Amino acid dipepetide frequency for Okibacterium fritillariae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.368AlaAla: 19.368 ± 0.235
0.54AlaCys: 0.54 ± 0.022
8.537AlaAsp: 8.537 ± 0.099
7.736AlaGlu: 7.736 ± 0.111
3.839AlaPhe: 3.839 ± 0.067
11.806AlaGly: 11.806 ± 0.131
2.251AlaHis: 2.251 ± 0.061
5.927AlaIle: 5.927 ± 0.083
2.816AlaLys: 2.816 ± 0.065
13.345AlaLeu: 13.345 ± 0.166
2.212AlaMet: 2.212 ± 0.048
2.642AlaAsn: 2.642 ± 0.063
6.759AlaPro: 6.759 ± 0.13
3.843AlaGln: 3.843 ± 0.066
8.154AlaArg: 8.154 ± 0.105
8.746AlaSer: 8.746 ± 0.108
7.838AlaThr: 7.838 ± 0.109
10.601AlaVal: 10.601 ± 0.124
1.656AlaTrp: 1.656 ± 0.044
2.244AlaTyr: 2.244 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.54CysAla: 0.54 ± 0.027
0.045CysCys: 0.045 ± 0.007
0.259CysAsp: 0.259 ± 0.016
0.218CysGlu: 0.218 ± 0.017
0.147CysPhe: 0.147 ± 0.014
0.491CysGly: 0.491 ± 0.02
0.1CysHis: 0.1 ± 0.012
0.176CysIle: 0.176 ± 0.013
0.047CysLys: 0.047 ± 0.007
0.402CysLeu: 0.402 ± 0.018
0.062CysMet: 0.062 ± 0.007
0.112CysAsn: 0.112 ± 0.012
0.242CysPro: 0.242 ± 0.02
0.104CysGln: 0.104 ± 0.012
0.266CysArg: 0.266 ± 0.017
0.289CysSer: 0.289 ± 0.018
0.308CysThr: 0.308 ± 0.019
0.364CysVal: 0.364 ± 0.019
0.054CysTrp: 0.054 ± 0.008
0.092CysTyr: 0.092 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
9.162AspAla: 9.162 ± 0.137
0.24AspCys: 0.24 ± 0.015
4.781AspAsp: 4.781 ± 0.092
4.414AspGlu: 4.414 ± 0.084
1.752AspPhe: 1.752 ± 0.046
6.2AspGly: 6.2 ± 0.198
1.072AspHis: 1.072 ± 0.034
2.635AspIle: 2.635 ± 0.054
1.218AspLys: 1.218 ± 0.048
6.005AspLeu: 6.005 ± 0.078
0.774AspMet: 0.774 ± 0.029
1.345AspAsn: 1.345 ± 0.038
3.747AspPro: 3.747 ± 0.084
1.721AspGln: 1.721 ± 0.041
4.217AspArg: 4.217 ± 0.091
3.13AspSer: 3.13 ± 0.08
3.547AspThr: 3.547 ± 0.101
5.583AspVal: 5.583 ± 0.084
0.911AspTrp: 0.911 ± 0.035
1.502AspTyr: 1.502 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
6.909GluAla: 6.909 ± 0.101
0.196GluCys: 0.196 ± 0.016
2.54GluAsp: 2.54 ± 0.059
2.615GluGlu: 2.615 ± 0.065
1.72GluPhe: 1.72 ± 0.044
3.777GluGly: 3.777 ± 0.073
1.356GluHis: 1.356 ± 0.043
2.627GluIle: 2.627 ± 0.067
1.736GluLys: 1.736 ± 0.051
5.908GluLeu: 5.908 ± 0.097
0.939GluMet: 0.939 ± 0.034
1.492GluAsn: 1.492 ± 0.043
2.917GluPro: 2.917 ± 0.065
2.196GluGln: 2.196 ± 0.049
5.001GluArg: 5.001 ± 0.097
3.049GluSer: 3.049 ± 0.061
3.366GluThr: 3.366 ± 0.068
4.047GluVal: 4.047 ± 0.068
0.792GluTrp: 0.792 ± 0.033
1.102GluTyr: 1.102 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.199PheAla: 4.199 ± 0.075
0.163PheCys: 0.163 ± 0.013
2.464PheAsp: 2.464 ± 0.056
1.808PheGlu: 1.808 ± 0.048
1.242PhePhe: 1.242 ± 0.051
3.677PheGly: 3.677 ± 0.069
0.499PheHis: 0.499 ± 0.023
1.299PheIle: 1.299 ± 0.047
0.475PheLys: 0.475 ± 0.026
2.846PheLeu: 2.846 ± 0.069
0.428PheMet: 0.428 ± 0.022
0.702PheAsn: 0.702 ± 0.035
1.376PhePro: 1.376 ± 0.033
0.871PheGln: 0.871 ± 0.032
1.73PheArg: 1.73 ± 0.047
1.967PheSer: 1.967 ± 0.051
2.113PheThr: 2.113 ± 0.051
3.006PheVal: 3.006 ± 0.066
0.498PheTrp: 0.498 ± 0.024
0.672PheTyr: 0.672 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
10.525GlyAla: 10.525 ± 0.138
0.506GlyCys: 0.506 ± 0.024
5.207GlyAsp: 5.207 ± 0.11
4.637GlyGlu: 4.637 ± 0.074
3.305GlyPhe: 3.305 ± 0.059
7.306GlyGly: 7.306 ± 0.104
1.787GlyHis: 1.787 ± 0.045
4.78GlyIle: 4.78 ± 0.096
2.304GlyLys: 2.304 ± 0.053
8.592GlyLeu: 8.592 ± 0.11
1.74GlyMet: 1.74 ± 0.045
2.034GlyAsn: 2.034 ± 0.058
3.692GlyPro: 3.692 ± 0.066
2.886GlyGln: 2.886 ± 0.077
5.756GlyArg: 5.756 ± 0.085
6.213GlySer: 6.213 ± 0.1
5.853GlyThr: 5.853 ± 0.101
7.631GlyVal: 7.631 ± 0.106
1.525GlyTrp: 1.525 ± 0.047
2.161GlyTyr: 2.161 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.243HisAla: 2.243 ± 0.054
0.074HisCys: 0.074 ± 0.009
1.295HisAsp: 1.295 ± 0.036
1.051HisGlu: 1.051 ± 0.035
0.519HisPhe: 0.519 ± 0.025
1.767HisGly: 1.767 ± 0.042
0.508HisHis: 0.508 ± 0.026
0.767HisIle: 0.767 ± 0.029
0.301HisLys: 0.301 ± 0.017
1.845HisLeu: 1.845 ± 0.051
0.292HisMet: 0.292 ± 0.017
0.412HisAsn: 0.412 ± 0.019
1.46HisPro: 1.46 ± 0.045
0.507HisGln: 0.507 ± 0.024
1.399HisArg: 1.399 ± 0.043
1.003HisSer: 1.003 ± 0.034
1.11HisThr: 1.11 ± 0.035
1.456HisVal: 1.456 ± 0.042
0.243HisTrp: 0.243 ± 0.017
0.42HisTyr: 0.42 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.665IleAla: 6.665 ± 0.103
0.213IleCys: 0.213 ± 0.015
3.673IleAsp: 3.673 ± 0.063
2.924IleGlu: 2.924 ± 0.06
1.376IlePhe: 1.376 ± 0.043
4.572IleGly: 4.572 ± 0.086
0.663IleHis: 0.663 ± 0.026
2.006IleIle: 2.006 ± 0.051
0.932IleLys: 0.932 ± 0.036
4.071IleLeu: 4.071 ± 0.087
0.637IleMet: 0.637 ± 0.028
1.029IleAsn: 1.029 ± 0.032
2.65IlePro: 2.65 ± 0.072
1.12IleGln: 1.12 ± 0.042
2.773IleArg: 2.773 ± 0.061
2.463IleSer: 2.463 ± 0.052
2.937IleThr: 2.937 ± 0.065
4.926IleVal: 4.926 ± 0.077
0.477IleTrp: 0.477 ± 0.022
0.866IleTyr: 0.866 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
2.618LysAla: 2.618 ± 0.053
0.065LysCys: 0.065 ± 0.008
1.218LysAsp: 1.218 ± 0.043
0.973LysGlu: 0.973 ± 0.037
0.589LysPhe: 0.589 ± 0.03
1.583LysGly: 1.583 ± 0.046
0.512LysHis: 0.512 ± 0.027
1.109LysIle: 1.109 ± 0.036
1.13LysLys: 1.13 ± 0.041
2.208LysLeu: 2.208 ± 0.046
0.464LysMet: 0.464 ± 0.022
0.803LysAsn: 0.803 ± 0.033
1.6LysPro: 1.6 ± 0.057
0.834LysGln: 0.834 ± 0.032
1.76LysArg: 1.76 ± 0.042
1.318LysSer: 1.318 ± 0.043
1.58LysThr: 1.58 ± 0.047
1.873LysVal: 1.873 ± 0.05
0.269LysTrp: 0.269 ± 0.015
0.489LysTyr: 0.489 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
13.424LeuAla: 13.424 ± 0.158
0.451LeuCys: 0.451 ± 0.02
6.575LeuAsp: 6.575 ± 0.097
5.037LeuGlu: 5.037 ± 0.094
3.087LeuPhe: 3.087 ± 0.073
8.934LeuGly: 8.934 ± 0.117
1.774LeuHis: 1.774 ± 0.045
4.8LeuIle: 4.8 ± 0.104
2.017LeuLys: 2.017 ± 0.052
9.671LeuLeu: 9.671 ± 0.146
1.548LeuMet: 1.548 ± 0.046
2.082LeuAsn: 2.082 ± 0.053
5.36LeuPro: 5.36 ± 0.075
2.479LeuGln: 2.479 ± 0.051
6.392LeuArg: 6.392 ± 0.088
6.133LeuSer: 6.133 ± 0.082
6.346LeuThr: 6.346 ± 0.09
9.082LeuVal: 9.082 ± 0.126
1.21LeuTrp: 1.21 ± 0.042
1.685LeuTyr: 1.685 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
1.909MetAla: 1.909 ± 0.049
0.088MetCys: 0.088 ± 0.011
0.694MetAsp: 0.694 ± 0.028
0.523MetGlu: 0.523 ± 0.024
0.525MetPhe: 0.525 ± 0.025
1.202MetGly: 1.202 ± 0.039
0.294MetHis: 0.294 ± 0.018
0.811MetIle: 0.811 ± 0.029
0.449MetLys: 0.449 ± 0.023
1.67MetLeu: 1.67 ± 0.041
0.291MetMet: 0.291 ± 0.02
0.47MetAsn: 0.47 ± 0.022
1.06MetPro: 1.06 ± 0.034
0.539MetGln: 0.539 ± 0.026
1.135MetArg: 1.135 ± 0.038
1.55MetSer: 1.55 ± 0.037
1.605MetThr: 1.605 ± 0.041
1.253MetVal: 1.253 ± 0.04
0.171MetTrp: 0.171 ± 0.014
0.261MetTyr: 0.261 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.93AsnAla: 2.93 ± 0.065
0.112AsnCys: 0.112 ± 0.011
1.413AsnAsp: 1.413 ± 0.043
1.192AsnGlu: 1.192 ± 0.039
0.744AsnPhe: 0.744 ± 0.03
2.349AsnGly: 2.349 ± 0.066
0.384AsnHis: 0.384 ± 0.023
1.016AsnIle: 1.016 ± 0.033
0.571AsnLys: 0.571 ± 0.028
2.098AsnLeu: 2.098 ± 0.05
0.376AsnMet: 0.376 ± 0.023
0.602AsnAsn: 0.602 ± 0.032
1.852AsnPro: 1.852 ± 0.044
0.673AsnGln: 0.673 ± 0.029
1.457AsnArg: 1.457 ± 0.042
1.133AsnSer: 1.133 ± 0.039
1.469AsnThr: 1.469 ± 0.049
1.998AsnVal: 1.998 ± 0.051
0.321AsnTrp: 0.321 ± 0.019
0.601AsnTyr: 0.601 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
