Amino acid dipepetide frequency for Acaryochloris sp. RCC1774

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.009AlaAla: 9.009 ± 0.092
0.938AlaCys: 0.938 ± 0.027
4.81AlaAsp: 4.81 ± 0.063
5.952AlaGlu: 5.952 ± 0.076
3.183AlaPhe: 3.183 ± 0.045
6.16AlaGly: 6.16 ± 0.078
1.69AlaHis: 1.69 ± 0.034
6.298AlaIle: 6.298 ± 0.064
3.626AlaLys: 3.626 ± 0.054
10.271AlaLeu: 10.271 ± 0.093
1.922AlaMet: 1.922 ± 0.036
3.032AlaAsn: 3.032 ± 0.054
3.703AlaPro: 3.703 ± 0.049
5.339AlaGln: 5.339 ± 0.064
3.868AlaArg: 3.868 ± 0.052
5.543AlaSer: 5.543 ± 0.063
5.229AlaThr: 5.229 ± 0.055
6.336AlaVal: 6.336 ± 0.071
1.136AlaTrp: 1.136 ± 0.027
2.34AlaTyr: 2.34 ± 0.038
0.001AlaXaa: 0.001 ± 0.001
Cys
0.687CysAla: 0.687 ± 0.021
0.181CysCys: 0.181 ± 0.013
0.759CysAsp: 0.759 ± 0.025
0.502CysGlu: 0.502 ± 0.019
0.419CysPhe: 0.419 ± 0.015
0.81CysGly: 0.81 ± 0.025
0.313CysHis: 0.313 ± 0.015
0.577CysIle: 0.577 ± 0.019
0.298CysLys: 0.298 ± 0.013
1.235CysLeu: 1.235 ± 0.023
0.171CysMet: 0.171 ± 0.01
0.303CysAsn: 0.303 ± 0.014
0.579CysPro: 0.579 ± 0.021
0.635CysGln: 0.635 ± 0.023
0.62CysArg: 0.62 ± 0.02
0.702CysSer: 0.702 ± 0.021
0.495CysThr: 0.495 ± 0.019
0.554CysVal: 0.554 ± 0.018
0.172CysTrp: 0.172 ± 0.009
0.31CysTyr: 0.31 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.519AspAla: 4.519 ± 0.059
0.615AspCys: 0.615 ± 0.021
2.563AspAsp: 2.563 ± 0.056
2.756AspGlu: 2.756 ± 0.044
2.291AspPhe: 2.291 ± 0.044
3.595AspGly: 3.595 ± 0.071
1.074AspHis: 1.074 ± 0.03
3.104AspIle: 3.104 ± 0.048
1.552AspLys: 1.552 ± 0.033
6.794AspLeu: 6.794 ± 0.078
0.791AspMet: 0.791 ± 0.02
1.549AspAsn: 1.549 ± 0.034
2.955AspPro: 2.955 ± 0.05
2.987AspGln: 2.987 ± 0.049
3.595AspArg: 3.595 ± 0.05
3.17AspSer: 3.17 ± 0.044
2.446AspThr: 2.446 ± 0.051
3.399AspVal: 3.399 ± 0.053
0.975AspTrp: 0.975 ± 0.025
1.763AspTyr: 1.763 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
6.195GluAla: 6.195 ± 0.063
0.42GluCys: 0.42 ± 0.015
2.808GluAsp: 2.808 ± 0.045
3.469GluGlu: 3.469 ± 0.053
1.992GluPhe: 1.992 ± 0.037
3.615GluGly: 3.615 ± 0.056
1.228GluHis: 1.228 ± 0.033
3.809GluIle: 3.809 ± 0.049
2.583GluLys: 2.583 ± 0.047
6.549GluLeu: 6.549 ± 0.068
1.324GluMet: 1.324 ± 0.027
2.0GluAsn: 2.0 ± 0.033
2.675GluPro: 2.675 ± 0.043
4.356GluGln: 4.356 ± 0.068
3.675GluArg: 3.675 ± 0.053
3.601GluSer: 3.601 ± 0.051
3.752GluThr: 3.752 ± 0.048
4.138GluVal: 4.138 ± 0.054
0.721GluTrp: 0.721 ± 0.026
