Amino acid dipepetide frequency for Erysipelotrichaceae bacterium 5_2_54FAA

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.436AlaAla: 5.436 ± 0.102	1.269AlaCys: 1.269 ± 0.041	3.895AlaAsp: 3.895 ± 0.076	3.853AlaGlu: 3.853 ± 0.08	3.449AlaPhe: 3.449 ± 0.065	4.366AlaGly: 4.366 ± 0.094	1.639AlaHis: 1.639 ± 0.041	6.228AlaIle: 6.228 ± 0.082	5.682AlaLys: 5.682 ± 0.084	7.557AlaLeu: 7.557 ± 0.103	2.627AlaMet: 2.627 ± 0.06	3.184AlaAsn: 3.184 ± 0.059	1.649AlaPro: 1.649 ± 0.048	2.82AlaGln: 2.82 ± 0.07	2.488AlaArg: 2.488 ± 0.057	4.06AlaSer: 4.06 ± 0.065	3.511AlaThr: 3.511 ± 0.092	4.452AlaVal: 4.452 ± 0.079	0.564AlaTrp: 0.564 ± 0.028	3.494AlaTyr: 3.494 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	1.073CysAla: 1.073 ± 0.035	0.266CysCys: 0.266 ± 0.017	0.989CysAsp: 0.989 ± 0.04	1.021CysGlu: 1.021 ± 0.037	0.722CysPhe: 0.722 ± 0.028	1.231CysGly: 1.231 ± 0.044	0.378CysHis: 0.378 ± 0.023	1.228CysIle: 1.228 ± 0.038	0.901CysLys: 0.901 ± 0.038	1.2CysLeu: 1.2 ± 0.038	0.555CysMet: 0.555 ± 0.027	0.561CysAsn: 0.561 ± 0.028	0.537CysPro: 0.537 ± 0.031	0.405CysGln: 0.405 ± 0.022	0.525CysArg: 0.525 ± 0.028	0.89CysSer: 0.89 ± 0.037	0.656CysThr: 0.656 ± 0.028	1.025CysVal: 1.025 ± 0.035	0.109CysTrp: 0.109 ± 0.01	0.621CysTyr: 0.621 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.643AspAla: 4.643 ± 0.076	0.735AspCys: 0.735 ± 0.027	3.321AspAsp: 3.321 ± 0.085	4.957AspGlu: 4.957 ± 0.082	2.577AspPhe: 2.577 ± 0.058	4.192AspGly: 4.192 ± 0.08	1.219AspHis: 1.219 ± 0.038	4.869AspIle: 4.869 ± 0.071	4.003AspLys: 4.003 ± 0.074	4.593AspLeu: 4.593 ± 0.072	1.951AspMet: 1.951 ± 0.048	2.186AspAsn: 2.186 ± 0.054	1.641AspPro: 1.641 ± 0.04	1.372AspGln: 1.372 ± 0.044	1.823AspArg: 1.823 ± 0.049	2.756AspSer: 2.756 ± 0.067	3.283AspThr: 3.283 ± 0.076	4.33AspVal: 4.33 ± 0.072	0.522AspTrp: 0.522 ± 0.024	2.598AspTyr: 2.598 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	4.791GluAla: 4.791 ± 0.084	0.757GluCys: 0.757 ± 0.031	4.401GluAsp: 4.401 ± 0.076	6.623GluGlu: 6.623 ± 0.109	2.153GluPhe: 2.153 ± 0.06	3.721GluGly: 3.721 ± 0.076	1.726GluHis: 1.726 ± 0.052	5.389GluIle: 5.389 ± 0.08	6.405GluLys: 6.405 ± 0.103	6.09GluLeu: 6.09 ± 0.087	2.274GluMet: 2.274 ± 0.053	3.715GluAsn: 3.715 ± 0.088	1.59GluPro: 1.59 ± 0.038	3.072GluGln: 3.072 ± 0.073	3.034GluArg: 3.034 ± 0.075	2.809GluSer: 2.809 ± 0.057	3.919GluThr: 3.919 ± 0.078	4.555GluVal: 4.555 ± 0.072	