Amino acid dipepetide frequency for Legionella adelaidensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.437AlaAla: 6.437 ± 0.136	1.022AlaCys: 1.022 ± 0.039	3.255AlaAsp: 3.255 ± 0.069	4.721AlaGlu: 4.721 ± 0.098	3.309AlaPhe: 3.309 ± 0.073	4.983AlaGly: 4.983 ± 0.121	1.763AlaHis: 1.763 ± 0.05	6.45AlaIle: 6.45 ± 0.103	5.01AlaLys: 5.01 ± 0.091	8.95AlaLeu: 8.95 ± 0.133	2.012AlaMet: 2.012 ± 0.059	3.444AlaAsn: 3.444 ± 0.073	2.698AlaPro: 2.698 ± 0.077	3.349AlaGln: 3.349 ± 0.086	3.433AlaArg: 3.433 ± 0.072	4.684AlaSer: 4.684 ± 0.084	4.026AlaThr: 4.026 ± 0.07	4.698AlaVal: 4.698 ± 0.084	0.783AlaTrp: 0.783 ± 0.032	2.517AlaTyr: 2.517 ± 0.054	0.003AlaXaa: 0.003 ± 0.002
Cys	0.799CysAla: 0.799 ± 0.035	0.162CysCys: 0.162 ± 0.017	0.529CysAsp: 0.529 ± 0.03	0.641CysGlu: 0.641 ± 0.031	0.669CysPhe: 0.669 ± 0.03	0.861CysGly: 0.861 ± 0.037	0.338CysHis: 0.338 ± 0.026	0.801CysIle: 0.801 ± 0.037	0.618CysLys: 0.618 ± 0.032	1.18CysLeu: 1.18 ± 0.041	0.248CysMet: 0.248 ± 0.021	0.478CysAsn: 0.478 ± 0.025	0.521CysPro: 0.521 ± 0.029	0.478CysGln: 0.478 ± 0.025	0.441CysArg: 0.441 ± 0.026	0.795CysSer: 0.795 ± 0.036	0.528CysThr: 0.528 ± 0.025	0.655CysVal: 0.655 ± 0.031	0.145CysTrp: 0.145 ± 0.016	0.412CysTyr: 0.412 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	3.379AspAla: 3.379 ± 0.083	0.563AspCys: 0.563 ± 0.028	1.986AspAsp: 1.986 ± 0.057	3.23AspGlu: 3.23 ± 0.085	2.425AspPhe: 2.425 ± 0.056	2.363AspGly: 2.363 ± 0.072	0.974AspHis: 0.974 ± 0.039	3.596AspIle: 3.596 ± 0.072	3.294AspLys: 3.294 ± 0.08	5.075AspLeu: 5.075 ± 0.091	0.961AspMet: 0.961 ± 0.044	2.05AspAsn: 2.05 ± 0.057	1.862AspPro: 1.862 ± 0.048	1.521AspGln: 1.521 ± 0.053	1.813AspArg: 1.813 ± 0.047	2.692AspSer: 2.692 ± 0.064	2.252AspThr: 2.252 ± 0.055	2.721AspVal: 2.721 ± 0.079	0.591AspTrp: 0.591 ± 0.03	1.869AspTyr: 1.869 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	4.813GluAla: 4.813 ± 0.099	0.574GluCys: 0.574 ± 0.027	2.843GluAsp: 2.843 ± 0.064	5.178GluGlu: 5.178 ± 0.125	2.476GluPhe: 2.476 ± 0.062	3.526GluGly: 3.526 ± 0.071	1.35GluHis: 1.35 ± 0.045	5.076GluIle: 5.076 ± 0.106	5.678GluLys: 5.678 ± 0.108	6.546GluLeu: 6.546 ± 0.115	1.621GluMet: 1.621 ± 0.054	3.425GluAsn: 3.425 ± 0.073	1.982GluPro: 1.982 ± 0.059	3.118GluGln: 3.118 ± 0.079	2.994GluArg: 2.994 ± 0.07	3.244GluSer: 3.244 ± 0.061	3.039GluThr: 3.039 ± 0.068	4.058GluVal: 4.058 ± 0.081	0.634GluTrp: 0.634 ± 0.03	1.921GluTyr: 1.921 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.48PheAla: 3.48 ± 0.07	0.597PheCys: 0.597 ± 0.027	2.304PheAsp: 2.304 ± 0.063	2.405PheGlu: 2.405 ± 0.058	2.671PhePhe: 2.671 ± 0.084	2.687PheGly: 2.687 ± 0.076	1.061PheHis: 1.061 ± 0.036	3.884PheIle: 3.884 ± 0.105	2.478PheLys: 2.478 ± 0.062	5.356PheLeu: 5.356 ± 0.114	0.843PheMet: 0.843 ± 0.033	2.369PheAsn: 2.369 ± 0.062	1.962PhePro: 1.962 ± 0.052	1.649PheGln: 1.649 ± 0.054	1.616PheArg: 1.616 ± 0.047	3.777PheSer: 3.777 ± 0.077	2.655PheThr: 2.655 ± 0.067	2.486PheVal: 2.486 ± 0.061	0.574PheTrp: 0.574 ± 0.036	1.723PheTyr: 1.723 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	4.294GlyAla: 4.294 ± 0.079	0.819GlyCys: 0.819 ± 0.036	2.655GlyAsp: 2.655 ± 0.066	3.636GlyGlu: 3.636 ± 0.079	3.226GlyPhe: 3.226 ± 0.077	4.198GlyGly: 4.198 ± 0.178	1.465GlyHis: 1.465 ± 0.047	5.083GlyIle: 5.083 ± 0.095	4.18GlyLys: 4.18 ± 0.087	6.444GlyLeu: 6.444 ± 0.107	1.699GlyMet: 1.699 ± 0.052	2.577GlyAsn: 2.577 ± 0.069	1.766GlyPro: 1.766 ± 0.053	2.258GlyGln: 2.258 ± 0.067	2.476GlyArg: 2.476 ± 0.062	3.673GlySer: 3.673 ± 0.079	3.149GlyThr: 3.149 ± 0.086	4.373GlyVal: 4.373 ± 0.096	0.843GlyTrp: 0.843 ± 0.04	2.319GlyTyr: 2.319 ± 0.063	0.001GlyXaa: 0.001 ± 0.001
His	1.837HisAla: 1.837 ± 0.05	0.391HisCys: 0.391 ± 0.022	0.923HisAsp: 0.923 ± 0.038	1.263HisGlu: 1.263 ± 0.04	1.358HisPhe: 1.358 ± 0.043	1.432HisGly: 1.432 ± 0.053	0.753HisHis: 0.753 ± 0.036	1.558HisIle: 1.558 ± 0.046	1.145HisLys: 1.145 ± 0.041	2.695HisLeu: 2.695 ± 0.064	0.487HisMet: 0.487 ± 0.023	0.912HisAsn: 0.912 ± 0.037	1.292HisPro: 1.292 ± 0.044	1.095HisGln: 1.095 ± 0.043	1.09HisArg: 1.09 ± 0.036	1.497HisSer: 1.497 ± 0.045	1.16HisThr: 1.16 ± 0.039	1.28HisVal: 1.28 ± 0.042	0.384HisTrp: 0.384 ± 0.023	0.986HisTyr: 0.986 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	6.639IleAla: 6.639 ± 0.106	0.84IleCys: 0.84 ± 0.037	3.842IleAsp: 3.842 ± 0.079	5.032IleGlu: 5.032 ± 0.103	3.185IlePhe: 3.185 ± 0.083	4.663IleGly: 4.663 ± 0.101	1.841IleHis: 1.841 ± 0.054	5.515IleIle: 5.515 ± 0.108	4.824IleLys: 4.824 ± 0.087	7.376IleLeu: 7.376 ± 0.14	1.323IleMet: 1.323 ± 0.045	4.081IleAsn: 4.081 ± 0.081	3.613IlePro: 3.613 ± 0.072	2.869IleGln: 2.869 ± 0.067	3.16IleArg: 3.16 ± 0.066	5.051IleSer: 5.051 ± 0.079	4.33IleThr: 4.33 ± 0.092	4.309IleVal: 4.309 ± 0.088	0.591IleTrp: 0.591 ± 0.032	2.267IleTyr: 2.267 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	4.856LysAla: 4.856 ± 0.08	0.423LysCys: 0.423 ± 0.025	3.182LysAsp: 3.182 ± 0.065	5.327LysGlu: 5.327 ± 0.095	1.809LysPhe: 1.809 ± 0.052	3.582LysGly: 3.582 ± 0.078	1.333LysHis: 1.333 ± 0.048	4.989LysIle: 4.989 ± 0.096	5.386LysLys: 5.386 ± 0.105	6.044LysLeu: 6.044 ± 0.085	1.567LysMet: 1.567 ± 0.047	3.932LysAsn: 3.932 ± 0.096	2.805LysPro: 2.805 ± 0.066	3.033LysGln: 3.033 ± 0.064	3.033LysArg: 3.033 ± 0.075	3.54LysSer: 3.54 ± 0.073	3.493LysThr: 3.493 ± 0.067	3.71LysVal: 3.71 ± 0.079	0.564LysTrp: 0.564 ± 0.028	1.76LysTyr: 1.76 ± 0.055	0.003LysXaa: 0.003 ± 0.003
Leu	8.944LeuAla: 8.944 ± 0.139	1.352LeuCys: 1.352 ± 0.048	4.735LeuAsp: 4.735 ± 0.091	6.337LeuGlu: 6.337 ± 0.126	5.26LeuPhe: 5.26 ± 0.101	6.565LeuGly: 6.565 ± 0.108	2.521LeuHis: 2.521 ± 0.061	7.86LeuIle: 7.86 ± 0.136	6.796LeuLys: 6.796 ± 0.118	12.313LeuLeu: 12.313 ± 0.184	2.352LeuMet: 2.352 ± 0.059	5.368LeuAsn: 5.368 ± 0.096	5.17LeuPro: 5.17 ± 0.092	4.833LeuGln: 4.833 ± 0.098	4.752LeuArg: 4.752 ± 0.083	7.904LeuSer: 7.904 ± 0.108	5.862LeuThr: 5.862 ± 0.088	6.216LeuVal: 6.216 ± 0.103	1.04LeuTrp: 1.04 ± 0.043	3.184LeuTyr: 3.184 ± 0.072	0.003LeuXaa: 0.003 ± 0.002
Met	1.951MetAla: 1.951 ± 0.062	0.187MetCys: 0.187 ± 0.016	1.079MetAsp: 1.079 ± 0.037	1.358MetGlu: 1.358 ± 0.044	0.695MetPhe: 0.695 ± 0.033	1.529MetGly: 1.529 ± 0.052	0.557MetHis: 0.557 ± 0.029	1.389MetIle: 1.389 ± 0.042	1.531MetLys: 1.531 ± 0.044	2.283MetLeu: 2.283 ± 0.057	0.664MetMet: 0.664 ± 0.036	1.04MetAsn: 1.04 ± 0.039	1.125MetPro: 1.125 ± 0.046	1.182MetGln: 1.182 ± 0.046	1.173MetArg: 1.173 ± 0.045	1.423MetSer: 1.423 ± 0.047	1.182MetThr: 1.182 ± 0.038	1.574MetVal: 1.574 ± 0.053	0.169MetTrp: 0.169 ± 0.015	0.533MetTyr: 0.533 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.61AsnAla: 3.61 ± 0.085	0.514AsnCys: 0.514 ± 0.028	2.146AsnAsp: 2.146 ± 0.058	3.036AsnGlu: 3.036 ± 0.071	2.16AsnPhe: 2.16 ± 0.054	2.606AsnGly: 2.606 ± 0.07	1.139AsnHis: 1.139 ± 0.043	3.39AsnIle: 3.39 ± 0.078	3.23AsnLys: 3.23 ± 0.075	4.973AsnLeu: 4.973 ± 0.088	0.914AsnMet: 0.914 ± 0.035	2.597AsnAsn: 2.597 ± 0.08	2.642AsnPro: 2.642 ± 0.067	2.395AsnGln: 2.395 ± 0.067	2.057AsnArg: 2.057 ± 0.054	2.905AsnSer: 2.905 ± 0.074	2.677AsnThr: 2.677 ± 0.064	2.486AsnVal: 2.486 ± 0.065	0.6AsnTrp: 0.6 ± 0.032	1.811AsnTyr: 1.811 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	3.079ProAla: 3.079 ± 0.076	0.44ProCys: 0.44 ± 0.025	2.081ProAsp: 2.081 ± 0.063	3.2ProGlu: 3.2 ± 0.077	2.074ProPhe: 2.074 ± 0.067	2.738ProGly: 2.738 ± 0.061	1.079ProHis: 1.079 ± 0.042	2.983ProIle: 2.983 ± 0.059	2.262ProLys: 2.262 ± 0.054	4.727ProLeu: 4.727 ± 0.076	0.925ProMet: 0.925 ± 0.037	1.682ProAsn: 1.682 ± 0.045	1.858ProPro: 1.858 ± 0.083	1.997ProGln: 1.997 ± 0.059	1.543ProArg: 1.543 ± 0.045	2.759ProSer: 2.759 ± 0.079	2.259ProThr: 2.259 ± 0.055	3.012ProVal: 3.012 ± 0.075	0.519ProTrp: 0.519 ± 0.029	1.494ProTyr: 1.494 ± 0.042	0.004ProXaa: 0.004 ± 0.002
Gln	3.741GlnAla: 3.741 ± 0.079	0.393GlnCys: 0.393 ± 0.024	1.723GlnAsp: 1.723 ± 0.054	3.022GlnGlu: 3.022 ± 0.076	1.948GlnPhe: 1.948 ± 0.049	2.583GlnGly: 2.583 ± 0.068	1.04GlnHis: 1.04 ± 0.038	3.035GlnIle: 3.035 ± 0.061	2.994GlnLys: 2.994 ± 0.074	4.883GlnLeu: 4.883 ± 0.107	1.028GlnMet: 1.028 ± 0.035	2.042GlnAsn: 2.042 ± 0.05	1.536GlnPro: 1.536 ± 0.05	2.46GlnGln: 2.46 ± 0.08	2.001GlnArg: 2.001 ± 0.06	2.437GlnSer: 2.437 ± 0.061	2.223GlnThr: 2.223 ± 0.051	2.657GlnVal: 2.657 ± 0.067	0.586GlnTrp: 0.586 ± 0.029	1.451GlnTyr: 1.451 ± 0.051	0.001GlnXaa: 0.001 ± 0.001
Arg	3.043ArgAla: 3.043 ± 0.067	0.446ArgCys: 0.446 ± 0.026	2.018ArgAsp: 2.018 ± 0.053	3.117ArgGlu: 3.117 ± 0.075	2.331ArgPhe: 2.331 ± 0.058	2.383ArgGly: 2.383 ± 0.058	1.042ArgHis: 1.042 ± 0.042	3.237ArgIle: 3.237 ± 0.058	2.76ArgLys: 2.76 ± 0.067	4.854ArgLeu: 4.854 ± 0.094	1.109ArgMet: 1.109 ± 0.046	1.944ArgAsn: 1.944 ± 0.048	1.538ArgPro: 1.538 ± 0.049	1.911ArgGln: 1.911 ± 0.05	2.064ArgArg: 2.064 ± 0.063	2.409ArgSer: 2.409 ± 0.062	2.019ArgThr: 2.019 ± 0.05	2.753ArgVal: 2.753 ± 0.073	0.531ArgTrp: 0.531 ± 0.031	1.687ArgTyr: 1.687 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	4.526SerAla: 4.526 ± 0.085	0.712SerCys: 0.712 ± 0.03	2.691SerAsp: 2.691 ± 0.069	3.628SerGlu: 3.628 ± 0.079	3.198SerPhe: 3.198 ± 0.081	4.106SerGly: 4.106 ± 0.084	1.565SerHis: 1.565 ± 0.048	4.72SerIle: 4.72 ± 0.088	3.526SerLys: 3.526 ± 0.073	7.863SerLeu: 7.863 ± 0.119	1.515SerMet: 1.515 ± 0.055	2.802SerAsn: 2.802 ± 0.073	2.96SerPro: 2.96 ± 0.068	2.693SerGln: 2.693 ± 0.069	2.602SerArg: 2.602 ± 0.058	4.461SerSer: 4.461 ± 0.104	3.294SerThr: 3.294 ± 0.087	3.664SerVal: 3.664 ± 0.068	0.734SerTrp: 0.734 ± 0.03	2.173SerTyr: 2.173 ± 0.051	0.001SerXaa: 0.001 ± 0.001
Thr	4.199ThrAla: 4.199 ± 0.076	0.55ThrCys: 0.55 ± 0.032	2.16ThrAsp: 2.16 ± 0.056	2.753ThrGlu: 2.753 ± 0.063	2.368ThrPhe: 2.368 ± 0.053	3.588ThrGly: 3.588 ± 0.078	1.397ThrHis: 1.397 ± 0.042	4.071ThrIle: 4.071 ± 0.082	2.606ThrLys: 2.606 ± 0.065	6.189ThrLeu: 6.189 ± 0.106	1.053ThrMet: 1.053 ± 0.045	2.262ThrAsn: 2.262 ± 0.065	2.904ThrPro: 2.904 ± 0.073	2.32ThrGln: 2.32 ± 0.056	2.258ThrArg: 2.258 ± 0.055	3.171ThrSer: 3.171 ± 0.07	3.0ThrThr: 3.0 ± 0.089	3.372ThrVal: 3.372 ± 0.072	0.581ThrTrp: 0.581 ± 0.027	1.738ThrTyr: 1.738 ± 0.049	0.003ThrXaa: 0.003 ± 0.002