1.362GluTyr: 1.362 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
3.25PheAla: 3.25 ± 0.044
0.531PheCys: 0.531 ± 0.019
2.315PheAsp: 2.315 ± 0.043
2.299PheGlu: 2.299 ± 0.035
1.637PhePhe: 1.637 ± 0.031
2.926PheGly: 2.926 ± 0.046
0.75PheHis: 0.75 ± 0.023
2.028PheIle: 2.028 ± 0.043
1.361PheLys: 1.361 ± 0.026
3.889PheLeu: 3.889 ± 0.06
0.691PheMet: 0.691 ± 0.02
1.406PheAsn: 1.406 ± 0.031
1.742PhePro: 1.742 ± 0.036
1.746PheGln: 1.746 ± 0.034
1.89PheArg: 1.89 ± 0.032
2.994PheSer: 2.994 ± 0.05
2.111PheThr: 2.111 ± 0.04
2.404PheVal: 2.404 ± 0.041
0.672PheTrp: 0.672 ± 0.026
1.189PheTyr: 1.189 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
5.467GlyAla: 5.467 ± 0.073
0.89GlyCys: 0.89 ± 0.025
3.765GlyAsp: 3.765 ± 0.075
3.823GlyGlu: 3.823 ± 0.06
3.13GlyPhe: 3.13 ± 0.058
5.152GlyGly: 5.152 ± 0.108
1.563GlyHis: 1.563 ± 0.037
4.47GlyIle: 4.47 ± 0.057
3.066GlyLys: 3.066 ± 0.044
7.777GlyLeu: 7.777 ± 0.083
1.578GlyMet: 1.578 ± 0.033
2.532GlyAsn: 2.532 ± 0.071
2.162GlyPro: 2.162 ± 0.04
3.863GlyGln: 3.863 ± 0.054
3.654GlyArg: 3.654 ± 0.045
4.471GlySer: 4.471 ± 0.063
4.035GlyThr: 4.035 ± 0.063
4.768GlyVal: 4.768 ± 0.059
1.161GlyTrp: 1.161 ± 0.03
2.237GlyTyr: 2.237 ± 0.037
0.0GlyXaa: 0.0 ± 0.0
His
1.369HisAla: 1.369 ± 0.032
0.334HisCys: 0.334 ± 0.017
0.937HisAsp: 0.937 ± 0.026
0.978HisGlu: 0.978 ± 0.025
0.853HisPhe: 0.853 ± 0.023
1.245HisGly: 1.245 ± 0.031
0.721HisHis: 0.721 ± 0.024
1.039HisIle: 1.039 ± 0.024
0.605HisLys: 0.605 ± 0.021
2.65HisLeu: 2.65 ± 0.05
0.316HisMet: 0.316 ± 0.016
0.683HisAsn: 0.683 ± 0.023
1.496HisPro: 1.496 ± 0.032
1.487HisGln: 1.487 ± 0.035
1.436HisArg: 1.436 ± 0.038
1.296HisSer: 1.296 ± 0.027
0.949HisThr: 0.949 ± 0.025
1.027HisVal: 1.027 ± 0.028
0.436HisTrp: 0.436 ± 0.016
0.706HisTyr: 0.706 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.399IleAla: 6.399 ± 0.072
0.706IleCys: 0.706 ± 0.023
3.509IleAsp: 3.509 ± 0.049
3.958IleGlu: 3.958 ± 0.053
2.128IlePhe: 2.128 ± 0.037
4.126IleGly: 4.126 ± 0.052
1.232IleHis: 1.232 ± 0.03
2.606IleIle: 2.606 ± 0.048
2.13IleLys: 2.13 ± 0.039
5.839IleLeu: 5.839 ± 0.053
0.839IleMet: 0.839 ± 0.02
2.098IleAsn: 2.098 ± 0.038
3.092IlePro: 3.092 ± 0.04
2.891IleGln: 2.891 ± 0.039
2.842IleArg: 2.842 ± 0.047
3.969IleSer: 3.969 ± 0.053
3.12IleThr: 3.12 ± 0.048
3.758IleVal: 3.758 ± 0.04
0.7IleTrp: 0.7 ± 0.022
1.608IleTyr: 1.608 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
3.922LysAla: 3.922 ± 0.054
