Amino acid dipepetide frequency for Geodermatophilus dictyosporus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	26.201AlaAla: 26.201 ± 0.268	0.934AlaCys: 0.934 ± 0.027	9.496AlaAsp: 9.496 ± 0.089	9.007AlaGlu: 9.007 ± 0.107	3.376AlaPhe: 3.376 ± 0.057	15.978AlaGly: 15.978 ± 0.138	2.605AlaHis: 2.605 ± 0.043	3.034AlaIle: 3.034 ± 0.056	1.494AlaLys: 1.494 ± 0.043	16.027AlaLeu: 16.027 ± 0.146	2.34AlaMet: 2.34 ± 0.044	1.545AlaAsn: 1.545 ± 0.036	8.131AlaPro: 8.131 ± 0.112	3.576AlaGln: 3.576 ± 0.058	11.838AlaArg: 11.838 ± 0.131	5.363AlaSer: 5.363 ± 0.066	7.743AlaThr: 7.743 ± 0.083	15.497AlaVal: 15.497 ± 0.137	1.978AlaTrp: 1.978 ± 0.044	2.151AlaTyr: 2.151 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.922CysAla: 0.922 ± 0.025	0.096CysCys: 0.096 ± 0.009	0.424CysAsp: 0.424 ± 0.018	0.313CysGlu: 0.313 ± 0.016	0.164CysPhe: 0.164 ± 0.011	0.852CysGly: 0.852 ± 0.028	0.133CysHis: 0.133 ± 0.01	0.135CysIle: 0.135 ± 0.01	0.055CysLys: 0.055 ± 0.006	0.654CysLeu: 0.654 ± 0.021	0.081CysMet: 0.081 ± 0.008	0.088CysAsn: 0.088 ± 0.007	0.47CysPro: 0.47 ± 0.017	0.128CysGln: 0.128 ± 0.009	0.584CysArg: 0.584 ± 0.019	0.343CysSer: 0.343 ± 0.016	0.467CysThr: 0.467 ± 0.019	0.55CysVal: 0.55 ± 0.019	0.106CysTrp: 0.106 ± 0.008	0.115CysTyr: 0.115 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.505AspAla: 8.505 ± 0.092	0.341AspCys: 0.341 ± 0.017	4.469AspAsp: 4.469 ± 0.069	3.885AspGlu: 3.885 ± 0.061	1.312AspPhe: 1.312 ± 0.031	6.75AspGly: 6.75 ± 0.081	1.131AspHis: 1.131 ± 0.027	1.044AspIle: 1.044 ± 0.033	0.601AspLys: 0.601 ± 0.025	7.258AspLeu: 7.258 ± 0.068	0.609AspMet: 0.609 ± 0.021	0.643AspAsn: 0.643 ± 0.024	5.198AspPro: 5.198 ± 0.066	1.362AspGln: 1.362 ± 0.034	5.713AspArg: 5.713 ± 0.069	2.005AspSer: 2.005 ± 0.039	2.967AspThr: 2.967 ± 0.044	6.87AspVal: 6.87 ± 0.075	0.969AspTrp: 0.969 ± 0.026	0.919AspTyr: 0.919 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.311GluAla: 7.311 ± 0.1	0.295GluCys: 0.295 ± 0.014	3.129GluAsp: 3.129 ± 0.051	3.493GluGlu: 3.493 ± 0.064	1.256GluPhe: 1.256 ± 0.03	4.343GluGly: 4.343 ± 0.062	1.536GluHis: 1.536 ± 0.032	1.524GluIle: 1.524 ± 0.036	0.778GluLys: 0.778 ± 0.031	6.678GluLeu: 6.678 ± 0.083	0.716GluMet: 0.716 ± 0.027	0.642GluAsn: 0.642 ± 0.024	3.296GluPro: 3.296 ± 0.056	2.328GluGln: 2.328 ± 0.045	5.38GluArg: 5.38 ± 0.067	2.028GluSer: 2.028 ± 0.045	2.58GluThr: 2.58 ± 0.046	5.886GluVal: 5.886 ± 0.076	0.725GluTrp: 0.725 ± 0.024	