Amino acid dipepetide frequency for Solemya velum gill symbiont

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.347AlaAla: 9.347 ± 0.147	1.016AlaCys: 1.016 ± 0.035	5.439AlaAsp: 5.439 ± 0.086	6.344AlaGlu: 6.344 ± 0.116	3.313AlaPhe: 3.313 ± 0.064	7.237AlaGly: 7.237 ± 0.105	1.873AlaHis: 1.873 ± 0.056	5.87AlaIle: 5.87 ± 0.096	3.596AlaLys: 3.596 ± 0.075	9.395AlaLeu: 9.395 ± 0.119	2.885AlaMet: 2.885 ± 0.07	2.867AlaAsn: 2.867 ± 0.069	3.246AlaPro: 3.246 ± 0.076	3.02AlaGln: 3.02 ± 0.062	4.795AlaArg: 4.795 ± 0.084	5.457AlaSer: 5.457 ± 0.08	4.48AlaThr: 4.48 ± 0.073	6.683AlaVal: 6.683 ± 0.096	1.197AlaTrp: 1.197 ± 0.04	2.303AlaTyr: 2.303 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.781CysAla: 0.781 ± 0.031	0.156CysCys: 0.156 ± 0.017	0.639CysAsp: 0.639 ± 0.024	0.637CysGlu: 0.637 ± 0.034	0.354CysPhe: 0.354 ± 0.021	1.017CysGly: 1.017 ± 0.035	0.46CysHis: 0.46 ± 0.034	0.55CysIle: 0.55 ± 0.029	0.392CysLys: 0.392 ± 0.022	0.822CysLeu: 0.822 ± 0.033	0.254CysMet: 0.254 ± 0.019	0.373CysAsn: 0.373 ± 0.027	0.555CysPro: 0.555 ± 0.031	0.342CysGln: 0.342 ± 0.022	0.639CysArg: 0.639 ± 0.027	0.695CysSer: 0.695 ± 0.035	0.48CysThr: 0.48 ± 0.025	0.632CysVal: 0.632 ± 0.03	0.121CysTrp: 0.121 ± 0.011	0.283CysTyr: 0.283 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	5.542AspAla: 5.542 ± 0.094	0.505AspCys: 0.505 ± 0.024	3.76AspAsp: 3.76 ± 0.08	4.736AspGlu: 4.736 ± 0.082	2.372AspPhe: 2.372 ± 0.062	4.418AspGly: 4.418 ± 0.079	1.34AspHis: 1.34 ± 0.034	3.683AspIle: 3.683 ± 0.063	2.718AspLys: 2.718 ± 0.064	5.334AspLeu: 5.334 ± 0.082	1.599AspMet: 1.599 ± 0.048	2.114AspAsn: 2.114 ± 0.057	2.58AspPro: 2.58 ± 0.058	1.972AspGln: 1.972 ± 0.049	2.978AspArg: 2.978 ± 0.066	3.571AspSer: 3.571 ± 0.069	2.973AspThr: 2.973 ± 0.07	3.952AspVal: 3.952 ± 0.072	0.854AspTrp: 0.854 ± 0.036	1.975AspTyr: 1.975 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.325GluAla: 6.325 ± 0.09	0.526GluCys: 0.526 ± 0.026	2.982GluAsp: 2.982 ± 0.064	5.238GluGlu: 5.238 ± 0.111	2.303GluPhe: 2.303 ± 0.047	4.179GluGly: 4.179 ± 0.077	1.514GluHis: 1.514 ± 0.042	4.571GluIle: 4.571 ± 0.093	3.985GluLys: 3.985 ± 0.081	7.107GluLeu: 7.107 ± 0.096	2.196GluMet: 2.196 ± 0.058	2.542GluAsn: 2.542 ± 0.056	2.529GluPro: 2.529 ± 0.084	3.417GluGln: 3.417 ± 0.077	4.265GluArg: 4.265 ± 0.087	4.425GluSer: 4.425 ± 0.082	3.752GluThr: 3.752 ± 0.072	4.476GluVal: 4.476 ± 0.09	0.907GluTrp: 0.907 ± 0.033	