0.22LysCys: 0.22 ± 0.012
1.828LysAsp: 1.828 ± 0.034
2.122LysGlu: 2.122 ± 0.04
1.322LysPhe: 1.322 ± 0.032
2.437LysGly: 2.437 ± 0.037
0.742LysHis: 0.742 ± 0.023
2.401LysIle: 2.401 ± 0.04
1.731LysLys: 1.731 ± 0.04
4.184LysLeu: 4.184 ± 0.053
0.745LysMet: 0.745 ± 0.023
1.324LysAsn: 1.324 ± 0.03
2.084LysPro: 2.084 ± 0.042
2.324LysGln: 2.324 ± 0.045
2.3LysArg: 2.3 ± 0.04
2.398LysSer: 2.398 ± 0.038
2.515LysThr: 2.515 ± 0.046
2.767LysVal: 2.767 ± 0.041
0.391LysTrp: 0.391 ± 0.017
0.936LysTyr: 0.936 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
10.171LeuAla: 10.171 ± 0.094
1.148LeuCys: 1.148 ± 0.029
5.859LeuAsp: 5.859 ± 0.067
7.447LeuGlu: 7.447 ± 0.075
3.875LeuPhe: 3.875 ± 0.058
8.107LeuGly: 8.107 ± 0.077
2.035LeuHis: 2.035 ± 0.036
5.975LeuIle: 5.975 ± 0.058
5.141LeuLys: 5.141 ± 0.068
12.01LeuLeu: 12.01 ± 0.123
2.447LeuMet: 2.447 ± 0.039
4.072LeuAsn: 4.072 ± 0.049
5.775LeuPro: 5.775 ± 0.065
6.428LeuGln: 6.428 ± 0.075
6.085LeuArg: 6.085 ± 0.063
8.303LeuSer: 8.303 ± 0.084
6.705LeuThr: 6.705 ± 0.065
7.17LeuVal: 7.17 ± 0.071
1.571LeuTrp: 1.571 ± 0.039
2.662LeuTyr: 2.662 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.029MetAla: 2.029 ± 0.035
0.127MetCys: 0.127 ± 0.008
0.876MetAsp: 0.876 ± 0.026
0.983MetGlu: 0.983 ± 0.026
0.557MetPhe: 0.557 ± 0.018
1.649MetGly: 1.649 ± 0.035
0.367MetHis: 0.367 ± 0.016
1.111MetIle: 1.111 ± 0.026
0.841MetLys: 0.841 ± 0.026
2.134MetLeu: 2.134 ± 0.04
0.491MetMet: 0.491 ± 0.02
0.76MetAsn: 0.76 ± 0.02
1.121MetPro: 1.121 ± 0.026
1.056MetGln: 1.056 ± 0.025
1.023MetArg: 1.023 ± 0.028
1.367MetSer: 1.367 ± 0.031
1.419MetThr: 1.419 ± 0.026
1.432MetVal: 1.432 ± 0.029
0.16MetTrp: 0.16 ± 0.009
0.304MetTyr: 0.304 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.795AsnAla: 2.795 ± 0.047
0.378AsnCys: 0.378 ± 0.015
1.7AsnAsp: 1.7 ± 0.058
1.477AsnGlu: 1.477 ± 0.032
1.352AsnPhe: 1.352 ± 0.033
2.427AsnGly: 2.427 ± 0.075
0.77AsnHis: 0.77 ± 0.021
2.011AsnIle: 2.011 ± 0.036
1.023AsnLys: 1.023 ± 0.023
4.268AsnLeu: 4.268 ± 0.069
0.525AsnMet: 0.525 ± 0.02
1.207AsnAsn: 1.207 ± 0.032
2.373AsnPro: 2.373 ± 0.041
2.082AsnGln: 2.082 ± 0.037
2.153AsnArg: 2.153 ± 0.04
2.107AsnSer: 2.107 ± 0.04
1.742AsnThr: 1.742 ± 0.037
2.024AsnVal: 2.024 ± 0.037
0.577AsnTrp: 0.577 ± 0.019
0.966AsnTyr: 0.966 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
4.139ProAla: 4.139 ± 0.058
0.398ProCys: 0.398 ± 0.015
3.151ProAsp: 3.151 ± 0.048