0.872GluTyr: 0.872 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.47PheAla: 3.47 ± 0.058	0.228PheCys: 0.228 ± 0.014	1.78PheAsp: 1.78 ± 0.039	1.2PheGlu: 1.2 ± 0.031	0.748PhePhe: 0.748 ± 0.023	2.825PheGly: 2.825 ± 0.053	0.421PheHis: 0.421 ± 0.019	0.513PheIle: 0.513 ± 0.021	0.287PheLys: 0.287 ± 0.017	2.496PheLeu: 2.496 ± 0.049	0.28PheMet: 0.28 ± 0.015	0.385PheAsn: 0.385 ± 0.018	1.311PhePro: 1.311 ± 0.032	0.512PheGln: 0.512 ± 0.02	1.732PheArg: 1.732 ± 0.036	1.267PheSer: 1.267 ± 0.035	1.697PheThr: 1.697 ± 0.04	2.417PheVal: 2.417 ± 0.043	0.358PheTrp: 0.358 ± 0.016	0.461PheTyr: 0.461 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	12.369GlyAla: 12.369 ± 0.109	0.779GlyCys: 0.779 ± 0.028	5.687GlyAsp: 5.687 ± 0.062	5.364GlyGlu: 5.364 ± 0.069	2.718GlyPhe: 2.718 ± 0.049	9.621GlyGly: 9.621 ± 0.103	1.999GlyHis: 1.999 ± 0.04	2.857GlyIle: 2.857 ± 0.058	1.387GlyLys: 1.387 ± 0.036	10.566GlyLeu: 10.566 ± 0.127	1.797GlyMet: 1.797 ± 0.041	1.384GlyAsn: 1.384 ± 0.038	5.89GlyPro: 5.89 ± 0.073	2.735GlyGln: 2.735 ± 0.051	9.045GlyArg: 9.045 ± 0.092	5.355GlySer: 5.355 ± 0.073	6.507GlyThr: 6.507 ± 0.081	9.157GlyVal: 9.157 ± 0.086	1.852GlyTrp: 1.852 ± 0.036	2.095GlyTyr: 2.095 ± 0.042	0.001GlyXaa: 0.001 ± 0.001
His	2.453HisAla: 2.453 ± 0.044	0.173HisCys: 0.173 ± 0.011	1.245HisAsp: 1.245 ± 0.029	1.044HisGlu: 1.044 ± 0.029	0.487HisPhe: 0.487 ± 0.018	2.187HisGly: 2.187 ± 0.04	0.565HisHis: 0.565 ± 0.027	0.283HisIle: 0.283 ± 0.014	0.181HisLys: 0.181 ± 0.013	2.361HisLeu: 2.361 ± 0.051	0.215HisMet: 0.215 ± 0.011	0.245HisAsn: 0.245 ± 0.013	1.719HisPro: 1.719 ± 0.035	0.472HisGln: 0.472 ± 0.017	1.93HisArg: 1.93 ± 0.041	0.755HisSer: 0.755 ± 0.023	0.938HisThr: 0.938 ± 0.026	1.994HisVal: 1.994 ± 0.039	0.292HisTrp: 0.292 ± 0.015	0.346HisTyr: 0.346 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.64IleAla: 3.64 ± 0.058	0.192IleCys: 0.192 ± 0.012	1.705IleAsp: 1.705 ± 0.039	1.45IleGlu: 1.45 ± 0.036	0.34IlePhe: 0.34 ± 0.018	2.871IleGly: 2.871 ± 0.057	0.323IleHis: 0.323 ± 0.015	0.495IleIle: 0.495 ± 0.024	0.343IleLys: 0.343 ± 0.018	1.437IleLeu: 1.437 ± 0.041	0.269IleMet: 0.269 ± 0.015	0.417IleAsn: 0.417 ± 0.018	1.248IlePro: 1.248 ± 0.036	0.478IleGln: 0.478 ± 0.019	1.693IleArg: 1.693 ± 0.042	1.185IleSer: 1.185 ± 0.029	1.541IleThr: 1.541 ± 0.035	2.09IleVal: 2.09 ± 0.044	0.26IleTrp: 0.26 ± 0.015	0.33IleTyr: 0.33 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	1.525LysAla: 