7.471ProAla: 7.471 ± 0.136
0.166ProCys: 0.166 ± 0.015
3.989ProAsp: 3.989 ± 0.135
3.608ProGlu: 3.608 ± 0.074
1.739ProPhe: 1.739 ± 0.041
5.057ProGly: 5.057 ± 0.089
1.124ProHis: 1.124 ± 0.031
2.162ProIle: 2.162 ± 0.039
1.179ProLys: 1.179 ± 0.038
4.921ProLeu: 4.921 ± 0.072
0.695ProMet: 0.695 ± 0.028
1.3ProAsn: 1.3 ± 0.044
2.12ProPro: 2.12 ± 0.067
1.621ProGln: 1.621 ± 0.049
3.22ProArg: 3.22 ± 0.069
3.599ProSer: 3.599 ± 0.077
4.006ProThr: 4.006 ± 0.113
4.77ProVal: 4.77 ± 0.081
0.754ProTrp: 0.754 ± 0.031
1.078ProTyr: 1.078 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.936GlnAla: 3.936 ± 0.074
0.096GlnCys: 0.096 ± 0.011
1.2GlnAsp: 1.2 ± 0.038
1.167GlnGlu: 1.167 ± 0.038
0.877GlnPhe: 0.877 ± 0.032
2.089GlnGly: 2.089 ± 0.057
0.64GlnHis: 0.64 ± 0.03
1.583GlnIle: 1.583 ± 0.043
0.961GlnLys: 0.961 ± 0.034
3.236GlnLeu: 3.236 ± 0.06
0.514GlnMet: 0.514 ± 0.024
0.91GlnAsn: 0.91 ± 0.037
1.877GlnPro: 1.877 ± 0.062
1.329GlnGln: 1.329 ± 0.057
2.245GlnArg: 2.245 ± 0.052
1.694GlnSer: 1.694 ± 0.044
1.776GlnThr: 1.776 ± 0.043
2.55GlnVal: 2.55 ± 0.054
0.399GlnTrp: 0.399 ± 0.017
0.655GlnTyr: 0.655 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
8.072ArgAla: 8.072 ± 0.111
0.236ArgCys: 0.236 ± 0.017
4.079ArgAsp: 4.079 ± 0.083
3.904ArgGlu: 3.904 ± 0.072
2.312ArgPhe: 2.312 ± 0.053
5.028ArgGly: 5.028 ± 0.079
1.4ArgHis: 1.4 ± 0.045
3.221ArgIle: 3.221 ± 0.059
1.422ArgLys: 1.422 ± 0.043
6.486ArgLeu: 6.486 ± 0.111
1.551ArgMet: 1.551 ± 0.042
1.441ArgAsn: 1.441 ± 0.037
3.291ArgPro: 3.291 ± 0.063
2.179ArgGln: 2.179 ± 0.046
5.809ArgArg: 5.809 ± 0.111
4.181ArgSer: 4.181 ± 0.073
4.021ArgThr: 4.021 ± 0.072
5.663ArgVal: 5.663 ± 0.086
1.044ArgTrp: 1.044 ± 0.033
1.525ArgTyr: 1.525 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
8.066SerAla: 8.066 ± 0.125
0.232SerCys: 0.232 ± 0.018
3.93SerAsp: 3.93 ± 0.085
3.029SerGlu: 3.029 ± 0.053
2.092SerPhe: 2.092 ± 0.05
6.407SerGly: 6.407 ± 0.102
1.061SerHis: 1.061 ± 0.032
2.996SerIle: 2.996 ± 0.065
1.472SerLys: 1.472 ± 0.05
5.676SerLeu: 5.676 ± 0.08
1.103SerMet: 1.103 ± 0.034
1.502SerAsn: 1.502 ± 0.047
3.436SerPro: 3.436 ± 0.068
1.62SerGln: 1.62 ± 0.041
3.902SerArg: 3.902 ± 0.073
4.357SerSer: 4.357 ± 0.086
4.38SerThr: 4.38 ± 0.075
5.111SerVal: 5.111 ± 0.08
0.917SerTrp: 0.917 ± 0.033
1.248SerTyr: 1.248 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
7.87ThrAla: 7.87 ± 0.128
0.264ThrCys: 0.264 ± 0.018