4.215ProGlu: 4.215 ± 0.054
1.815ProPhe: 1.815 ± 0.031
3.129ProGly: 3.129 ± 0.052
1.021ProHis: 1.021 ± 0.023
2.796ProIle: 2.796 ± 0.036
2.048ProLys: 2.048 ± 0.037
5.141ProLeu: 5.141 ± 0.062
0.956ProMet: 0.956 ± 0.023
1.824ProAsn: 1.824 ± 0.034
2.431ProPro: 2.431 ± 0.05
2.912ProGln: 2.912 ± 0.045
2.085ProArg: 2.085 ± 0.036
3.42ProSer: 3.42 ± 0.048
2.967ProThr: 2.967 ± 0.045
3.486ProVal: 3.486 ± 0.046
0.659ProTrp: 0.659 ± 0.02
1.273ProTyr: 1.273 ± 0.031
0.001ProXaa: 0.001 ± 0.001
Gln
6.063GlnAla: 6.063 ± 0.079
0.431GlnCys: 0.431 ± 0.017
2.67GlnAsp: 2.67 ± 0.044
3.322GlnGlu: 3.322 ± 0.053
1.889GlnPhe: 1.889 ± 0.032
3.88GlnGly: 3.88 ± 0.053
1.144GlnHis: 1.144 ± 0.032
3.362GlnIle: 3.362 ± 0.055
2.349GlnLys: 2.349 ± 0.045
6.571GlnLeu: 6.571 ± 0.086
1.187GlnMet: 1.187 ± 0.025
1.809GlnAsn: 1.809 ± 0.035
3.151GlnPro: 3.151 ± 0.05
4.55GlnGln: 4.55 ± 0.093
3.568GlnArg: 3.568 ± 0.057
3.674GlnSer: 3.674 ± 0.052
3.498GlnThr: 3.498 ± 0.043
4.341GlnVal: 4.341 ± 0.056
0.881GlnTrp: 0.881 ± 0.026
1.343GlnTyr: 1.343 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
3.908ArgAla: 3.908 ± 0.051
0.618ArgCys: 0.618 ± 0.021
2.771ArgAsp: 2.771 ± 0.036
3.035ArgGlu: 3.035 ± 0.046
2.312ArgPhe: 2.312 ± 0.039
3.172ArgGly: 3.172 ± 0.048
1.172ArgHis: 1.172 ± 0.03
3.159ArgIle: 3.159 ± 0.043
2.118ArgLys: 2.118 ± 0.037
6.431ArgLeu: 6.431 ± 0.069
1.166ArgMet: 1.166 ± 0.025
1.863ArgAsn: 1.863 ± 0.035
2.477ArgPro: 2.477 ± 0.043
3.79ArgGln: 3.79 ± 0.056
3.427ArgArg: 3.427 ± 0.064
3.925ArgSer: 3.925 ± 0.055
2.728ArgThr: 2.728 ± 0.039
3.492ArgVal: 3.492 ± 0.052
0.98ArgTrp: 0.98 ± 0.026
1.802ArgTyr: 1.802 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
5.485SerAla: 5.485 ± 0.062
0.636SerCys: 0.636 ± 0.021
3.54SerAsp: 3.54 ± 0.056
3.96SerGlu: 3.96 ± 0.059
2.574SerPhe: 2.574 ± 0.043
5.082SerGly: 5.082 ± 0.079
1.41SerHis: 1.41 ± 0.03
3.547SerIle: 3.547 ± 0.053
2.399SerLys: 2.399 ± 0.046
7.657SerLeu: 7.657 ± 0.071
1.448SerMet: 1.448 ± 0.029
2.234SerAsn: 2.234 ± 0.042
3.632SerPro: 3.632 ± 0.045
3.865SerGln: 3.865 ± 0.049
3.385SerArg: 3.385 ± 0.045
4.783SerSer: 4.783 ± 0.079
3.623SerThr: 3.623 ± 0.047
4.366SerVal: 4.366 ± 0.059
0.902SerTrp: 0.902 ± 0.025
1.685SerTyr: 1.685 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.499ThrAla: 5.499 ± 0.059
0.526ThrCys: 0.526 ± 0.018
2.955ThrAsp: 2.955 ± 0.045
3.331ThrGlu: 3.331 ± 0.039
2.248ThrPhe: 2.248 ± 0.035
4.254ThrGly: 4.254 ± 0.051
1.233ThrHis: 1.233 ± 0.029
3.06ThrIle: 3.06 ± 0.042
1.748ThrLys: 1.748 ± 0.034
7.092ThrLeu: 7.092 ± 0.068
0.93ThrMet: 0.93 ± 0.027
1.64ThrAsn: 1.64 ± 0.035
3.251ThrPro: 3.251 ± 0.052
3.22ThrGln: 3.22 ± 0.047
2.416ThrArg: 2.416 ± 0.036
3.34ThrSer: 3.34 ± 0.054
3.259ThrThr: 3.259 ± 0.05
4.398ThrVal: 4.398 ± 0.056
0.698ThrTrp: 0.698 ± 0.02
1.625ThrTyr: 1.625 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
6.44ValAla: 6.44 ± 0.07
0.694ValCys: 0.694 ± 0.021
3.655ValAsp: 3.655 ± 0.054
4.408ValGlu: 4.408 ± 0.056
2.477ValPhe: 2.477 ± 0.043
4.834ValGly: 4.834 ± 0.073
1.16ValHis: 1.16 ± 0.026
4.047ValIle: 4.047 ± 0.059
2.694ValLys: 2.694 ± 0.04
7.337ValLeu: 7.337 ± 0.069
1.508ValMet: 1.508 ± 0.027
2.389ValAsn: 2.389 ± 0.042
3.167ValPro: 3.167 ± 0.046
3.284ValGln: 3.284 ± 0.044
3.297ValArg: 3.297 ± 0.05
4.475ValSer: 4.475 ± 0.054
3.991ValThr: 3.991 ± 0.053
5.041ValVal: 5.041 ± 0.071
0.853ValTrp: 0.853 ± 0.025
1.689ValTyr: 1.689 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
0.981TrpAla: 0.981 ± 0.027
0.145TrpCys: 0.145 ± 0.009
0.633TrpAsp: 0.633 ± 0.023
0.724TrpGlu: 0.724 ± 0.022
0.596TrpPhe: 0.596 ± 0.02
1.008TrpGly: 1.008 ± 0.024
0.37TrpHis: 0.37 ± 0.017
0.821TrpIle: 0.821 ± 0.025
0.547TrpLys: 0.547 ± 0.017
1.933TrpLeu: 1.933 ± 0.045
0.372TrpMet: 0.372 ± 0.015
0.457TrpAsn: 0.457 ± 0.019
0.518TrpPro: 0.518 ± 0.018
1.167TrpGln: 1.167 ± 0.029
0.881TrpArg: 0.881 ± 0.022
0.933TrpSer: 0.933 ± 0.027
0.708TrpThr: 0.708 ± 0.021
1.002TrpVal: 1.002 ± 0.028
0.251TrpTrp: 0.251 ± 0.015
0.333TrpTyr: 0.333 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.058TyrAla: 2.058 ± 0.039
0.383TyrCys: 0.383 ± 0.016
1.39TyrAsp: 1.39 ± 0.027
1.509TyrGlu: 1.509 ± 0.032
1.181TyrPhe: 1.181 ± 0.025
1.955TyrGly: 1.955 ± 0.036
0.57TyrHis: 0.57 ± 0.021
1.326TyrIle: 1.326 ± 0.03
0.835TyrLys: 0.835 ± 0.024
3.224TyrLeu: 3.224 ± 0.049
0.399TyrMet: 0.399 ± 0.016
0.773TyrAsn: 0.773 ± 0.02
1.481TyrPro: 1.481 ± 0.027
1.7TyrGln: 1.7 ± 0.037
2.148TyrArg: 2.148 ± 0.044
1.746TyrSer: 1.746 ± 0.031
1.433TyrThr: 1.433 ± 0.03
1.537TyrVal: 1.537 ± 0.031
0.484TyrTrp: 0.484 ± 0.019
0.785TyrTyr: 0.785 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.001XaaGln: 0.001 ± 0.001
0.001XaaArg: 0.001 ± 0.001
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.003
Statistics based on 5409 proteins (1670264 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski