± 0.045	5.157AlaIle: 5.157 ± 0.122	4.78AlaLys: 4.78 ± 0.126	6.599AlaLeu: 6.599 ± 0.137	1.935AlaMet: 1.935 ± 0.075	2.636AlaAsn: 2.636 ± 0.077	2.576AlaPro: 2.576 ± 0.086	1.91AlaGln: 1.91 ± 0.071	2.542AlaArg: 2.542 ± 0.081	4.137AlaSer: 4.137 ± 0.112	3.665AlaThr: 3.665 ± 0.106	7.145AlaVal: 7.145 ± 0.146	0.5AlaTrp: 0.5 ± 0.032	2.292AlaTyr: 2.292 ± 0.072	0.0AlaXaa: 0.0 ± 0.0
Cys	0.886CysAla: 0.886 ± 0.054	0.338CysCys: 0.338 ± 0.047	0.747CysAsp: 0.747 ± 0.046	0.611CysGlu: 0.611 ± 0.058	0.489CysPhe: 0.489 ± 0.033	1.295CysGly: 1.295 ± 0.068	0.239CysHis: 0.239 ± 0.021	0.714CysIle: 0.714 ± 0.039	0.626CysLys: 0.626 ± 0.04	0.955CysLeu: 0.955 ± 0.047	0.296CysMet: 0.296 ± 0.025	0.439CysAsn: 0.439 ± 0.042	0.728CysPro: 0.728 ± 0.044	0.298CysGln: 0.298 ± 0.028	0.571CysArg: 0.571 ± 0.045	0.718CysSer: 0.718 ± 0.044	0.527CysThr: 0.527 ± 0.039	0.817CysVal: 0.817 ± 0.051	0.065CysTrp: 0.065 ± 0.01	0.497CysTyr: 0.497 ± 0.038	0.0CysXaa: 0.0 ± 0.0
Asp	4.568AspAla: 4.568 ± 0.103	0.684AspCys: 0.684 ± 0.053	3.55AspAsp: 3.55 ± 0.105	5.082AspGlu: 5.082 ± 0.119	3.031AspPhe: 3.031 ± 0.083	4.656AspGly: 4.656 ± 0.135	0.827AspHis: 0.827 ± 0.046	4.882AspIle: 4.882 ± 0.122	3.667AspLys: 3.667 ± 0.096	5.462AspLeu: 5.462 ± 0.108	1.728AspMet: 1.728 ± 0.067	2.319AspAsn: 2.319 ± 0.093	2.412AspPro: 2.412 ± 0.076	1.345AspGln: 1.345 ± 0.057	2.177AspArg: 2.177 ± 0.073	3.797AspSer: 3.797 ± 0.108	2.699AspThr: 2.699 ± 0.079	4.79AspVal: 4.79 ± 0.105	0.594AspTrp: 0.594 ± 0.041	2.403AspTyr: 2.403 ± 0.079	0.002AspXaa: 0.002 ± 0.002
Glu	5.149GluAla: 5.149 ± 0.118	0.722GluCys: 0.722 ± 0.045	4.013GluAsp: 4.013 ± 0.107	6.285GluGlu: 6.285 ± 0.175	2.932GluPhe: 2.932 ± 0.084	3.749GluGly: 3.749 ± 0.098	0.993GluHis: 0.993 ± 0.047	7.17GluIle: 7.17 ± 0.157	7.068GluLys: 7.068 ± 0.154	5.995GluLeu: 5.995 ± 0.124	2.748GluMet: 2.748 ± 0.077	4.813GluAsn: 4.813 ± 0.113	2.114GluPro: 2.114 ± 0.076	1.95GluGln: 1.95 ± 0.08	2.779GluArg: 2.779 ± 0.099	4.33GluSer: 4.33 ± 0.095	4.756GluThr: 4.756 ± 0.099	4.032GluVal: 4.032 ± 0.1	0.529GluTrp: 0.529 ± 0.034	2.676GluTyr: 2.676 ± 0.084	0.0GluXaa: 0.0 ± 0.0
Phe	3.035PheAla: 3.035 ± 0.092	0.525PheCys: 0.525 ± 0.041	3.058PheAsp: 3.058 ± 0.081	3.329PheGlu: 3.329 ± 0.091	1.944PhePhe: 1.944 ± 0.078	3.258PheGly: 3.258 ± 0.095	0.586PheHis: 0.586 ± 0.037	3.258PheIle: 3.258 ± 0.111	2.785PheLys: 2.785 ± 0.084	3.764PheLeu: 3.764 ± 0.1	1.14PheMet: 1.14 ± 0.047	1.776PheAsn: 1.776 ± 0.069	1.446PhePro: 1.446 ± 0.065	0.961PheGln: 0.961 ± 0.044	1.329PheArg: 1.329 ± 0.052	3.262PheSer: 3.262 ± 0.089	2.328PheThr: 2.328 ± 0.082	3.14PheVal: 3.14 ± 0.099	0.365PheTrp: 0.365 ± 0.029	1.57PheTyr: 1.57 ± 0.068	0.0PheXaa: 0.0 ± 0.0
Gly	5.38GlyAla: 5.38 ± 0.141	1.083GlyCys: 1.083 ± 0.062	4.162GlyAsp: 4.162 ± 0.117	4.288GlyGlu: 4.288 ± 0.106	3.371GlyPhe: 3.371 ± 0.077	5.835GlyGly: 5.835 ± 0.23	1.157GlyHis: 1.157 ± 0.048	6.173GlyIle: 6.173 ± 0.127	5.468GlyLys: 5.468 ± 0.11	5.724GlyLeu: 5.724 ± 0.13	1.963GlyMet: 1.963 ± 0.08	3.451GlyAsn: 3.451 ± 0.136	1.95GlyPro: 1.95 ± 0.059	1.564GlyGln: 1.564 ± 0.068	2.664GlyArg: 2.664 ± 0.072	4.74GlySer: 4.74 ± 0.149	4.796GlyThr: 4.796 ± 0.141	5.073GlyVal: 5.073 ± 0.128	0.743GlyTrp: 0.743 ± 0.053	2.582GlyTyr: 2.582 ± 0.084	0.0GlyXaa: 0.0 ± 0.0
His	1.083HisAla: 1.083 ± 0.05	0.254HisCys: 0.254 ± 0.026	0.877HisAsp: 0.877 ± 0.046	1.016HisGlu: 1.016 ± 0.051	0.688HisPhe: 0.688 ± 0.039	1.033HisGly: 1.033 ± 0.053	0.334HisHis: 0.334 ± 0.028	1.222HisIle: 1.222 ± 0.053	0.875HisLys: 0.875 ± 0.041	1.373HisLeu: 1.373 ± 0.064	0.464HisMet: 0.464 ± 0.029	0.563HisAsn: 0.563 ± 0.037	0.936HisPro: 0.936 ± 0.041	0.414HisGln: 0.414 ± 0.028	0.596HisArg: 0.596 ± 0.038	0.947HisSer: 0.947 ± 0.05	0.856HisThr: 0.856 ± 0.043	1.14HisVal: 1.14 ± 0.049	0.132HisTrp: 0.132 ± 0.018	0.594HisTyr: 0.594 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.119IleAla: 6.119 ± 0.126	1.012IleCys: 1.012 ± 0.048	4.763IleAsp: 4.763 ± 0.106	5.905IleGlu: 5.905 ± 0.128	3.302IlePhe: 3.302 ± 0.099	6.104IleGly: 6.104 ± 0.142	1.312IleHis: 1.312 ± 0.048	5.804IleIle: 5.804 ± 0.141	4.318IleLys: 4.318 ± 0.09	7.303IleLeu: 7.303 ± 0.157	1.906IleMet: 1.906 ± 0.065	3.063IleAsn: 3.063 ± 0.097	3.552IlePro: 3.552 ± 0.078	2.468IleGln: 2.468 ± 0.079	3.298IleArg: 3.298 ± 0.101	5.615IleSer: 5.615 ± 0.116	4.33IleThr: 4.33 ± 0.102	5.443IleVal: 5.443 ± 0.098	0.596IleTrp: 0.596 ± 0.037	2.746IleTyr: 2.746 ± 0.076	0.0IleXaa: 0.0 ± 0.0
Lys	5.115LysAla: 5.115 ± 0.12	0.749LysCys: 0.749 ± 0.047	4.089LysAsp: 4.089 ± 0.092	6.354LysGlu: 6.354 ± 0.148	2.095LysPhe: 2.095 ± 0.068	3.864LysGly: 3.864 ± 0.091	1.012LysHis: 1.012 ± 0.047	5.846LysIle: 5.846 ± 0.112	6.22LysLys: 6.22 ± 0.151	4.801LysLeu: 4.801 ± 0.101	2.464LysMet: 2.464 ± 0.074	4.028LysAsn: 4.028 ± 0.1	2.479LysPro: 2.479 ± 0.081	1.818LysGln: 1.818 ± 0.064	2.869LysArg: 2.869 ± 0.084	4.236LysSer: 4.236 ± 0.089	5.13LysThr: 5.13 ± 0.115	3.661LysVal: 3.661 ± 0.099	0.504LysTrp: 0.504 ± 0.036	2.609LysTyr: 2.609 ± 0.079	0.0LysXaa: 0.0 ± 0.0
Leu	6.295LeuAla: 6.295 ± 0.13	0.877LeuCys: 0.877 ± 0.043	4.738LeuAsp: 4.738 ± 0.097	5.607LeuGlu: 5.607 ± 0.136	3.946LeuPhe: 3.946 ± 0.126	5.38LeuGly: 5.38 ± 0.13	1.251LeuHis: 1.251 ± 0.056	6.96LeuIle: 6.96 ± 0.142	6.406LeuLys: 6.406 ± 0.133	7.796LeuLeu: 7.796 ± 0.198	2.441LeuMet: 2.441 ± 0.079	3.923LeuAsn: 3.923 ± 0.093	3.699LeuPro: 3.699 ± 0.094	1.971LeuGln: 1.971 ± 0.061	3.275LeuArg: 3.275 ± 0.117	6.261LeuSer: 6.261 ± 0.138	4.966LeuThr: 4.966 ± 0.111	5.029LeuVal: 5.029 ± 0.113	0.56LeuTrp: 0.56 ± 0.037	2.739LeuTyr: 2.739 ± 0.084	0.0LeuXaa: 0.0 ± 0.0
Met	2.154MetAla: 2.154 ± 0.075	0.283MetCys: 0.283 ± 0.023	1.61MetAsp: 1.61 ± 0.064	1.914MetGlu: 1.914 ± 0.062	0.959MetPhe: 0.959 ± 0.048	1.633MetGly: 1.633 ± 0.072	0.411MetHis: 0.411 ± 0.028	2.332MetIle: 2.332 ± 0.082	2.322MetLys: 2.322 ± 0.075	1.99MetLeu: 1.99 ± 0.07	0.779MetMet: 0.779 ± 0.041	1.446MetAsn: 1.446 ± 0.055	1.159MetPro: 1.159 ± 0.043	0.682MetGln: 0.682 ± 0.035	1.077MetArg: 1.077 ± 0.044	1.799MetSer: 1.799 ± 0.06	2.259MetThr: 2.259 ± 0.064	1.753MetVal: 1.753 ± 0.07	0.162MetTrp: 0.162 ± 0.015	0.701MetTyr: 0.701 ± 0.037	0.0MetXaa: 0.0 ± 0.0
Asn	3.696AsnAla: 3.696 ± 0.096	0.588AsnCys: 0.588 ± 0.042	2.525AsnAsp: 2.525 ± 0.076	3.293AsnGlu: 3.293 ± 0.096	1.688AsnPhe: 1.688 ± 0.059	3.612AsnGly: 3.612 ± 0.115	0.651AsnHis: 0.651 ± 0.037	3.627AsnIle: 3.627 ± 0.111	2.756AsnLys: 2.756 ± 0.086	3.724AsnLeu: 3.724 ± 0.096	1.28AsnMet: 1.28 ± 0.045	2.277AsnAsn: 2.277 ± 0.114	2.366AsnPro: 2.366 ± 0.079	1.369AsnGln: 1.369 ± 0.059	1.736AsnArg: 1.736 ± 0.059	3.044AsnSer: 3.044 ± 0.105	2.378AsnThr: 2.378 ± 0.094	3.302AsnVal: 3.302 ± 0.105	0.397AsnTrp: 0.397 ± 0.033	1.566AsnTyr: 1.566 ± 0.07	0.0AsnXaa: 0.0 ± 0.0