1.783GluTyr: 1.783 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.143PheAla: 3.143 ± 0.075	0.462PheCys: 0.462 ± 0.026	2.754PheAsp: 2.754 ± 0.057	2.442PheGlu: 2.442 ± 0.052	1.632PhePhe: 1.632 ± 0.055	2.933PheGly: 2.933 ± 0.073	0.902PheHis: 0.902 ± 0.037	2.276PheIle: 2.276 ± 0.057	1.408PheLys: 1.408 ± 0.042	3.596PheLeu: 3.596 ± 0.079	0.914PheMet: 0.914 ± 0.038	1.538PheAsn: 1.538 ± 0.046	1.62PhePro: 1.62 ± 0.043	1.186PheGln: 1.186 ± 0.04	1.897PheArg: 1.897 ± 0.042	2.831PheSer: 2.831 ± 0.067	2.022PheThr: 2.022 ± 0.055	2.461PheVal: 2.461 ± 0.064	0.525PheTrp: 0.525 ± 0.029	1.128PheTyr: 1.128 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.744GlyAla: 5.744 ± 0.091	0.942GlyCys: 0.942 ± 0.037	4.39GlyAsp: 4.39 ± 0.091	5.128GlyGlu: 5.128 ± 0.092	3.266GlyPhe: 3.266 ± 0.066	5.695GlyGly: 5.695 ± 0.121	1.868GlyHis: 1.868 ± 0.048	5.277GlyIle: 5.277 ± 0.088	4.142GlyLys: 4.142 ± 0.07	7.19GlyLeu: 7.19 ± 0.122	2.571GlyMet: 2.571 ± 0.065	2.558GlyAsn: 2.558 ± 0.068	2.06GlyPro: 2.06 ± 0.053	2.423GlyGln: 2.423 ± 0.065	3.963GlyArg: 3.963 ± 0.078	4.596GlySer: 4.596 ± 0.084	3.938GlyThr: 3.938 ± 0.071	5.5GlyVal: 5.5 ± 0.089	1.074GlyTrp: 1.074 ± 0.041	2.524GlyTyr: 2.524 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.074HisAla: 2.074 ± 0.057	0.303HisCys: 0.303 ± 0.02	1.362HisAsp: 1.362 ± 0.036	1.479HisGlu: 1.479 ± 0.05	1.0HisPhe: 1.0 ± 0.04	1.889HisGly: 1.889 ± 0.061	0.732HisHis: 0.732 ± 0.027	1.316HisIle: 1.316 ± 0.043	0.945HisLys: 0.945 ± 0.039	2.574HisLeu: 2.574 ± 0.056	0.58HisMet: 0.58 ± 0.027	0.794HisAsn: 0.794 ± 0.036	1.368HisPro: 1.368 ± 0.041	0.93HisGln: 0.93 ± 0.035	1.334HisArg: 1.334 ± 0.04	1.309HisSer: 1.309 ± 0.041	1.105HisThr: 1.105 ± 0.042	1.477HisVal: 1.477 ± 0.045	0.386HisTrp: 0.386 ± 0.021	0.815HisTyr: 0.815 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.198IleAla: 6.198 ± 0.089	0.58IleCys: 0.58 ± 0.028	4.58IleAsp: 4.58 ± 0.074	4.777IleGlu: 4.777 ± 0.077	2.011IlePhe: 2.011 ± 0.059	5.013IleGly: 5.013 ± 0.1	1.381IleHis: 1.381 ± 0.039	3.609IleIle: 3.609 ± 0.073	2.584IleLys: 2.584 ± 0.058	5.494IleLeu: 5.494 ± 0.094	1.349IleMet: 1.349 ± 0.043	2.439IleAsn: 2.439 ± 0.053	2.852IlePro: 2.852 ± 0.065	1.76IleGln: 1.76 ± 0.048	3.412IleArg: 3.412 ± 0.067	4.139IleSer: 4.139 ± 0.083	3.4IleThr: 3.4 ± 0.064	3.882IleVal: 3.882 ± 0.087	0.578IleTrp: 0.578 ± 0.029	1.638IleTyr: 1.638 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.134LysAla: 