Val	4.83ValAla: 4.83 ± 0.098	0.669ValCys: 0.669 ± 0.031	3.146ValAsp: 3.146 ± 0.077	3.741ValGlu: 3.741 ± 0.081	2.873ValPhe: 2.873 ± 0.069	3.936ValGly: 3.936 ± 0.093	1.185ValHis: 1.185 ± 0.038	4.838ValIle: 4.838 ± 0.095	3.696ValLys: 3.696 ± 0.071	6.253ValLeu: 6.253 ± 0.112	1.433ValMet: 1.433 ± 0.045	3.093ValAsn: 3.093 ± 0.068	2.546ValPro: 2.546 ± 0.067	2.049ValGln: 2.049 ± 0.055	2.478ValArg: 2.478 ± 0.063	4.124ValSer: 4.124 ± 0.074	3.22ValThr: 3.22 ± 0.074	4.199ValVal: 4.199 ± 0.099	0.616ValTrp: 0.616 ± 0.031	1.817ValTyr: 1.817 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.692TrpAla: 0.692 ± 0.034	0.131TrpCys: 0.131 ± 0.014	0.496TrpAsp: 0.496 ± 0.027	0.667TrpGlu: 0.667 ± 0.034	0.603TrpPhe: 0.603 ± 0.036	0.68TrpGly: 0.68 ± 0.033	0.277TrpHis: 0.277 ± 0.02	0.758TrpIle: 0.758 ± 0.04	0.511TrpLys: 0.511 ± 0.031	1.486TrpLeu: 1.486 ± 0.054	0.267TrpMet: 0.267 ± 0.019	0.471TrpAsn: 0.471 ± 0.028	0.44TrpPro: 0.44 ± 0.026	0.677TrpGln: 0.677 ± 0.035	0.553TrpArg: 0.553 ± 0.033	0.649TrpSer: 0.649 ± 0.035	0.469TrpThr: 0.469 ± 0.03	0.787TrpVal: 0.787 ± 0.038	0.166TrpTrp: 0.166 ± 0.016	0.386TrpTyr: 0.386 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.393TyrAla: 2.393 ± 0.057	0.514TyrCys: 0.514 ± 0.026	1.421TyrAsp: 1.421 ± 0.049	1.801TyrGlu: 1.801 ± 0.055	1.939TyrPhe: 1.939 ± 0.06	2.122TyrGly: 2.122 ± 0.057	0.861TyrHis: 0.861 ± 0.036	2.118TyrIle: 2.118 ± 0.061	1.848TyrLys: 1.848 ± 0.048	3.877TyrLeu: 3.877 ± 0.077	0.599TyrMet: 0.599 ± 0.031	1.318TyrAsn: 1.318 ± 0.047	1.499TyrPro: 1.499 ± 0.049	1.898TyrGln: 1.898 ± 0.054	1.657TyrArg: 1.657 ± 0.051	2.235TyrSer: 2.235 ± 0.058	1.7TyrThr: 1.7 ± 0.055	1.731TyrVal: 1.731 ± 0.045	0.517TyrTrp: 0.517 ± 0.03	1.294TyrTyr: 1.294 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.003	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.003XaaMet: 0.003 ± 0.002	0.003XaaAsn: 0.003 ± 0.002	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.003XaaSer: 0.003 ± 0.002	0.004XaaThr: 0.004 ± 0.002	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.053XaaXaa: 0.053 ± 0.021

Statistics based on 2194 proteins (718026 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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