0.555GluTrp: 0.555 ± 0.023	2.689GluTyr: 2.689 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	3.282PheAla: 3.282 ± 0.072	0.628PheCys: 0.628 ± 0.026	2.704PheAsp: 2.704 ± 0.058	2.405PheGlu: 2.405 ± 0.06	1.803PhePhe: 1.803 ± 0.049	2.605PheGly: 2.605 ± 0.065	1.287PheHis: 1.287 ± 0.038	3.122PheIle: 3.122 ± 0.071	2.141PheLys: 2.141 ± 0.058	4.376PheLeu: 4.376 ± 0.097	1.326PheMet: 1.326 ± 0.04	1.514PheAsn: 1.514 ± 0.041	1.266PhePro: 1.266 ± 0.033	1.633PheGln: 1.633 ± 0.041	1.281PheArg: 1.281 ± 0.039	2.649PheSer: 2.649 ± 0.058	2.784PheThr: 2.784 ± 0.067	2.75PheVal: 2.75 ± 0.056	0.342PheTrp: 0.342 ± 0.019	1.843PheTyr: 1.843 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.003GlyAla: 4.003 ± 0.083	1.159GlyCys: 1.159 ± 0.048	3.002GlyAsp: 3.002 ± 0.064	3.576GlyGlu: 3.576 ± 0.068	2.805GlyPhe: 2.805 ± 0.058	3.781GlyGly: 3.781 ± 0.102	1.153GlyHis: 1.153 ± 0.038	5.657GlyIle: 5.657 ± 0.083	5.262GlyLys: 5.262 ± 0.092	4.811GlyLeu: 4.811 ± 0.093	2.185GlyMet: 2.185 ± 0.059	3.068GlyAsn: 3.068 ± 0.064	1.091GlyPro: 1.091 ± 0.045	1.559GlyGln: 1.559 ± 0.042	2.174GlyArg: 2.174 ± 0.055	3.635GlySer: 3.635 ± 0.082	3.532GlyThr: 3.532 ± 0.1	4.214GlyVal: 4.214 ± 0.078	0.635GlyTrp: 0.635 ± 0.029	3.259GlyTyr: 3.259 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	1.816HisAla: 1.816 ± 0.044	0.344HisCys: 0.344 ± 0.021	1.374HisAsp: 1.374 ± 0.045	1.595HisGlu: 1.595 ± 0.044	1.025HisPhe: 1.025 ± 0.035	1.55HisGly: 1.55 ± 0.046	0.774HisHis: 0.774 ± 0.041	1.922HisIle: 1.922 ± 0.05	1.489HisLys: 1.489 ± 0.041	2.047HisLeu: 2.047 ± 0.056	0.826HisMet: 0.826 ± 0.032	0.857HisAsn: 0.857 ± 0.029	1.09HisPro: 1.09 ± 0.037	0.841HisGln: 0.841 ± 0.039	0.922HisArg: 0.922 ± 0.033	1.134HisSer: 1.134 ± 0.033	1.291HisThr: 1.291 ± 0.041	1.655HisVal: 1.655 ± 0.051	0.18HisTrp: 0.18 ± 0.014	0.99HisTyr: 0.99 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.545IleAla: 6.545 ± 0.109	1.289IleCys: 1.289 ± 0.038	4.295IleAsp: 4.295 ± 0.079	5.059IleGlu: 5.059 ± 0.076	3.031IlePhe: 3.031 ± 0.061	4.938IleGly: 4.938 ± 0.089	1.878IleHis: 1.878 ± 0.05	5.475IleIle: 5.475 ± 0.104	4.907IleLys: 4.907 ± 0.084	7.461IleLeu: 7.461 ± 0.111	2.113IleMet: 2.113 ± 0.048	3.06IleAsn: 3.06 ± 0.079	2.888IlePro: 2.888 ± 0.063	3.139IleGln: 3.139 ± 0.059	3.26IleArg: 3.26 ± 0.076	4.947IleSer: 4.947 ± 0.082	4.808IleThr: 4.808 ± 0.077	5.173IleVal: 5.173 ± 0.084	0.555IleTrp: 0.555 ± 0.025	2.86IleTyr: 2.86 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	5.854LysAla: 5.854 ± 0.097	0.64LysCys: 0.64 ± 0.03	5.301LysAsp: 5.301 ± 0.094	7.82LysGlu: 7.82 ± 0.108	1.838LysPhe: 1.838 ± 0.05	4.493LysGly: 4.493 ± 0.072	1.553LysHis: 1.553 ± 0.047	4.818LysIle: 4.818 ± 0.086	6.912LysLys: 6.912 ± 0.106	5.953LysLeu: 5.953 ± 0.083	2.328LysMet: 2.328 ± 0.051	3.524LysAsn: 3.524 ± 0.077	2.13LysPro: 2.13 ± 0.064	4.0LysGln: 4.0 ± 0.082	3.385LysArg: 3.385 ± 0.066	3.274LysSer: 3.274 ± 0.064	4.466LysThr: 4.466 ± 0.088	4.617LysVal: 4.617 ± 0.085	0.553LysTrp: 0.553 ± 0.025	2.507LysTyr: 2.507 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	6.725LeuAla: 6.725 ± 0.093	1.794LeuCys: 1.794 ± 0.05	5.143LeuAsp: 5.143 ± 0.077	5.595LeuGlu: 5.595 ± 0.096	4.159LeuPhe: 4.159 ± 0.079	5.136LeuGly: 5.136 ± 0.092	2.661LeuHis: 2.661 ± 0.066	6.348LeuIle: 6.348 ± 0.097	6.861LeuLys: 6.861 ± 0.099	10.042LeuLeu: 10.042 ± 0.164	2.845LeuMet: 2.845 ± 0.058	3.741LeuAsn: 3.741 ± 0.064	3.687LeuPro: 3.687 ± 0.07	4.592LeuGln: 4.592 ± 0.089	3.814LeuArg: 3.814 ± 0.078	6.229LeuSer: 6.229 ± 0.096	4.732LeuThr: 4.732 ± 0.072	4.816LeuVal: 4.816 ± 0.084	0.779LeuTrp: 0.779 ± 0.033	3.97LeuTyr: 3.97 ± 0.078	0.0LeuXaa: 0.0 ± 0.0
Met	2.179MetAla: 2.179 ± 0.049	0.332MetCys: 0.332 ± 0.019	1.897MetAsp: 1.897 ± 0.045	2.666MetGlu: 2.666 ± 0.066	1.109MetPhe: 1.109 ± 0.035	1.721MetGly: 1.721 ± 0.053	0.657MetHis: 0.657 ± 0.025	2.358MetIle: 2.358 ± 0.051	3.21MetLys: 3.21 ± 0.068	3.036MetLeu: 3.036 ± 0.064	1.202MetMet: 1.202 ± 0.043	1.659MetAsn: 1.659 ± 0.045	1.049MetPro: 1.049 ± 0.039	1.65MetGln: 1.65 ± 0.05	1.276MetArg: 1.276 ± 0.038	1.772MetSer: 1.772 ± 0.051	1.423MetThr: 1.423 ± 0.04	1.834MetVal: 1.834 ± 0.038	0.189MetTrp: 0.189 ± 0.014	1.036MetTyr: 1.036 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	3.492AsnAla: 3.492 ± 0.068	0.585AsnCys: 0.585 ± 0.029	2.631AsnAsp: 2.631 ± 0.068	3.207AsnGlu: 3.207 ± 0.075	1.599AsnPhe: 1.599 ± 0.043	3.338AsnGly: 3.338 ± 0.079	1.034AsnHis: 1.034 ± 0.035	3.463AsnIle: 3.463 ± 0.073	3.085AsnLys: 3.085 ± 0.067	3.461AsnLeu: 3.461 ± 0.063	1.317AsnMet: 1.317 ± 0.032	1.837AsnAsn: 1.837 ± 0.056	1.66AsnPro: 1.66 ± 0.053	1.57AsnGln: 1.57 ± 0.046	1.819AsnArg: 1.819 ± 0.046	2.16AsnSer: 2.16 ± 0.059	2.517AsnThr: 2.517 ± 0.065	3.006AsnVal: 3.006 ± 0.064	0.377AsnTrp: 0.377 ± 0.02	1.877AsnTyr: 1.877 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	1.906ProAla: 1.906 ± 0.048	0.433ProCys: 0.433 ± 0.024	1.724ProAsp: 1.724 ± 0.06	1.943ProGlu: 1.943 ± 0.056	1.614ProPhe: 1.614 ± 0.045	1.47ProGly: 1.47 ± 0.044	0.721ProHis: 0.721 ± 0.031	2.589ProIle: 2.589 ± 0.05	2.17ProLys: 2.17 ± 0.05	2.888ProLeu: 2.888 ± 0.058	0.913ProMet: 0.913 ± 0.033	1.48ProAsn: 1.48 ± 0.047	0.581ProPro: 0.581 ± 0.028	1.157ProGln: 1.157 ± 0.044	0.891ProArg: 0.891 ± 0.03	1.911ProSer: 1.911 ± 0.05	1.743ProThr: 1.743 ± 0.05	2.062ProVal: 2.062 ± 0.048	0.298ProTrp: 0.298 ± 0.022	1.663ProTyr: 1.663 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	2.82GlnAla: 2.82 ± 0.067	0.482GlnCys: 0.482 ± 0.023	2.209GlnAsp: 2.209 ± 0.055	3.319GlnGlu: 3.319 ± 0.067	1.421GlnPhe: 1.421 ± 0.042	2.202GlnGly: 2.202 ± 0.059	0.984GlnHis: 0.984 ± 0.034	2.799GlnIle: 2.799 ± 0.059	3.595GlnLys: 3.595 ± 0.071	3.986GlnLeu: 3.986 ± 0.082	1.289GlnMet: 1.289 ± 0.041	1.66GlnAsn: 1.66 ± 0.043	1.178GlnPro: 1.178 ± 0.04	2.183GlnGln: 2.183 ± 0.074	1.767GlnArg: 1.767 ± 0.051	1.899GlnSer: 1.899 ± 0.049	1.91GlnThr: 1.91 ± 0.048	2.275GlnVal: 2.275 ± 0.048	0.376GlnTrp: 0.376 ± 0.021	1.67GlnTyr: 1.67 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	2.09ArgAla: 2.09 ± 0.053	0.597ArgCys: 0.597 ± 0.03	1.788ArgAsp: 1.788 ± 0.05	2.58ArgGlu: 2.58 ± 0.059	1.83ArgPhe: 1.83 ± 0.047	1.82ArgGly: 1.82 ± 0.048	0.877ArgHis: 0.877 ± 0.035	3.489ArgIle: 3.489 ± 0.064	3.585ArgLys: 3.585 ± 0.077	3.632ArgLeu: 3.632 ± 0.065	1.466ArgMet: 1.466 ± 0.044	2.041ArgAsn: 2.041 ± 0.055	0.983ArgPro: 0.983 ± 0.036	1.488ArgGln: 1.488 ± 0.043	1.71ArgArg: 1.71 ± 0.051	2.113ArgSer: 2.113 ± 0.048	1.736ArgThr: 1.736 ± 0.043	2.304ArgVal: 2.304 ± 0.05	0.346ArgTrp: 0.346 ± 0.021	2.093ArgTyr: 2.093 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	3.76SerAla: 3.76 ± 0.068	0.911SerCys: 0.911 ± 0.032	3.286SerAsp: 3.286 ± 0.06	3.428SerGlu: 3.428 ± 0.062	2.948SerPhe: 2.948 ± 0.065	3.874SerGly: 3.874 ± 0.078	1.115SerHis: 1.115 ± 0.039	4.579SerIle: 4.579 ± 0.082	3.557SerLys: 3.557 ± 0.072	5.307SerLeu: 5.307 ± 0.09	1.892SerMet: 1.892 ± 0.048	2.449SerAsn: 2.449 ± 0.063	1.402SerPro: 1.402 ± 0.036	1.76SerGln: 1.76 ± 0.051	1.93SerArg: 1.93 ± 0.048	3.442SerSer: 3.442 ± 0.074	2.773SerThr: 2.773 ± 0.064	3.845SerVal: 3.845 ± 0.083	0.514SerTrp: 0.514 ± 0.027	2.91SerTyr: 2.91 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	3.771ThrAla: 3.771 ± 0.079	0.806ThrCys: 0.806 ± 0.031	2.485ThrAsp: 2.485 ± 0.073	2.43ThrGlu: 2.43 ± 0.071	2.529ThrPhe: 2.529 ± 0.068	3.472ThrGly: 3.472 ± 0.12	1.206ThrHis: 1.206 ± 0.038	4.905ThrIle: 4.905 ± 0.101	3.842ThrLys: 3.842 ± 0.09	5.807ThrLeu: 5.807 ± 0.078	1.808ThrMet: 1.808 ± 0.048	2.36ThrAsn: 2.36 ± 0.073	2.159ThrPro: 2.159 ± 0.059	1.95ThrGln: 1.95 ± 0.046	1.848ThrArg: 1.848 ± 0.047	3.53ThrSer: 3.53 ± 0.087	3.238ThrThr: 3.238 ± 0.092	3.281ThrVal: 3.281 ± 0.075	0.528ThrTrp: 0.528 ± 0.024	2.748ThrTyr: 2.748 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	4.307ValAla: 4.307 ± 0.071	1.114ValCys: 1.114 ± 0.037	3.676ValAsp: 3.676 ± 0.067	4.268ValGlu: 4.268 ± 0.068	2.885ValPhe: 2.885 ± 0.06	3.352ValGly: 3.352 ± 0.073	1.329ValHis: 1.329 ± 0.04	4.963ValIle: 4.963 ± 0.077	5.152ValLys: 5.152 ± 0.096	6.336ValLeu: 6.336 ± 0.091	1.934ValMet: 1.934 ± 0.046	3.065ValAsn: 3.065 ± 0.064	1.842ValPro: 1.842 ± 0.048	2.141ValGln: 2.141 ± 0.048	2.237ValArg: 2.237 ± 0.056	4.045ValSer: 4.045 ± 0.069	3.565ValThr: 3.565 ± 0.089	4.197ValVal: 4.197 ± 0.073	0.537ValTrp: 0.537 ± 0.025	2.753ValTyr: 2.753 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.43TrpAla: 0.43 ± 0.024	0.154TrpCys: 0.154 ± 0.016	0.485TrpAsp: 0.485 ± 0.027	0.588TrpGlu: 0.588 ± 0.029	0.378TrpPhe: 0.378 ± 0.021	0.472TrpGly: 0.472 ± 0.029	0.197TrpHis: 0.197 ± 0.013	0.67TrpIle: 0.67 ± 0.029	0.808TrpLys: 0.808 ± 0.031	0.873TrpLeu: 0.873 ± 0.027	0.3TrpMet: 0.3 ± 0.018	0.47TrpAsn: 0.47 ± 0.025	0.159TrpPro: 0.159 ± 0.014	0.442TrpGln: 0.442 ± 0.021	0.323TrpArg: 0.323 ± 0.019	0.399TrpSer: 0.399 ± 0.023	0.346TrpThr: 0.346 ± 0.021	0.445TrpVal: 0.445 ± 0.024	0.098TrpTrp: 0.098 ± 0.011	0.401TrpTyr: 0.401 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.301TyrAla: 3.301 ± 0.075	0.599TyrCys: 0.599 ± 0.03	2.967TyrAsp: 2.967 ± 0.066	3.337TyrGlu: 3.337 ± 0.057	1.863TyrPhe: 1.863 ± 0.055	2.825TyrGly: 2.825 ± 0.057	1.333TyrHis: 1.333 ± 0.043	2.81TyrIle: 2.81 ± 0.06	2.4TyrLys: 2.4 ± 0.066	4.214TyrLeu: 4.214 ± 0.076	1.104TyrMet: 1.104 ± 0.034	1.602TyrAsn: 1.602 ± 0.049	1.576TyrPro: 1.576 ± 0.042	2.252TyrGln: 2.252 ± 0.063	2.062TyrArg: 2.062 ± 0.057	2.027TyrSer: 2.027 ± 0.048	2.471TyrThr: 2.471 ± 0.059	2.861TyrVal: 2.861 ± 0.063	0.382TyrTrp: 0.382 ± 0.023	2.154TyrTyr: 2.154 ± 0.063	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2871 proteins (916794 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---