Pro	3.272ProAla: 3.272 ± 0.095	0.405ProCys: 0.405 ± 0.029	2.882ProAsp: 2.882 ± 0.073	3.94ProGlu: 3.94 ± 0.096	1.719ProPhe: 1.719 ± 0.067	2.67ProGly: 2.67 ± 0.083	0.674ProHis: 0.674 ± 0.04	2.697ProIle: 2.697 ± 0.085	2.21ProLys: 2.21 ± 0.074	3.157ProLeu: 3.157 ± 0.089	0.884ProMet: 0.884 ± 0.044	1.45ProAsn: 1.45 ± 0.067	1.455ProPro: 1.455 ± 0.063	0.928ProGln: 0.928 ± 0.045	1.165ProArg: 1.165 ± 0.056	2.17ProSer: 2.17 ± 0.074	2.143ProThr: 2.143 ± 0.075	3.344ProVal: 3.344 ± 0.087	0.25ProTrp: 0.25 ± 0.022	1.379ProTyr: 1.379 ± 0.061	0.0ProXaa: 0.0 ± 0.0
Gln	1.65GlnAla: 1.65 ± 0.062	0.239GlnCys: 0.239 ± 0.023	1.033GlnAsp: 1.033 ± 0.041	1.688GlnGlu: 1.688 ± 0.06	0.978GlnPhe: 0.978 ± 0.047	1.178GlnGly: 1.178 ± 0.053	0.321GlnHis: 0.321 ± 0.027	2.557GlnIle: 2.557 ± 0.078	2.869GlnLys: 2.869 ± 0.069	2.028GlnLeu: 2.028 ± 0.071	0.825GlnMet: 0.825 ± 0.039	1.654GlnAsn: 1.654 ± 0.062	0.882GlnPro: 0.882 ± 0.046	0.653GlnGln: 0.653 ± 0.04	1.092GlnArg: 1.092 ± 0.046	1.589GlnSer: 1.589 ± 0.06	1.837GlnThr: 1.837 ± 0.059	1.312GlnVal: 1.312 ± 0.053	0.229GlnTrp: 0.229 ± 0.033	0.859GlnTyr: 0.859 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	2.68ArgAla: 2.68 ± 0.084	0.508ArgCys: 0.508 ± 0.042	2.183ArgAsp: 2.183 ± 0.077	2.995ArgGlu: 2.995 ± 0.091	1.704ArgPhe: 1.704 ± 0.066	2.334ArgGly: 2.334 ± 0.082	0.611ArgHis: 0.611 ± 0.037	3.117ArgIle: 3.117 ± 0.08	2.874ArgLys: 2.874 ± 0.084	3.392ArgLeu: 3.392 ± 0.088	1.003ArgMet: 1.003 ± 0.04	1.793ArgAsn: 1.793 ± 0.064	1.45ArgPro: 1.45 ± 0.059	1.073ArgGln: 1.073 ± 0.05	1.814ArgArg: 1.814 ± 0.064	2.137ArgSer: 2.137 ± 0.073	1.807ArgThr: 1.807 ± 0.06	2.489ArgVal: 2.489 ± 0.078	0.3ArgTrp: 0.3 ± 0.03	1.406ArgTyr: 1.406 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	4.958SerAla: 4.958 ± 0.111	0.686SerCys: 0.686 ± 0.04	4.309SerAsp: 4.309 ± 0.108	4.687SerGlu: 4.687 ± 0.117	3.039SerPhe: 3.039 ± 0.082	5.976SerGly: 5.976 ± 0.151	1.06SerHis: 1.06 ± 0.047	4.412SerIle: 4.412 ± 0.116	4.446SerLys: 4.446 ± 0.103	4.989SerLeu: 4.989 ± 0.103	1.539SerMet: 1.539 ± 0.064	2.84SerAsn: 2.84 ± 0.105	2.256SerPro: 2.256 ± 0.073	1.602SerGln: 1.602 ± 0.062	2.309SerArg: 2.309 ± 0.067	4.217SerSer: 4.217 ± 0.143	3.266SerThr: 3.266 ± 0.099	5.103SerVal: 5.103 ± 0.096	0.502SerTrp: 0.502 ± 0.033	2.12SerTyr: 2.12 ± 0.071	0.0SerXaa: 0.0 ± 0.0