1.525 ± 0.039	0.048LysCys: 0.048 ± 0.005	0.698LysAsp: 0.698 ± 0.028	0.587LysGlu: 0.587 ± 0.023	0.216LysPhe: 0.216 ± 0.012	0.965LysGly: 0.965 ± 0.039	0.242LysHis: 0.242 ± 0.013	0.366LysIle: 0.366 ± 0.02	0.347LysLys: 0.347 ± 0.021	1.113LysLeu: 1.113 ± 0.037	0.209LysMet: 0.209 ± 0.014	0.219LysAsn: 0.219 ± 0.014	0.72LysPro: 0.72 ± 0.024	0.374LysGln: 0.374 ± 0.019	0.934LysArg: 0.934 ± 0.031	0.542LysSer: 0.542 ± 0.026	0.766LysThr: 0.766 ± 0.029	1.149LysVal: 1.149 ± 0.034	0.134LysTrp: 0.134 ± 0.012	0.228LysTyr: 0.228 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	17.944LeuAla: 17.944 ± 0.174	0.704LeuCys: 0.704 ± 0.023	7.129LeuAsp: 7.129 ± 0.089	4.902LeuGlu: 4.902 ± 0.067	2.485LeuPhe: 2.485 ± 0.058	10.245LeuGly: 10.245 ± 0.125	2.056LeuHis: 2.056 ± 0.042	1.863LeuIle: 1.863 ± 0.047	1.032LeuLys: 1.032 ± 0.03	12.363LeuLeu: 12.363 ± 0.14	1.209LeuMet: 1.209 ± 0.03	1.156LeuAsn: 1.156 ± 0.032	7.102LeuPro: 7.102 ± 0.093	2.585LeuGln: 2.585 ± 0.045	8.987LeuArg: 8.987 ± 0.09	4.983LeuSer: 4.983 ± 0.067	6.897LeuThr: 6.897 ± 0.075	11.718LeuVal: 11.718 ± 0.124	1.241LeuTrp: 1.241 ± 0.031	1.509LeuTyr: 1.509 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.081MetAla: 2.081 ± 0.043	0.094MetCys: 0.094 ± 0.007	0.754MetAsp: 0.754 ± 0.021	0.539MetGlu: 0.539 ± 0.021	0.281MetPhe: 0.281 ± 0.017	1.193MetGly: 1.193 ± 0.032	0.254MetHis: 0.254 ± 0.013	0.378MetIle: 0.378 ± 0.015	0.218MetLys: 0.218 ± 0.014	1.216MetLeu: 1.216 ± 0.035	0.173MetMet: 0.173 ± 0.013	0.264MetAsn: 0.264 ± 0.013	0.94MetPro: 0.94 ± 0.028	0.367MetGln: 0.367 ± 0.017	1.178MetArg: 1.178 ± 0.03	1.202MetSer: 1.202 ± 0.026	1.556MetThr: 1.556 ± 0.037	1.25MetVal: 1.25 ± 0.027	0.15MetTrp: 0.15 ± 0.009	0.214MetTyr: 0.214 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	1.759AsnAla: 1.759 ± 0.036	0.104AsnCys: 0.104 ± 0.009	0.704AsnAsp: 0.704 ± 0.026	0.591AsnGlu: 0.591 ± 0.02	0.345AsnPhe: 0.345 ± 0.018	1.275AsnGly: 1.275 ± 0.036	0.263AsnHis: 0.263 ± 0.012	0.35AsnIle: 0.35 ± 0.018	0.181AsnLys: 0.181 ± 0.013	1.298AsnLeu: 1.298 ± 0.029	0.19AsnMet: 0.19 ± 0.014	0.242AsnAsn: 0.242 ± 0.015	1.002AsnPro: 1.002 ± 0.029	0.313AsnGln: 0.313 ± 0.017	1.029AsnArg: 1.029 ± 0.028	0.567AsnSer: 0.567 ± 0.021	0.757AsnThr: 0.757 ± 0.027	1.214AsnVal: 1.214 ± 0.032	0.188AsnTrp: 0.188 ± 0.014	0.27AsnTyr: 0.27 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	10.547ProAla: 10.547 ± 0.114	0.283ProCys: 0.283 ± 0.014	