Amino acid dipepetide frequency for Aureibaculum marinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.605AlaAla: 3.605 ± 0.073	0.486AlaCys: 0.486 ± 0.022	3.068AlaAsp: 3.068 ± 0.065	3.7AlaGlu: 3.7 ± 0.061	2.959AlaPhe: 2.959 ± 0.058	3.634AlaGly: 3.634 ± 0.06	0.993AlaHis: 0.993 ± 0.033	5.473AlaIle: 5.473 ± 0.08	4.689AlaLys: 4.689 ± 0.082	5.666AlaLeu: 5.666 ± 0.081	1.364AlaMet: 1.364 ± 0.04	3.427AlaAsn: 3.427 ± 0.061	1.661AlaPro: 1.661 ± 0.042	2.14AlaGln: 2.14 ± 0.047	1.735AlaArg: 1.735 ± 0.045	3.869AlaSer: 3.869 ± 0.056	3.552AlaThr: 3.552 ± 0.065	3.638AlaVal: 3.638 ± 0.07	0.59AlaTrp: 0.59 ± 0.023	2.416AlaTyr: 2.416 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.354CysAla: 0.354 ± 0.018	0.073CysCys: 0.073 ± 0.009	0.428CysAsp: 0.428 ± 0.022	0.375CysGlu: 0.375 ± 0.02	0.317CysPhe: 0.317 ± 0.016	0.545CysGly: 0.545 ± 0.031	0.161CysHis: 0.161 ± 0.016	0.513CysIle: 0.513 ± 0.023	0.537CysLys: 0.537 ± 0.023	0.526CysLeu: 0.526 ± 0.023	0.119CysMet: 0.119 ± 0.011	0.432CysAsn: 0.432 ± 0.019	0.278CysPro: 0.278 ± 0.017	0.179CysGln: 0.179 ± 0.013	0.17CysArg: 0.17 ± 0.013	0.476CysSer: 0.476 ± 0.023	0.43CysThr: 0.43 ± 0.019	0.358CysVal: 0.358 ± 0.019	0.068CysTrp: 0.068 ± 0.009	0.267CysTyr: 0.267 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.421AspAla: 3.421 ± 0.07	0.365AspCys: 0.365 ± 0.022	2.995AspAsp: 2.995 ± 0.071	3.59AspGlu: 3.59 ± 0.06	3.518AspPhe: 3.518 ± 0.053	3.921AspGly: 3.921 ± 0.136	0.778AspHis: 0.778 ± 0.028	4.597AspIle: 4.597 ± 0.066	4.78AspLys: 4.78 ± 0.067	4.96AspLeu: 4.96 ± 0.083	1.006AspMet: 1.006 ± 0.032	3.717AspAsn: 3.717 ± 0.081	1.464AspPro: 1.464 ± 0.045	1.392AspGln: 1.392 ± 0.04	1.721AspArg: 1.721 ± 0.038	3.404AspSer: 3.404 ± 0.066	2.801AspThr: 2.801 ± 0.05	3.681AspVal: 3.681 ± 0.066	0.772AspTrp: 0.772 ± 0.025	2.893AspTyr: 2.893 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	3.92GluAla: 3.92 ± 0.071	0.287GluCys: 0.287 ± 0.018	3.433GluAsp: 3.433 ± 0.056	4.525GluGlu: 4.525 ± 0.082	2.859GluPhe: 2.859 ± 0.06	3.619GluGly: 3.619 ± 0.062	1.124GluHis: 1.124 ± 0.033	5.739GluIle: 5.739 ± 0.079	6.242GluLys: 6.242 ± 0.079	6.07GluLeu: 6.07 ± 0.085	1.508GluMet: 1.508 ± 0.042	5.176GluAsn: 5.176 ± 0.082	1.566GluPro: 1.566 ± 0.039	2.253GluGln: 2.253 ± 0.053	2.162GluArg: 2.162 ± 0.049	3.265GluSer: 3.265 ± 0.059	3.397GluThr: 3.397 ± 0.064	4.277GluVal: 4.277 ± 0.073	0.635GluTrp: 0.635 ± 0.023	2.397GluTyr: 2.397 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	2.575PheAla: 2.575 ± 0.056	0.336PheCys: 0.336 ± 0.02	3.284PheAsp: 3.284 ± 0.055	3.288PheGlu: 3.288 ± 0.057	2.481PhePhe: 2.481 ± 0.062	3.437PheGly: 3.437 ± 0.061	0.765PheHis: 0.765 ± 0.032	4.178PheIle: 4.178 ± 0.089	4.264PheLys: 4.264 ± 0.064	4.723PheLeu: 4.723 ± 0.082	1.008PheMet: 1.008 ± 0.031	3.649PheAsn: 3.649 ± 0.069	1.645PhePro: 1.645 ± 0.045	1.327PheGln: 1.327 ± 0.038	1.479PheArg: 1.479 ± 0.036	3.934PheSer: 3.934 ± 0.066	3.1PheThr: 3.1 ± 0.055	2.896PheVal: 2.896 ± 0.053	0.557PheTrp: 0.557 ± 0.023	2.291PheTyr: 2.291 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	3.968GlyAla: 3.968 ± 0.086	0.503GlyCys: 0.503 ± 0.025	3.352GlyAsp: 3.352 ± 0.089	3.503GlyGlu: 3.503 ± 0.075	3.421GlyPhe: 3.421 ± 0.062	4.405GlyGly: 4.405 ± 0.089	1.064GlyHis: 1.064 ± 0.032	5.554GlyIle: 5.554 ± 0.089	5.202GlyLys: 5.202 ± 0.081	5.749GlyLeu: 5.749 ± 0.09	1.429GlyMet: 1.429 ± 0.04	3.836GlyAsn: 3.836 ± 0.075	1.316GlyPro: 1.316 ± 0.041	1.763GlyGln: 1.763 ± 0.041	1.915GlyArg: 1.915 ± 0.042	3.83GlySer: 3.83 ± 0.068	3.874GlyThr: 3.874 ± 0.087	4.363GlyVal: 4.363 ± 0.076	0.764GlyTrp: 0.764 ± 0.028	2.939GlyTyr: 2.939 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	0.862HisAla: 0.862 ± 0.03	0.15HisCys: 0.15 ± 0.011	0.775HisAsp: 0.775 ± 0.027	0.825HisGlu: 0.825 ± 0.03	1.093HisPhe: 1.093 ± 0.036	1.073HisGly: 1.073 ± 0.033	0.427HisHis: 0.427 ± 0.022	1.404HisIle: 1.404 ± 0.042	1.323HisLys: 1.323 ± 0.04	1.768HisLeu: 1.768 ± 0.045	0.281HisMet: 0.281 ± 0.015	1.049HisAsn: 1.049 ± 0.03	0.835HisPro: 0.835 ± 0.034	0.699HisGln: 0.699 ± 0.025	0.63HisArg: 0.63 ± 0.023	1.063HisSer: 1.063 ± 0.035	0.892HisThr: 0.892 ± 0.03	0.818HisVal: 0.818 ± 0.03	0.214HisTrp: 0.214 ± 0.016	0.822HisTyr: 0.822 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.535IleAla: 5.535 ± 0.085	0.615IleCys: 0.615 ± 0.026	5.497IleAsp: 5.497 ± 0.078	5.854IleGlu: 5.854 ± 0.072	3.768IlePhe: 3.768 ± 0.066	5.286IleGly: 5.286 ± 0.075	1.376IleHis: 1.376 ± 0.038	6.834IleIle: 6.834 ± 0.093	6.948IleLys: 6.948 ± 0.095	7.395IleLeu: 7.395 ± 0.12	1.383IleMet: 1.383 ± 0.039	5.489IleAsn: 5.489 ± 0.084	3.329IlePro: 3.329 ± 0.063	2.435IleGln: 2.435 ± 0.051	2.607IleArg: 2.607 ± 0.047	6.003IleSer: 6.003 ± 0.068	5.167IleThr: 5.167 ± 0.081	5.0IleVal: 5.0 ± 0.078	0.692IleTrp: 0.692 ± 0.028	3.13IleTyr: 3.13 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	4.897LysAla: 4.897 ± 0.069	0.364LysCys: 0.364 ± 0.019	4.688LysAsp: 4.688 ± 0.075	6.63LysGlu: 6.63 ± 0.105	3.378LysPhe: 3.378 ± 0.058	4.926LysGly: 4.926 ± 0.083	1.494LysHis: 1.494 ± 0.037	7.304LysIle: 7.304 ± 0.098	8.101LysLys: 8.101 ± 0.11	7.381LysLeu: 7.381 ± 0.097	2.032LysMet: 2.032 ± 0.048	6.616LysAsn: 6.616 ± 0.106	2.684LysPro: 2.684 ± 0.053	2.942LysGln: 2.942 ± 0.055	2.933LysArg: 2.933 ± 0.064	4.997LysSer: 4.997 ± 0.079	5.02LysThr: 5.02 ± 0.066	4.967LysVal: 4.967 ± 0.079	0.851LysTrp: 0.851 ± 0.028	3.495LysTyr: 3.495 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	5.42LeuAla: 5.42 ± 0.086	0.589LeuCys: 0.589 ± 0.025	5.037LeuAsp: 5.037 ± 0.082	6.137LeuGlu: 6.137 ± 0.086	4.914LeuPhe: 4.914 ± 0.086	5.607LeuGly: 5.607 ± 0.082	1.561LeuHis: 1.561 ± 0.035	7.383LeuIle: 7.383 ± 0.112	8.562LeuLys: 8.562 ± 0.107	8.671LeuLeu: 8.671 ± 0.125	1.95LeuMet: 1.95 ± 0.045	6.063LeuAsn: 6.063 ± 0.088	3.38LeuPro: 3.38 ± 0.059	2.951LeuGln: 2.951 ± 0.055	2.871LeuArg: 2.871 ± 0.052	6.626LeuSer: 6.626 ± 0.082	5.274LeuThr: 5.274 ± 0.07	5.324LeuVal: 5.324 ± 0.076	0.784LeuTrp: 0.784 ± 0.034	3.192LeuTyr: 3.192 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.492MetAla: 1.492 ± 0.036	0.132MetCys: 0.132 ± 0.01	1.047MetAsp: 1.047 ± 0.031	1.195MetGlu: 1.195 ± 0.034	0.781MetPhe: 0.781 ± 0.03	1.251MetGly: 1.251 ± 0.036	0.338MetHis: 0.338 ± 0.016	1.492MetIle: 1.492 ± 0.04	1.975MetLys: 1.975 ± 0.039	1.875MetLeu: 1.875 ± 0.047	0.541MetMet: 0.541 ± 0.026	1.22MetAsn: 1.22 ± 0.033	0.846MetPro: 0.846 ± 0.025	0.785MetGln: 0.785 ± 0.025	0.781MetArg: 0.781 ± 0.027	1.42MetSer: 1.42 ± 0.04	1.018MetThr: 1.018 ± 0.031	1.337MetVal: 1.337 ± 0.038	0.172MetTrp: 0.172 ± 0.013	0.736MetTyr: 0.736 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.849AsnAla: 3.849 ± 0.06	0.447AsnCys: 0.447 ± 0.021	3.556AsnAsp: 3.556 ± 0.066	3.881AsnGlu: 3.881 ± 0.057	3.451AsnPhe: 3.451 ± 0.06	4.141AsnGly: 4.141 ± 0.086	1.148AsnHis: 1.148 ± 0.033	5.459AsnIle: 5.459 ± 0.072	5.451AsnLys: 5.451 ± 0.086	6.057AsnLeu: 6.057 ± 0.083	1.313AsnMet: 1.313 ± 0.036	4.743AsnAsn: 4.743 ± 0.088	2.836AsnPro: 2.836 ± 0.06	2.333AsnGln: 2.333 ± 0.054	2.197AsnArg: 2.197 ± 0.044	4.365AsnSer: 4.365 ± 0.073	4.113AsnThr: 4.113 ± 0.064	3.751AsnVal: 3.751 ± 0.074	0.835AsnTrp: 0.835 ± 0.027	3.531AsnTyr: 3.531 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	1.567ProAla: 1.567 ± 0.037	0.198ProCys: 0.198 ± 0.014	2.014ProAsp: 2.014 ± 0.058	2.63ProGlu: 2.63 ± 0.052	1.791ProPhe: 1.791 ± 0.041	1.754ProGly: 1.754 ± 0.042	0.583ProHis: 0.583 ± 0.021	3.001ProIle: 3.001 ± 0.044	2.83ProLys: 2.83 ± 0.059	2.925ProLeu: 2.925 ± 0.057	0.635ProMet: 0.635 ± 0.03	2.328ProAsn: 2.328 ± 0.053	0.814ProPro: 0.814 ± 0.029	0.983ProGln: 0.983 ± 0.027	0.874ProArg: 0.874 ± 0.03	2.19ProSer: 2.19 ± 0.045	2.014ProThr: 2.014 ± 0.046	1.949ProVal: 1.949 ± 0.044	0.384ProTrp: 0.384 ± 0.023	1.458ProTyr: 1.458 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	1.656GlnAla: 1.656 ± 0.043	0.144GlnCys: 0.144 ± 0.011	1.502GlnAsp: 1.502 ± 0.036	2.091GlnGlu: 2.091 ± 0.047	1.681GlnPhe: 1.681 ± 0.046	1.771GlnGly: 1.771 ± 0.059	0.642GlnHis: 0.642 ± 0.026	2.639GlnIle: 2.639 ± 0.049	2.856GlnLys: 2.856 ± 0.053	3.559GlnLeu: 3.559 ± 0.066	0.736GlnMet: 0.736 ± 0.026	2.121GlnAsn: 2.121 ± 0.047	1.007GlnPro: 1.007 ± 0.032	1.401GlnGln: 1.401 ± 0.044	1.095GlnArg: 1.095 ± 0.032	1.865GlnSer: 1.865 ± 0.044	1.693GlnThr: 1.693 ± 0.048	1.641GlnVal: 1.641 ± 0.037	0.352GlnTrp: 0.352 ± 0.016	1.307GlnTyr: 1.307 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	1.956ArgAla: 1.956 ± 0.042	0.163ArgCys: 0.163 ± 0.012	1.589ArgAsp: 1.589 ± 0.036	1.919ArgGlu: 1.919 ± 0.048	1.687ArgPhe: 1.687 ± 0.04	1.825ArgGly: 1.825 ± 0.045	0.567ArgHis: 0.567 ± 0.025	2.785ArgIle: 2.785 ± 0.05	2.846ArgLys: 2.846 ± 0.061	2.959ArgLeu: 2.959 ± 0.059	0.781ArgMet: 0.781 ± 0.025	2.067ArgAsn: 2.067 ± 0.045	1.05ArgPro: 1.05 ± 0.031	0.906ArgGln: 0.906 ± 0.03	1.214ArgArg: 1.214 ± 0.042	1.748ArgSer: 1.748 ± 0.044	1.78ArgThr: 1.78 ± 0.04	1.992ArgVal: 1.992 ± 0.042	0.392ArgTrp: 0.392 ± 0.02	1.412ArgTyr: 1.412 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.383SerAla: 3.383 ± 0.065	0.614SerCys: 0.614 ± 0.027	3.624SerAsp: 3.624 ± 0.076	4.112SerGlu: 4.112 ± 0.068	3.852SerPhe: 3.852 ± 0.069	4.395SerGly: 4.395 ± 0.074	1.025SerHis: 1.025 ± 0.029	5.84SerIle: 5.84 ± 0.073	5.442SerLys: 5.442 ± 0.079	5.898SerLeu: 5.898 ± 0.08	1.132SerMet: 1.132 ± 0.031	4.264SerAsn: 4.264 ± 0.069	2.014SerPro: 2.014 ± 0.05	1.859SerGln: 1.859 ± 0.039	1.984SerArg: 1.984 ± 0.048	4.345SerSer: 4.345 ± 0.082	3.723SerThr: 3.723 ± 0.063	3.88SerVal: 3.88 ± 0.065	0.738SerTrp: 0.738 ± 0.028	2.931SerTyr: 2.931 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	3.408ThrAla: 3.408 ± 0.073	0.306ThrCys: 0.306 ± 0.021	3.315ThrAsp: 3.315 ± 0.077	3.565ThrGlu: 3.565 ± 0.057	2.962ThrPhe: 2.962 ± 0.051	3.936ThrGly: 3.936 ± 0.087	1.015ThrHis: 1.015 ± 0.03	5.429ThrIle: 5.429 ± 0.085	4.375ThrLys: 4.375 ± 0.066	5.396ThrLeu: 5.396 ± 0.065	0.983ThrMet: 0.983 ± 0.034	3.643ThrAsn: 3.643 ± 0.069	2.32ThrPro: 2.32 ± 0.056	1.687ThrGln: 1.687 ± 0.041	1.507ThrArg: 1.507 ± 0.04	3.888ThrSer: 3.888 ± 0.066	3.667ThrThr: 3.667 ± 0.069	3.745ThrVal: 3.745 ± 0.072	0.539ThrTrp: 0.539 ± 0.025	2.47ThrTyr: 2.47 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	3.774ValAla: 3.774 ± 0.071	0.44ValCys: 0.44 ± 0.022	3.557ValAsp: 3.557 ± 0.063	3.846ValGlu: 3.846 ± 0.065	3.18ValPhe: 3.18 ± 0.06	3.83ValGly: 3.83 ± 0.058	0.9ValHis: 0.9 ± 0.028	4.857ValIle: 4.857 ± 0.077	4.876ValLys: 4.876 ± 0.072	5.819ValLeu: 5.819 ± 0.086	1.21ValMet: 1.21 ± 0.036	3.822ValAsn: 3.822 ± 0.072	2.075ValPro: 2.075 ± 0.051	1.668ValGln: 1.668 ± 0.04	1.785ValArg: 1.785 ± 0.04	4.333ValSer: 4.333 ± 0.07	3.588ValThr: 3.588 ± 0.08	4.124ValVal: 4.124 ± 0.074	0.556ValTrp: 0.556 ± 0.023	2.385ValTyr: 2.385 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.605TrpAla: 0.605 ± 0.03	0.084TrpCys: 0.084 ± 0.009	0.619TrpAsp: 0.619 ± 0.025	0.601TrpGlu: 0.601 ± 0.024	0.556TrpPhe: 0.556 ± 0.025	0.668TrpGly: 0.668 ± 0.026	0.22TrpHis: 0.22 ± 0.015	0.825TrpIle: 0.825 ± 0.03	0.855TrpLys: 0.855 ± 0.025	0.987TrpLeu: 0.987 ± 0.035	0.291TrpMet: 0.291 ± 0.017	0.729TrpAsn: 0.729 ± 0.026	0.247TrpPro: 0.247 ± 0.017	0.446TrpGln: 0.446 ± 0.021	0.386TrpArg: 0.386 ± 0.019	0.681TrpSer: 0.681 ± 0.031	0.506TrpThr: 0.506 ± 0.022	0.614TrpVal: 0.614 ± 0.024	0.155TrpTrp: 0.155 ± 0.014	0.466TrpTyr: 0.466 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.419TyrAla: 2.419 ± 0.045	0.31TyrCys: 0.31 ± 0.018	2.396TyrAsp: 2.396 ± 0.047	2.188TyrGlu: 2.188 ± 0.045	2.566TyrPhe: 2.566 ± 0.051	2.725TyrGly: 2.725 ± 0.058	0.824TyrHis: 0.824 ± 0.03	3.039TyrIle: 3.039 ± 0.056	3.544TyrLys: 3.544 ± 0.065	3.913TyrLeu: 3.913 ± 0.068	0.727TyrMet: 0.727 ± 0.025	3.065TyrAsn: 3.065 ± 0.06	1.557TyrPro: 1.557 ± 0.037	1.607TyrGln: 1.607 ± 0.042	1.594TyrArg: 1.594 ± 0.041	2.754TyrSer: 2.754 ± 0.058	2.545TyrThr: 2.545 ± 0.047	2.27TyrVal: 2.27 ± 0.049	0.493TyrTrp: 0.493 ± 0.025	2.062TyrTyr: 2.062 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3096 proteins (1089046 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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