Thr	5.002ThrAla: 5.002 ± 0.103	0.497ThrCys: 0.497 ± 0.037	3.69ThrAsp: 3.69 ± 0.084	4.053ThrGlu: 4.053 ± 0.091	2.527ThrPhe: 2.527 ± 0.092	4.939ThrGly: 4.939 ± 0.135	0.959ThrHis: 0.959 ± 0.041	4.486ThrIle: 4.486 ± 0.104	3.48ThrLys: 3.48 ± 0.09	4.605ThrLeu: 4.605 ± 0.107	1.19ThrMet: 1.19 ± 0.054	2.389ThrAsn: 2.389 ± 0.1	2.859ThrPro: 2.859 ± 0.091	1.438ThrGln: 1.438 ± 0.059	1.935ThrArg: 1.935 ± 0.067	3.17ThrSer: 3.17 ± 0.093	3.34ThrThr: 3.34 ± 0.118	5.256ThrVal: 5.256 ± 0.121	0.405ThrTrp: 0.405 ± 0.034	2.08ThrTyr: 2.08 ± 0.116	0.002ThrXaa: 0.002 ± 0.002
Val	4.95ValAla: 4.95 ± 0.103	1.043ValCys: 1.043 ± 0.057	3.988ValAsp: 3.988 ± 0.101	4.586ValGlu: 4.586 ± 0.112	3.249ValPhe: 3.249 ± 0.084	5.082ValGly: 5.082 ± 0.127	1.108ValHis: 1.108 ± 0.045	5.527ValIle: 5.527 ± 0.118	4.276ValLys: 4.276 ± 0.099	6.717ValLeu: 6.717 ± 0.134	1.776ValMet: 1.776 ± 0.064	2.876ValAsn: 2.876 ± 0.089	2.853ValPro: 2.853 ± 0.082	1.816ValGln: 1.816 ± 0.064	2.802ValArg: 2.802 ± 0.09	5.271ValSer: 5.271 ± 0.107	4.547ValThr: 4.547 ± 0.134	5.097ValVal: 5.097 ± 0.115	0.644ValTrp: 0.644 ± 0.045	2.534ValTyr: 2.534 ± 0.079	0.0ValXaa: 0.0 ± 0.0
Trp	0.502TrpAla: 0.502 ± 0.036	0.09TrpCys: 0.09 ± 0.013	0.554TrpAsp: 0.554 ± 0.041	0.558TrpGlu: 0.558 ± 0.034	0.365TrpPhe: 0.365 ± 0.025	0.493TrpGly: 0.493 ± 0.034	0.094TrpHis: 0.094 ± 0.015	0.628TrpIle: 0.628 ± 0.041	0.6TrpLys: 0.6 ± 0.041	0.678TrpLeu: 0.678 ± 0.043	0.227TrpMet: 0.227 ± 0.02	0.474TrpAsn: 0.474 ± 0.036	0.193TrpPro: 0.193 ± 0.022	0.264TrpGln: 0.264 ± 0.023	0.277TrpArg: 0.277 ± 0.026	0.483TrpSer: 0.483 ± 0.043	0.516TrpThr: 0.516 ± 0.038	0.449TrpVal: 0.449 ± 0.034	0.086TrpTrp: 0.086 ± 0.013	0.357TrpTyr: 0.357 ± 0.031	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.691TyrAla: 2.691 ± 0.083	0.403TyrCys: 0.403 ± 0.028	2.387TyrAsp: 2.387 ± 0.075	2.487TyrGlu: 2.487 ± 0.088	1.7TyrPhe: 1.7 ± 0.06	2.58TyrGly: 2.58 ± 0.084	0.621TyrHis: 0.621 ± 0.034	2.389TyrIle: 2.389 ± 0.076	1.898TyrLys: 1.898 ± 0.067	3.069TyrLeu: 3.069 ± 0.092	0.835TyrMet: 0.835 ± 0.049	1.665TyrAsn: 1.665 ± 0.064	1.432TyrPro: 1.432 ± 0.063	0.947TyrGln: 0.947 ± 0.04	1.366TyrArg: 1.366 ± 0.055	2.393TyrSer: 2.393 ± 0.092	2.154TyrThr: 2.154 ± 0.076	2.368TyrVal: 2.368 ± 0.08	0.327TyrTrp: 0.327 ± 0.029	1.511TyrTyr: 1.511 ± 0.064	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.002XaaSer: 0.002 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.003

Statistics based on 1537 proteins (476405 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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