4.812ProAsp: 4.812 ± 0.066	4.173ProGlu: 4.173 ± 0.06	1.519ProPhe: 1.519 ± 0.035	7.703ProGly: 7.703 ± 0.09	1.251ProHis: 1.251 ± 0.032	1.11ProIle: 1.11 ± 0.029	0.585ProLys: 0.585 ± 0.023	5.675ProLeu: 5.675 ± 0.064	0.902ProMet: 0.902 ± 0.028	0.67ProAsn: 0.67 ± 0.021	4.55ProPro: 4.55 ± 0.097	1.498ProGln: 1.498 ± 0.034	4.476ProArg: 4.476 ± 0.064	2.968ProSer: 2.968 ± 0.054	3.445ProThr: 3.445 ± 0.061	6.81ProVal: 6.81 ± 0.088	0.979ProTrp: 0.979 ± 0.025	0.986ProTyr: 0.986 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.67GlnAla: 3.67 ± 0.057	0.132GlnCys: 0.132 ± 0.011	1.181GlnAsp: 1.181 ± 0.03	1.32GlnGlu: 1.32 ± 0.029	0.637GlnPhe: 0.637 ± 0.019	1.932GlnGly: 1.932 ± 0.037	0.572GlnHis: 0.572 ± 0.017	0.735GlnIle: 0.735 ± 0.025	0.335GlnLys: 0.335 ± 0.018	3.131GlnLeu: 3.131 ± 0.051	0.427GlnMet: 0.427 ± 0.019	0.336GlnAsn: 0.336 ± 0.017	1.606GlnPro: 1.606 ± 0.04	1.111GlnGln: 1.111 ± 0.034	2.519GlnArg: 2.519 ± 0.042	0.917GlnSer: 0.917 ± 0.026	1.308GlnThr: 1.308 ± 0.031	2.835GlnVal: 2.835 ± 0.047	0.375GlnTrp: 0.375 ± 0.017	0.499GlnTyr: 0.499 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	11.542ArgAla: 11.542 ± 0.118	0.535ArgCys: 0.535 ± 0.02	4.609ArgAsp: 4.609 ± 0.066	4.743ArgGlu: 4.743 ± 0.062	2.228ArgPhe: 2.228 ± 0.047	6.612ArgGly: 6.612 ± 0.08	1.836ArgHis: 1.836 ± 0.039	2.258ArgIle: 2.258 ± 0.044	0.945ArgLys: 0.945 ± 0.031	9.591ArgLeu: 9.591 ± 0.1	1.64ArgMet: 1.64 ± 0.032	1.029ArgAsn: 1.029 ± 0.027	5.872ArgPro: 5.872 ± 0.086	2.269ArgGln: 2.269 ± 0.038	9.167ArgArg: 9.167 ± 0.099	4.249ArgSer: 4.249 ± 0.059	5.278ArgThr: 5.278 ± 0.055	7.475ArgVal: 7.475 ± 0.082	1.579ArgTrp: 1.579 ± 0.038	1.695ArgTyr: 1.695 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.382SerAla: 6.382 ± 0.073	0.33SerCys: 0.33 ± 0.017	2.367SerAsp: 2.367 ± 0.04	1.897SerGlu: 1.897 ± 0.043	1.334SerPhe: 1.334 ± 0.032	5.358SerGly: 5.358 ± 0.07	0.795SerHis: 0.795 ± 0.021	1.206SerIle: 1.206 ± 0.032	0.513SerLys: 0.513 ± 0.022	4.413SerLeu: 4.413 ± 0.069	0.914SerMet: 0.914 ± 0.024	0.612SerAsn: 0.612 ± 0.021	3.164SerPro: 3.164 ± 0.051	0.991SerGln: 0.991 ± 0.029	3.668SerArg: 3.668 ± 0.051	2.642SerSer: 2.642 ± 0.057	2.954SerThr: 2.954 ± 0.047	4.186SerVal: 4.186 ± 0.058	0.834SerTrp: 0.834 ± 0.029	0.938SerTyr: 0.938 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.253ThrAla: 9.253 ± 0.097	0.386ThrCys: 0.386 ± 0.018	3.62ThrAsp: 3.62 ± 0.051	2.977ThrGlu: 2.977 ± 0.051	1.392ThrPhe: 1.392 ± 0.034	7.094ThrGly: 7.094 ± 0.074	1.017ThrHis: 1.017 ± 0.023	1.443ThrIle: 1.443 ± 0.035	0.64ThrLys: 0.64 ± 0.029	5.532ThrLeu: 5.532 ± 0.064	0.799ThrMet: 0.799 ± 0.022	0.802ThrAsn: 0.802 ± 0.024	4.251ThrPro: 4.251 ± 0.066	1.195ThrGln: 1.195 ± 0.032	4.171ThrArg: 4.171 ± 0.057	2.877ThrSer: 2.877 ± 0.044	3.937ThrThr: 3.937 ± 0.087	6.491ThrVal: 6.491 ± 0.075	0.964ThrTrp: 0.964 ± 0.031	0.999ThrTyr: 0.999 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	14.619ValAla: 14.619 ± 0.136	0.747ValCys: 0.747 ± 0.024	6.67ValAsp: 6.67 ± 0.068	5.72ValGlu: 5.72 ± 0.071	2.63ValPhe: 2.63 ± 0.049	8.416ValGly: 8.416 ± 0.088	2.249ValHis: 2.249 ± 0.049	2.085ValIle: 2.085 ± 0.049	1.076ValLys: 1.076 ± 0.028	12.611ValLeu: 12.611 ± 0.123	1.156ValMet: 1.156 ± 0.034	1.463ValAsn: 1.463 ± 0.034	6.728ValPro: 6.728 ± 0.065	2.371ValGln: 2.371 ± 0.044	8.154ValArg: 8.154 ± 0.089	4.473ValSer: 4.473 ± 0.051	6.564ValThr: 6.564 ± 0.069	12.355ValVal: 12.355 ± 0.132	1.175ValTrp: 1.175 ± 0.033	1.568ValTyr: 1.568 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.798TrpAla: 1.798 ± 0.043	0.137TrpCys: 0.137 ± 0.01	0.854TrpAsp: 0.854 ± 0.027	0.632TrpGlu: 0.632 ± 0.021	0.473TrpPhe: 0.473 ± 0.021	1.046TrpGly: 1.046 ± 0.029	0.358TrpHis: 0.358 ± 0.015	0.355TrpIle: 0.355 ± 0.015	0.169TrpLys: 0.169 ± 0.012	1.861TrpLeu: 1.861 ± 0.043	0.223TrpMet: 0.223 ± 0.013	0.254TrpAsn: 0.254 ± 0.015	0.854TrpPro: 0.854 ± 0.029	0.49TrpGln: 0.49 ± 0.019	1.398TrpArg: 1.398 ± 0.033	1.001TrpSer: 1.001 ± 0.03	0.999TrpThr: 0.999 ± 0.031	1.229TrpVal: 1.229 ± 0.032	0.358TrpTrp: 0.358 ± 0.017	0.308TrpTyr: 0.308 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.323TyrAla: 2.323 ± 0.041	0.141TyrCys: 0.141 ± 0.011	1.221TyrAsp: 1.221 ± 0.028	0.956TyrGlu: 0.956 ± 0.024	0.446TyrPhe: 0.446 ± 0.017	1.9TyrGly: 1.9 ± 0.053	0.278TyrHis: 0.278 ± 0.014	0.273TyrIle: 0.273 ± 0.015	0.215TyrLys: 0.215 ± 0.014	1.832TyrLeu: 1.832 ± 0.035	0.153TyrMet: 0.153 ± 0.01	0.246TyrAsn: 0.246 ± 0.013	0.888TyrPro: 0.888 ± 0.028	0.424TyrGln: 0.424 ± 0.02	1.553TyrArg: 1.553 ± 0.035	0.775TyrSer: 0.775 ± 0.024	0.941TyrThr: 0.941 ± 0.03	1.656TyrVal: 1.656 ± 0.037	0.283TyrTrp: 0.283 ± 0.017	0.324TyrTyr: 0.324 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.01XaaXaa: 0.01 ± 0.011

Statistics based on 4366 proteins (1400948 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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