4.134 ± 0.092	0.344LysCys: 0.344 ± 0.022	2.076LysAsp: 2.076 ± 0.053	3.104LysGlu: 3.104 ± 0.068	1.181LysPhe: 1.181 ± 0.042	3.204LysGly: 3.204 ± 0.072	1.075LysHis: 1.075 ± 0.037	2.563LysIle: 2.563 ± 0.058	2.791LysLys: 2.791 ± 0.088	4.442LysLeu: 4.442 ± 0.074	1.304LysMet: 1.304 ± 0.041	1.583LysAsn: 1.583 ± 0.047	2.178LysPro: 2.178 ± 0.049	2.323LysGln: 2.323 ± 0.055	2.988LysArg: 2.988 ± 0.062	2.947LysSer: 2.947 ± 0.068	2.375LysThr: 2.375 ± 0.056	2.963LysVal: 2.963 ± 0.061	0.53LysTrp: 0.53 ± 0.028	1.04LysTyr: 1.04 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	9.656LeuAla: 9.656 ± 0.13	0.967LeuCys: 0.967 ± 0.038	6.164LeuAsp: 6.164 ± 0.088	6.715LeuGlu: 6.715 ± 0.104	4.405LeuPhe: 4.405 ± 0.094	7.18LeuGly: 7.18 ± 0.102	2.357LeuHis: 2.357 ± 0.054	5.909LeuIle: 5.909 ± 0.098	4.551LeuLys: 4.551 ± 0.073	11.676LeuLeu: 11.676 ± 0.184	2.643LeuMet: 2.643 ± 0.062	3.384LeuAsn: 3.384 ± 0.06	5.049LeuPro: 5.049 ± 0.091	3.81LeuGln: 3.81 ± 0.074	5.37LeuArg: 5.37 ± 0.085	6.572LeuSer: 6.572 ± 0.097	5.266LeuThr: 5.266 ± 0.085	7.406LeuVal: 7.406 ± 0.115	1.087LeuTrp: 1.087 ± 0.048	2.698LeuTyr: 2.698 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.687MetAla: 2.687 ± 0.068	0.209MetCys: 0.209 ± 0.016	1.447MetAsp: 1.447 ± 0.04	1.639MetGlu: 1.639 ± 0.039	0.813MetPhe: 0.813 ± 0.036	1.906MetGly: 1.906 ± 0.048	0.698MetHis: 0.698 ± 0.03	1.691MetIle: 1.691 ± 0.046	1.564MetLys: 1.564 ± 0.049	2.961MetLeu: 2.961 ± 0.058	0.888MetMet: 0.888 ± 0.033	1.158MetAsn: 1.158 ± 0.041	1.486MetPro: 1.486 ± 0.043	1.382MetGln: 1.382 ± 0.04	1.636MetArg: 1.636 ± 0.045	1.943MetSer: 1.943 ± 0.059	1.676MetThr: 1.676 ± 0.048	1.793MetVal: 1.793 ± 0.052	0.229MetTrp: 0.229 ± 0.017	0.466MetTyr: 0.466 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.946AsnAla: 2.946 ± 0.067	0.417AsnCys: 0.417 ± 0.024	1.902AsnAsp: 1.902 ± 0.051	2.054AsnGlu: 2.054 ± 0.052	1.271AsnPhe: 1.271 ± 0.045	2.74AsnGly: 2.74 ± 0.068	0.872AsnHis: 0.872 ± 0.034	2.179AsnIle: 2.179 ± 0.052	1.58AsnLys: 1.58 ± 0.05	3.446AsnLeu: 3.446 ± 0.071	0.963AsnMet: 0.963 ± 0.032	1.387AsnAsn: 1.387 ± 0.043	2.073AsnPro: 2.073 ± 0.049	1.348AsnGln: 1.348 ± 0.039	2.192AsnArg: 2.192 ± 0.052	2.309AsnSer: 2.309 ± 0.065	1.677AsnThr: 1.677 ± 0.055	1.975AsnVal: 1.975 ± 0.042	0.567AsnTrp: 0.567 ± 0.027	1.061AsnTyr: 1.061 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.904ProAla: 3.904 ± 0.086	0.337ProCys: 0.337 ± 0.02	3.227ProAsp: 3.227 ± 0.065	3.633ProGlu: 3.633 ± 0.09	1.737ProPhe: 1.737 ± 0.043	3.619ProGly: 3.619 ± 0.074	0.985ProHis: 0.985 ± 0.033	2.156ProIle: 2.156 ± 0.057	1.561ProLys: 1.561 ± 0.045	4.394ProLeu: 4.394 ± 0.079	1.176ProMet: 1.176 ± 0.046	1.304ProAsn: 1.304 ± 0.041	1.762ProPro: 1.762 ± 0.058	1.656ProGln: 1.656 ± 0.044	1.835ProArg: 1.835 ± 0.052	2.216ProSer: 2.216 ± 0.051	1.946ProThr: 1.946 ± 0.054	3.995ProVal: 3.995 ± 0.065	0.609ProTrp: 0.609 ± 0.025	1.224ProTyr: 1.224 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.638GlnAla: 3.638 ± 0.074	0.324GlnCys: 0.324 ± 0.022	1.583GlnAsp: 1.583 ± 0.046	2.446GlnGlu: 2.446 ± 0.064	1.295GlnPhe: 1.295 ± 0.04	2.532GlnGly: 2.532 ± 0.055	1.034GlnHis: 1.034 ± 0.039	1.994GlnIle: 1.994 ± 0.053	1.789GlnLys: 1.789 ± 0.051	4.655GlnLeu: 4.655 ± 0.097	1.129GlnMet: 1.129 ± 0.042	1.097GlnAsn: 1.097 ± 0.039	1.707GlnPro: 1.707 ± 0.046	2.539GlnGln: 2.539 ± 0.075	2.475GlnArg: 2.475 ± 0.068	2.144GlnSer: 2.144 ± 0.062	1.734GlnThr: 1.734 ± 0.053	2.728GlnVal: 2.728 ± 0.063	0.492GlnTrp: 0.492 ± 0.028	0.862GlnTyr: 0.862 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	4.122ArgAla: 4.122 ± 0.082	0.584ArgCys: 0.584 ± 0.027	3.169ArgAsp: 3.169 ± 0.073	4.184ArgGlu: 4.184 ± 0.081	2.383ArgPhe: 2.383 ± 0.055	3.38ArgGly: 3.38 ± 0.082	1.52ArgHis: 1.52 ± 0.046	3.882ArgIle: 3.882 ± 0.077	2.782ArgLys: 2.782 ± 0.06	6.238ArgLeu: 6.238 ± 0.1	1.649ArgMet: 1.649 ± 0.048	2.083ArgAsn: 2.083 ± 0.047	2.153ArgPro: 2.153 ± 0.057	2.417ArgGln: 2.417 ± 0.062	3.517ArgArg: 3.517 ± 0.071	3.098ArgSer: 3.098 ± 0.062	2.539ArgThr: 2.539 ± 0.059	3.844ArgVal: 3.844 ± 0.079	0.783ArgTrp: 0.783 ± 0.03	1.81ArgTyr: 1.81 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.516SerAla: 5.516 ± 0.079	0.734SerCys: 0.734 ± 0.032	3.905SerAsp: 3.905 ± 0.075	4.1SerGlu: 4.1 ± 0.085	2.39SerPhe: 2.39 ± 0.051	5.675SerGly: 5.675 ± 0.107	1.544SerHis: 1.544 ± 0.045	3.722SerIle: 3.722 ± 0.073	2.494SerLys: 2.494 ± 0.059	6.585SerLeu: 6.585 ± 0.103	1.867SerMet: 1.867 ± 0.055	2.249SerAsn: 2.249 ± 0.055	2.45SerPro: 2.45 ± 0.058	2.109SerGln: 2.109 ± 0.061	3.755SerArg: 3.755 ± 0.071	3.986SerSer: 3.986 ± 0.091	2.875SerThr: 2.875 ± 0.058	4.371SerVal: 4.371 ± 0.066	0.825SerTrp: 0.825 ± 0.034	1.776SerTyr: 1.776 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.772ThrAla: 4.772 ± 0.076	0.533ThrCys: 0.533 ± 0.027	3.068ThrAsp: 3.068 ± 0.068	3.02ThrGlu: 3.02 ± 0.074	1.721ThrPhe: 1.721 ± 0.049	4.595ThrGly: 4.595 ± 0.082	1.197ThrHis: 1.197 ± 0.04	3.305ThrIle: 3.305 ± 0.07	1.629ThrLys: 1.629 ± 0.049	5.736ThrLeu: 5.736 ± 0.103	1.251ThrMet: 1.251 ± 0.04	1.62ThrAsn: 1.62 ± 0.046	2.892ThrPro: 2.892 ± 0.058	1.62ThrGln: 1.62 ± 0.049	2.826ThrArg: 2.826 ± 0.063	3.24ThrSer: 3.24 ± 0.062	2.826ThrThr: 2.826 ± 0.064	3.733ThrVal: 3.733 ± 0.076	0.619ThrTrp: 0.619 ± 0.033	1.236ThrTyr: 1.236 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.68ValAla: 6.68 ± 0.108	0.745ValCys: 0.745 ± 0.035	4.343ValAsp: 4.343 ± 0.065	5.011ValGlu: 5.011 ± 0.091	2.436ValPhe: 2.436 ± 0.054	4.654ValGly: 4.654 ± 0.091	1.426ValHis: 1.426 ± 0.042	4.836ValIle: 4.836 ± 0.075	2.877ValLys: 2.877 ± 0.063	6.542ValLeu: 6.542 ± 0.099	2.02ValMet: 2.02 ± 0.047	2.461ValAsn: 2.461 ± 0.06	2.976ValPro: 2.976 ± 0.071	2.005ValGln: 2.005 ± 0.049	3.66ValArg: 3.66 ± 0.063	4.85ValSer: 4.85 ± 0.074	4.404ValThr: 4.404 ± 0.074	5.453ValVal: 5.453 ± 0.096	0.774ValTrp: 0.774 ± 0.034	1.706ValTyr: 1.706 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.825TrpAla: 0.825 ± 0.036	0.17TrpCys: 0.17 ± 0.013	0.588TrpAsp: 0.588 ± 0.029	0.698TrpGlu: 0.698 ± 0.03	0.607TrpPhe: 0.607 ± 0.035	0.843TrpGly: 0.843 ± 0.041	0.372TrpHis: 0.372 ± 0.023	0.804TrpIle: 0.804 ± 0.035	0.648TrpLys: 0.648 ± 0.029	1.647TrpLeu: 1.647 ± 0.058	0.407TrpMet: 0.407 ± 0.023	0.471TrpAsn: 0.471 ± 0.027	0.489TrpPro: 0.489 ± 0.029	0.697TrpGln: 0.697 ± 0.035	0.776TrpArg: 0.776 ± 0.029	0.768TrpSer: 0.768 ± 0.031	0.531TrpThr: 0.531 ± 0.023	0.838TrpVal: 0.838 ± 0.034	0.196TrpTrp: 0.196 ± 0.016	0.383TrpTyr: 0.383 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.326TyrAla: 2.326 ± 0.053	0.328TyrCys: 0.328 ± 0.02	1.599TyrAsp: 1.599 ± 0.047	1.637TyrGlu: 1.637 ± 0.042	1.182TyrPhe: 1.182 ± 0.044	2.138TyrGly: 2.138 ± 0.052	0.623TyrHis: 0.623 ± 0.026	1.484TyrIle: 1.484 ± 0.039	1.11TyrLys: 1.11 ± 0.042	3.032TyrLeu: 3.032 ± 0.068	0.622TyrMet: 0.622 ± 0.023	0.937TyrAsn: 0.937 ± 0.038	1.251TyrPro: 1.251 ± 0.042	1.242TyrGln: 1.242 ± 0.039	1.823TyrArg: 1.823 ± 0.052	1.831TyrSer: 1.831 ± 0.043	1.44TyrThr: 1.44 ± 0.042	1.698TyrVal: 1.698 ± 0.047	0.406TyrTrp: 0.406 ± 0.024	0.943TyrTyr: 0.943 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2657 proteins (796070 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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