4.224ThrAsp: 4.224 ± 0.093
3.118ThrGlu: 3.118 ± 0.056
2.066ThrPhe: 2.066 ± 0.051
6.194ThrGly: 6.194 ± 0.1
1.102ThrHis: 1.102 ± 0.035
3.157ThrIle: 3.157 ± 0.065
1.429ThrLys: 1.429 ± 0.048
6.346ThrLeu: 6.346 ± 0.096
0.862ThrMet: 0.862 ± 0.032
1.507ThrAsn: 1.507 ± 0.048
4.709ThrPro: 4.709 ± 0.108
1.695ThrGln: 1.695 ± 0.038
3.646ThrArg: 3.646 ± 0.062
4.069ThrSer: 4.069 ± 0.078
4.225ThrThr: 4.225 ± 0.08
6.026ThrVal: 6.026 ± 0.098
0.869ThrTrp: 0.869 ± 0.031
1.274ThrTyr: 1.274 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
11.232ValAla: 11.232 ± 0.131
0.435ValCys: 0.435 ± 0.021
5.759ValAsp: 5.759 ± 0.088
4.687ValGlu: 4.687 ± 0.072
2.858ValPhe: 2.858 ± 0.06
7.088ValGly: 7.088 ± 0.094
1.575ValHis: 1.575 ± 0.047
4.503ValIle: 4.503 ± 0.08
1.788ValLys: 1.788 ± 0.048
8.924ValLeu: 8.924 ± 0.116
1.392ValMet: 1.392 ± 0.045
1.928ValAsn: 1.928 ± 0.056
4.633ValPro: 4.633 ± 0.071
2.271ValGln: 2.271 ± 0.05
5.357ValArg: 5.357 ± 0.076
5.51ValSer: 5.51 ± 0.078
6.073ValThr: 6.073 ± 0.104
8.452ValVal: 8.452 ± 0.117
1.139ValTrp: 1.139 ± 0.034
1.53ValTyr: 1.53 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
1.482TrpAla: 1.482 ± 0.048
0.103TrpCys: 0.103 ± 0.009
0.679TrpAsp: 0.679 ± 0.033
0.513TrpGlu: 0.513 ± 0.025
0.539TrpPhe: 0.539 ± 0.021
0.994TrpGly: 0.994 ± 0.035
0.294TrpHis: 0.294 ± 0.018
0.627TrpIle: 0.627 ± 0.03
0.361TrpLys: 0.361 ± 0.019
1.646TrpLeu: 1.646 ± 0.044
0.352TrpMet: 0.352 ± 0.018
0.463TrpAsn: 0.463 ± 0.025
0.701TrpPro: 0.701 ± 0.026
0.619TrpGln: 0.619 ± 0.026
1.081TrpArg: 1.081 ± 0.038
0.89TrpSer: 0.89 ± 0.038
0.855TrpThr: 0.855 ± 0.032
1.104TrpVal: 1.104 ± 0.036
0.342TrpTrp: 0.342 ± 0.022
0.268TrpTyr: 0.268 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.236TyrAla: 2.236 ± 0.056
0.095TyrCys: 0.095 ± 0.011
1.438TyrAsp: 1.438 ± 0.046
1.132TyrGlu: 1.132 ± 0.04
0.706TyrPhe: 0.706 ± 0.029
1.92TyrGly: 1.92 ± 0.057
0.274TyrHis: 0.274 ± 0.016
0.771TyrIle: 0.771 ± 0.033
0.389TyrLys: 0.389 ± 0.021
2.193TyrLeu: 2.193 ± 0.052
0.262TyrMet: 0.262 ± 0.019
0.517TyrAsn: 0.517 ± 0.024
1.1TyrPro: 1.1 ± 0.038
0.626TyrGln: 0.626 ± 0.027
1.565TyrArg: 1.565 ± 0.045
1.243TyrSer: 1.243 ± 0.038
1.243TyrThr: 1.243 ± 0.042
1.636TyrVal: 1.636 ± 0.044
0.325TyrTrp: 0.325 ± 0.017
0.5TyrTyr: 0.5 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2806 proteins (947544 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski